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Article

Distribution of fibroblast growth factors and their roles in skin fibroblast cell migration

  • Authors:
    • Yong Huan Song
    • Yu Ting Zhu
    • Jian Ding
    • Fei Ya Zhou
    • Ji Xin Xue
    • Jin Hee Jung
    • Zhi Jie Li
    • Wei Yang Gao
  • View Affiliations / Copyright

    Affiliations: Department of Hand and Plastic Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China, The Key Zhejiang Province Laboratory of Biomedicine, School of Pharmaceutical Science, Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China, Molecular Evolution Team, Department of Biotechnology R&D, Amicogen, Inc., Jinju, South Gyeongsang 660701, Republic of Korea
  • Pages: 3336-3342
    |
    Published online on: August 19, 2016
       https://doi.org/10.3892/mmr.2016.5646
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Abstract

Fibroblast growth factor (FGF)2/basic FGF is a member of the fibroblast growth factor family. Its function in skin wound healing has been well-characterized. However, the function of other FGFs in skin tissues remains to be elucidated. In the present study, FGF expression patterns in heart, liver, skin and kidney tissues were analyzed. Notably, in contrast to other tissues, only four FGFs, FGF2, 7, 10 and 21, were dominant in the skin. To examine FGF function in the wound healing process, mouse NIH3T3 fibroblast cells were treated with FGF2, FGF10 and FGF21, and cell migration was monitored. The results revealed that FGF treatment promoted cell migration, which is an important step in wound healing. In addition, FGF treatment enhanced the activity of c-Jun N-terminal kinase (JNK), a key regulator of fibroblast cell migration. To analyze its role in cell migration, FGF7 was overexpressed in fibroblast cells via a lentivirus system; however, this did not change cell migration speed. FGF2, 7, 10 and 21 were highly expressed in skin tissue, and all except FGF7 regulated fibroblast cell migration and activated JNK. The results of the present study increase our understanding of the role of FGFs in skin wound healing.
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1 

Mohammadi M, Olsen SK and Ibrahimi OA: Structural basis for fibroblast growth factor receptor activation. Cytokine Growth Factor Rev. 16:107–137. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Feldman B, Poueymirou W, Papaioannou VE, DeChiara TM and Goldfarb M: Requirement of FGF-4 for postimplantation mouse development. Science. 267:246–249. 1995. View Article : Google Scholar : PubMed/NCBI

3 

Dubrulle J and Pourquié O: fgf8 mRNA decay establishes a gradient that couples axial elongation to patterning in the vertebrate embryo. Nature. 427:419–422. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Sun X, Meyers EN, Lewandoski M and Martin GR: Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo. Genes Dev. 13:1834–1846. 1999. View Article : Google Scholar : PubMed/NCBI

5 

Martin GR: The roles of FGFs in the early development of vertebrate limbs. Genes Dev. 12:1571–1586. 1998. View Article : Google Scholar : PubMed/NCBI

6 

Goldfarb M: Functions of fibroblast growth factors in vertebrate development. Cytokine Growth Factor Rev. 7:311–325. 1996. View Article : Google Scholar : PubMed/NCBI

7 

Kanazawa S, Fujiwara T, Matsuzaki S, Shingaki K, Taniguchi M, Miyata S, Tohyama M, Sakai Y, Yano K, Hosokawa K and Kubo T: bFGF regulates PI3-kinase-Rac1-JNK pathway and promotes fibroblast migration in wound healing. PloS One. 5:e122282010. View Article : Google Scholar : PubMed/NCBI

8 

Nishimura T, Nakatake Y, Konishi M and Itoh N: Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim Biophys Acta. 1492:203–206. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Liang Q, Zhong L, Zhang J, Wang Y, Bornstein SR, Triggle CR, Ding H, Lam KS and Xu A: FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting. Diabetes. 63:4064–4075. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Lin Z, Tian H, Lam KS, Lin S, Hoo RC, Konishi M, Itoh N, Wang Y, Bornstein SR, Xu A and Li X: Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metab. 17:779–789. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Lin Z, Wu F, Lin S, Pan X, Jin L, Lu T, Shi L, Wang Y, Xu A and Li X: Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice. J Hepatol. 61:825–831. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Yie J, Wang W, Deng L, Tam LT, Stevens J, Chen MM, Li Y, Xu J, Lindberg R, Hecht R, et al: Understanding the physical interactions in the FGF21/FGFR/beta-Klotho complex: structural requirements and implications in FGF21 signaling. Chem Biol Drug Des. 79:398–410. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Belov AA and Mohammadi M: Molecular mechanisms of fibroblast growth factor signaling in physiology and pathology. Cold Spring Harb Perspect Biol. 5:pii: a015958. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, van Dijk TH, et al: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature. 513:436–439. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Brem H and Tomic-Canic M: Cellular and molecular basis of wound healing in diabetes. J Clin Invest. 117:1219–1222. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Xuan YH, Huang BB, Tian HS, Chi LS, Duan YM, Wang X, Zhu ZX, Cai WH, Zhu YT, Wei TM, et al: High-glucose inhibits human fibroblast cell migration in wound healing via repression of bFGF-regulating JNK phosphorylation. PloS One. 9:e1081822014. View Article : Google Scholar : PubMed/NCBI

17 

Zittermann SI and Issekutz AC: Basic fibroblast growth factor (bFGF, FGF-2) potentiates leukocyte recruitment to inflammation by enhancing endothelial adhesion molecule expression. Am J Pathol. 168:835–846. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using realtime quantitative PCR and the 2ΔΔCt method. Methods. 25:402–408. 2001. View Article : Google Scholar

19 

Saitou N and Nei M: The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol. 4:406–425. 1987.PubMed/NCBI

20 

Iyer VR, Eisen MB, Ross DT, Schuler G, Moore T, Lee JC, Trent JM, Staudt LM, Hudson J Jr, Boguski MS, et al: The transcriptional program in the response of human fibroblasts to serum. Science. 283:83–87. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Martin P: Wound healing - aiming for perfect skin regeneration. Science. 276:75–81. 1997. View Article : Google Scholar : PubMed/NCBI

22 

Cao C, Sun Y, Healey S, Bi Z, Hu G, Wan S, Kouttab N, Chu W and Wan Y: EGFR-mediated expression of aquaporin-3 is involved in human skin fibroblast migration. Biochem J. 400:225–234. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Iino M, Ehama R, Nakazawa Y, Iwabuchi T, Ogo M, Tajima M and Arase S: Adenosine stimulates fibroblast growth factor-7 gene expression via adenosine A2b receptor signaling in dermal papilla cells. J Invest Dermatol. 127:1318–1325. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Song YH, Zhu YT, Ding J, Zhou FY, Xue JX, Jung JH, Li ZJ and Gao WY: Distribution of fibroblast growth factors and their roles in skin fibroblast cell migration. Mol Med Rep 14: 3336-3342, 2016.
APA
Song, Y.H., Zhu, Y.T., Ding, J., Zhou, F.Y., Xue, J.X., Jung, J.H. ... Gao, W.Y. (2016). Distribution of fibroblast growth factors and their roles in skin fibroblast cell migration. Molecular Medicine Reports, 14, 3336-3342. https://doi.org/10.3892/mmr.2016.5646
MLA
Song, Y. H., Zhu, Y. T., Ding, J., Zhou, F. Y., Xue, J. X., Jung, J. H., Li, Z. J., Gao, W. Y."Distribution of fibroblast growth factors and their roles in skin fibroblast cell migration". Molecular Medicine Reports 14.4 (2016): 3336-3342.
Chicago
Song, Y. H., Zhu, Y. T., Ding, J., Zhou, F. Y., Xue, J. X., Jung, J. H., Li, Z. J., Gao, W. Y."Distribution of fibroblast growth factors and their roles in skin fibroblast cell migration". Molecular Medicine Reports 14, no. 4 (2016): 3336-3342. https://doi.org/10.3892/mmr.2016.5646
Copy and paste a formatted citation
x
Spandidos Publications style
Song YH, Zhu YT, Ding J, Zhou FY, Xue JX, Jung JH, Li ZJ and Gao WY: Distribution of fibroblast growth factors and their roles in skin fibroblast cell migration. Mol Med Rep 14: 3336-3342, 2016.
APA
Song, Y.H., Zhu, Y.T., Ding, J., Zhou, F.Y., Xue, J.X., Jung, J.H. ... Gao, W.Y. (2016). Distribution of fibroblast growth factors and their roles in skin fibroblast cell migration. Molecular Medicine Reports, 14, 3336-3342. https://doi.org/10.3892/mmr.2016.5646
MLA
Song, Y. H., Zhu, Y. T., Ding, J., Zhou, F. Y., Xue, J. X., Jung, J. H., Li, Z. J., Gao, W. Y."Distribution of fibroblast growth factors and their roles in skin fibroblast cell migration". Molecular Medicine Reports 14.4 (2016): 3336-3342.
Chicago
Song, Y. H., Zhu, Y. T., Ding, J., Zhou, F. Y., Xue, J. X., Jung, J. H., Li, Z. J., Gao, W. Y."Distribution of fibroblast growth factors and their roles in skin fibroblast cell migration". Molecular Medicine Reports 14, no. 4 (2016): 3336-3342. https://doi.org/10.3892/mmr.2016.5646
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