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Article Open Access

Anti-wrinkle effects of Sargassum muticum ethyl acetate fraction on ultraviolet B-irradiated hairless mouse skin and mechanistic evaluation in the human HaCaT keratinocyte cell line

  • Authors:
    • Jae Hyoung Song
    • Mei Jing Piao
    • Xia Han
    • Kyoung Ah Kang
    • Hee Kyoung Kang
    • Weon Jong Yoon
    • Mi Hee Ko
    • Nam Ho Lee
    • Mi Young Lee
    • Sungwook Chae
    • Jin Won Hyun
  • View Affiliations / Copyright

    Affiliations: KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea, School of Medicine, Jeju National University, Jeju 63243, Republic of Korea, Jeju Biodiversity Research Institute, Jeju High‑Tech Development Institute, Jeju 63612, Republic of Korea, Department of Chemistry, College of Natural Sciences, Jeju National University, Jeju 63243, Republic of Korea
    Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2937-2944
    |
    Published online on: August 19, 2016
       https://doi.org/10.3892/mmr.2016.5655
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Abstract

The present study investigated the photoprotective properties of the ethyl acetate fraction of Sargassum muticum (SME) against ultraviolet B (UVB)‑induced skin damage and photoaging in a mouse model. HR‑1 strain hairless male mice were divided into three groups: An untreated control group, a UVB‑irradiated vehicle group and a UVB‑irradiated SME group. The UVB‑irradiated mice in the SME group were orally administered with SME (100 mg/kg body weight in 0.1 ml water per day) and then exposed to radiation at a dose of 60‑120 mJ/cm2. Wrinkle formation and skin damage were evaluated by analysis of skin replicas, epidermal thickness and collagen fiber integrity in the dermal connective tissue. The mechanism underlying the action of SME was also investigated in the human HaCaT keratinocyte cell line following exposure of the cells to UVB at a dose of 30 mJ/cm2. The protein expression levels and activity of matrix metalloproteinase‑1 (MMP‑1), and the binding of activator protein‑1 (AP‑1) to the MMP‑1 promoter were assessed in the HaCaT cells using western blot analysis, an MMP‑1 fluorescent assay and a chromatin immune‑precipitation assay, respectively. The results showed that the mean length and depth of the wrinkles in the UVB‑exposed hairless mice were significantly improved by oral administration of SME, which also prevented the increase in epidermal thickness triggered by UVB irradiation. Furthermore, a marked increase in collagen bundle formation was observed in the UVB‑treated mice with SME administration. SME pretreatment also significantly inhibited the UVB‑induced upregulation in the expression and activity of MMP‑1 in the cultured HaCaT keratinocytes, and the UVB‑enhanced association of AP‑1 with the MMP‑1 promoter. These results suggested that SME may be useful as an anti-photoaging resource for the skin.
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1 

Avila Acevedo JG, Espinosa González AM, De Maria y Campos DM, Benitez Flores Jdel C, Hernandez Delgado T, Flores Maya S, Campos Contreras J, Muñoz López JL and García Bores AM: Photoprotection of Buddleja cordata extract against UVB-induced skin damage in SKH-1 hairless mice. BMC Complement Altern Med. 14:2812014. View Article : Google Scholar : PubMed/NCBI

2 

Hwang E, Park SY, Lee HJ, Lee TY, Sun ZW and Yi TH: Gallic acid regulates skin photoaging in UVB-exposed fibroblast and hairless mice. Phytother Res. 28:1778–1788. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Kim JE, Song D, Kim J, Choi J, Kim JR, Yoon HS, Bae JS, Han M, Lee S, Hong JS, et al: Oral supplementation with cocoa extract reduces UVB-induced wrinkles in hairless mouse skin. J Invest Dermatol. 136:1012–1021. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Petrova A, Davids LM, Rautenbach F and Marnewick JL: Photoprotection by honeybush extracts, hesperidin and mangiferin against UVB-induced skin damage in SKH-1 mice. J Photochem Photobiol B. 103:126–139. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Mittal A, Elmets CA and Katiyar SK: Dietary feeding of proanthocyanidin from grape seeds prevents photocarcinogenesis in SKH-1 hariless mice: Relationship to decreased fat and lid peroxidation. Carcinogenesis. 24:1379–1388. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Vayalil PK, Mittal A, Hara Y, Elmets CA and Katiyar SK: Green tea polyphenols prevent ultraviolet light-induced oxidative damage and matrix metalloproteinases expression in mouse skin. J Invest Dermatol. 122:1480–1487. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Yasui H, Hakozaki T, Date A, Yoshii T and Sakurai H: Real-time chemiluminescent imaging and detection of reactive oxygen species generated in the UVB-exposed human skin equivalent model. Biochem Biophys Res Commun. 347:83–88. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Morena M, Delbosc S, Dupuy AM, Canaud B and Cristol JP: Overproduction of reactive oxygen species in end-stage renal disease patients: A potential component of hemodialysis-associated inflammation. Hemodial Int. 9:37–46. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Pashkow FJ: Oxidative sress and inflammation in heart disease: Do antioxidants have a role in treatment and/or prevention? Int J Inflam. 2011:5146232011. View Article : Google Scholar

10 

Zhang N, Andresen BT and Zhang C: Inflammation and reactive oxygen species in cardiovascular disease. World J Cardiol. 2:408–410. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Hong YF, Lee HY, Jung BJ, Jang S, Chung DK and Kim H: Lipoteichoic acid isolated from Lactobacillus plantarum down-regulates UV-induced MMP-1 expression and up-regulates type I procollagen through the inhibition of reactive oxygen species generation. Mol Immunol. 67:248–255. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Chen L, Hu JY and Wang SQ: The role of antioxidants in photoprotection: A critical review. J Am Acad Dermatol. 67:1013–1024. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Kim JY, Lee JA, Kim KN, Yoon WJ, Lee WJ and Park SY: Antioxidative and antimicrobial activities of Sargassum muticum extracts. J Korean Soc Food Sci Nutr. 36:663–669. 2007. View Article : Google Scholar

14 

Yoon WJ, Ham YM, Lee WJ, Lee NH and Hyun CG: Brown alga Sargassum muticum inhibits proinflammatory cytokines, iNOS and COX-2 expression in macrophage RAW 264.7 cells. Turk J Biol. 34:25–34. 2010.

15 

Piao MJ, Yoon WJ, Kang HK, Yoo ES, Koh YS, Kim DS, Lee NH and Hyun JW: Protective effect of the ethyl acetate fraction of Sargassum muticum against ultraviolet B-irradiated damage in human keratinocytes. Int J Mol Sci. 12:8146–8160. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Gilchrest BA: A review of skin ageing and its medical therapy. Br J Dermatol. 135:867–875. 1996. View Article : Google Scholar : PubMed/NCBI

17 

Goffin L, Seguin-Estévez Q, Alvarez M, Reith W and Chizzolini C: Transcriptional regulation of matrix metalloproteinase-1 and collagen 1A2 explains the anti-fibrotic effect exerted by proteasome inhibition in human dermal fibroblasts. Arthritis Res Ther. 12:R732010. View Article : Google Scholar : PubMed/NCBI

18 

Sinha RP, Klisch M, Gröniger A and Häder DP: Ultraviolet-absorbing/screening substances in cyanobacteria, phytoplankton and macroalgae. J Photochem Photobiol B. 47:83–94. 1998. View Article : Google Scholar

19 

Pallela R, Na-Young Y and Kim SK: Anti-photoaging and photoprotective compounds derived from marine organisms. Mar Drugs. 8:1189–1202. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Thomas NV and Kim SK: Potential pharmacological applications of polyphenolic derivatives from marine brown algae. Environ Toxicol Pharmacol. 32:325–335. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Abdul QA, Choi RJ, Jung HA and Choi JS: Health benefit of fucosterol from marine algae: A review. J Sci Food Agric. 96:1856–1866. 2016. View Article : Google Scholar

22 

Fan X, Bai L, Zhu L, Yang L and Zhang X: Marine algae-derived bioactive peptides for human nutrition and health. J Agric Food Chem. 62:9211–9222. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Kim SK and Karagozlu MZ: Marine algae: natural product source for gastrointestinal cancer treatment. Adv Food Nutr Res. 64:225–233. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Torres MA, Barros MP, Campos SC, Pinto E, Rajamani S, Sayre RT and Colepicolo P: Biochemical biomarkers in algae and marine pollution: A review. Ecotoxicol Environ Saf. 71:1–15. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Jiménez-Escrig A, Jiménez-Jiménez I, Pulido R and Saura-Calixto F: Antioxidant activity of fresh and processed edible seaweeds. J Sci Food Agric. 81:530–534. 2001. View Article : Google Scholar

26 

Heo SJ, Ko SC, Cha SH, Kang DH, Park HS, Choi YU, Kim D, Jung WK and Jeon YJ: Effect of phlorotannins isolated from Ecklonia cava on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation. Toxicol In Vitro. 23:1123–1130. 2009. View Article : Google Scholar : PubMed/NCBI

27 

McLellan DS and Jurd KM: Anticoagulants from marine algae. Blood Coagul Fibrinolysis. 3:69–77. 1992. View Article : Google Scholar : PubMed/NCBI

28 

Henry BE and Alstyne KLV: Effects of UV radiation on growth and phlorotannins in Focus gardneri (phaeophyceae) juveniles and embryos. J Phycol. 40:527–533. 2004. View Article : Google Scholar

29 

Kang TH, Park HM, Kim YB, Kim H, Kim N, Do JH, Kang C, Cho Y and Kim SY: Effects of red ginseng extract on UVB irradiation-induced skin aging in hairless mice. J Ethnopharmacol. 123:446–451. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Ananthi S, Raghavendran HR, Sunil AG, Gayathri V, Ramakrishnan G and Vasanthi HR: In vitro antioxidant and in vivo anti-inflammatory potential of crude polysaccharide from Turbinaria ornata (Marine Brown Alga). Food Chem Toxicol. 48:187–192. 2010. View Article : Google Scholar

31 

Kondo S: The roles of cytokines in photoaging. J Dermatol Sci. 23(Suppl 1): S30–S36. 2000. View Article : Google Scholar : PubMed/NCBI

32 

Rittié L and Fisher GJ: UV-light-induced signal cascades and skin aging. Ageing Res. 1:705–720. 2002. View Article : Google Scholar

33 

Son ED, Choi GH, Kim H, Lee B, Chang IS and Hwang JS: Alpha-ketoglutarate stimulates procollagen production in cultured human dermal fibroblasts, and decreases UVB-induced wrinkle formation following topical application on the dorsal skin of hairless mice. Biol Pharm Bull. 30:1395–1399. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Ryoo IJ, Moon EY, Kim YH, Lee IS, Choo SJ, Bae KH and Yoo ID: Anti-Skin Aging effect of Syriacusins from Hibiscus syriacus on ultraviolet-irradiated human dermal fibroblast cells. Biomol Ther. 18:300–307. 2010. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Song JH, Piao MJ, Han X, Kang KA, Kang HK, Yoon WJ, Ko MH, Lee NH, Lee MY, Chae S, Chae S, et al: Anti-wrinkle effects of Sargassum muticum ethyl acetate fraction on ultraviolet B-irradiated hairless mouse skin and mechanistic evaluation in the human HaCaT keratinocyte cell line. Mol Med Rep 14: 2937-2944, 2016.
APA
Song, J.H., Piao, M.J., Han, X., Kang, K.A., Kang, H.K., Yoon, W.J. ... Hyun, J.W. (2016). Anti-wrinkle effects of Sargassum muticum ethyl acetate fraction on ultraviolet B-irradiated hairless mouse skin and mechanistic evaluation in the human HaCaT keratinocyte cell line. Molecular Medicine Reports, 14, 2937-2944. https://doi.org/10.3892/mmr.2016.5655
MLA
Song, J. H., Piao, M. J., Han, X., Kang, K. A., Kang, H. K., Yoon, W. J., Ko, M. H., Lee, N. H., Lee, M. Y., Chae, S., Hyun, J. W."Anti-wrinkle effects of Sargassum muticum ethyl acetate fraction on ultraviolet B-irradiated hairless mouse skin and mechanistic evaluation in the human HaCaT keratinocyte cell line". Molecular Medicine Reports 14.4 (2016): 2937-2944.
Chicago
Song, J. H., Piao, M. J., Han, X., Kang, K. A., Kang, H. K., Yoon, W. J., Ko, M. H., Lee, N. H., Lee, M. Y., Chae, S., Hyun, J. W."Anti-wrinkle effects of Sargassum muticum ethyl acetate fraction on ultraviolet B-irradiated hairless mouse skin and mechanistic evaluation in the human HaCaT keratinocyte cell line". Molecular Medicine Reports 14, no. 4 (2016): 2937-2944. https://doi.org/10.3892/mmr.2016.5655
Copy and paste a formatted citation
x
Spandidos Publications style
Song JH, Piao MJ, Han X, Kang KA, Kang HK, Yoon WJ, Ko MH, Lee NH, Lee MY, Chae S, Chae S, et al: Anti-wrinkle effects of Sargassum muticum ethyl acetate fraction on ultraviolet B-irradiated hairless mouse skin and mechanistic evaluation in the human HaCaT keratinocyte cell line. Mol Med Rep 14: 2937-2944, 2016.
APA
Song, J.H., Piao, M.J., Han, X., Kang, K.A., Kang, H.K., Yoon, W.J. ... Hyun, J.W. (2016). Anti-wrinkle effects of Sargassum muticum ethyl acetate fraction on ultraviolet B-irradiated hairless mouse skin and mechanistic evaluation in the human HaCaT keratinocyte cell line. Molecular Medicine Reports, 14, 2937-2944. https://doi.org/10.3892/mmr.2016.5655
MLA
Song, J. H., Piao, M. J., Han, X., Kang, K. A., Kang, H. K., Yoon, W. J., Ko, M. H., Lee, N. H., Lee, M. Y., Chae, S., Hyun, J. W."Anti-wrinkle effects of Sargassum muticum ethyl acetate fraction on ultraviolet B-irradiated hairless mouse skin and mechanistic evaluation in the human HaCaT keratinocyte cell line". Molecular Medicine Reports 14.4 (2016): 2937-2944.
Chicago
Song, J. H., Piao, M. J., Han, X., Kang, K. A., Kang, H. K., Yoon, W. J., Ko, M. H., Lee, N. H., Lee, M. Y., Chae, S., Hyun, J. W."Anti-wrinkle effects of Sargassum muticum ethyl acetate fraction on ultraviolet B-irradiated hairless mouse skin and mechanistic evaluation in the human HaCaT keratinocyte cell line". Molecular Medicine Reports 14, no. 4 (2016): 2937-2944. https://doi.org/10.3892/mmr.2016.5655
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