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Article

Possible tumor suppressive role of the miR-144/451 cluster in esophageal carcinoma as determined by principal component regression analysis

  • Authors:
    • Zhikui Gao
    • Ran Liu
    • Juan Liao
    • Miao Yang
    • Enchun Pan
    • Lihong Yin
    • Yuepu Pu
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu 210009, P.R. China, Huaian Center for Disease Control and Prevention, Huaian, Jiangsu 223001, P.R. China
  • Pages: 3805-3813
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    Published online on: August 30, 2016
       https://doi.org/10.3892/mmr.2016.5691
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Abstract

MicroRNA (miRNA) clusters are expressed universally across different types of organisms, and an accumulating number of studies have demonstrated that miRNA clusters function more efficiently compared with single miRNAs during the development of certain cancer types. miRNA clusters may have increased stability and reliability over individual miRNAs as diagnostic or therapeutic biomarkers. In the present study, the expression levels of mature miRNAs within the miR-144/451 cluster were examined using stem‑loop reverse transcription‑quantitative polymerase chain reaction in 102 patients pathologically diagnosed with esophageal carcinoma. Bioinformatics tools were used to identify a possible miRNA‑mediated network of the miR‑144/451 cluster. The expression levels of hsa‑miR‑451a, hsa‑miR‑144‑3p and hsa‑miR‑144‑5p in tumor tissues were significantly lower compared with those in adjacent non‑tumor tissues (P<0.05). Pearson correlation analysis demonstrated that the expression levels of individual miR‑144/451 cluster members were correlated with each other, except for the pair of hsa‑miR‑144‑3p and hsa‑miR‑4732‑3p. In particular, hsa‑miR‑144‑5p expression was highly associated with hsa-miR-4732‑5p and hsa-miR-451a expression levels, with correlation coefficients of 0.729 and 0.608, respectively. Furthermore, the low expression levels of hsa‑miR‑144‑3p [odds ratio (OR), 0.85; P<0.05] and hsa-miR-144-5p (OR, 0.84; P<0.05) were determined to be risk factors for esophageal carcinoma development. Kyoto Encyclopedia of Genes and Genomes pathway analysis demonstrated that miRNAs forming the miR‑144/451 cluster may cooperate to regulate the cell cycle. Therefore, the miR‑144/451 cluster may serve an important role in the progression of esophageal carcinoma and may be considered as a biomarker for the detection of esophageal carcinoma at an early stage.
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1 

Stewart W and Wild P: World Cancer Report 2014. IARC Press; Lyon, France: 2015

2 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Shadfan A, Hellebust A, Richards-Kortum R and Tkaczyk T: Confocal foveated endomicroscope for the detection of esophageal carcinoma. Biomed Opt Express. 6:2311–2324. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Wang S, Du Z, Luo J, Wang X, Li H, Liu Y, Zhang Y, Ma J, Xiao W, Wang Y and Zhong X: Inhibition of heat shock protein 90 suppresses squamous carcinogenic progression in a mouse model of esophageal cancer. J Cancer Res Clin Oncol. 141:1405–1416. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, Rougvie AE, Horvitz HR and Ruvkun G: The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature. 403:901–906. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Lagos-Quintana M, Rauhut R, Lendeckel W and Tuschl T: Identification of novel genes coding for small expressed RNAs. Science. 294:853–858. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Yue J and Tigyi G: Conservation of miR-15a/16-1 and miR-15b/16-2 clusters. Mamm Genome. 21:88–94. 2010. View Article : Google Scholar :

8 

Chan WC, Ho MR, Li SC, Tsai KW, Lai CH, Hsu CN and Lin WC: MetaMirClust: Discovery of miRNA cluster patterns using a data-mining approach. Genomics. 100:141–148. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Olive V, Li Q and He L: miR-17-92: A polycistronic oncomir with pleiotropic functions. Immunol Rev. 253:158–166. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Mohan S, Wergedal JE, Das S and Kesavan C: Conditional disruption of miR17-92 cluster in collagen type I-producing osteoblasts results in reduced periosteal bone formation and bone anabolic response to exercise. Physiol Genomics. 47:33–43. 2015. View Article : Google Scholar :

11 

Luo T, Cui S, Bian C and Yu X: Crosstalk between TGF-β/Smad3 and BMP/BMPR2 signaling pathways via miR-17-92 cluster in carotid artery restenosis. Mol Cell Biochem. 389:169–176. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Brockway S and Zeleznik-Le NJ: WEE1 is a validated target of the microRNA miR-17-92 cluster in leukemia. Cancer Genet. 208:279–287. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Bazot Q, Paschos K, Skalska L, Kalchschmidt JS, Parker GA and Allday MJ: Epsteinbarr virus proteins EBNA3A and EBNA3C together induce expression of the oncogenic MicroRNA cluster miR-221/miR-222 and ablate expression of its target p57KIP2. PLoS Pathog. 11:e10050312015. View Article : Google Scholar

14 

Zhu H, Han C, Lu D and Wu T: miR-17-92 cluster promotes cholangiocarcinoma growth: Evidence for PTEN as downstream target and IL-6/Stat3 as upstream activator. Am J Pathol. 184:2828–2839. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Besser J, Malan D, Wystub K, Bachmann A, Wietelmann A, Sasse P, Fleischmann BK, Braun T and Boettger T: MiRNA-1/133a clusters regulate adrenergic control of cardiac repolarization. PloS One. 9:e1134492014. View Article : Google Scholar : PubMed/NCBI

16 

Gits CM, van Kuijk PF, Jonkers MB, Boersma AW, Smid M, van Ijcken WF, Coindre JM, Chibon F, Verhoef C, Mathijssen RH, et al: MicroRNA expression profiles distinguish liposarcoma subtypes and implicate miR-145 and miR-451 as tumor suppressors. Int J Cancer. 135:348–361. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Li Y, Li W, Ying Z, Tian H, Zhu X, Li J and Li M: Metastatic heterogeneity of breast cancer cells is associated with expression of a heterogeneous TGFβ-activating miR424-503 gene cluster. Cancer Res. 74:6107–6118. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Wystub K, Besser J, Bachmann A, Boettger T and Braun T: miR-1/133a clusters cooperatively specify the cardiomyogenic lineage by adjustment of myocardin levels during embryonic heart development. PLoS Genet. 9:e10037932013. View Article : Google Scholar : PubMed/NCBI

19 

Yang M, Liu R, Sheng J, Liao J, Wang Y, Pan E, Guo W, Pu Y and Yin L: Differential expression profiles of microRNAs as potential biomarkers for the early diagnosis of esophageal squamous cell carcinoma. Oncol Rep. 29:169–176. 2013.

20 

Liu L, Wang S, Chen R, Wu Y, Zhang B, Huang S, Zhang J, Xiao F, Wang M and Liang Y: Myc induced miR-144/451 contributes to the acquired imatinib resistance in chronic myelogenous leukemia cell K562. Biochem Biophys Res Commun. 425:368–373. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Wang X, Zhu H, Zhang X, Liu Y, Chen J, Medvedovic M, Li H, Weiss MJ, Ren X and Fan GC: Loss of the miR-144/451 cluster impairs ischaemic preconditioning-mediated cardioprotection by targeting Rac-1. Cardiovasc Res. 94:379–390. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Zang WQ, Yang X, Wang T, Wang YY, Du YW, Chen XN, Li M and Zhao GQ: MiR-451 inhibits proliferation of esophageal carcinoma cell line EC9706 by targeting CDKN2D and MAP3K1. World J Gastroenterol. 21:5867–5876. 2015.PubMed/NCBI

23 

Wang T, Zang WQ, Li M, Wang N, Zheng YL and Zhao GQ: Effect of miR-451 on the biological behavior of the esophageal carcinoma cell line EC9706. Dig Dis Sci. 58:706–714. 2013. View Article : Google Scholar

24 

Xie Z, Chen G, Zhang X, Li D, Huang J, Yang C, Zhang P, Qin Y, Duan Y, Gong B and Li Z: Salivary microRNAs as promising biomarkers for detection of esophageal cancer. PloS One. 8:e575022013. View Article : Google Scholar : PubMed/NCBI

25 

Jiang X, Shan A, Su Y, Cheng Y, Gu W, Wang W, Ning G and Cao Y: miR-144/451 promote cell proliferation via targeting PTEN/AKT pathway in insulinomas. Endocrinology. 156:2429–2439. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Rice TW, Blackstone EH and Rusch VW: 7th Edition of the AJCC cancer staging manual: Esophagus and esophagogastric junction. Ann Surg Oncol. 17:1721–1724. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)). Method. 25:402–408. 2001. View Article : Google Scholar

28 

Lee Y, Kim M, Han J, Yeom KH, Lee S, Baek SH and Kim VN: MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 23:4051–4060. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Yu J, Wang F, Yang GH, Wang FL, Ma YN, Du ZW and Zhang JW: Human microRNA clusters: Genomic organization and expression profile in leukemia cell lines. Biochem Biophys Res Commun. 349:59–68. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Tian Y, Pan Q, Shang Y, Zhu R, Ye J, Liu Y, Zhong X, Li S, He Y, Chen L, et al: MicroRNA-200 (miR-200) cluster regulation by achaete scute-like 2 (Ascl2): Impact on the epithelial-mesenchymal transition in colon cancer cells. J Biol Chem. 289:36101–36115. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Zhang X, Wang X, Zhu H, Zhu C, Wang Y, Pu WT, Jegga AG and Fan GC: Synergistic effects of the GATA-4-mediated miR-144/451 cluster in protection against simulated ischemia/reperfusion-induced cardiomyocyte death. J Mol Cell Cardiol. 49:841–850. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Turczynska KM, Bhattachariya A, Säll J, Göransson O, Swärd K, Hellstrand P and Albinsson S: Stretch-sensitive down-regulation of the miR-144/451 cluster in vascular smooth muscle and its role in AMP-activated protein kinase signaling. PloS One. 8:e651352013. View Article : Google Scholar : PubMed/NCBI

33 

Fukumoto I, Kinoshita T, Hanazawa T, Kikkawa N, Chiyomaru T, Enokida H, Yamamoto N, Goto Y, Nishikawa R, Nakagawa M, et al: Identification of tumour suppressive microRNA-451a in hypopharyngeal squamous cell carcinoma based on microRNA expression signature. Br J Cancer. 111:386–394. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Moreira FC, Assumpção M, Hamoy IG, Darnet S, Burbano R, Khayat A, Gonçalves AN, Alencar DO, Cruz A, Magalhães L, et al: MiRNA expression profile for the human gastric antrum region using ultra-deep sequencing. PloS One. 9:e923002014. View Article : Google Scholar : PubMed/NCBI

35 

Ouyang M, Li Y, Ye S, Ma J, Lu L, Lv W, Chang G, Li X, Li Q, Wang S and Wang W: MicroRNA profiling implies new markers of chemoresistance of triple-negative breast cancer. PloS One. 9:e962282014. View Article : Google Scholar : PubMed/NCBI

36 

Babapoor S, Fleming E, Wu R and Dadras SS: A novel miR-451a isomiR, associated with amelanotypic phenotype, acts as a tumor suppressor in melanoma by retarding cell migration and invasion. PloS One. 9:e1075022014. View Article : Google Scholar : PubMed/NCBI

37 

Li M, Song Q, Li H, Lou Y and Wang L: Circulating miR-25-3p and miR-451a may be potential biomarkers for the diagnosis of papillary thyroid carcinoma. PloS One. 10:e01324032015. View Article : Google Scholar : PubMed/NCBI

38 

Liu Z, Miao T, Feng T, Jiang Z, Li M, Zhou L and Li H: miR-451a inhibited cell proliferation and enhanced tamoxifen sensitive in breast cancer via macrophage migration inhibitory factor. Biomed Res Int. 2015:2076842015. View Article : Google Scholar : PubMed/NCBI

39 

Katsuura S, Kuwano Y, Yamagishi N, Kurokawa K, Kajita K, Akaike Y, Nishida K, Masuda K, Tanahashi T and Rokutan K: MicroRNAs miR-144/144* and miR-16 in peripheral blood are potential biomarkers for naturalistic stress in healthy Japanese medical students. Neurosci Lett. 516:79–84. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Keller A, Leidinger P, Vogel B, Backes C, ElSharawy A, Galata V, Mueller SC, Marquart S, Schrauder MG, Strick R, et al: miRNAs can be generally associated with human pathologies as exemplified for miR-144. BMC Med. 12:2242014. View Article : Google Scholar : PubMed/NCBI

41 

Chen S, Li P, Li J, Wang Y, Du Y, Chen X, Zang W, Wang H, Chu H, Zhao G and Zhang G: MiR-144 inhibits proliferation and induces apoptosis and autophagy in lung cancer cells by targeting TIGAR. Cell Physiol Biochem. 35:997–1007. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Guan H, Liang W, Xie Z, Li H, Liu J, Liu L, Xiu L and Li Y: Down-regulation of miR-144 promotes thyroid cancer cell invasion by targeting ZEB1 and ZEB2. Endocrine. 48:566–574. 2015. View Article : Google Scholar

43 

Guo Y, Ying L, Tian Y, Yang P, Zhu Y, Wang Z, Qiu F and Lin J: miR-144 downregulation increases bladder cancer cell proliferation by targeting EZH2 and regulating Wnt signaling. FEBS J. 280:4531–4538. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Matsushita R, Seki N, Chiyomaru T, Inoguchi S, Ishihara T, Goto Y, Nishikawa R, Mataki H, Tatarano S, Itesako T, et al: Tumour-suppressive microRNA-144-5p directly targets CCNE1/2 as potential prognostic markers in bladder cancer. Br J Cancer. 113:282–289. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Omura T, Shimada Y, Nagata T, Okumura T, Fukuoka J, Yamagishi F, Tajika S, Nakajima S, Kawabe A and Tsukada K: Relapse-associated microRNA in gastric cancer patients after S-1 adjuvant chemotherapy. Oncol Rep. 31:613–618. 2014.

46 

Pouladi N, Kouhsari SM, Feizi MH, Gavgani RR and Azarfam P: Overlapping region of p53/Wrap53 transcripts: Mutational analysis and sequence similarity with microRNA-4732-5p. Asian Pac J Cancer Prev. 14:3503–3507. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Wu J, Bao J, Kim M, Yuan S, Tang C, Zheng H, Mastick GS, Xu C and Yan W: Two miRNA clusters, miR-34b/c and miR-449, are essential for normal brain development, motile ciliogenesis, and spermatogenesis. Proc Natl Acad Sci USA. 111:E2851–E2857. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Gao Z, Liu R, Liao J, Yang M, Pan E, Yin L and Pu Y: Possible tumor suppressive role of the miR-144/451 cluster in esophageal carcinoma as determined by principal component regression analysis. Mol Med Rep 14: 3805-3813, 2016.
APA
Gao, Z., Liu, R., Liao, J., Yang, M., Pan, E., Yin, L., & Pu, Y. (2016). Possible tumor suppressive role of the miR-144/451 cluster in esophageal carcinoma as determined by principal component regression analysis. Molecular Medicine Reports, 14, 3805-3813. https://doi.org/10.3892/mmr.2016.5691
MLA
Gao, Z., Liu, R., Liao, J., Yang, M., Pan, E., Yin, L., Pu, Y."Possible tumor suppressive role of the miR-144/451 cluster in esophageal carcinoma as determined by principal component regression analysis". Molecular Medicine Reports 14.4 (2016): 3805-3813.
Chicago
Gao, Z., Liu, R., Liao, J., Yang, M., Pan, E., Yin, L., Pu, Y."Possible tumor suppressive role of the miR-144/451 cluster in esophageal carcinoma as determined by principal component regression analysis". Molecular Medicine Reports 14, no. 4 (2016): 3805-3813. https://doi.org/10.3892/mmr.2016.5691
Copy and paste a formatted citation
x
Spandidos Publications style
Gao Z, Liu R, Liao J, Yang M, Pan E, Yin L and Pu Y: Possible tumor suppressive role of the miR-144/451 cluster in esophageal carcinoma as determined by principal component regression analysis. Mol Med Rep 14: 3805-3813, 2016.
APA
Gao, Z., Liu, R., Liao, J., Yang, M., Pan, E., Yin, L., & Pu, Y. (2016). Possible tumor suppressive role of the miR-144/451 cluster in esophageal carcinoma as determined by principal component regression analysis. Molecular Medicine Reports, 14, 3805-3813. https://doi.org/10.3892/mmr.2016.5691
MLA
Gao, Z., Liu, R., Liao, J., Yang, M., Pan, E., Yin, L., Pu, Y."Possible tumor suppressive role of the miR-144/451 cluster in esophageal carcinoma as determined by principal component regression analysis". Molecular Medicine Reports 14.4 (2016): 3805-3813.
Chicago
Gao, Z., Liu, R., Liao, J., Yang, M., Pan, E., Yin, L., Pu, Y."Possible tumor suppressive role of the miR-144/451 cluster in esophageal carcinoma as determined by principal component regression analysis". Molecular Medicine Reports 14, no. 4 (2016): 3805-3813. https://doi.org/10.3892/mmr.2016.5691
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