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Article Open Access

Curcumin ameliorates high‑fat diet‑induced spermatogenesis dysfunction

  • Authors:
    • Yang Mu
    • Wen‑Jie Yan
    • Tai‑Lang Yin
    • Jing Yang
  • View Affiliations / Copyright

    Affiliations: Reproductive Medical Center, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
    Copyright: © Mu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3588-3594
    |
    Published online on: September 5, 2016
       https://doi.org/10.3892/mmr.2016.5712
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Abstract

Curcumin, a type of natural active ingredient, is derived from rhizoma of Curcuma, which possesses antioxidant, antitumorigenic and anti‑inflammatory activities. The present study aimed to investigate whether treatment with curcumin reduced high‑fat diet (HFD)‑induced spermatogenesis dysfunction. Sprague‑Dawley rats fed a HFD were treated with or without curcumin for 8 weeks. The testis/body weight, histological analysis and serum hormone levels were used to evaluate the effects of curcumin treatment on spermatogenesis dysfunction induced by the HFD. In addition, the expression levels of apoptosis associated proteins, Fas, B‑cell lymphoma (Bcl)‑xl, Bcl‑associated X protein (Bax) and cleaved‑caspase 3, were determined in the testis. The results of the present study suggested that curcumin treatment attenuated decreased testis/body weight and abnormal hormone levels. Morphological changes induced by a HFD were characterized as atrophied seminiferous tubules, decreased spermatogenetic cells and interstitial cells were improved by curcumin treatment. In addition, curcumin treatment reduced apoptosis in the testis, and decreased expression of Fas, Bax and cleaved‑caspase 3, as well as increased expression of Bcl‑xl. In conclusion, the present study revealed that curcumin treatment reduced HFD‑induced spermatogenesis dysfunction in male rats.
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Copy and paste a formatted citation
Spandidos Publications style
Mu Y, Yan WJ, Yin TL and Yang J: Curcumin ameliorates high‑fat diet‑induced spermatogenesis dysfunction. Mol Med Rep 14: 3588-3594, 2016.
APA
Mu, Y., Yan, W., Yin, T., & Yang, J. (2016). Curcumin ameliorates high‑fat diet‑induced spermatogenesis dysfunction. Molecular Medicine Reports, 14, 3588-3594. https://doi.org/10.3892/mmr.2016.5712
MLA
Mu, Y., Yan, W., Yin, T., Yang, J."Curcumin ameliorates high‑fat diet‑induced spermatogenesis dysfunction". Molecular Medicine Reports 14.4 (2016): 3588-3594.
Chicago
Mu, Y., Yan, W., Yin, T., Yang, J."Curcumin ameliorates high‑fat diet‑induced spermatogenesis dysfunction". Molecular Medicine Reports 14, no. 4 (2016): 3588-3594. https://doi.org/10.3892/mmr.2016.5712
Copy and paste a formatted citation
x
Spandidos Publications style
Mu Y, Yan WJ, Yin TL and Yang J: Curcumin ameliorates high‑fat diet‑induced spermatogenesis dysfunction. Mol Med Rep 14: 3588-3594, 2016.
APA
Mu, Y., Yan, W., Yin, T., & Yang, J. (2016). Curcumin ameliorates high‑fat diet‑induced spermatogenesis dysfunction. Molecular Medicine Reports, 14, 3588-3594. https://doi.org/10.3892/mmr.2016.5712
MLA
Mu, Y., Yan, W., Yin, T., Yang, J."Curcumin ameliorates high‑fat diet‑induced spermatogenesis dysfunction". Molecular Medicine Reports 14.4 (2016): 3588-3594.
Chicago
Mu, Y., Yan, W., Yin, T., Yang, J."Curcumin ameliorates high‑fat diet‑induced spermatogenesis dysfunction". Molecular Medicine Reports 14, no. 4 (2016): 3588-3594. https://doi.org/10.3892/mmr.2016.5712
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