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Article Open Access

Antiviral activities of atractylon from Atractylodis Rhizoma

  • Authors:
    • Yang Cheng
    • Jing‑Yin Mai
    • Tian‑Lu Hou
    • Jian Ping
    • Jian‑Jie Chen
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Disease, Hospital for Infectious Diseases of Pudong New Area, Shanghai 201299, P.R. China, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China
    Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3704-3710
    |
    Published online on: September 5, 2016
       https://doi.org/10.3892/mmr.2016.5713
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Abstract

Atractylodis Rhizoma is a traditional medicinal herb, which has antibacterial, antiviral, anti‑inflammatory and anti‑allergic, anticancer, gastroprotective and neuroprotective activities. It is widely used for treating fever, cold, phlegm, edema and arthralgia syndrome in South‑East Asian nations. In this study, 6 chemical compositions of Atractylodis Rhizoma were characterized by spectral analysis and their antiviral activities were evaluated in vitro and in vivo. Among them, atractylon showed most significant antiviral activities. Atractylon treatment at doses of 10‑40 mg/kg for 5 days attenuated influenza A virus (IAV)‑induced pulmonary injury and decreased the serum levels of interleukin (IL)‑6, tumor necrosis factor‑α and IL‑1β, but increased interferon‑β (IFN‑β) levels. Atractylon treatment upregulated the expression of Τoll‑like receptor 7 (TLR7), MyD88, tumor necrosis factor receptor‑associated factor 6 and IFN‑β mRNA but downregulated nuclear factor‑κB p65 protein expression in the lung tissues of IAV‑infected mice. These results demonstrated that atractylon significantly alleviated IAV‑induced lung injury via regulating the TLR7 signaling pathway, and may warrant further evaluation as a possible agent for IAV treatment.
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1 

Richard M and Fouchier RA: Influenza A virus transmission via respiratory aerosols or droplets as it relates to pandemic potential. FEMS Microbiol Rev. 40:68–85. 2016. View Article : Google Scholar

2 

Li TC, Chan MC and Lee N: Clinical implications of antiviral resistance in influenza. Viruses. 7:4929–4944. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Shen Z, Lou K and Wang W: New small-molecule drug design strategies for fighting resistant influenza A. Acta Pharm Sin B. 5:419–430. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Watanabe T and Kawaoka Y: Influenza virus-host interactomes as a basis for antiviral drug development. Curr Opin Virol. 14:71–78. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Ganjhu RK, Mudgal PP, Maity H, Dowarha D, Devadiga S, Nag S and Arunkumar G: Herbal plants and plant preparations as remedial approach for viral diseases. Virusdisease. 26:225–236. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Koonrungsesomboon N, Na-Bangchang K and Karbwang J: Therapeutic potential and pharmacological activities of Atractylodes lancea (Thunb.) DC. Asian Pac J Trop Med. 7:421–428. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Zhong Y, Wang X, Xu G, Mao B, Zhou W, Min J, Jiang H, Diao X and Fu J: Modified Yupingfeng formula for the treatment of stable chronic obstructive pulmonary disease: A systematic review of randomized controlled trials. Afr J Tradit Complement Altern Med. 11:1–14. 2013. View Article : Google Scholar

8 

Xu J, Chen D, Liu C, Wu XZ, Dong CX and Zhou J: Structural characterization and anti-tumor effects of an insulin-type fructan from Atractylodes chinensis. Int J Biol Macromol. 82:765–771. 2016. View Article : Google Scholar

9 

Wang C, He L, Wang N and Liu F: Screening anti-inflammatory components from Chinese traditional medicines using a peritoneal macrophage/cell membrane chromatography-offline-GC/MS method. J Chromatogr B Analyt Technol Biomed Life Sci. 877:3019–3024. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Zhang JL, Huang WM and Zeng QY: Atractylenolide I protects mice from lipopolysaccharide-induced acute lung injury. Eur J Pharmacol. 765:94–99. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Ji ZH, Liu C, Zhao H and Yu XY: Neuroprotective effect of biatractylenolide against memory impairment in D-galactose-induced aging mice. J Mol Neurosci. 55:678–683. 2015. View Article : Google Scholar

12 

Wang S, Cai R, Ma J, Liu T, Ke X, Lu H and Fu J: The natural compound codonolactone impairs tumor induced angiogenesis by downregulating BMP signaling in endothelial cells. Phytomedicine. 22:1017–1026. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Masuda Y, Kadokura T, Ishii M, Takada K and Kitajima J: Hinesol, a compound isolated from the essential oils of Atractylodes lancea rhizome, inhibits cell growth and induces apoptosis in human leukemia HL-60 cells. J Nat Med. 69:332–339. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Liu H, Zhu Y, Zhang T, Zhao Z, Zhao Y, Cheng P, Li H, Gao H and Su X: Anti-tumor effects of atractylenolide I isolated from Atractylodes macrocephala in human lung carcinoma cell lines. Molecules. 18:13357–13368. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Ji GQ, Chen RQ and Wang L: Anti-inflammatory activity of atractylenolide III through inhibition of nuclear factor-κB and mitogen-activated protein kinase pathways in mouse macrophages. Immunopharmacol Immunotoxicol. 15:1–5. 2015.

16 

Zhang NN, Park DK and Park HJ: The inhibitory activity of atractylenolide III, a sesquiterpenoid, on IgE-mediated mast cell activation and passive cutaneous anaphylaxis (PCA). J Ethnopharmacol. 145:278–285. 2013. View Article : Google Scholar

17 

Wu Q, Yu C, Yan Y, Chen J, Zhang C and Wen X: Antiviral flavonoids from Mosla scabra. Fitoterapia. 81:429–433. 2010. View Article : Google Scholar

18 

Yu CH, Yu WY, Fang J, Zhang HH, Ma Y, Yu B, Wu F and Wu XN: Mosla scabra flavonoids ameliorate the influenza A virus-induced lung injury and water transport abnormality via the inhibition of PRR and AQP signaling pathways in mice. J Ethnopharmacol. 179:146–155. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Chen ZB: Study and application of herbal disinfectants in China. Biomed Environ Sci. 17:492–498. 2004.

20 

Zhao C and He C: Preparative isolation and purification of atractylon and atractylenolide III from the Chinese medicinal plant atractylodes macrocephala by high-speed counter-current chromatography. J Sep Sci. 29:1630–1636. 2006. View Article : Google Scholar : PubMed/NCBI

21 

Li CQ, He LC, Dong HY and Jin JQ: Screening for the anti-inflammatory activity of fractions and compounds from Atractylodes macrocephala koidz. J Ethnopharmacol. 114:212–217. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Li J, Li F, Xu Y, Yang W, Qu L, Xiang Q, Liu C and Li D: Chemical composition and synergistic antioxidant activities of essential oils from Atractylodes macrocephala and Astragalus membranaceus. Nat Prod Commun. 8:1321–1324. 2013.PubMed/NCBI

23 

Ozçelik B, Gürbüz I, Karaoglu T and Yeşilada E: Antiviral and antimicrobial activities of three sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis. Microbiol Res. 164:545–552. 2009. View Article : Google Scholar

24 

Zhang HJ, Nguyen VH, Nguyen MC, Soejarto DD, Pezzuto JM, Fong HH and Tan GT: Sesquiterpenes and butenolides, natural anti-HIV constituents from Litsea verticillata. Planta Med. 71:452–457. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Harmatha J, Vokáč K, Buděšínský M, Zídek Z and Kmoníčková E: Immunobiological properties of sesquiterpene lactones obtained by chemically transformed structural modifications of trilobolide. Fitoterapia. 107:90–99. 2015. View Article : Google Scholar : PubMed/NCBI

26 

De Ford C, Ulloa JL, Catalán CA, Grau A, Martino VS, Muschietti LV and Merfort I: The sesquiterpene lactone polymatin B from Smallanthus sonchifolius induces different cell death mechanisms in three cancer cell lines. Phytochemistry. 117:332–339. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Felix S, Sandjo LP, Opatz T and Erkel G: Anti-inflammatory drimane sesquiterpene lactones from an Aspergillus species. Bioorg Med Chem. 22:2912–2918. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Hwang DR, Wu YS, Chang CW, Lien TW, Chen WC, Tan UK, Hsu JT and Hsieh HP: Synthesis and anti-viral activity of a series of sesquiterpene lactones and analogues in the subgenomic HCV replicon system. Bioorg Med Chem. 14:83–91. 2006. View Article : Google Scholar

29 

Guo J, Cao Y, Qin K, Zhao X, Wang D, Li Z, Xin L, Shu Y and Zhou J: Limited effect of recombinant human mannose-binding lectin on the infection of novel influenza A (H7N9) virus in vitro. Biochem Biophys Res Commun. 458:77–81. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Sawai-Kuroda R, Kikuchi S, Shimizu YK, Sasaki Y, Kuroda K, Tanaka T, Yamamoto T, Sakurai K and Shimizu K: A polyphenol-rich extract from Chaenomeles sinensis (Chinese quince) inhibits influenza A virus infection by preventing primary transcription in vitro. J Ethnopharmacol. 146:866–872. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Chen S, Cheng A and Wang M: Innate sensing of viruses by pattern recognition receptors in birds. Vet Res. 44:822013. View Article : Google Scholar : PubMed/NCBI

32 

Raj RS, Bonney EA and Phillippe M: Influenza, immune system, and pregnancy. Reprod Sci. 21:1434–1451. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Yoo JK, Kim TS, Hufford MM and Braciale TJ: Viral infection of the lung: Host response and sequelae. J Allergy Clin Immunol. 132:1263–1276. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Ichinohe T: Respective roles of TLR, RIG-I and NLRP3 in influenza virus infection and immunity: Impact on vaccine design. Expert Rev Vaccines. 9:1315–1324. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Dash P and Thomas PG: Host detection and the stealthy phenotype in influenza virus infection. Curr Top Microbiol Immunol. 386:121–147. 2015.

36 

Ramirez-Ortiz ZG, Prasad A, Griffith JW, Pendergraft WF III, Cowley GS, Root DE, Tai M, Luster AD, El Khoury J, Hacohen N, et al: The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity. Nat Immunol. 16:495–504. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Goff PH, Hayashi T, Martínez-Gil L, Corr M, Crain B, Yao S, Cottam HB, Chan M, Ramos I, Eggink D, et al: Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses. J Virol. 89:3221–3235. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Ramos I and Fernandez-Sesma A: Modulating the innate immune response to influenza A virus: Potential therapeutic use of anti-inflammatory drugs. Front Immunol. 6:3612015. View Article : Google Scholar : PubMed/NCBI

39 

Kell AM and Gale M Jr: RIG-I in RNA virus recognition. Virology. 479–480:110–121. 2015. View Article : Google Scholar

40 

Gambhir S, Vyas D, Hollis M, Aekka A and Vyas A: Nuclear factor kappa B role in inflammation associated gastrointestinal malignancies. World J Gastroenterol. 21:3174–3183. 2015.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cheng Y, Mai JY, Hou TL, Ping J and Chen JJ: Antiviral activities of atractylon from Atractylodis Rhizoma. Mol Med Rep 14: 3704-3710, 2016.
APA
Cheng, Y., Mai, J., Hou, T., Ping, J., & Chen, J. (2016). Antiviral activities of atractylon from Atractylodis Rhizoma. Molecular Medicine Reports, 14, 3704-3710. https://doi.org/10.3892/mmr.2016.5713
MLA
Cheng, Y., Mai, J., Hou, T., Ping, J., Chen, J."Antiviral activities of atractylon from Atractylodis Rhizoma". Molecular Medicine Reports 14.4 (2016): 3704-3710.
Chicago
Cheng, Y., Mai, J., Hou, T., Ping, J., Chen, J."Antiviral activities of atractylon from Atractylodis Rhizoma". Molecular Medicine Reports 14, no. 4 (2016): 3704-3710. https://doi.org/10.3892/mmr.2016.5713
Copy and paste a formatted citation
x
Spandidos Publications style
Cheng Y, Mai JY, Hou TL, Ping J and Chen JJ: Antiviral activities of atractylon from Atractylodis Rhizoma. Mol Med Rep 14: 3704-3710, 2016.
APA
Cheng, Y., Mai, J., Hou, T., Ping, J., & Chen, J. (2016). Antiviral activities of atractylon from Atractylodis Rhizoma. Molecular Medicine Reports, 14, 3704-3710. https://doi.org/10.3892/mmr.2016.5713
MLA
Cheng, Y., Mai, J., Hou, T., Ping, J., Chen, J."Antiviral activities of atractylon from Atractylodis Rhizoma". Molecular Medicine Reports 14.4 (2016): 3704-3710.
Chicago
Cheng, Y., Mai, J., Hou, T., Ping, J., Chen, J."Antiviral activities of atractylon from Atractylodis Rhizoma". Molecular Medicine Reports 14, no. 4 (2016): 3704-3710. https://doi.org/10.3892/mmr.2016.5713
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