Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
October-2016 Volume 14 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2016 Volume 14 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Glucocorticoid treatment inhibits intracerebral hemorrhage‑induced inflammation by targeting the microRNA‑155/SOCS‑1 signaling pathway

  • Authors:
    • Hong‑Fei Xu
    • Xiao‑Yun Fang
    • Shao‑Hua Zhu
    • Xue‑Hua Xu
    • Zhi‑Xiang Zhang
    • Zu‑Feng Wang
    • Zi‑Qin Zhao
    • Yu‑Jie Ding
    • Lu‑Yang Tao
  • View Affiliations / Copyright

    Affiliations: Department of Forensic Medicine, Soochow University, Suzhou, Jiangsu 215123, P.R. China, Jiangsu Patent Examination Assistance Center Under State Intellectual Property Office of The People's Republic of China, Suzhou, Jiangsu 215163, P.R. China, Department of Forensic Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China, Department of Dermatology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215123, P.R. China
  • Pages: 3798-3804
    |
    Published online on: September 6, 2016
       https://doi.org/10.3892/mmr.2016.5716
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Intracerebral hemorrhage (ICH) results in inflammation, and glucocorticoids have been proven to be effective inhibitors of ICH‑induced inflammation. However, the precise underlying mechanisms of ICH‑induced inflammation and glucocorticoid function remain largely undefined. Using a mouse ICH model, the present study demonstrated that the short non‑coding RNA molecule microRNA‑155 (miR‑155) is involved in the inflammatory process initiated by ICH in mice. Increased mRNA expression levels of miR‑155, as well as the pro‑inflammatory cytokines interferon‑β (IFN‑β), tumor necrosis factor‑α (TNF‑α) and interleukin‑6 (IL‑6), were observed in vivo following ICH. By contrast, the expression level of suppressor of cytokine signaling 1 (SOCS‑1) protein was reduced in the ICH group compared with control mice. Similar results were observed in vitro using astrocytes, the primary effector cells in ICH. Compared with wild type astrocytes, astrocytes overexpressing miR‑155 exhibited significant inhibition of SOCS‑1 protein expression levels. These results suggest that miR‑155 contributes to the development of ICH‑induced inflammation in mice by downregulating SOCS‑1 protein expression levels and promoting pro‑inflammatory cytokine (IFN‑β, TNF‑α and IL‑6) production. Expression levels of miR‑155 and pro‑inflammatory cytokines in the ICH group were significantly decreased following dexamethasone administration. This suggests that glucocorticoids attenuate ICH‑induced inflammation by targeting the miR‑155/SOCS‑1 signaling pathway in mice. In conclusion, the results of the present study demonstrated that the miR‑155/SOCS‑1 signaling pathway is required for ICH‑induced inflammation, and glucocorticoids inhibit this process by targeting the miR‑155/SOCS‑1 signaling pathway.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Magistris FB, Bazak SB and Martin J: Intracerebral hemorrhage: Pathophysiology, diagnosis and management. Clinical Review. 10:14–22. 2013.

2 

Derex L and Nighoghossian N: Intracerebral haemorrhage after thrombolysis for acute ischaemic stroke: An update. J Neurol Neurosurg Psychiatry. 79:1093–1099. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Wang C, Ji B, Cheng B, Chen J and Bai B: Neuroprotection of microRNA in neurological disorders (Review). Biomed Rep. 2:611–619. 2014.PubMed/NCBI

4 

Jickling GC, Ander BP, Zhan X, Noblett D, Stamova B and Liu D: microRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets. PLoS One. 9:e992832014. View Article : Google Scholar : PubMed/NCBI

5 

Tan JR, Koo YX, Kaur P, Liu F, Armugam A, Wong PT and Jeyaseelan K: microRNAs in stroke pathogenesis. Curr Mol Med. 11:76–92. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Cardoso AL, Guedes JR, Pereira de Almeida L and Pedroso de Lima MC: miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production. Immunology. 135:73–88. 2012. View Article : Google Scholar :

7 

Lansberg MG, Albers GW and Wijman CA: Symptomatic intracerebral hemorrhage following thrombolytic therapy for acute ischemic stroke: A review of the risk factors. Cerebrovasc Dis. 24:1–10. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Coutinho AE and Chapman KE: The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights. Mol Cell Endocrinol. 335:2–13. 2011. View Article : Google Scholar :

9 

Zheng Y, Xiong S, Jiang P, Liu R, Liu X, Qian J, Zheng X and Chu Y: Glucocorticoids inhibit lipopolysaccharide-mediated inflammatory response by downregulating microRNA-155: A novel anti-inflammation mechanism. Free Radic Biol Med. 52:1307–1317. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Spies CM, Strehl C, van der Goes MC, Bijlsma JW and Buttgereit F: Glucocorticoids. Best Pract Res Clin Rheumatol. 25:891–900. 2011. View Article : Google Scholar

11 

McMaster A and Ray DW: Modelling the glucocorticoid receptor and producing therapeutic agents with anti-inflammatory effects but reduced side-effects. Exp Physiol. 92:299–309. 2007. View Article : Google Scholar

12 

Kreitzer N and Adeoye O: An update on surgical and medical management strategies for intracerebral hemorrhage. Semin Neurol. 33:462–467. 2013. View Article : Google Scholar

13 

Gu YT, Zhang H and Xue YX: Dexamethasone treatment modulates aquaporin-4 expression after intracerebral hemorrhage in rats. Neurosci Lett. 413:126–131. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Vandevyver S, Dejager L, Tuckermann J and Libert C: New insights into the anti-inflammatory mechanisms of glucocorticoids: An emerging role for glucocorticoid-receptor-mediated transactivation. Endocrinology. 154:993–1007. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Jing J, Wu J, Liu W, Xiong S, Ma W, Zhang J, Wang W, Gui JF and Mei J: Sex-biased miRNAs in gonad and their potential roles for testis development in yellow catfish. PLoS One. 9:e1079462014. View Article : Google Scholar : PubMed/NCBI

16 

Lin F, Yao L, Xiao J, Liu D and Ni Z: MiR-206 functions as a tumor suppressor and directly targets K-Ras in human oral squamous cell carcinoma. Onco Targets Ther. 7:1583–1591. 2014.PubMed/NCBI

17 

Liu H, Yang Y, Zhang L, Liang R, Ge RS, Zhang Y, Zhang Q, Xiang Q, Huang Y and Su Z: Basic fibroblast growth factor promotes stem Leydig cell development and inhibits LH-stimulated androgen production by regulating microRNA expression. J Steroid Biochem Mol Biol. 144:483–491. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Ramirez-Salazar EG, Salinas-Silva LC, Vázquez-Manríquez ME, Gayosso-Gómez LV, Negrete-Garcia MC, Ramírez-Rodriguez SL, Chávez R, Zenteno E, Santillán P, Kelly-García J and Ortiz-Quintero B: Analysis of microRNA expression signatures in malignant pleural mesothelioma, pleural inflammation and atypical mesothelial hyperplasia reveals common predictive tumorigenesis-related targets. Exp Mol Pathol. 97:375–385. 2014. View Article : Google Scholar

19 

Lu C, Huang X, Zhang X, Roensch K, Cao Q, Nakayama KI, Blazar BR, Zeng Y and Zhou X: miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27kip1, KPC1, and SOCS-1. Blood. 117:4293–4303. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Jiang S, Zhang HW, Lu MH, He XH, Li Y, Gu H, Liu MF and Wang ED: MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 gene. Cancer Res. 70:3119–3127. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Yao R, Ma YL, Liang W, Li HH, Ma ZJ, Yu X and Liao YH: MicroRNA-155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1. PLoS One. 7:e460822012. View Article : Google Scholar : PubMed/NCBI

22 

Kanwal N, John P and Bhatti A: MicroRNA-155 as a therapeutic target for inflammatory diseases. Rheumatol Int. 33:557–560. 2013. View Article : Google Scholar

23 

Liu DZ, Tian Y, Ander BP, Xu H, Stamova BS, Zhan X, Turner RJ, Jickling G and Sharp FR: Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J Cereb Blood Flow Metab. 30:92–101. 2010. View Article : Google Scholar

24 

Zhu GF, Yang LX, Guo RW, Liu H, Shi YK, Wang H, Ye JS, Yang ZH and Liang X: miR-155 inhibits oxidized low-density lipoprotein-induced apoptosis of RAW264.7 cells. Mol Cell Biochem. 382:253–261. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Xue H, Hua LM, Guo M and Luo JM: SHIP1 is targeted by miR-155 in acute myeloid leukemia. Oncol Rep. 32:2253–2259. 2014.PubMed/NCBI

26 

O'Connell RM, Chaudhuri AA, Rao DS and Baltimore D: Inositol phosphatase SHIP1 is a primary target of miR-155. Proc Natl Acad Sci USA. 106:7113–7118. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Chang P, Dong W, Zhang M, Wang Z, Wang Y, Wang T, Gao Y, Meng H, Luo B, Luo C, et al: Anti-necroptosis chemical necrostatin-1 can also suppress apoptotic and autophagic pathway to exert neuroprotective effect in mice intracerebral hemorrhage model. J Mol Neurosci. 52:242–249. 2014. View Article : Google Scholar

28 

Wang T, Huang Y, Zhang M, Wang L, Wang Y, Zhang L, Dong W, Chang P, Wang Z, Chen X and Tao L: [Gly14]-Humanin offers neuroprotection through glycogen synthase kinase-3β inhibition in a mouse model of intracerebral hemorrhage. Behav Brain Res. 247:132–139. 2013. View Article : Google Scholar : PubMed/NCBI

29 

McGlone JJ and Swanson J: Update on the guide for the care and use of agricultural animals in research and teaching. J Dairy Sci. 93:122010.

30 

Wang T, Zhang L, Zhang M, Bao H, Liu W, Wang Y, Wang L, Dai D, Chang P, Dong W, et al: [Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice. Neuroscience. 231:70–81. 2013. View Article : Google Scholar

31 

Luo X, Xiao J, Lin H, Li B, Lu Y, Yang B and Wang Z: Transcriptional activation by stimulating protein 1 and post-transcriptional repression by muscle-specific microRNAs of IKs-encoding genes and potential implications in regional heterogeneity of their expressions. J Cell Physiol. 212:358–367. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Roth-Cross JK, Martínez-Sobrido L, Scott EP, García-Sastre A and Weiss SR: Inhibition of the alpha/beta interferon response by mouse hepatitis virus at multiple levels. J Virol. 81:7189–7199. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Fang X, Hu H, Xie J, Zhu H, Zhang D, Mo W, Zhang R and Yu M: An involvement of neurokinin-1 receptor in FcεRI-mediated RBL-2H3 mast cell activation. Inflamm Res. 61:1257–1263. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Tallant EA and Higson JT: Angiotensin II activates distinct signal transduction pathways in astrocytes isolated from neonatal rat brain. Glia. 19:333–342. 1997. View Article : Google Scholar : PubMed/NCBI

35 

Caplen NJ, Parrish S, Imani F, Fire A and Morgan RA: Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc Natl Acad Sci USA. 98:9742–9747. 2001. View Article : Google Scholar : PubMed/NCBI

36 

van der Velden VH: Glucocorticoids: Mechanisms of action and anti-inflammatory potential in asthma. Mediators Inflamm. 7:229–237. 1998. View Article : Google Scholar : PubMed/NCBI

37 

Schleimer RP: An overview of glucocorticoid anti-inflammatory actions. Eur J Clin Pharmacol. 45(Suppl 1): S3–S7; discussion S43–S44. 1993. View Article : Google Scholar : PubMed/NCBI

38 

Wang YC, Zhou Y, Fang H, Lin S, Wang PF, Xiong RP, Chen J, Xiong XY, Lv FL, Liang QL and Yang QW: Toll-like receptor 2/4 heterodimer mediates inflammatory injury in intracerebral hemorrhage. Ann Neurol. 75:876–889. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Arroyo DS, Soria JA, Gaviglio EA, Rodriguez-Galan MC and Iribarren P: Toll-like receptors are key players in neurodegeneration. Int Immunopharmacol. 11:1415–1421. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Kong Y and Le Y: Toll-like receptors in inflammation of the central nervous system. Int Immunopharmacol. 11:1407–1414. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Eberle ME and Dalpke AH: Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses. J Immunol. 188:5644–5654. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Chen Y, Liu W, Sun T, Huang Y, Wang Y, Deb DK, Yoon D, Kong J, Thadhani R and Li YC: 1,25-Dihydroxyvitamin D promotes negative feedback regulation of TLR signaling via targeting microRNA-155-SOCS1 in macrophages. J Immunol. 190:3687–3695. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Li ZQ, Liang GB, Xue YX and Liu YH: Effects of combination treatment of dexamethasone and melatonin on brain injury in intracerebral hemorrhage model in rats. Brain Res. 1264:98–103. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Lema PP, Girard C and Vachon P: Evaluation of dexamethasone for the treatment of intracerebral hemorrhage using a collagenase-induced intracerebral hematoma model in rats. J Vet Pharmacol Ther. 27:321–328. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xu HF, Fang XY, Zhu SH, Xu XH, Zhang ZX, Wang ZF, Zhao ZQ, Ding YJ and Tao LY: Glucocorticoid treatment inhibits intracerebral hemorrhage‑induced inflammation by targeting the microRNA‑155/SOCS‑1 signaling pathway. Mol Med Rep 14: 3798-3804, 2016.
APA
Xu, H., Fang, X., Zhu, S., Xu, X., Zhang, Z., Wang, Z. ... Tao, L. (2016). Glucocorticoid treatment inhibits intracerebral hemorrhage‑induced inflammation by targeting the microRNA‑155/SOCS‑1 signaling pathway. Molecular Medicine Reports, 14, 3798-3804. https://doi.org/10.3892/mmr.2016.5716
MLA
Xu, H., Fang, X., Zhu, S., Xu, X., Zhang, Z., Wang, Z., Zhao, Z., Ding, Y., Tao, L."Glucocorticoid treatment inhibits intracerebral hemorrhage‑induced inflammation by targeting the microRNA‑155/SOCS‑1 signaling pathway". Molecular Medicine Reports 14.4 (2016): 3798-3804.
Chicago
Xu, H., Fang, X., Zhu, S., Xu, X., Zhang, Z., Wang, Z., Zhao, Z., Ding, Y., Tao, L."Glucocorticoid treatment inhibits intracerebral hemorrhage‑induced inflammation by targeting the microRNA‑155/SOCS‑1 signaling pathway". Molecular Medicine Reports 14, no. 4 (2016): 3798-3804. https://doi.org/10.3892/mmr.2016.5716
Copy and paste a formatted citation
x
Spandidos Publications style
Xu HF, Fang XY, Zhu SH, Xu XH, Zhang ZX, Wang ZF, Zhao ZQ, Ding YJ and Tao LY: Glucocorticoid treatment inhibits intracerebral hemorrhage‑induced inflammation by targeting the microRNA‑155/SOCS‑1 signaling pathway. Mol Med Rep 14: 3798-3804, 2016.
APA
Xu, H., Fang, X., Zhu, S., Xu, X., Zhang, Z., Wang, Z. ... Tao, L. (2016). Glucocorticoid treatment inhibits intracerebral hemorrhage‑induced inflammation by targeting the microRNA‑155/SOCS‑1 signaling pathway. Molecular Medicine Reports, 14, 3798-3804. https://doi.org/10.3892/mmr.2016.5716
MLA
Xu, H., Fang, X., Zhu, S., Xu, X., Zhang, Z., Wang, Z., Zhao, Z., Ding, Y., Tao, L."Glucocorticoid treatment inhibits intracerebral hemorrhage‑induced inflammation by targeting the microRNA‑155/SOCS‑1 signaling pathway". Molecular Medicine Reports 14.4 (2016): 3798-3804.
Chicago
Xu, H., Fang, X., Zhu, S., Xu, X., Zhang, Z., Wang, Z., Zhao, Z., Ding, Y., Tao, L."Glucocorticoid treatment inhibits intracerebral hemorrhage‑induced inflammation by targeting the microRNA‑155/SOCS‑1 signaling pathway". Molecular Medicine Reports 14, no. 4 (2016): 3798-3804. https://doi.org/10.3892/mmr.2016.5716
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team