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Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury

  • Authors:
    • Yang Wang
    • Chunhu Zhang
    • Weijun Peng
    • Zian Xia
    • Pingping Gan
    • Wei Huang
    • Yafei Shi
    • Rong Fan
  • View Affiliations / Copyright

    Affiliations: Department of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, College of Basic Medicine, Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3690-3696
    |
    Published online on: September 6, 2016
       https://doi.org/10.3892/mmr.2016.5720
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Abstract

Free radical-induced oxidative damage occurs rapidly and is of primary importance during the secondary pathophysiological cascades of traumatic brain injury (TBI). Hydroxysafflor yellow A (HSYA) is a constituent of the flower petals of Carthamus tinctorius (safflower) and may represent a potential therapeutic strategy to improve outcomes following TBI. The present study aimed to identify HSYA in the brain tissues of rats exposed to TBI to determine its absorption and to investigate the underlying effects of HSYA on antioxidant enzymes in the brain tissues of TBI rats. To determine the absorption of HSYA for the investigation of the underlying antioxidant effects of HSYA in TBI, the presence of HSYA in the brain tissues of the TBI rats was identified using an ultra performance liquid chromatography‑tandem mass spectrometry method. Subsequently, the state of oxidative stress in the TBI rat model following the administration of HSYA was investigated by determining the levels of antioxidant enzymes, including superoxide dismutase (SOD), malondialdehyde (MDA) and catalase (CAT), and the ratio of glutathione (GSH)/glutathione disulfide (GSSG). The data obtained demonstrated that HSYA was absorbed in the brain tissues of the TBI rats. HSYA increased the activities of SOD and CAT, the level of GSH and the GSH/GSSG ratio. However, HSYA concomitantly decreased the levels of MDA and GSSG. These preliminary data suggest that HSYA has the potential to be utilized as a neuroprotective drug in cases of TBI.
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1 

Harrison-Felix C, Kolakowsky-Hayner SA, Hammond FM, Wang R, Englander J, Dams-O'Connor K, Kreider SE, Novack TA and Diaz-Arrastia R: Mortality after surviving traumatic brain injury: Risks based on age groups. J Head Trauma Rehabil. 27:E45–E56. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Roozenbeek B, Maas AI and Menon DK: Changing patterns in the epidemiology of traumatic brain injury. Nat Rev Neurol. 9:231–236. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Corps KN, Roth TL and McGavern DB: Inflammation and neuroprotection in traumatic brain injury. JAMA Neurol. 72:355–362. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Wu X, Hu J, Zhuo L, Fu C, Hui G, Wang Y, Yang W, Teng L, Lu S and Xu G: Epidemiology of traumatic brain injury in eastern China, 2004: A prospective large case study. J Trauma. 64:1313–1319. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Tuominen R, Joelsson P and Tenovuo O: Treatment costs and productivity losses caused by traumatic brain injuries. Brain Inj. 26:1697–1701. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Lei J, Gao G and Jiang J: Acute traumatic brain injury: Is current management evidence based? An empirical analysis of systematic reviews. J Neurotrauma. 30:529–537. 2013. View Article : Google Scholar

7 

Kou K, Hou XY, Sun JD and Chu K: Current pre-hospital traumatic brain injury management in China. World J Emerg Med. 5:245–254. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Jin W, Wang H, Yan W, Zhu L, Hu Z, Ding Y and Tang K: Role of Nrf2 in protection against traumatic brain injury in mice. J Neurotrauma. 26:131–139. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Smith JA, Park S, Krause JS and Banik NL: Oxidative stress, DNA damage and the telomeric complex as therapeutic targets in acute neurodegeneration. Neurochem Int. 62:764–775. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Adibhatla RM and Hatcher JF: Lipid oxidation and peroxidation in CNS health and disease: From molecular mechanisms to therapeutic opportunities. Antioxid Redox Sign. 12:125–169. 2010. View Article : Google Scholar

11 

Hall ED, Detloff MR, Johnson K and Kupina NC: Peroxynitrite-mediated protein nitration and lipid peroxidation in a mouse model of traumatic brain injury. J Neurotrauma. 21:9–20. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Sun L, Yang L, Xu YW, Liang H, Han J, Zhao RJ and Cheng Y: Neuroprotection of hydroxysafflor yellow A in the transient focal ischemia: Inhibition of protein oxidation/nitration, 12/15-lipoxy-genase and blood-brain barrier disruption. Brain Res. 1473:227–235. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Fan L, Dang X, Shi Z, Zhang C and Wang K: Hydroxysafflor yellow A protects PC12 cells against the apoptosis induced by oxygen and glucose deprivation. Cell Mol Neurobiol. 31:1187–1194. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Gracy RW, Talent JM, Kong Y and Conrad CC: Reactive oxygen species: The unavoidable environmental insult? Mutat Res. 428:17–22. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Pharmacopoeia Commission of PRC: Pharmacopoeia of the People's Republic of China. Chemical Industry Press; Beijing: pp. 1412010

16 

Qi Z, Yan F, Shi W, Dong W, Zhao Y, Shen J, Ji X, Liu KJ and Luo Y: AKT-related autophagy contributes to the neuroprotective efficacy of hydroxysafflor yellow A against ischemic stroke in rats. Transl Stroke Res. 5:501–509. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Li J, Zhang S, Lu M, Chen Z, Chen C, Han L, Zhang M and Xu Y: Hydroxysafflor yellow A suppresses inflammatory responses of BV2 microglia after oxygen-glucose deprivation. Neurosci Lett. 535:51–56. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Bie XD, Han J and Dai HB: Effects of hydroxysafflor yellow A on the experimental traumatic brain injury in rats. J Asian Nat Prod Res. 12:239–247. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Guo Y, Wang Y, Huang X, Lv H, Fan R, Huang W, Gan P, Liu W, Yan K, Xia Z and Liu J: Determination of hydroxysafflor yellow A in biological fluids of patients with traumatic brain injury by UPLC-ESI-MS/MS after injection of Xuebijing. Biomed Chromatogr. 28:1090–1095. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Sharma SK and Babitch JA: Application of Bradford's protein assay to chick brain subcellular fractions. J Biochem Biophys Methods. 2:247–250. 1980. View Article : Google Scholar : PubMed/NCBI

21 

Zhao H, Chai W, Gao W, Xu L, Zhang H and Yang Y: Hyperoxygenated solution: Effects on acute hypobaric hypoxia-induced oxidative damage in rabbits. High Alt Med Biol. 10:283–291. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Wang Y, Huang X, Liang Q, Fan R, Qin F, Guo Y, Yan KP, Liu W, Luo JK, Li YH, et al: A strategy for detecting absorbed bioactive compounds for quality control in water extract of rhubarb by ultra performance liquid chromatography with photodiode array detector. Chin J Integr Med. 18:690–698. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Qi J, Zhuang J, Wu W, Lu Y, Song Y, Zhang Z, Jia J and Ping Q: Enhanced effect and mechanism of water-in-oil microemulsion as an oral delivery system of hydroxysafflor yellow A. Int J Nanomedicine. 6:985–991. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Lv LZ, Tong CQ, Yu J, Han M and Gao JQ: Mechanism of enhanced oral absorption of hydrophilic drug incorporated in hydrophobic nanoparticles. Int J Nanomedicine. 8:2709–2717. 2013.PubMed/NCBI

25 

Wei X, Liu H, Sun X, Fu F, Zhang X, Wang J, An J and Ding H: Hydroxysafflor yellow A protects rat brains against ischemia-reperfusion injury by antioxidant action. Neurosci Lett. 386:58–62. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Zhu H, Wang Z, Ma C, Tian J, Fu F, Li C, Guo D, Roeder E and Liu K: Neuroprotective effects of hydroxysafflor yellow A: In vivo and in vitro studies. Planta Med. 69:429–433. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Habgood MD, Bye N, Dziegielewska KM, Ek CJ, Lane MA, Potter A, Morganti-Kossmann C and Saunders NR: Changes in blood-brain barrier permeability to large and small molecules following traumatic brain injury in mice. Eur J Neurosci. 25:231–238. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Wang CY, Liu Q, Huang QX, Liu JT, He YH, Lu JJ and Bai XY: Activation of PPARγ is required for hydroxysafflor yellow A of Carthamus tinctorius to attenuate hepatic fibrosis induced by oxidative stress. Phytomedicine. 20:592–599. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Mojtahedzadeh M, Ahmadi A, Mahmoodpoor A, Beigmohammadi MT, Abdollahi M, Khazaeipour Z, Shaki F, Kuochaki B and Hendouei N: Hypertonic saline solution reduces the oxidative stress responses in traumatic brain injury patients. J Res Med Sci. 19:867–874. 2014.PubMed/NCBI

30 

Gan L, Wang ZH, Zhang H, Zhou R, Sun C, Liu Y, Si J, Liu YY and Wang ZG: Protective effects of shikonin on brain injury induced by carbon ion beam irradiation in mice. Biomed Environ Sci. 28:148–151. 2015.PubMed/NCBI

31 

Li J and Wang Y: Effect of different methods of hypoxic exercise training on free radical oxidation and antioxidant enzyme activity in the rat brain. Biomed Rep. 1:925–929. 2013.

32 

Xie Z, Lei B, Huang Q, Deng J, Wu M, Shen W and Cheng Y: Neuroprotective effect of Cyclosporin A on the development of early brain injury in a subarachnoid hemorrhage model: A pilot study. Brain Res. 1472:113–123. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Yakovlev AG, Knoblach SM, Fan L, Fox GB, Goodnight R and Faden AI: Activation of CPP32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. J Neurosci. 17:7415–7424. 1997.PubMed/NCBI

34 

Kim JY, Kim N, Yenari MA and Chang W: Hypothermia and pharmacological regimens that prevent overexpression and overactivity of the extracellular calcium-sensing receptor protect neurons against traumatic brain injury. J Neurotrauma. 30:1170–1176. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Schoch KM, Evans HN, Brelsfoard JM, Madathil SK, Takano J, Saido TC and Saatman KE: Calpastatin overexpression limits calpain-mediated proteolysis and behavioral deficits following traumatic brain injury. Exp Neurol. 236:371–382. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Sullivan PG, Rabchevsky AG, Waldmeier PC and Springer JE: Mitochondrial permeability transition in CNS trauma: Cause or effect of neuronal cell death? J Neurosci Res. 79:231–239. 2005. View Article : Google Scholar

37 

Alexi T, Borlongan CV, Faull R, Williams CE, Clark RG, Gluckman PD and Hughes PE: Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases. Prog Neurobiol. 60:409–470. 2000. View Article : Google Scholar : PubMed/NCBI

38 

Bar-Or D, Bar-Or R, Rael LT and Brody EN: Oxidative stress in severe acute illness. Redox Biol. 4:340–345. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Ehsaei M, Khajavi M, Arjmand MH, Abuee MA, Ghayour-Mobarhan M and Hamidi Alamdari D: Prooxidant-antioxidant balance in patients with traumatic brain injury. Acta Neurol Belg. 115:69–73. 2015. View Article : Google Scholar

40 

Freire MA: Pathophysiology of neurodegeneration following traumatic brain injury. West Indian Med J. 61:751–755. 2012.

41 

Xue T, Luo P, Zhu H, Zhao Y, Wu H, Gai R, Wu Y, Yang B, Yang X and He Q: Oxidative stress is involved in Dasatinib-induced apoptosis in rat primary hepatocytes. Toxicol Appl Pharmacol. 261:280–291. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Lau WK, Mak JC, Chan KH and Law AC: Cigarette smoke-induced cerebral cortical interleukin-6 elevation is not mediated through oxidative stress. Neurotox Res. 22:170–176. 2012. View Article : Google Scholar :

43 

Zelko IN, Mariani TJ and Folz RJ: Superoxide dismutase multigene family: A comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radic Biol Med. 33:337–349. 2002. View Article : Google Scholar : PubMed/NCBI

44 

Chelikani P, Fita I and Loewen PC: Diversity of structures and properties among catalases. Cell Mol Life Sci. 61:192–208. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Ansari MA, Roberts KN and Scheff SW: Oxidative stress and modification of synaptic proteins in hippocampus after traumatic brain injury. Free Radic Biol Med. 45:443–452. 2008. View Article : Google Scholar : PubMed/NCBI

46 

Wang D, Yuan X, Liu T, Liu L, Hu Y, Wang Z and Zheng Q: Neuroprotective activity of lavender oil on transient focal cerebral ischemia in mice. Molecules. 17:9803–9817. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Zhang C, Peng W, Xia Z, Gan P, Huang W, Shi Y and Fan R: Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury. Mol Med Rep 14: 3690-3696, 2016.
APA
Wang, Y., Zhang, C., Peng, W., Xia, Z., Gan, P., Huang, W. ... Fan, R. (2016). Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury. Molecular Medicine Reports, 14, 3690-3696. https://doi.org/10.3892/mmr.2016.5720
MLA
Wang, Y., Zhang, C., Peng, W., Xia, Z., Gan, P., Huang, W., Shi, Y., Fan, R."Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury". Molecular Medicine Reports 14.4 (2016): 3690-3696.
Chicago
Wang, Y., Zhang, C., Peng, W., Xia, Z., Gan, P., Huang, W., Shi, Y., Fan, R."Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury". Molecular Medicine Reports 14, no. 4 (2016): 3690-3696. https://doi.org/10.3892/mmr.2016.5720
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Zhang C, Peng W, Xia Z, Gan P, Huang W, Shi Y and Fan R: Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury. Mol Med Rep 14: 3690-3696, 2016.
APA
Wang, Y., Zhang, C., Peng, W., Xia, Z., Gan, P., Huang, W. ... Fan, R. (2016). Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury. Molecular Medicine Reports, 14, 3690-3696. https://doi.org/10.3892/mmr.2016.5720
MLA
Wang, Y., Zhang, C., Peng, W., Xia, Z., Gan, P., Huang, W., Shi, Y., Fan, R."Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury". Molecular Medicine Reports 14.4 (2016): 3690-3696.
Chicago
Wang, Y., Zhang, C., Peng, W., Xia, Z., Gan, P., Huang, W., Shi, Y., Fan, R."Hydroxysafflor yellow A exerts antioxidant effects in a rat model of traumatic brain injury". Molecular Medicine Reports 14, no. 4 (2016): 3690-3696. https://doi.org/10.3892/mmr.2016.5720
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