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Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs

  • Authors:
    • Changhwan Ahn
    • Da‑Hye Shin
    • Dongoh Lee
    • Su‑Myung Kang
    • Ju‑Hyung Seok
    • Hee Young Kang
    • Eui‑Bae Jeung
  • View Affiliations / Copyright

    Affiliations: Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea
    Copyright: © Ahn et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3697-3703
    |
    Published online on: September 6, 2016
       https://doi.org/10.3892/mmr.2016.5725
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Abstract

Tight junctions are the outermost structures of intercellular junctions and are classified as transmembrane proteins. These factors form selective permeability barriers between cells, act as paracellular transporters and regulate structural and functional polarity of cells. Although tight junctions have been previously studied, comparison of the transcriptional‑translational levels of these molecules in canine organs remains to be investigated. In the present study, organ‑specific expression of the tight junction proteins, claudin, occludin, junction adhesion molecule A and zona occludens 1 was examined in the canine duodenum, lung, liver and kidney. Results of immunohistochemistry analysis demonstrated that the tight junctions were localized in intestinal villi and glands of the duodenum, bronchiolar epithelia and alveolar walls of the lung, endometrium and myometrium of the hepatocytes, and the distal tubules and glomeruli of the kidney. These results suggest that tight junctions are differently expressed in organs, and therefore may be involved in organ‑specific functions to maintain physiological homeostasis.
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1 

Green KJ, Getsios S, Troyanovsky S and Godsel LM: Intercellular junction assembly, dynamics, and homeostasis. Cold Spring Harb Perspect Biol. 2:a0001252010. View Article : Google Scholar : PubMed/NCBI

2 

Martin TA and Jiang WG: Tight junctions and their role in cancer metastasis. Histol Histopathol. 16:1183–1195. 2001.PubMed/NCBI

3 

Gumbiner BM: Cell adhesion: The molecular basis of tissue architecture and morphogenesis. Cell. 84:345–357. 1996. View Article : Google Scholar : PubMed/NCBI

4 

Tamura A, Yamazaki Y, Hayashi D, Suzuki K, Sentani K, Yasui W and Tsukita S: Claudin-based paracellular proton barrier in the stomach. Ann N Y Acad Sci. 1258:108–114. 2012. View Article : Google Scholar : PubMed/NCBI

5 

González-Mariscal L, Betanzos A, Nava P and Jaramillo BE: Tight junction proteins. Prog Biophys Mol Biol. 81:1–44. 2003. View Article : Google Scholar

6 

Findley MK and Koval M: Regulation and roles for claudin-family tight junction proteins. IUBMB Life. 61:431–437. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Angelow S, Ahlstrom R and Yu AS: Biology of claudins. Am J Physiol Renal Physiol. 295:F867–F876. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Tsukita S and Furuse M: The structure and function of claudins, cell adhesion molecules at tight junctions. Ann NY Acad Sci. 915:129–135. 2000. View Article : Google Scholar

9 

Tsukita S and Furuse M: Occludin and claudins in tight-junction strands: Leading or supporting players? Trends Cell Biol. 9:268–273. 1999. View Article : Google Scholar : PubMed/NCBI

10 

Ando-Akatsuka Y, Saitou M, Hirase T, Kishi M, Sakakibara A, Itoh M, Yonemura S, Furuse M and Tsukita S: Interspecies diversity of the occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. J Cell Biol. 133:43–47. 1996. View Article : Google Scholar : PubMed/NCBI

11 

Balda MS, Whitney JA, Flores C, González S, Cereijido M and Matter K: Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein. J Cell Biol. 134:1031–1049. 1996. View Article : Google Scholar : PubMed/NCBI

12 

McCarthy KM, Skare IB, Stankewich MC, Furuse M, Tsukita S, Rogers RA, Lynch RD and Schneeberger EE: Occludin is a functional component of the tight junction. J Cell Sci. 109:2287–2298. 1996.PubMed/NCBI

13 

Gye MC: Expression of occludin in canine testis and epididymis. Reprod Domest Anim. 39:43–47. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Kimura Y, Shiozaki H, Hirao M, Maeno Y, Doki Y, Inoue M, Monden T, Ando-Akatsuka Y, Furuse M, Tsukita S and Monden M: Expression of occludin, tight-junction-associated protein, in human digestive tract. Am J Pathol. 151:45–54. 1997.PubMed/NCBI

15 

Mandell KJ and Parkos CA: The JAM family of proteins. Adv Drug Deliv Rev. 57:857–867. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Niessen CM: Tight junctions/adherens junctions: Basic structure and function. J Invest Dermatol. 127:2525–2532. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Islas S, Vega J, Ponce L and Gonzalez-Mariscal L: Nuclear localization of the tight junction protein ZO-2 in epithelial cells. Exp Cell Res. 274:138–148. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Balda MS and Matter K: The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression. EMBO J. 19:2024–2033. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Stevenson BR, Siliciano JD, Mooseker MS and Goodenough DA: Identification of ZO-1: A high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia. J Cell Biol. 103:755–766. 1986. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar

21 

Ohta H, Yamaguchi T, Rajapakshage BK, Murakami M, Sasaki N, Nakamura K, Hwang SJ, Yamasaki M and Takiguchi M: Expression and subcellular localization of apical junction proteins in canine duodenal and colonic mucosa. Am J Vet Res. 72:1046–1051. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Hwang I, Yang H, Kang HS, Ahn CH, Lee GS, Hong EJ, An BS and Jeung EB: Spatial expression of claudin family members in various organs of mice. Mol Med Rep. 9:1806–1812. 2014.PubMed/NCBI

23 

Hewitt KJ, Agarwal R and Morin PJ: The claudin gene family: Expression in normal and neoplastic tissues. BMC Cancer. 6:1862006. View Article : Google Scholar : PubMed/NCBI

24 

Balkovetz DF: Tight junction claudins and the kidney in sickness and in health. Biochim Biophys Acta. 1788:858–863. 2009. View Article : Google Scholar

25 

Hwang I, An BS, Yang H, Kang HS, Jung EM and Jeung EB: Tissue-specific expression of occludin, zona occludens-1, and junction adhesion molecule A in the duodenum, ileum, colon, kidney, liver, lung, brain, and skeletal muscle of C57BL mice. J Physiol Pharmacol. 64:11–18. 2013.PubMed/NCBI

26 

Laukoetter MG, Nava P, Lee WY, Severson EA, Capaldo CT, Babbin BA, Williams IR, Koval M, Peatman E, Campbell JA, et al: JAM-A regulates permeability and inflammation in the intestine in vivo. J Exp Med. 204:3067–3076. 2007. View Article : Google Scholar : PubMed/NCBI

27 

Ridyard AE, Brown JK, Rhind SM, Else RW, Simpson JW and Miller HR: Apical junction complex protein expression in the canine colon: Differential expression of claudin-2 in the colonic mucosa in dogs with idiopathic colitis. J Histochem Cytochem. 55:1049–1058. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Hartsock A and Nelson WJ: Adherens and tight junctions: Structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta. 1778:660–669. 2008. View Article : Google Scholar

29 

Lambrecht BN and Hammad H: Biology of lung dendritic cells at the origin of asthma. Immunity. 31:412–424. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Nagai M, Yaoita E, Yoshida Y, Kuwano R, Nameta M, Ohshiro K, Isome M, Fujinaka H, Suzuki S, Suzuki J, et al: Coxsackievirus and adenovirus receptor, a tight junction membrane protein, is expressed in glomerular podocytes in the kidney. Lab Invest. 83:901–911. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Lee NP and Luk JM: Hepatic tight junctions: From viral entry to cancer metastasis. World J Gastroenterol. 16:289–295. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ahn C, Shin DH, Lee D, Kang SM, Seok JH, Kang HY and Jeung EB: Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs. Mol Med Rep 14: 3697-3703, 2016.
APA
Ahn, C., Shin, D., Lee, D., Kang, S., Seok, J., Kang, H.Y., & Jeung, E. (2016). Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs. Molecular Medicine Reports, 14, 3697-3703. https://doi.org/10.3892/mmr.2016.5725
MLA
Ahn, C., Shin, D., Lee, D., Kang, S., Seok, J., Kang, H. Y., Jeung, E."Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs". Molecular Medicine Reports 14.4 (2016): 3697-3703.
Chicago
Ahn, C., Shin, D., Lee, D., Kang, S., Seok, J., Kang, H. Y., Jeung, E."Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs". Molecular Medicine Reports 14, no. 4 (2016): 3697-3703. https://doi.org/10.3892/mmr.2016.5725
Copy and paste a formatted citation
x
Spandidos Publications style
Ahn C, Shin DH, Lee D, Kang SM, Seok JH, Kang HY and Jeung EB: Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs. Mol Med Rep 14: 3697-3703, 2016.
APA
Ahn, C., Shin, D., Lee, D., Kang, S., Seok, J., Kang, H.Y., & Jeung, E. (2016). Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs. Molecular Medicine Reports, 14, 3697-3703. https://doi.org/10.3892/mmr.2016.5725
MLA
Ahn, C., Shin, D., Lee, D., Kang, S., Seok, J., Kang, H. Y., Jeung, E."Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs". Molecular Medicine Reports 14.4 (2016): 3697-3703.
Chicago
Ahn, C., Shin, D., Lee, D., Kang, S., Seok, J., Kang, H. Y., Jeung, E."Expression of claudins, occludin, junction adhesion molecule A and zona occludens 1 in canine organs". Molecular Medicine Reports 14, no. 4 (2016): 3697-3703. https://doi.org/10.3892/mmr.2016.5725
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