Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November-2016 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2016 Volume 14 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Chlorogenic acid prevents isoproterenol-induced DNA damage in vascular smooth muscle cells

  • Authors:
    • Jingshuai Wang
    • Jiyang Li
    • Jie Liu
    • Mengjiao Xu
    • Xiaowen Tong
    • Jianjun Wang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital, Shanghai 201204, P.R. China, Department of General Medicine, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200000, P.R. China, Department of Cardiovascular and Thoracic Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, P.R. China, Department of Obstetrics and Gynecology, Tongji Hospital of Tongji University, Tongji University School of Medicine, Shanghai 200065, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4063-4068
    |
    Published online on: September 15, 2016
       https://doi.org/10.3892/mmr.2016.5743
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Numerous clinical therapeutic agents have been identified as DNA damaging. The present study revealed that isoproterenol (Iso) resulted in DNA damage in vascular smooth muscle cells (VSMCs) and increased the levels of intracellular oxygen free radicals. Administration of chlorogenic acid (CGA) inhibited this effect. Pretreatment with CGA abrogated the increase in protein expression levels of γ‑H2A histone family member X, phosphorylated ataxia telangiectasia mutated, phosphorylated Rad3‑related protein, breast cancer 1 and C‑terminal Src homologous kinase induced by Iso. In addition, the increase in levels of intracellular reactive oxygen species (ROS) induced by Iso was inhibited by CGA pretreatment in a dose‑dependent manner. The results of the present study suggest that CGA may inhibit Iso‑induced VSMC damage via the suppression of ROS generation. Therefore, CGA may be a novel agent for the treatment of vascular diseases.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Zhang C, Luo T, Cui S, Gu Y, Bian C, Chen Y, Yu X and Wang Z: Poly(ADP-ribose) protects vascular smooth muscle cells from oxidative DNA damage. BMB Rep. 48:354–359. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Lord CJ and Ashworth A: The DNA damage response and cancer therapy. Nature. 481:287–294. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Gasser S and Raulet D: The DNA damage response, immunity and cancer. Semin Cancer Biol. 16:344–347. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Lee SH and Blair IA: Oxidative DNA damage and cardiovascular disease. Trends Cardiovasc Med. 11:148–155. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Narayanaswamy PB, Hodjat M, Haller H, Dumler I and Kiyan Y: Loss of urokinase receptor sensitizes cells to DNA damage and delays DNA repair. PLoS One. 9:e1015292014. View Article : Google Scholar : PubMed/NCBI

6 

Valko M, Jomova K, Rhodes CJ, Kuča K and Musílek K: Redox- and non-redox-metal-induced formation of free radicals and their role in human disease. Arch Toxicol. 90:1–37. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Gray K, Kumar S, Figg N, Harrison J, Baker L, Mercer J, Littlewood T and Bennett M: Effects of DNA damage in smooth muscle cells in atherosclerosis. Circ Res. 116:816–826. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Weber C and Noels H: Atherosclerosis: Current pathogenesis and therapeutic options. Nat Med. 17:1410–1422. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Fryburg DA and Vassileva MT: Atherosclerosis drug development in jeopardy: The need for predictive biomarkers of treatment response. Science Transl. 3:72cm62011.

10 

Kunieda T, Minamino T, Nishi J, Tateno K, Oyama T, Katsuno T, Miyauchi H, Orimo M, Okada S, Takamura M, et al: Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation. 114:953–960. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Matthews C, Gorenne I, Scott S, Figg N, Kirkpatrick P, Ritchie A, Goddard M and Bennett M: Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: Effects of telomerase and oxidative stress. Circ Res. 99:156–164. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Lebwohl M, Ting PT and Koo JY: Psoriasis treatment: Traditional therapy. Ann Rheum Dis. 64:Suppl 2. ii83–ii86. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Havelka AM, Berndtsson M, Olofsson MH, Shoshan MC and Linder S: Mechanisms of action of DNA-damaging anticancer drugs in treatment of carcinomas: Is acute apoptosis an ‘off-target’ effect? Mini Rev Med Chem. 7:1035–1039. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Cheung-Ong K, Giaever G and Nislow C: DNA-damaging agents in cancer chemotherapy: Serendipity and chemical biology. Chem Biol. 20:648–659. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Leone M, Boyadjiev I, Boulos E, Antonini F, Visintini P, Albanèse J and Martin C: A reappraisal of isoproterenol in goal-directed therapy of septic shock. Shock. 26:353–357. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Wiramus S, Textoris J, Bardin R, Vigne C, Kelway C, Martin C and Leone M: Isoproterenol infusion and microcirculation in septic shock. Heart Lung Vessel. 6:274–279. 2014.PubMed/NCBI

17 

Hara MR, Kovacs JJ, Whalen EJ, Rajagopal S, Strachan RT, Grant W, Towers AJ, Williams B, Lam CM, Xiao K, et al: A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. Nature. 477:349–353. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Parthasarathy A, Gopi V, Devi KMS, Balaji N and Vellaichamy E: Aminoguanidine inhibits ventricular fibrosis and remodeling process in isoproterenol-induced hypertrophied rat hearts by suppressing ROS and MMPs. Life Sci. 118:15–26. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Kim HK, Park WS, Warda M, Park SY, Ko EA, Kim MH, Jeong SH, Heo HJ, Choi TH, Hwang YW, et al: Beta adrenergic overstimulation impaired vascular contractility via actin-cytoskeleton disorganization in rabbit cerebral artery. PLoS One. 7:e438842012. View Article : Google Scholar : PubMed/NCBI

20 

Feng R, Lu Y, Bowman LL, Qian Y, Castranova V and Ding M: Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid. J Biol Chem. 280:27888–27895. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Yun N, Kang JW and Lee SM: Protective effects of chlorogenic acid against ischemia/reperfusion injury in rat liver: Molecular evidence of its antioxidant and anti-inflammatory properties. J Nutr Biochem. 23:1249–1255. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Li Y, Shen D, Tang X, Li X, Wo D, Yan H, Song R, Feng J, Li P, Zhang J and Li J: Chlorogenic acid prevents isoproterenol-induced hypertrophy in neonatal rat myocytes. Toxicol Lett. 226:257–263. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Esposti M Degli: Measuring mitochondrial reactive oxygen species. Methods. 26:335–340. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Choudhury S, Ghosh S, Gupta P, Mukherjee S and Chattopadhyay S: Inflammation-induced ROS generation causes pancreatic cell death through modulation of Nrf2/NF-κB and SAPK/JNK pathway. Free Radic Res. 49:1371–1383. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Kim W, Youn H, Kang C and Youn B: Inflammation-induced radioresistance is mediated by ROS-dependent inactivation of protein phosphatase 1 in non-small cell lung cancer cells. Apoptosis. 20:1242–1252. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Li Y, Shen D, Tang X, Li X, Wo D, Yan H, Song R, Feng J, Li P, Zhang J and Li J: Chlorogenic acid prevents isoproterenol-induced hypertrophy in neonatal rat myocytes. Toxicol Lett. 226:257–263. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Shi H, Shi A, Dong L, Lu X, Wang Y, Zhao J, Dai F and Guo X: Chlorogenic acid protects against liver fibrosis in vivo and in vitro through inhibition of oxidative stress. Clin Nutr S0261-5614. 00093–00095. 2016.

28 

Pruett ND, Hajdu Z, Zhang J, Visconti RP, Kern MJ, Wellik DM, Majesky MW and Awgulewitsch A: Changing topographic Hox expression in blood vessels results in regionally distinct vessel wall remodeling. Biol Open. 1:430–435. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Chen J, Xu L and Huang C: DHEA inhibits vascular remodeling following arterial injury: A possible role in suppression of inflammation and oxidative stress derived from vascular smooth muscle cells. Mol Cell Biochem. 388:75–84. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Kurz DJ, Decary S, Hong Y, Trivier E, Akhmedov A and Erusalimsky JD: Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in humanendothelial cells. J Cell Sci. 117:2417–2426. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Pang C, Sheng YC, Jiang P, Wei H and Ji LL: Chlorogenic acid prevents acetaminophen-induced liver injury: The involvement of CYP450 metabolic enzymes and some antioxidant signals. J Zhejiang Univ Sci B. 16:602–610. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Cha JW, Piao MJ, Kim KC, Yao CW, Zheng J, Kim SM, Hyun CL, Ahn YS and Hyun JW: The polyphenol chlorogenic acid attenuates UVB-mediated oxidative stress in human HaCaT keratinocytes. Biomol Ther. 22:136–142. 2014. View Article : Google Scholar

33 

Cinkilic N, Cetintas SK, Zorlu T, Vatan O, Yilmaz D, Cavas T, Tunc S, Ozkan L and Bilaloglu R: Radioprotection by two phenolic compounds: Chlorogenic and quinic acid, on X-ray induced DNA damage in human blood lymphocytes in vitro. Food Chem Toxicol. 53:359–363. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Wang Y, Zhang X, Zhang Q and Yang Z: Oxidative damage to DNA by 1,10-phenanthroline/L: -Threonine copper (II) complexes with chlorogenic acid. Biometals. 23:265–273. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Chen X, Sang X, Li S, Zhang S and Bai L: Studies on a chlorogenic acid-producing endophytic fungi isolated from Eucommia ulmoides Oliver. J Ind Microbiol Biotechnol. 37:447–454. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Yuan Y, Wang Z, Jiang C, Wang X and Huang L: Exploiting genes and functional diversity of chlorogenic acid and luteolin biosyntheses in Lonicera japonica and their substitutes. Gene. 534:408–416. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang J, Li J, Liu J, Xu M, Tong X and Wang J: Chlorogenic acid prevents isoproterenol-induced DNA damage in vascular smooth muscle cells. Mol Med Rep 14: 4063-4068, 2016.
APA
Wang, J., Li, J., Liu, J., Xu, M., Tong, X., & Wang, J. (2016). Chlorogenic acid prevents isoproterenol-induced DNA damage in vascular smooth muscle cells. Molecular Medicine Reports, 14, 4063-4068. https://doi.org/10.3892/mmr.2016.5743
MLA
Wang, J., Li, J., Liu, J., Xu, M., Tong, X., Wang, J."Chlorogenic acid prevents isoproterenol-induced DNA damage in vascular smooth muscle cells". Molecular Medicine Reports 14.5 (2016): 4063-4068.
Chicago
Wang, J., Li, J., Liu, J., Xu, M., Tong, X., Wang, J."Chlorogenic acid prevents isoproterenol-induced DNA damage in vascular smooth muscle cells". Molecular Medicine Reports 14, no. 5 (2016): 4063-4068. https://doi.org/10.3892/mmr.2016.5743
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Li J, Liu J, Xu M, Tong X and Wang J: Chlorogenic acid prevents isoproterenol-induced DNA damage in vascular smooth muscle cells. Mol Med Rep 14: 4063-4068, 2016.
APA
Wang, J., Li, J., Liu, J., Xu, M., Tong, X., & Wang, J. (2016). Chlorogenic acid prevents isoproterenol-induced DNA damage in vascular smooth muscle cells. Molecular Medicine Reports, 14, 4063-4068. https://doi.org/10.3892/mmr.2016.5743
MLA
Wang, J., Li, J., Liu, J., Xu, M., Tong, X., Wang, J."Chlorogenic acid prevents isoproterenol-induced DNA damage in vascular smooth muscle cells". Molecular Medicine Reports 14.5 (2016): 4063-4068.
Chicago
Wang, J., Li, J., Liu, J., Xu, M., Tong, X., Wang, J."Chlorogenic acid prevents isoproterenol-induced DNA damage in vascular smooth muscle cells". Molecular Medicine Reports 14, no. 5 (2016): 4063-4068. https://doi.org/10.3892/mmr.2016.5743
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team