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Article

Cardioprotective potential of Dendrobium officinale Kimura et Migo against myocardial ischemia in mice

  • Authors:
    • Meng‑Meng Dou
    • Zhi‑Hao Zhang
    • Zhu‑Bo Li
    • Jie Zhang
    • Xiao‑Yan Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, P.R. China, Department of Neurology, The Ninth People's Hospital of Chongqing, Chongqing 400700, P.R. China
  • Pages: 4407-4414
    |
    Published online on: September 26, 2016
       https://doi.org/10.3892/mmr.2016.5789
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Abstract

Dendrobium officinale Kimura et Migo has been used for thousands of years to promote body fluid production; however, little is currently known regarding its effects on the heart. The present study aimed to explore the cardioprotective potential of the water extract of Dendrobium officinale Kimura et Migo (DOE) on myocardial ischemia in mice. A mouse model of myocardial ischemia was induced following ligation of the left anterior descending coronary artery. Prior to the operation, mice were administered a vehicle or DOE for 2 weeks. Following the operation, ST elevation was measured. To estimate the extent of myocardial damage, infarct size analysis and histopathological examination were performed. The activities of cardiac marker enzymes [creatine kinase (CK)‑MB and lactate dehydrogenase (LDH)] and antioxidative indicators [malondialdehyde (MDA) and superoxide dismutase (SOD)] were also analyzed to explore the underlying mechanisms. Treatment with DOE decreased infarct size and the number of apoptotic cardiomyocytes; reduced serum CK‑MB, LDH and MDA activities; and increased SOD levels. According to western blotting, DOE conferred protection against myocardial ischemic injury via the regulation of Meis1 expression. These results indicated that DOE may exert potential cardioprotective effects against myocardial ischemia; these effects may be associated with its antioxidant activity, and its ability to inhibit cardiac cell apoptosis and to regulate Meis1 expression.
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View References

1 

World Health Organization, . Global status report on noncommunicable disease 2014. World Health Organization; Geneva, Switzerland: pp. 9–14. 2014

2 

Gao E, Lei YH, Shang X, Huang ZM, Zuo L, Boucher M, Fan Q, Chuprun JK, Ma XL and Koch WJ: A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse. Circ Res. 107:1445–1453. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Hori M and Nishida K: Oxidative stress and left ventricular remodelling after myocardial infarction. Cardiovasc Res. 81:457–464. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Sun J, Nguyen T, Aponte AM, Menazza S, Kohr MJ, Roth DM, Patel HH, Murphy E and Steenbergen C: Ischaemic preconditioning preferentially increases protein S-nitrosylation in subsarcolemmal mitochondria. Cardiovasc Res. 106:227–236. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Abbate A, Bussani R, Amin MS, Vetrovec GW and Baldi A: Acute myocardial infarction and heart failure: Role of apoptosis. Int J Biochem Cell Biol. 38:1834–1840. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Han SY, Li HX, Ma X, Zhang K, Ma ZZ and Tu PF: Protective effects of purified safflower extract on myocardial ischemia in vivo and in vitro. Phytomedicine. 16:694–702. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Ma X, Zhang K, Li H, Han S, Ma Z and Tu P: Extracts from Astragalus membranaceus limit myocardial cell death and improve cardiac function in a rat model of myocardial ischemia. J Ethnopharmacol. 149:720–728. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Ng TB, Liu J, Wong JH, Ye X, Sze SC Wing, Tong Y and Zhang KY: Review of research on Dendrobium, a prized folk medicine. Appl Microbiol Biotechnol. 93:1795–1803. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Lin X, Shaw PC, Sze SC, Tong Y and Zhang Y: Dendrobium officinale polysaccharides ameliorate the abnormality of aquaporin 5, pro-inflammatory cytokines and inhibit apoptosis in the experimental Sjögren's syndrome mice. Int Immunopharmacol. 11:2025–2032. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Xia L, Liu X, Guo H, Zhang H, Zhu J and Ren F: Partial characterization and immunomodulatory activity of polysaccharides from the stem of Dendrobium officinale (Tiepishihu) in vitro. J Funct Foods. 4:294–301. 2012. View Article : Google Scholar

11 

Wang Q, Gong Q, Wu Q and Shi J: Neuroprotective effects of Dendrobium alkaloids on rat cortical neurons injured by oxygen-glucose deprivation and reperfusion. Phytomedicine. 17:108–115. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Zhao X, Sun P, Qian Y and Suo H: D. candidum has in vitro anticancer effects in HCT-116 cancer cells and exerts in vivo anti-metastatic effects in mice. Nutr Res Pract. 8:487–493. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Lin X, Sze SCW, Tong Y, Zhang Z, Feng Y, Chen JP, Ng TB, Lin X, Shaw PC and Zhang KY: Protective effect of Dendrobium officinale polysaccharides on experimental Sjögren's syndrome. J Complement Integr Med. 7(1)2010. View Article : Google Scholar : PubMed/NCBI

14 

Yang L, Liu SJ, Luo HR, Cui J, Zhou J, Wang XJ, Sheng J and Hu JM: Two new dendrocandins with neurite outgrowth-promoting activity from Dendrobium officinale. J Asian Nat Prod Res. 17:125–131. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Chen CC, Wu LG, Ko FN and Teng CM: Antiplatelet aggregation principles of Dendrobium Loddigesii. J Nat Prod. 57:1271–1274. 1994. View Article : Google Scholar : PubMed/NCBI

16 

Cui L, Li M, Feng F, Yang Y, Hang X, Cui J and Gao J: Meis1 functions as a potential AR negative regulator. Exp Cell Res. 328:58–68. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Yuan X and Braun T: An unexpected switch: Regulation of cardiomyocyte proliferation by the homeobox gene meis1. Circ Res. 113:245–248. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Azcoitia V, Aracil M, Martinez-A C and Torres M: The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo. Dev Biol. 280:307–320. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Mahmoud AI, Kocabas F, Muralidhar SA, Kimura W, Koura AS, Thet S, Porrello ER and Sadek HA: Meis1 regulates postnatal cardiomyocyte cell cycle arrest. Nature. 497:249–253. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Ahn D, Cheng L, Moon C, Spurgeon H, Lakatta EG and Talan MI: Induction of myocardial infarcts of a predictable size and location by branch pattern probability-assisted coronary ligation in C57BL/6 mice. Am J Physiol Heart Circ Physiol. 286:H1201–H1207. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Samsamshariat SA, Samsamshariat ZA and Movahed MR: A novel method for safe and accurate left anterior descending coronary artery ligation for research in rats. Cardiovasc Revasc Med. 6:121–123. 2005. View Article : Google Scholar : PubMed/NCBI

22 

Chu W, Qiao G, Bai Y, Pan Z, Li G, Piao X, Wu L, Lu Y and Yang B: Flavonoids from Chinese Viscum coloratum produce cytoprotective effects against ischemic myocardial injuries: Inhibitory effect of flavonoids on PAF-induced Ca2+ overload. Phytother Res. 22:134–137. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Zhao XY, Li GY, Liu Y, Chai LM, Chen JX, Zhang Y, Du ZM, Lu YJ and Yang BF: Resveratrol protects against arsenic trioxide-induced cardiotoxicity in vitro and in vivo. Br J Pharmacol. 154:105–113. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Plummer BN, Liu H, Wan X, Deschênes I and Laurita KR: Targeted antioxidant treatment decreases cardiac alternans associated with chronic myocardial infarction. Circ Arrhythm Electrophysiol. 8:165–173. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Queenthy SS and John B: Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infarcted rats. Eur J Pharmacol. 718:213–218. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Gong LL, Fang LH, Wang SB, Sun JL, Qin HL, Li XX, Wang SB and Du GH: Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats. Atherosclerosis. 222:50–58. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Radhiga T, Rajamanickam C, Senthil S and Pugalendi KV: Effect of ursolic acid on cardiac marker enzymes, lipid profile and macroscopic enzyme mapping assay in isoproterenol-induced myocardial ischemic rats. Food Chem Toxicol. 50:3971–3977. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Derbali A, Mnafgui K, Affes M, Derbali F, Hajji R, Gharsallah N, Allouche N and El Feki A: Cardioprotective effect of linseed oil against isoproterenol-induced myocardial infarction in Wistar rats: A biochemical and electrocardiographic study. J Physiol Biochem. 71:281–288. 2015. View Article : Google Scholar : PubMed/NCBI

29 

He H, Xu J, Xu Y, Zhang C, Wang H, He Y, Wang T and Yuan D: Cardioprotective effects of saponins from Panax japonicus on acute myocardial ischemia against oxidative stress-triggered damage and cardiac cell death in rats. J Ethnopharmacol. 140:73–82. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Quan W, Wu B, Bai Y, Zhang X, Yin J, Xi M, Guan Y, Shao Q, Chen Y, Wu Q and Wen A: Magnesium lithospermate B improves myocardial function and prevents simulated ischemia/reperfusion injury-induced H9c2 cardiomyocytes apoptosis through Akt-dependent pathway. J Ethnopharmacol. 151:714–721. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Wu L, Qiao H, Li Y and Li L: Protective roles of puerarin and Danshensu on acute ischemic myocardial injury in rats. Phytomedicine. 14:652–658. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Qin F, Liu YX, Zhao HW, Huang X, Ren P and Zhu ZY: Chinese medicinal formula Guan-Xin-Er-Hao protects the heart against oxidative stress induced by acute ischemic myocardial injury in rats. Phytomedicine. 16:215–221. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Yu C, Fu F, Yu X, Han B and Zhu M: Cardioprotective effect of Ocotillol, a derivate of pseudoginsenoside F11, on myocardial injury induced by isoproterenol in rats. Arzneimittelforschung. 57:568–572. 2007.PubMed/NCBI

34 

Borst O, Ochmann C, Schönberger T, Jacoby C, Stellos K, Seizer P, Flögel U, Lang F and Gawaz M: Methods employed for induction and analysis of experimental myocardial infarction in mice. Cell Physiol Biochem. 28:1–12. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Stankunas K, Shang C, Twu KY, Kao SC, Jenkins NA, Copeland NG, Sanyal M, Selleri L, Cleary ML and Chang CP: Pbx/Meis deficiencies demonstrate multigenetic origins of congenital heart disease. Circ Res. 103:702–709. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Dou MM, Zhang ZH, Li ZB, Zhang J and Zhao XY: Cardioprotective potential of Dendrobium officinale Kimura et Migo against myocardial ischemia in mice. Mol Med Rep 14: 4407-4414, 2016.
APA
Dou, M., Zhang, Z., Li, Z., Zhang, J., & Zhao, X. (2016). Cardioprotective potential of Dendrobium officinale Kimura et Migo against myocardial ischemia in mice. Molecular Medicine Reports, 14, 4407-4414. https://doi.org/10.3892/mmr.2016.5789
MLA
Dou, M., Zhang, Z., Li, Z., Zhang, J., Zhao, X."Cardioprotective potential of Dendrobium officinale Kimura et Migo against myocardial ischemia in mice". Molecular Medicine Reports 14.5 (2016): 4407-4414.
Chicago
Dou, M., Zhang, Z., Li, Z., Zhang, J., Zhao, X."Cardioprotective potential of Dendrobium officinale Kimura et Migo against myocardial ischemia in mice". Molecular Medicine Reports 14, no. 5 (2016): 4407-4414. https://doi.org/10.3892/mmr.2016.5789
Copy and paste a formatted citation
x
Spandidos Publications style
Dou MM, Zhang ZH, Li ZB, Zhang J and Zhao XY: Cardioprotective potential of Dendrobium officinale Kimura et Migo against myocardial ischemia in mice. Mol Med Rep 14: 4407-4414, 2016.
APA
Dou, M., Zhang, Z., Li, Z., Zhang, J., & Zhao, X. (2016). Cardioprotective potential of Dendrobium officinale Kimura et Migo against myocardial ischemia in mice. Molecular Medicine Reports, 14, 4407-4414. https://doi.org/10.3892/mmr.2016.5789
MLA
Dou, M., Zhang, Z., Li, Z., Zhang, J., Zhao, X."Cardioprotective potential of Dendrobium officinale Kimura et Migo against myocardial ischemia in mice". Molecular Medicine Reports 14.5 (2016): 4407-4414.
Chicago
Dou, M., Zhang, Z., Li, Z., Zhang, J., Zhao, X."Cardioprotective potential of Dendrobium officinale Kimura et Migo against myocardial ischemia in mice". Molecular Medicine Reports 14, no. 5 (2016): 4407-4414. https://doi.org/10.3892/mmr.2016.5789
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