|
1
|
Bianconi E, Piovesan A, Facchin F, Beraudi
A, Casadei R, Frabetti F, Vitale L, Pelleri MC, Tassani S, Piva F,
et al: An estimation of the number of cells in the human body. Ann
Hum Biol. 40:463–471. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Bonewald LF: Osteocytes as dynamic
multifunctional cells. Ann N Y Acad Sci. 1116:281–290. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Busse B, Djonic D, Milovanovic P, Hahn M,
Püschel K, Ritchie RO, Djuric M and Amling M: Decrease in the
osteocyte lacunar density accompanied by hypermineralized lacunar
occlusion reveals failure and delay of remodeling in aged human
bone. Aging Cell. 9:1065–1075. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Bonewald LF: The amazing osteocyte. J Bone
Miner Res. 26:229–238. 2011. View
Article : Google Scholar : PubMed/NCBI
|
|
5
|
Nakashima T, Hayashi M, Fukunaga T, Kurata
K, Oh-Hora M, Feng JQ, Bonewald LF, Kodama T, Wutz A, Wagner EF, et
al: Evidence for osteocyte regulation of bone homeostasis through
RANKL expression. Nat Med. 17:1231–1234. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Baron R and Kneissel M: WNT signaling in
bone homeostasis and disease: From human mutations to treatments.
Nat Med. 19:179–192. 2013. View
Article : Google Scholar : PubMed/NCBI
|
|
7
|
Javaheri B, Stern AR, Lara N, Dallas M,
Zhao H, Liu Y, Bonewald LF and Johnson ML: Deletion of a single
b-catenin allele in osteocytes abolishes the bone anabolic response
to loading. J Bone Miner Res. 29:705–715. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Robling AG, Niziolek PJ, Baldridge LA,
Condon KW, Allen MR, Alam I, Mantila SM, Gluhak-Heinrich J, Bellido
TM, Harris SE and Turner CH: Mechanical stimulation of bone in vivo
reduces osteocyte expression of Sost/sclerostin. J Biol Chem.
283:5866–5875. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Paszty C, Turner CH and Robinson MK:
Sclerostin: A gem from the genome leads to bone-building
antibodies. J Bone Miner Res. 25:1897–1904. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Xiong J and O'Brien CA: Osteocyte RANKL:
New insights into the control of bone remodeling. J Bone Miner Res.
27:499–505. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Burgers TA and Williams BO: Regulation of
Wnt/b-catenin signaling within and from osteocytes. Bone.
54:244–249. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Tate ML Knothe, Niederer P and Knothe U:
In vivo tracer transport through the lacunocanalicular system of
rat bone in an environment devoid of mechanical loading. Bone.
22:107–117. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Gortazar AR, Martin-Millan M, Bravo B,
Plotkin LI and Bellido T: Crosstalk between
caveolin-1/extracellular signal-regulated kinase (ERK) and
b-catenin survival pathways in osteocyte mechanotransduction. J
Biol Chem. 288:8168–8175. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Tate ML Knothe: ‘Whither flows the fluid
in bone?’ An osteocyte's perspective. J Biomech. 36:1409–1424.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Dufour C, Holy X and Marie PJ:
Transforming growth factor-beta prevents osteoblast apoptosis
induced by skeletal unloading via PI3K/Akt, Bcl-2 and phospho-Bad
signaling. Am J Physiol Endocrinol Metab. 294:E794–E801. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Jilka RL, Noble B and Weinstein RS:
Osteocyte apoptosis. Bone. 54:264–271. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Bikle DD and Halloran BP: The response of
bone to unloading. J Bone Miner Metab. 17:233–244. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Ontiveros C, Irwin R, Wiseman RW and
McCabe LR: Hypoxia suppresses runx2 independent of modeled
microgravity. J Cell Physiol. 200:169–176. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Stevens HY, Meays DR and Frangos JA:
Pressure gradients and transport in the murine femur upon hindlimb
suspension. Bone. 39:565–572. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Dodd JS, Raleigh JA and Gross TS:
Osteocyte hypoxia: A novel mechanotransduction pathway. Am J
Physiol. 277:C598–C602. 1999.PubMed/NCBI
|
|
21
|
Hinoi E, Ochi H, Takarada T, Nakatani E,
Iezaki T, Nakajima H, Fujita H, Takahata Y, Hidano S, Kobayashi T,
et al: Positive regulation of osteoclastic differentiation by
growth differentiation factor 15 upregulated in osteocytic cells
under hypoxia. J Bone Miner Res. 27:938–949. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Plotkin LI, Mathov I, Aguirre JI, Parfitt
AM, Manolagas SC and Bellido T: Mechanical stimulation prevents
osteocyte apoptosis: Requirement of integrins, Src kinases, and
ERKs. Am J Physiol Cell Physiol. 289:C633–C643. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Wang H, Ji B, Liu XS, Nakatani E, Iezaki
T, Nakajima H, Fujita H, Takahata Y, Hidano S and Kobayashi T:
Osteocyte-viability-based simulations of trabecular bone loss and
recovery in disuse and reloading. Biomech Model Mechanobiol.
13:153–166. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Aguirre JI, Plotkin LI, Stewart SA,
Weinstein RS, Parfitt AM, Manolagas SC and Bellido T: Osteocyte
apoptosis is induced by weightlessness in mice and precedes
osteoclast recruitment and bone loss. J Bone Miner Res. 21:605–615.
2006. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Bellido T: Osteocyte-driven bone
remodeling. Calcif Tissue Int. 94:25–34. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Gross TS, Akeno N, Clemens TL, Komarova S,
Srinivasan S, Weimer DA and Mayorov S: Selected contribution:
Osteocytes upregulate HIF-1alpha in response to acute disuse and
oxygen deprivation. J Appl Physiol (1985). 90:2514–2519.
2001.PubMed/NCBI
|
|
27
|
Noble BS, Peet N, Stevens HY, Brabbs A,
Mosley JR, Reilly GC, Reeve J, Skerry TM and Lanyon LE: Mechanical
loading: Biphasic osteocyte survival and targeting of osteoclasts
for bone destruction in rat cortical bone. Am J Physiol Cell
Physiol. 284:C934–C943. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Jung TW, Lee KT, Lee MW and Ka KH: SIRT1
attenuates palmitate-induced endoplasmic reticulum stress and
insulin resistance in HepG2 cells via induction of oxygen-regulated
protein 150. Biochem Biophys Res Commun. 422:229–232. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Kuwabara K, Matsumoto M, Ikeda J, Hori O,
Ogawa S, Maeda Y, Kitagawa K, Imuta N, Kinoshita T, Stern DM, et
al: Purification and characterization of a novel stress protein,
the 150-kDa oxygen-regulated protein (ORP150), from cultured rat
astrocytes and its expression in ischemic mouse brain. J Biol Chem.
271:5025–5032. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Guo D, Keightley A, Guthrie J, Veno PA,
Harris SE and Bonewald LF: Identification of osteocyte-selective
proteins. Proteomics. 10:3688–3698. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Boraldi F, Annovi G, Carraro F, Naldini A,
Tiozzo R, Sommer P and Quaglino D: Hypoxia influences the cellular
cross-talk of human dermal fibroblasts. A proteomic approach.
Biochim Biophys Acta. 1774:1402–1413. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Ozawa K, Kuwabara K, Tamatani M, Takatsuji
K, Tsukamoto Y, Kaneda S, Yanagi H, Stern DM, Eguchi Y, Tsujimoto
Y, et al: 150-kDa oxygen-regulated protein (ORP150) suppresses
hypoxia-induced apoptotic cell death. J Biol Chem. 274:6397–6404.
1999. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Kretowski R, Borzym-Kluczyk M and
Cechowska-Pasko M: Hypoxia enhances the senescence effect of
bortezomib-the proteasome inhibitor-on human skin fibroblasts.
Biomed Res Int. 2014:1962492014. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Kretowski R, Stypulkowska A and
Cechowska-Pasko M: Low-glucose medium induces ORP150 expression and
exerts inhibitory effect on apoptosis and senescence of human
breast MCF7 cells. Acta Biochim Pol. 60:167–173. 2013.PubMed/NCBI
|
|
35
|
Tamatani M, Matsuyama T, Yamaguchi A,
Mitsuda N, Tsukamoto Y, Taniguchi M, Che YH, Ozawa K, Hori O,
Nishimura H, et al: ORP150 protects against
hypoxia/ischemia-induced neuronal death. Nat Med. 7:317–323. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Bonewald LF: Establishment and
characterization of an osteocyte-like cell line, MLO-Y4. J Bone
Miner Metab. 17:61–65. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Kato Y, Windle JJ, Koop BA, Mundy GR and
Bonewald LF: Establishment of an osteocyte-like cell line, MLO-Y4.
J Bone Miner Res. 12:2014–2023. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Raleigh JA, Chou SC, Bono EL, Thrall DE
and Varia MA: Semiquantitative immunohistochemical analysis for
hypoxia in human tumors. Int J Radiat Oncol Biol Phys. 49:569–574.
2001. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Ahuja SS, Zhao S, Bellido T, Plotkin LI,
Jimenez F and Bonewald LF: CD40 ligand blocks apoptosis induced by
tumor necrosis factor alpha, glucocorticoids, and etoposide in
osteoblasts and the osteocyte-like cell line murine long bone
osteocyte-Y4. Endocrinology. 144:1761–1769. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Jilka RL, Weinstein RS, Bellido T, Parfitt
AM and Manolagas SC: Osteoblast programmed cell death (apoptosis):
Modulation by growth factors and cytokines. J Bone Miner Res.
13:793–802. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Plotkin LI, Weinstein RS, Parfitt AM,
Roberson PK, Manolagas SC and Bellido T: Prevention of osteocyte
and osteoblast apoptosis by bisphosphonates and calcitonin. J Clin
Invest. 104:1363–1374. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2 (−Delta Delta C (T)) Method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Al Hadi H, Smerdon GR and Fox SW:
Hyperbaric oxygen therapy suppresses osteoclast formation and bone
resorption. J Orthop Res. 31:1839–1844. 2013.PubMed/NCBI
|
|
44
|
Arnett TR: Acidosis, hypoxia and bone.
Arch Biochem Biophys. 503:103–109. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Hirao M, Hashimoto J, Yamasaki N, Ando W,
Tsuboi H, Myoui A and Yoshikawa H: Oxygen tension is an important
mediator of the transformation of osteoblasts to osteocytes. J Bone
Miner Metab. 25:266–276. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Harrison JS, Rameshwar P, Chang V and
Bandari P: Oxygen saturation in the bone marrow of healthy
volunteers. Blood. 99:3942002. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Hou M, Liu J, Liu F, Liu K and Yu B: C1q
tumor necrosis factor-related protein-3 protects mesenchymal stem
cells against hypoxia- and serum deprivation-induced apoptosis
through the phosphoinositide 3-kinase/Akt pathway. Int J Mol Med.
33:97–104. 2014.PubMed/NCBI
|
|
48
|
Rouault-Pierre K, Lopez-Onieva L, Foster
K, Anjos-Afonso F, Lamrissi-Garcia I, Serrano-Sanchez M, Mitter R,
Ivanovic Z, de Verneuil H, Gribben J, et al: HIF-2α protects human
hematopoietic stem/progenitors and acute myeloid leukemic cells
from apoptosis induced by endoplasmic reticulum stress. Cell Stem
Cell. 13:549–563. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Cechowska-Pasko M, Bankowski E and Chene
P: The effect of hypoxia on the expression of 150 kDa
oxygen-regulated protein (ORP 150) in HeLa cells. Cell Physiol
Biochem. 17:89–96. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Kitano H, Nishimura H, Tachibana H,
Yoshikawa H and Matsuyama T: ORP150 ameliorates
ischemia/reperfusion injury from middle cerebral artery occlusion
in mouse brain. Brain Res. 1015:122–128. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Ogawa S: ORP150 (150 kDa oxygen regulated
protein) suppressed neuronal cell death. Nihon Yakurigaku Zasshi.
121:43–48. 2003.(In Japanese). View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Riezzo I, Neri M, De Stefano F, Fulcheri
E, Ventura F, Pomara C, Rabozzi R, Turillazzi E and Fineschi V: The
timing of perinatal hypoxia/ischemia events in term neonates: A
retrospective autopsy study. HSPs, ORP-150 and COX2 are reliable
markers to classify acute, perinatal events. Diagn Pathol.
5:492010. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Arrington DD and Schnellmann RG: Targeting
of the molecular chaperone oxygen-regulated protein 150 (ORP150) to
mitochondria and its induction by cellular stress. Am J Physiol
Cell Physiol. 294:C641–C650. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Aleshin AN, Sawa Y, Kitagawa-Sakakida S,
Bando Y, Ono M, Memon IA, Tohyama M, Ogawa S and Matsuda H: 150-kDa
oxygen-regulated protein attenuates myocardial ischemia-reperfusion
injury in rat heart. J Mol Cell Cardiol. 38:517–525. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Matsusue A, Hara K, Kageura M, Kashiwagi
M, Lu W, Ishigami A, Gotohda T, Tokunaga I, Nisimura A, Sugimura T
and Kubo S: An autopsy case of rhabdomyolysis related to vegetamin
and genetic analysis of the rhabdomyolysis-associated genes. J
Forensic Leg Med. 17:46–49. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Dallas SL and Bonewald LF: Dynamics of the
transition from osteoblast to osteocyte. Ann N Y Acad Sci.
1192:437–443. 2010. View Article : Google Scholar : PubMed/NCBI
|
