Open Access

Occupational exposure to carcinogens: Benzene, pesticides and fibers (Review)

  • Authors:
    • Luca Falzone
    • Andrea Marconi
    • Carla Loreto
    • Sabrina Franco
    • Demetrios A. Spandidos
    • Massimo Libra
  • View Affiliations

  • Published online on: October 3, 2016     https://doi.org/10.3892/mmr.2016.5791
  • Pages: 4467-4474
  • Copyright: © Falzone et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

It is well known that the occupational exposure to contaminants and carcinogens leads to the development of cancer in exposed workers. In the 18th century, Percivall Pott was the first to hypothesize that chronic exposure to dust in the London chimney sweeps was associated with an increased risk of developing cancer. Subsequently a growing body of evidence indicated that other physical factors were also responsible for oncogenic mutations. Over the past decades, many carcinogens have been found in the occupational environment and their presence is often associated with an increased incidence of cancer. Occupational exposure involves several factors and the association between carcinogens, occupational exposure and cancer is still unclear. Only a fraction of factors is recognized as occupational carcinogens and for each factor, there is an increased risk of cancer development associated with a specific work activity. According to the International Agency for Research on Cancer (IARC), the majority of carcinogens are classified as ‘probable’ and ‘possible’ human carcinogens, while, direct evidence of carcinogenicity is provided in epidemiological and experimental studies. In the present review, exposures to benzene, pesticides and mineral fibers are discussed as the most important cancer risk factors during work activities.
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November-2016
Volume 14 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Falzone L, Marconi A, Loreto C, Franco S, Spandidos DA and Libra M: Occupational exposure to carcinogens: Benzene, pesticides and fibers (Review). Mol Med Rep 14: 4467-4474, 2016
APA
Falzone, L., Marconi, A., Loreto, C., Franco, S., Spandidos, D.A., & Libra, M. (2016). Occupational exposure to carcinogens: Benzene, pesticides and fibers (Review). Molecular Medicine Reports, 14, 4467-4474. https://doi.org/10.3892/mmr.2016.5791
MLA
Falzone, L., Marconi, A., Loreto, C., Franco, S., Spandidos, D. A., Libra, M."Occupational exposure to carcinogens: Benzene, pesticides and fibers (Review)". Molecular Medicine Reports 14.5 (2016): 4467-4474.
Chicago
Falzone, L., Marconi, A., Loreto, C., Franco, S., Spandidos, D. A., Libra, M."Occupational exposure to carcinogens: Benzene, pesticides and fibers (Review)". Molecular Medicine Reports 14, no. 5 (2016): 4467-4474. https://doi.org/10.3892/mmr.2016.5791