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Protective effect of resveratrol on spermatozoa function in male infertility induced by excess weight and obesity

  • Authors:
    • Xiangrong Cui
    • Xuan Jing
    • Xueqing Wu
    • Meiqin Yan
  • View Affiliations / Copyright

    Affiliations: Reproductive Medicine Center, Children's Hospital of Shanxi and Women Health Center of Shanxi, Taiyuan, Shanxi 030000, P.R. China, Clinical Laboratory, Shanxi Province People's Hospital, Taiyuan, Shanxi 030000, P.R. China
    Copyright: © Cui et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4659-4665
    |
    Published online on: October 12, 2016
       https://doi.org/10.3892/mmr.2016.5840
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Abstract

Male infertility is a complex, multifactorial and polygenic disease that contributes to ~50% cases of infertility. Previous studies have demonstrated that excess weight and obesity factors serve an important role in the development of male infertility. An increasing number of studies have reported that resveratrol may regulate the response of cells to specific stimuli that induce cell injury, as well as decrease germ cell apoptosis in mice or rats. In the present study, the semen quality and serum sex hormone levels were evaluated in 324 men, which included 73 underweight, 82 normal weight, 95 overweight and 74 obese men. All patients were referred to The Reproductive Medicine Center of Shanxi Women and Infants Hospital (Taiyuan, China) between January 2013 and January 2015. The aim of the present study was to investigate the effects of resveratrol treatment on the motility, plasma zinc concentration and acrosin activity of sperm from obese males. The sperm concentration, normal sperm morphology, semen volumes, DNA fragmentation rates and testosterone levels in men from the overweight and obese groups were markedly decreased when compared with men in the normal weight group. In addition, the progressive motility, seminal plasma zinc concentration and spermatozoa acrosin activity were notably decreased in the obese group compared with the normal weight group. However, estradiol levels were significantly increased in the overweight, obese and underweight groups compared with the normal weight group. Notably, semen samples from obese males with astenospermia treated with 0‑100 µmol/l resveratrol for 30 min demonstrated varying degrees of improvement in sperm motility. When these semen samples were treated with 30 µmol/l resveratrol, sperm motility improved when compared to other doses of resveratrol. Therefore, 30 µmol/l resveratrol was selected for further experiments. Upon treatment of semen samples with resveratrol (30 µmol/l) for 30 min, the seminal plasma zinc concentration and spermatozoa acrosin activity increased significantly in the experimental group compared with the control group. These data suggest that male obesity negatively impacts on male reproductive potential, not only through altering hormone levels, but also by directly altering sperm function. In addition, resveratrol may have a therapeutic and protective effect against obesity-induced abnormalities in semen.
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1 

Drobnis EZ and Johnson M: The question of sperm DNA fragmentation testing in the male infertility work-up: A response to Professor Lewis' commentary. Reprod Biomed Online. 31:138–139. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Whitfield M, Pollet-Villard X, Levy R, Drevet JR and Saez F: Posttesticular sperm maturation, infertility, and hypercholesterolemia. Asian J Androl. 17:742–748. 2015.PubMed/NCBI

3 

Hammoud AO, Wilde N, Gibson M, Parks A, Carell DT and Meikle AW: Male obesity and alteration in sperm parameters. Fertil Steril. 90:2222–2225. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Ring JD, Lwin AA and Köhler TS: Current medical management of endocrine-related male infertility. Asian J Androl. 18:357–363. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Cissen M, Bensdorp A, Cohlen BJ, Repping S, de Bruin JP and van Wely M: Assisted reproductive technologies for male subfertility. Cochrane Database Syst Rev. 2:CD0003602016.PubMed/NCBI

6 

Dağ ZÖ and Dilbaz B: Impact of obesity on infertility in women. J Turk Ger Gynecol Assoc. 16:111–117. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Katib A: Mechanisms linking obesity to male infertility. Cent European J Urol. 68:79–85. 2015.PubMed/NCBI

8 

Esmaeilzadeh S, Andarieh MG, Ghadimi R and Delavar MA: Body mass index and gonadotropin hormones (LH & FSH) associate with clinical symptoms among women with polycystic ovary syndrome. Glob J Health Sci. 7:101–106. 2014.PubMed/NCBI

9 

Zhou Y, Chen K, He L, Xia Y, Dai W, Wang F, Li J, Li S, Liu T, Zheng Y, et al: The protective effect of resveratrol on concanavalin-A-Induced acute hepatic injury in mice. Gastroenterol Res Pract. 2015:5063902015. View Article : Google Scholar : PubMed/NCBI

10 

Lang F, Qin Z, Li F, Zhang H, Fang Z and Hao E: Apoptotic cell death induced by resveratrol is partially mediated by the autophagy pathway in human ovarian cancer cells. PLoS One. 10:e01291962015. View Article : Google Scholar : PubMed/NCBI

11 

Orihuela-Campos RC, Tamaki N, Mukai R, Fukui M, Miki K, Terao J and Ito HO: Biological impacts of resveratrol, quercetin, and N-acetylcysteine on oxidative stress in human gingival fibroblasts. J Clin Biochem Nutr. 56:220–227. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Jiao Y, Li H, Liu Y, Guo A, Xu X, Qu X, Wang S, Zhao J, Li Y and Cao Y: Resveratrol inhibits the invasion of Glioblastoma-Initiating cells via Down-Regulation of the PI3K/Akt/NF-kappaB signaling pathway. Nutrients. 7:4383–4402. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Liu J, Yi L, Xiang Z, Zhong J, Zhang H and Sun T: Resveratrol attenuates spinal cord injury-induced inflammatory damage in rat lungs. Int J Clin Exp Pathol. 8:1237–1246. 2015.PubMed/NCBI

14 

Sharma P, Huq AU and Singh R: Cypermethrin-induced reproductive toxicity in the rat is prevented by resveratrol. J Hum Reprod Sci. 7:99–106. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Eleawa SM, Alkhateeb MA, Alhashem FH, Bin-Jaliah I, Sakr HF, Elrefaey HM, Elkarib AO, Alessa RM, Haidara MA, Shatoor AS and Khalil MA: Resveratrol reverses cadmium chloride-induced testicular damage and subfertility by downregulating p53 and Bax and upregulating gonadotropins and Bcl-2 gene expression. J Reprod Dev. 60:115–127. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Juan ME, González-Pons E, Munuera T, Ballester J, Rodríguez-Gil JE and Planas JM: trans-Resveratrol, a natural antioxidant from grapes, increases sperm output in healthy rats. J Nutr. 135:757–760. 2005.PubMed/NCBI

17 

Asia-Pacific Perspective, . Redefining obesity and its treatment. Health Communications Australia; Melbourne: 2000

18 

World Health Organization, . WHO laboratory manual for the examination and processing of human semen. 5th. Geneva: World Health Organization; 2010

19 

Auger J, Eustache F, Andersen AG, Irvine DS, Jørgensen N, Skakkebaek NE, Suominen J, Toppari J, Vierula M and Jouannet P: Sperm morphological defects related to environment, lifestyle and medical history of 1001 male partners of pregnant women from four European cities. Hum Reprod. 16:2710–2717. 2001. View Article : Google Scholar : PubMed/NCBI

20 

McTigue KM, Hess R and Ziouras J: Diagnosis and treatment of obesity in the elderly. AHRQ Technology Assessments; Rockville (MD): 2003

21 

Goulão B, Santos O and Carmo Id: The impact of migration on body weight: A review. Cad Saude Publica. 31:229–245. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Jungheim ES, Schon SB, Schulte MB, DeUgarte DA, Fowler SA and Tuuli MG: IVF outcomes in obese donor oocyte recipients: A systematic review and meta-analysis. Hum Reprod. 28:2720–2727. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Sermondade N, Faure C, Fezeu L, Shayeb AG, Bonde JP, Jensen TK, Van Wely M, Cao J, Martini AC, Eskandar M, et al: BMI in relation to sperm count: An updated systematic review and collaborative meta-analysis. Hum Reprod Update. 19:221–231. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Samavat J, Natali I, Degl'Innocenti S, Filimberti E, Cantini G, Di Franco A, Danza G, Seghieri G, Lucchese M, Baldi E, et al: Acrosome reaction is impaired in spermatozoa of obese men: A preliminary study. Fertil Steril. 102:1274–1281.e2. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Macdonald AA, Stewart AW and Farquhar CM: Body mass index in relation to semen quality and reproductive hormones in New Zealand men: A cross-sectional study in fertility clinics. Hum Reprod. 28:3178–3187. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Hammoud AO, Meikle AW, Peterson CM, Stanford J, Gibson M and Carrell DT: Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters. Asian J Androl. 14:855–859. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Eskandar M, Al-Asmari M, Chaduvula S Babu, Al-Shahrani M, Al-Sunaidi M, Almushait M, Donia O and Al-Fifi S: Impact of male obesity on semen quality and serum sex hormones. Adv Urol. 2012:4076012012. View Article : Google Scholar : PubMed/NCBI

28 

Yan WJ, Mu Y, Yu N, Yi TL, Zhang Y, Pang XL, Cheng D and Yang J: Protective effects of metformin on reproductive function in obese male rats induced by high-fat diet. J Assist Reprod Genet. 32:1097–1104. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Hofny ER, Ali ME, Abdel-Hafez HZ, Kamal Eel-D, Mohamed EE, Abd El-Azeem HG and Mostafa T: Semen parameters and hormonal profile in obese fertile and infertile males. Fertil Steril. 94:581–584. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Trotta V, Lee WH, Loo CY, Haghi M, Young PM, Scalia S and Traini D: In vitro biological activity of resveratrol using a novel inhalable resveratrol spray-dried formulation. Int J Pharm. 491:190–197. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Cui X, Jing X, Wu X and Yan M: Protective effect of resveratrol on spermatozoa function in male infertility induced by excess weight and obesity. Mol Med Rep 14: 4659-4665, 2016.
APA
Cui, X., Jing, X., Wu, X., & Yan, M. (2016). Protective effect of resveratrol on spermatozoa function in male infertility induced by excess weight and obesity. Molecular Medicine Reports, 14, 4659-4665. https://doi.org/10.3892/mmr.2016.5840
MLA
Cui, X., Jing, X., Wu, X., Yan, M."Protective effect of resveratrol on spermatozoa function in male infertility induced by excess weight and obesity". Molecular Medicine Reports 14.5 (2016): 4659-4665.
Chicago
Cui, X., Jing, X., Wu, X., Yan, M."Protective effect of resveratrol on spermatozoa function in male infertility induced by excess weight and obesity". Molecular Medicine Reports 14, no. 5 (2016): 4659-4665. https://doi.org/10.3892/mmr.2016.5840
Copy and paste a formatted citation
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Spandidos Publications style
Cui X, Jing X, Wu X and Yan M: Protective effect of resveratrol on spermatozoa function in male infertility induced by excess weight and obesity. Mol Med Rep 14: 4659-4665, 2016.
APA
Cui, X., Jing, X., Wu, X., & Yan, M. (2016). Protective effect of resveratrol on spermatozoa function in male infertility induced by excess weight and obesity. Molecular Medicine Reports, 14, 4659-4665. https://doi.org/10.3892/mmr.2016.5840
MLA
Cui, X., Jing, X., Wu, X., Yan, M."Protective effect of resveratrol on spermatozoa function in male infertility induced by excess weight and obesity". Molecular Medicine Reports 14.5 (2016): 4659-4665.
Chicago
Cui, X., Jing, X., Wu, X., Yan, M."Protective effect of resveratrol on spermatozoa function in male infertility induced by excess weight and obesity". Molecular Medicine Reports 14, no. 5 (2016): 4659-4665. https://doi.org/10.3892/mmr.2016.5840
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