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Article Open Access

MCM2 and TIP30 are prognostic markers in squamous cell/adenosquamous carcinoma and adenocarcinoma of the gallbladder

  • Authors:
    • Ziru Liu
    • Zhulin Yang
    • Song Jiang
    • Qiong Zou
    • Yuan Yuan
    • Jinghe Li
    • Daiqiang Li
    • Lufeng Liang
    • Meigui Chen
    • Senlin Chen
  • View Affiliations / Copyright

    Affiliations: Department of Minimal Invasive Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China, Research Laboratory of Hepatobiliary Diseases, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China, Department of Pathology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China, Department of Pathology, Basic School of Medicine, Changsha, Hunan 410078, P.R. China, Department of Pathology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China, Department of Hepatobiliary and Pancreatic Surgery, Hunan Provincial People's Hospital, Changsha, Hunan 410007, P.R. China, Department of Pathology, Loudi Central Hospital, Loudi, Hunan 417011, P.R. China, Department of Pathology, Hunan Provincial Tumor Hospital, Changsha, Hunan 410013, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4581-4592
    |
    Published online on: October 13, 2016
       https://doi.org/10.3892/mmr.2016.5851
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Abstract

The clinicopathological and biological characteristics of squamous cell/adenosquamous carcinoma (SC/ASC) of the gallbladder remain to be fully elucidated, due to the fact that it is a rare gallbladder cancer subtype. In the current study, the expression of minichromosome maintenance complex component 2 (MCM2) and HIV‑1 tat interactive protein 2 (TIP30) was measured in 46 cases of SC/ASC and 80 adenocarcinomas (AC) using immunohistochemistry. Positive MCM2 and negative TIP30 expression were significantly associated with large tumor size, high TNM stage, invasion, lymph node metastasis and lack of surgical curability in SC/ASC and AC. Positive MCM2 and negative TIP30 expression were significantly associated with poor differentiation in AC, whereas only MCM2 was correlated with differentiation in SC/ASC. Univariate Kaplan‑Meier analysis demonstrated that positive MCM2 and negative TIP30 expression, the degree of differentiation, tumor size, TNM stage, invasion, lymph node metastasis and surgical curability were significantly associated with post‑operative survival in patients with SC/ASC and AC. Multivariate Cox regression analysis demonstrated that positive MCM2 and negative TIP30 expression, the degree of differentiation, tumor size, TNM stage, invasion, lymph node metastasis and lack of surgical curability were also independent predictors of poor prognosis in patients with SC/ASC and AC. These data suggest that positive MCM2 and negative TIP30 expression are closely correlated with the clinical, pathological and biological parameters, in addition to poor prognosis in patients with gallbladder cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Liu Z, Yang Z, Jiang S, Zou Q, Yuan Y, Li J, Li D, Liang L, Chen M, Chen S, Chen S, et al: MCM2 and TIP30 are prognostic markers in squamous cell/adenosquamous carcinoma and adenocarcinoma of the gallbladder. Mol Med Rep 14: 4581-4592, 2016.
APA
Liu, Z., Yang, Z., Jiang, S., Zou, Q., Yuan, Y., Li, J. ... Chen, S. (2016). MCM2 and TIP30 are prognostic markers in squamous cell/adenosquamous carcinoma and adenocarcinoma of the gallbladder. Molecular Medicine Reports, 14, 4581-4592. https://doi.org/10.3892/mmr.2016.5851
MLA
Liu, Z., Yang, Z., Jiang, S., Zou, Q., Yuan, Y., Li, J., Li, D., Liang, L., Chen, M., Chen, S."MCM2 and TIP30 are prognostic markers in squamous cell/adenosquamous carcinoma and adenocarcinoma of the gallbladder". Molecular Medicine Reports 14.5 (2016): 4581-4592.
Chicago
Liu, Z., Yang, Z., Jiang, S., Zou, Q., Yuan, Y., Li, J., Li, D., Liang, L., Chen, M., Chen, S."MCM2 and TIP30 are prognostic markers in squamous cell/adenosquamous carcinoma and adenocarcinoma of the gallbladder". Molecular Medicine Reports 14, no. 5 (2016): 4581-4592. https://doi.org/10.3892/mmr.2016.5851
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Z, Yang Z, Jiang S, Zou Q, Yuan Y, Li J, Li D, Liang L, Chen M, Chen S, Chen S, et al: MCM2 and TIP30 are prognostic markers in squamous cell/adenosquamous carcinoma and adenocarcinoma of the gallbladder. Mol Med Rep 14: 4581-4592, 2016.
APA
Liu, Z., Yang, Z., Jiang, S., Zou, Q., Yuan, Y., Li, J. ... Chen, S. (2016). MCM2 and TIP30 are prognostic markers in squamous cell/adenosquamous carcinoma and adenocarcinoma of the gallbladder. Molecular Medicine Reports, 14, 4581-4592. https://doi.org/10.3892/mmr.2016.5851
MLA
Liu, Z., Yang, Z., Jiang, S., Zou, Q., Yuan, Y., Li, J., Li, D., Liang, L., Chen, M., Chen, S."MCM2 and TIP30 are prognostic markers in squamous cell/adenosquamous carcinoma and adenocarcinoma of the gallbladder". Molecular Medicine Reports 14.5 (2016): 4581-4592.
Chicago
Liu, Z., Yang, Z., Jiang, S., Zou, Q., Yuan, Y., Li, J., Li, D., Liang, L., Chen, M., Chen, S."MCM2 and TIP30 are prognostic markers in squamous cell/adenosquamous carcinoma and adenocarcinoma of the gallbladder". Molecular Medicine Reports 14, no. 5 (2016): 4581-4592. https://doi.org/10.3892/mmr.2016.5851
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