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Article

Alterations in ACE and ABCG2 expression levels in the testes of rats subjected to atropine-induced toxicity

  • Authors:
    • Xue‑Fang Li
    • Quan‑Yong Huang
    • Wen‑Zhong Yang
    • Hui‑Jie Wang
    • Can‑Wei Li
  • View Affiliations / Copyright

    Affiliations: Library of Dali University, Dali, Yunnan 671003, P.R. China, Department of Pathology, School of Basic Medical Sciences, Dali University, Dali, Yunnan 671000, P.R. China, Department of Histology and Embryology, School of Basic Medical Sciences, Dali University, Dali, Yunnan 671000, P.R. China, Department of Epidemiology and Health Statistics, School of Public Health, Dali University, Dali, Yunnan 671000, P.R. China
  • Pages: 5211-5216
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    Published online on: October 19, 2016
       https://doi.org/10.3892/mmr.2016.5857
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Abstract

Atropine-induced damage is associated with enzyme and protein alterations. The aim of the present study was to investigate atropine‑induced alterations in testicular expression levels of angiotensin‑converting enzyme (ACE) and adenosine 5'-triphosphate binding cassette sub‑family G member 2 (ABCG2) following atropine treatment. Male Wistar rats received 15 mg/kg/day atropine for 7 days; control rats received an identical volume of saline, Following treatment, the testes were harvested for immunohistochemistry and in situ hybridization to examine the protein and gene expression levels of ACE and ABCG2 by digital image analysis. ACE gene and protein expression levels were significantly reduced in the testes of atropine‑treated rats, compared with control rats (P=0.0001 and P<0.001, respectively). In addition, ABCG2 gene and protein expression levels were significantly increased in the testes of atropine‑treated rats, compared with control rats (P=0.0017 and P<0.001, respectively). Thus, the results of the present study demonstrate that testicular protein and gene expression levels of ACE and ABCG2 were altered as a result of atropine‑induced toxicity in the rats. These alterations may result in abnormal testicular function, and the proteins and genes identified in the present study may be useful to elucidate the mechanisms underlying atropine‑induced toxicity and provide a direction for further studies.
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View References

1 

Byadagi KS, Nandibewoor ST and Chimatadar SA: Catalytic activity of ruthenium (III) on the oxidation of an anticholinergic drug-atropine sulfate monohydrate by copper (III) periodate complex in aqueous alkaline medium - decarboxylation and free radical mechanism. Acta Chim Slov. 60:617–627. 2013.PubMed/NCBI

2 

Konickx LA, Bingham K and Eddleston M: Is oxygen required before atropine administration in organophosphorus or carbamate pesticide poisoning? - A cohort study. Clin Toxicol (Phila). 52:531–537. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Papoutsis I, Nikolaou P, Spiliopoulou C, Pistos C, Stefanidou M and Athanaselis S: A simple and sensitive GC/MS method for the determination of atropine during therapy of anticholinesterase poisoning in serum samples. Drug Test Anal. 4:229–234. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Stephenson M, Wong A, Rotella JA, Crump N, Kerr F and Greene SL: Deliberate fingolimod overdose presenting with delayed hypotension and bradycardia responsive to atropine. J Med Toxicol. 10:215–218. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Li SM, Wu SS, Kang MT, Liu Y, Jia SM, Li SY, Zhan SY, Liu LR, Li H, Chen W, et al: Atropine slows myopia progression more in Asian than white children by meta-analysis. Optom Vis Sci. 91:342–350. 2014.PubMed/NCBI

6 

Baciarello M, Cornini A, Zasa M, Pedrona P, Scrofani G, Venuti FS and Fanelli G: Intrathecal atropine to prevent postoperative nausea and vomiting after Cesarean section: A randomized, controlled trial. Minerva Anestesiol. 77:781–788. 2011.PubMed/NCBI

7 

Jandrić Z, Rathor MN, Chhem-Kieth S, Adu-Gyamfi J, Mayr L, Resch C, Bado S, Švarc-Gajić J and Cannavan A: Uptake of (14)C-atropine and/or its transformation products from soil by wheat (Triticum aestivum var Kronjet) and their translocation to shoots. J Environ Sci Health B. 48:1034–1042. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Wilson ME, Lee GK, Chandra A and Kane GC: Central anticholinergic syndrome following dobutamine-atropine stress echocardiography. Echocardiography. 28:E205–E206. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Tian CL, Wen Q and Fan TJ: Cytotoxicity of atropine to human corneal epithelial cells by inducing cell cycle arrest and mitochondrion-dependent apoptosis. Exp Toxicol Pathol. 67:517–524. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Huang QY, Li XF and Liu SP: E-cadherin and 5-HT alterations in the heart of rats having undergone atropine-induced toxicity. Mol Med Rep. 5:700–704. 2012.PubMed/NCBI

11 

Gaspari RJ and Paydarfar D: Pulmonary effects of intravenous atropine induce ventilation perfusion mismatch. Can J Physiol Pharmacol. 92:399–404. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Fry JR and Burr SA: A double-blind atropine trial for active learning of autonomic function. Adv Physiol Educ. 35:438–444. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Stellpflug SJ, Cole JB, Isaacson BA, Lintner CP and Bilden EF: Massive atropine eye drop ingestion treated with high-dose physostigmine to avoid intubation. West J Emerg Med. 13:77–79. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Cooper J, Eisenberg N, Schulman E and Wang FM: Maximum atropine dose without clinical signs or symptoms. Optom Vis Sci. 90:1467–1472. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Sato T, Ban Y, Uchida M, Gondo E, Yamamoto M, Sekiguchi Y, Sakaue A, Kemi M and Nakatsuka T: Atropine-induced inhibition of sperm and semen transport impairs fertility in male rats. J Toxicol Sci. 30:207–212. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Hahnova-Cygalova L, Ceckova M and Staud F: Fetoprotective activity of breast cancer resistance protein (BCRP, ABCG2): Expression and function throughout pregnancy. Drug Metab Rev. 43:53–68. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Khalid A, Khudhair N, He H, Peng Z, Yaguang T and Guixue Z: Effects of dietary selenium supplementation on seminiferous tubules and SelW, GPx4, LHCGR and ACE expression in chicken testis. Biol Trace Elem Res. 173:202–209. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Helin HO, Lundin ME, Laakso M, Lundin J, Helin HJ and Isola J: Virtual microscopy in prostate histopathology: Simultaneous viewing of biopsies stained sequentially with hematoxylin and eosin and alpha-methylacyl-coenzyme A racemase/p63 immunohistochemistry. J Urol. 175:495–499. 2006. View Article : Google Scholar : PubMed/NCBI

19 

De Rossi A, Rocha LB and Rossi MA: Application of fluorescence microscopy on hematoxylin and eosin-stained sections of healthy and diseased teeth and supporting structures. J Oral Pathol Med. 36:377–381. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Smith PS, Parkinson IH and Leong AS: Principles of ploidy analysis by static cytometry. Clin Mol Pathol. 49:M104–M111. 1996. View Article : Google Scholar : PubMed/NCBI

21 

Dong J, Yin H, Liu W, Wang P, Jiang Y and Chen J: Congenital iodine deficiency and hypothyroidism impair LTP and decrease C-fos and C-jun expression in rat hippocampus. Neurotoxicology. 26:417–426. 2005. View Article : Google Scholar : PubMed/NCBI

22 

van Kuijk AW, Gerlag DM, Vos K, Wolbink G, de Groot M, de Rie MA, Zwinderman AH, Dijkmans BA and Tak PP: A prospective, randomised, placebo-controlled study to identify biomarkers associated with active treatment in psoriatic arthritis: Effects of adalimumab treatment on synovial tissue. Ann Rheum Dis. 68:1303–1309. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Seo HW, Han K, Oh Y, Kang I, Park C, Joo HE, Kim SH, Lee BH and Chae C: Evaluation of commercial polyclonal- and monoclonal-antibody-based immunohistochemical tests for 2 genotypes of Porcine circovirus type 2 and comparison with in-situ hybridization assays. Can J Vet Res. 78:233–236. 2014.PubMed/NCBI

24 

Rashed L, Hay R Abdel, Mahmoud R, Hasan N, Zahra A and Fayez S: Association of Angiotensin-Converting Enzyme (ACE) gene polymorphism with inflammation and cellular cytotoxicity in vitiligo patients. PLoS One. 10:e01329152015. View Article : Google Scholar : PubMed/NCBI

25 

Miao HW and Gong H: Association of ACE insertion or deletion polymorphisms with the risk of coronary restenosis after percutaneous coronary intervention: A meta-analysis. J Renin Angiotensin Aldosterone Syst. 16:844–850. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Goessler KF, Cornelissen VA, de Oliveira EM, de Mota FG and Polito MD: ACE polymorphisms and the acute response of blood pressure to a walk in medicated hypertensive patients. J Renin Angiotensin Aldosterone Syst. 16:720–729. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Miao HW and Gong H: Correlation of ACE gene deletion/insertion polymorphism and risk of pregnancy-induced hypertension: A meta-analysis based on 10,236 subjects. J Renin Angiotensin Aldosterone Syst. 16:982–994. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Betancur-Ancona D, Dávila-Ortiz G, Chel-Guerrero LA and Torruco-Uco JG: ACE-I inhibitory activity from phaseolus lunatus and phaseolus vulgaris peptide fractions obtained by ultrafiltration. J Med Food. 18:1247–1254. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Avila-Vanzzini N, Posadas-Romero C, Gonzalez-Salazar Mdel C, Maass-Iturbide C, Melendez-Ramirez G, Perez-Mendez O, Del Valle-Mondragon L, Masso-Rojas F, Lopez E Varela, Herrera-Bello H, et al: The ACE I/D polymorphism is associated with nitric oxide metabolite and blood pressure levels in healthy Mexican men. Arch Cardiol Mex. 85:105–110. 2015.PubMed/NCBI

30 

Reshetnikov EA, Akulova LY, Dobrodomova IS, Dvornyk VY, Polonikov AV and Churnosov MI: The insertion-deletion polymorphism of the ACE gene is associated with increased blood pressure in women at the end of pregnancy. J Renin Angiotensin Aldosterone Syst. 16:623–632. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Yilin Z, Yandong N and Faguang J: Role of angiotensin-converting enzyme (ACE) and ACE2 in a rat model of smoke inhalation induced acute respiratory distress syndrome. Burns. 41:1468–1477. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Bhagi S, Srivastava S, Tomar A, Bala SS and Sarkar S: Positive association of D allele of ACE gene with high altitude pulmonary edema in indian population. Wilderness Environ Med. 26:124–132. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Gorukmez O, Sag ŞO, Gorukmez Ö, Ture M, Topak A, Sahinturk S, Ozkaya G, Gulten T, Ali R and Yakut T: Association of the ACE I/D gene polymorphisms with JAK2V617F-positive polycythemia vera and essential thrombocythemia. Genet Test Mol Biomarkers. 19:303–308. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Cakmak B, Inanir A, Karakus N, Ates O and Yigit S: Association between the ACE gene I/D polymorphism and osteoporosis in a Turkish population. Z Rheumatol. 74:346–350. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Gulec-Yilmaz S, Gulec H, Dalan AB, Cetın B, Tımırcı-Kahraman O, Ogut DB, Atasoy H, Dırımen GA, Gultekın GI and Isbır T: The relationship between ACE polymorphism and panic disorder. In Vivo. 28:885–889. 2014.PubMed/NCBI

36 

Badran DI, Nada H and Hassan R: Association of Angiotensin-Converting Enzyme ACE gene polymorphism with ACE activity and susceptibility to Vitiligo in Egyptian population. Genet Test Mol Biomarkers. 19:258–263. 2015. View Article : Google Scholar : PubMed/NCBI

37 

Fujihara Y, Tokuhiro K, Muro Y, Kondoh G, Araki Y, Ikawa M and Okabe M: Expression of TEX101, regulated by ACE, is essential for the production of fertile mouse spermatozoa. Proc Natl Acad Sci USA. 110:8111–8116. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Shi CL, Täljedal IB and Mattsson MO: Effect of carbachol on regulation of the mACh receptor mRNA expression ADN insulin secretion in mouse pancreatic islets. Acta Physiol Scand. 167:A181999. View Article : Google Scholar : PubMed/NCBI

39 

Balyasnikova IV, Metzger R, Franke FE, Conrad N, Towbin H, Schwartz DE, Sturrock ED and Danilov SM: Epitope mapping of mAbs to denatured human testicular ACE (CD143). Tissue Antigens. 72:354–368. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Rushworth CA, Guy JL and Turner AJ: Residues affecting the chloride regulation and substrate selectivity of the angiotensin-converting enzymes (ACE and ACE2) identified by site-directed mutagenesis. FEBS J. 275:6033–6042. 2008. View Article : Google Scholar : PubMed/NCBI

41 

Schnepf R and Zolk O: Effect of the ATP-binding cassette transporter ABCG2 on pharmacokinetics: Experimental findings and clinical implications. Expert Opin Drug Metab Toxicol. 9:287–306. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Erdei Z, Sarkadi B, Brózik A, Szebényi K, Várady G, Makó V, Péntek A, Orbán TI and Apáti Á: Dynamic ABCG2 expression in human embryonic stem cells provides the basis for stress response. Eur Biophys J. 42:169–179. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Yang B, Ma YF and Liu Y: Elevated expression of Nrf-2 and ABCG2 involved in multi-drug resistance of lung cancer SP cells. Drug Res (Stuttg). 65:526–531. 2015.PubMed/NCBI

44 

Xie J, Jin B, Li DW, Shen B, Cong N, Zhang TZ and Dong P: ABCG2 regulated by MAPK pathways is associated with cancer progression in laryngeal squamous cell carcinoma. Am J Cancer Res. 4:698–709. 2014.PubMed/NCBI

45 

Kalalinia F, Elahian F, Mosaffa F and Behravan J: Celecoxib up regulates the expression of drug efflux transporter ABCG2 in breast cancer cell lines. Iran J Pharm Res. 13:1393–1401. 2014.PubMed/NCBI

46 

Lecerf-Schmidt F, Peres B, Valdameri G, Gauthier C, Winter E, Payen L, Di Pietro A and Boumendjel A: ABCG2: Recent discovery of potent and highly selective inhibitors. Future Med Chem. 5:1037–1045. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Juvale K and Wiese M: Design of inhibitors of BCRP/ABCG2. Future Med Chem. 7:1521–1527. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Wang DS, Patel A, Shukla S, Zhang YK, Wang YJ, Kathawala RJ, Robey RW, Zhang L, Yang DH, Talele TT, et al: Icotinib antagonizes ABCG2-mediated multidrug resistance, but not the pemetrexed resistance mediated by thymidylate synthase and ABCG2. Oncotarget. 5:4529–4542. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Fehér Á, Juhász A, László A, Pákáski M, Kálmán J and Janka Z: Association between the ABCG2 C421A polymorphism and Alzheimer's disease. Neurosci Lett. 550:51–54. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Wang X, Xia B, Liang Y, Peng L, Wang Z, Zhuo J, Wang W and Jiang B: Membranous ABCG2 expression in colorectal cancer independently correlates with shortened patient survival. Cancer Biomark. 13:81–88. 2013.PubMed/NCBI

51 

Hou H, Sun H, Lu P, Ge C, Zhang L, Li H, Zhao F, Tian H, Zhang L, Chen T, et al: Tunicamycin potentiates cisplatin anticancer efficacy through the DPAGT1/Akt/ABCG2 pathway in mouse Xenograft models of human hepatocellular carcinoma. Mol Cancer Ther. 12:2874–2884. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Deppe S, Ripperger A, Weiss J, Ergun S and Benndorf RA: Impact of genetic variability in the ABCG2 gene on ABCG2 expression, function, and interaction with AT1 receptor antagonist telmisartan. Biochem Biophys Res Commun. 443:1211–1217. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Damiani D, Tiribelli M, Geromin A, Michelutti A, Cavallin M, Sperotto A and Fanin R: ABCG2 overexpression in patients with acute myeloid leukemia: Impact on stem cell transplantation outcome. Am J Hematol. 90:784–789. 2015. View Article : Google Scholar : PubMed/NCBI

54 

Lin YH, Chang HM, Chang FP, Shen CR, Liu CL, Mao WY, Lin CC, Lee HS and Shen CN: Protoporphyrin IX accumulation disrupts mitochondrial dynamics and function in ABCG2-deficient hepatocytes. FEBS Lett. 587:3202–3209. 2013. View Article : Google Scholar : PubMed/NCBI

55 

To KK, Hu M and Tomlinson B: Expression and activity of ABCG2, but not ABCB1 or OATP1B1, are associated with cholesterol levels: Evidence from in vitro and in vivo experiments. Pharmacogenomics. 15:1091–1104. 2014. View Article : Google Scholar : PubMed/NCBI

56 

Zeng Y, Callaghan D, Xiong H, Yang Z, Huang P and Zhang W: Abcg2 deficiency augments oxidative stress and cognitive deficits in Tg-SwDI transgenic mice. J Neurochem. 122:456–469. 2012. View Article : Google Scholar : PubMed/NCBI

57 

Natarajan K, Xie Y, Baer MR and Ross DD: Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance. Biochem Pharmacol. 83:1084–1103. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li XF, Huang QY, Yang WZ, Wang HJ and Li CW: Alterations in ACE and ABCG2 expression levels in the testes of rats subjected to atropine-induced toxicity. Mol Med Rep 14: 5211-5216, 2016.
APA
Li, X., Huang, Q., Yang, W., Wang, H., & Li, C. (2016). Alterations in ACE and ABCG2 expression levels in the testes of rats subjected to atropine-induced toxicity. Molecular Medicine Reports, 14, 5211-5216. https://doi.org/10.3892/mmr.2016.5857
MLA
Li, X., Huang, Q., Yang, W., Wang, H., Li, C."Alterations in ACE and ABCG2 expression levels in the testes of rats subjected to atropine-induced toxicity". Molecular Medicine Reports 14.6 (2016): 5211-5216.
Chicago
Li, X., Huang, Q., Yang, W., Wang, H., Li, C."Alterations in ACE and ABCG2 expression levels in the testes of rats subjected to atropine-induced toxicity". Molecular Medicine Reports 14, no. 6 (2016): 5211-5216. https://doi.org/10.3892/mmr.2016.5857
Copy and paste a formatted citation
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Spandidos Publications style
Li XF, Huang QY, Yang WZ, Wang HJ and Li CW: Alterations in ACE and ABCG2 expression levels in the testes of rats subjected to atropine-induced toxicity. Mol Med Rep 14: 5211-5216, 2016.
APA
Li, X., Huang, Q., Yang, W., Wang, H., & Li, C. (2016). Alterations in ACE and ABCG2 expression levels in the testes of rats subjected to atropine-induced toxicity. Molecular Medicine Reports, 14, 5211-5216. https://doi.org/10.3892/mmr.2016.5857
MLA
Li, X., Huang, Q., Yang, W., Wang, H., Li, C."Alterations in ACE and ABCG2 expression levels in the testes of rats subjected to atropine-induced toxicity". Molecular Medicine Reports 14.6 (2016): 5211-5216.
Chicago
Li, X., Huang, Q., Yang, W., Wang, H., Li, C."Alterations in ACE and ABCG2 expression levels in the testes of rats subjected to atropine-induced toxicity". Molecular Medicine Reports 14, no. 6 (2016): 5211-5216. https://doi.org/10.3892/mmr.2016.5857
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