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Article

Effect of zinc deficiency on mouse renal interstitial fibrosis in diabetic nephropathy

  • Authors:
    • Xiuli Zhang
    • Dan Liang
    • Xu Lian
    • Zhi‑Hong Chi
    • Xuemei Wang
    • Yue Zhao
    • Zhang Ping
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Medical Cell Biology, Ministry of Education, Shenyang, Liaoning 110001, P.R. China, Troops of 95935 Unit, Harbin, Heilongjiang 150111, P.R. China, Department of Endocrinology, Mudanjiang, Heilongjiang 157000, P.R. China, Department of Histology and Embryology, Liaoning Medical University, Jinzhou, Liaoning 121001, P.R. China
  • Pages: 5245-5252
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    Published online on: October 20, 2016
       https://doi.org/10.3892/mmr.2016.5870
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Abstract

There is emerging evidence that tubulointerstitial fibrosis is the final common pathway of the majority of chronic progressive renal diseases, including diabetic nephropathy (DN). Zinc, an essential dietary element, has been suggested to be important for a number of protein functions during fibrosis in vivo and in vitro. However, the effect of zinc deficiency (ZnD) on renal interstitial fibrosis in DN remains unclear. The present study investigated the effect and the underlying mechanisms of ZnD on renal interstitial fibrosis during DN using an streptozotocin‑induced model of diabetes with immunofluorescence staining and western blot analysis. The present study identified that dietary zinc restriction significantly decreased zinc concentrations in the plasma and mouse kidney. ZnD enhanced albuminuria and extracellular matrix protein expression, associated with diabetic renal interstitial fibrosis by activation of renal interstitial fibroblasts and regulation of the expression of fibrosis‑associated factors, which may be mediated by the activation of fibroblasts via the TGF‑β/Smad signaling pathway. The data indicates that ZnD serves an important role in the pathogenic mechanisms of renal interstitial fibrosis during the development of DN.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang X, Liang D, Lian X, Chi ZH, Wang X, Zhao Y and Ping Z: Effect of zinc deficiency on mouse renal interstitial fibrosis in diabetic nephropathy. Mol Med Rep 14: 5245-5252, 2016.
APA
Zhang, X., Liang, D., Lian, X., Chi, Z., Wang, X., Zhao, Y., & Ping, Z. (2016). Effect of zinc deficiency on mouse renal interstitial fibrosis in diabetic nephropathy. Molecular Medicine Reports, 14, 5245-5252. https://doi.org/10.3892/mmr.2016.5870
MLA
Zhang, X., Liang, D., Lian, X., Chi, Z., Wang, X., Zhao, Y., Ping, Z."Effect of zinc deficiency on mouse renal interstitial fibrosis in diabetic nephropathy". Molecular Medicine Reports 14.6 (2016): 5245-5252.
Chicago
Zhang, X., Liang, D., Lian, X., Chi, Z., Wang, X., Zhao, Y., Ping, Z."Effect of zinc deficiency on mouse renal interstitial fibrosis in diabetic nephropathy". Molecular Medicine Reports 14, no. 6 (2016): 5245-5252. https://doi.org/10.3892/mmr.2016.5870
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang X, Liang D, Lian X, Chi ZH, Wang X, Zhao Y and Ping Z: Effect of zinc deficiency on mouse renal interstitial fibrosis in diabetic nephropathy. Mol Med Rep 14: 5245-5252, 2016.
APA
Zhang, X., Liang, D., Lian, X., Chi, Z., Wang, X., Zhao, Y., & Ping, Z. (2016). Effect of zinc deficiency on mouse renal interstitial fibrosis in diabetic nephropathy. Molecular Medicine Reports, 14, 5245-5252. https://doi.org/10.3892/mmr.2016.5870
MLA
Zhang, X., Liang, D., Lian, X., Chi, Z., Wang, X., Zhao, Y., Ping, Z."Effect of zinc deficiency on mouse renal interstitial fibrosis in diabetic nephropathy". Molecular Medicine Reports 14.6 (2016): 5245-5252.
Chicago
Zhang, X., Liang, D., Lian, X., Chi, Z., Wang, X., Zhao, Y., Ping, Z."Effect of zinc deficiency on mouse renal interstitial fibrosis in diabetic nephropathy". Molecular Medicine Reports 14, no. 6 (2016): 5245-5252. https://doi.org/10.3892/mmr.2016.5870
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