Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
December-2016 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2016 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Long non‑coding RNA AK055347 is upregulated in patients with atrial fibrillation and regulates mitochondrial energy production in myocardiocytes

  • Authors:
    • Guiying Chen
    • Hong Guo
    • Ying Song
    • Huiying Chang
    • Shaojun Wang
    • Miaomiao Zhang
    • Chang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China
  • Pages: 5311-5317
    |
    Published online on: October 26, 2016
       https://doi.org/10.3892/mmr.2016.5893
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The role of long non-coding RNAs (lncRNAs) in atrial fibrillation remains to be fully elucidated. The current study performed microarray analysis to investigate differential lncRNA expression profiling in atrial samples from the pulmonary vein and the surrounding left atrial area (LA‑PV) and from the left atrial appendage (LAA) in 16 patients with atrial fibrillation (AF). Microarray analysis identified 94 lncRNAs that were differentially expressed between the LA‑PV and LAA in patients with AF. AK055347 was one of lncRNAs with the most significant alterations observed. Knockdown of AK055347 inhibited cell viability of H9C2 cardiomyocytes, accompanied by downregulation of Cyp450 and ATP synthases. In addition, microarray analysis identified that MSS51 was a target of AK055347. Knockdown of AK055347 inhibited the expression of MSS51 in H9C2 cells. The observations of the current study suggest that lncRNAs are differentially expressed in the LA‑PV and LAA in patients with AF. AK055347 may contribute to the pathogenesis of AF by dysregulating mitochondrial energy production via regulation of Cyp450, ATP synthase and MSS51.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Gialdini G, Nearing K, Bhave PD, Bonuccelli U, Iadecola C, Healey JS and Kamel H: Perioperative atrial fibrillation and the long-term risk of ischemic stroke. JAMA. 312:616–622. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Healey JS and Connolly SJ: Atrial fibrillation: Hypertension as a causative agent, risk factor for complications, and potential therapeutic target. Am J Cardiol. 91:9G–14G. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Oluleye OW, Rector TS, Win S, McMurray JJ, Zile MR, Komajda M, McKelvie RS, Massie B, Carson PE and Anand IS: History of atrial fibrillation as a risk factor in patients with heart failure and preserved ejection fraction. Circ Heart Fail. 7:960–966. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Kannel WB, Wolf PA, Benjamin EJ and Levy D: Prevalence, incidence, prognosis, and predisposing conditions for atrial fibrillation: Population-based estimates. Am J Cardiol. 82:2N–9N. 1998. View Article : Google Scholar : PubMed/NCBI

5 

Nattel S: New ideas about atrial fibrillation 50 years on. Nature. 415:219–226. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Zöller B, Ohlsson H, Sundquist J and Sundquist K: High familial risk of atrial fibrillation/atrial flutter in multiplex families: A nationwide family study in Sweden. J Am Heart Assoc. 2:e0033842013.

7 

Ou F, Rao N, Jiang X, Qian M, Feng W, Yin L and Chen X: Analysis on differential gene expression data for prediction of new biological features in permanent atrial fibrillation. PLoS One. 8:e761662013. View Article : Google Scholar : PubMed/NCBI

8 

Yeh YH, Kuo CT, Lee YS, Lin YM, Nattel S, Tsai FC and Chen WJ: Region-specific gene expression profiles in the left atria of patients with valvular atrial fibrillation. Heart Rhythm. 10:383–391. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Goodrich JA and Kugel JF: Non-coding-RNA regulators of RNA polymerase II transcription. Nat Rev Mol Cell Biol. 7:612–616. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Yu FJ, Zheng JJ, Dong PH and Fan XM: Long non-coding RNAs and hepatocellular carcinoma. Mol Clin Oncol. 3:13–17. 2015.PubMed/NCBI

11 

Sun M and Kraus WL: Minireview: Long noncoding RNAs: New ‘links’ between gene expression and cellular outcomes in endocrinology. Mol Endocrinol. 27:1390–1402. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Quagliata L and Terracciano LM: Liver diseases and long non-coding RNAs: New insight and perspective. Front Med (Lausanne). 1:352014.PubMed/NCBI

13 

Li J, Xuan Z and Liu C: Long non-coding RNAs and complex human diseases. Int J Mol Sci. 14:18790–18808. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Scheuermann JC and Boyer LA: Getting to the heart of the matter: Long non-coding RNAs in cardiac development and disease. EMBO J. 32:1805–1816. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Ishii N, Ozaki K, Sato H, Mizuno H, Saito S, Takahashi A, Miyamoto Y, Ikegawa S, Kamatani N, Hori M, et al: Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction. J Hum Genet. 51:1087–1099. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Di Salvo TG, Guo Y, Su YR, Clark T, Brittain E, Absi T, Maltais S and Hemnes A: Right ventricular long noncoding RNA expression in human heart failure. Pulm Circ. 5:135–161. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Zhang L, Hamad EA, Vausort M, Funakoshi H, Feldman AM, Wagner DR and Devaux Y: Identification of candidate long noncoding RNAs associated with left ventricular hypertrophy. Clin Transl Sci. 8:100–106. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Ausma J, Coumans WA, Duimel H, Van der Vusse GJ, Allessie MA and Borgers M: Atrial high energy phosphate content and mitochondrial enzyme activity during chronic atrial fibrillation. Cardiovasc Res. 47:788–796. 2000. View Article : Google Scholar : PubMed/NCBI

19 

Barbey O, Pierre S, Duran MJ, Sennoune S, Lévy S and Maixent JM: Specific up-regulation of mitochondrial F0F1-ATPase activity after short episodes of atrial fibrillation in sheep. J Cardiovasc Electrophysiol. 11:432–438. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Tsuboi M, Hisatome I, Morisaki T, Tanaka M, Tomikura Y, Takeda S, Shimoyama M, Ohtahara A, Ogino K, Igawa O, et al: Mitochondrial DNA deletion associated with the reduction of adenine nucleotides in human atrium and atrial fibrillation. Eur J Clin Invest. 31:489–496. 2001. View Article : Google Scholar : PubMed/NCBI

21 

Cha YM, Dzeja PP, Shen WK, Jahangir A, Hart CY, Terzic A and Redfield MM: Failing atrial myocardium: Energetic deficits accompany structural remodeling and electrical instability. Am J Physiol Heart Circ Physiol. 284:H1313–H1320. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Seppet E, Eimre M, Peet N, Paju K, Orlova E, Ress M, Kõvask S, Piirsoo A, Saks VA, Gellerich FN, et al: Compartmentation of energy metabolism in atrial myocardium of patients undergoing cardiac surgery. Mol Cell Biochem. 270:49–61. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Zhang J, Cui X, Shen Y, Pang L, Zhang A, Fu Z, Chen J, Guo X, Gan W and Ji C: Distinct expression profiles of LncRNAs between brown adipose tissue and skeletal muscle. Biochem Biophys Res Commun. 443:1028–1034. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Rinn JL and Chang HY: Genome regulation by long noncoding RNAs. Annu Rev Biochem. 81:145–166. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Ounzain S, Crippa S and Pedrazzini T: Small and long non-coding RNAs in cardiac homeostasis and regeneration. Biochim Biophys Acta. 1833:923–933. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Bruneau BG: Signaling and transcriptional networks in heart development and regeneration. Cold Spring Harb Perspect Biol. 5:a0082922013. View Article : Google Scholar : PubMed/NCBI

28 

Grote P, Wittler L, Hendrix D, Koch F, Währisch S, Beisaw A, Macura K, Bläss G, Kellis M, Werber M and Herrmann BG: The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse. Dev Cell. 24:206–214. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Klattenhoff CA, Scheuermann JC, Surface LE, Bradley RK, Fields PA, Steinhauser ML, Ding H, Butty VL, Torrey L, Haas S, et al: Braveheart, a long noncoding RNA required for cardiovascular lineage commitment. Cell. 152:570–583. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Kabra R and Singh JP: Catheter ablation targeting complex fractionated atrial electrograms for the control of atrial fibrillation. Curr Opin Cardiol. 27:49–54. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Montaigne D, Marechal X, Lefebvre P, Modine T, Fayad G, Dehondt H, Hurt C, Coisne A, Koussa M, Remy-Jouet I, et al: Mitochondrial dysfunction as an arrhythmogenic substrate: A translational proof-of-concept study in patients with metabolic syndrome in whom post-operative atrial fibrillation develops. J Am Coll Cardiol. 62:1466–1473. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Slagsvold KH, Johnsen AB, Rognmo O, Høydal MA, Wisløff U and Wahba A: Mitochondrial respiration and microRNA expression in right and left atrium of patients with atrial fibrillation. Physiol Genomics. 46:505–511. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Fontanesi F, Clemente P and Barrientos A: Cox25 teams up with Mss51, Ssc1, and Cox14 to regulate mitochondrial cytochrome c oxidase subunit 1 expression and assembly in Saccharomyces cerevisiae. J Biol Chem. 286:555–566. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Pierrel F, Bestwick ML, Cobine PA, Khalimonchuk O, Cricco JA and Winge DR: Coa1 links the Mss51 post-translational function to Cox1 cofactor insertion in cytochrome c oxidase assembly. EMBO J. 26:4335–4346. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Perez-Martinez X, Broadley SA and Fox TD: Mss51p promotes mitochondrial Cox1p synthesis and interacts with newly synthesized Cox1p. EMBO J. 22:5951–5961. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Barrientos A, Zambrano A and Tzagoloff A: Mss51p and Cox14p jointly regulate mitochondrial Cox1p expression in Saccharomyces cerevisiae. EMBO J. 23:3472–3482. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Perez-Martinez X, Butler CA, Shingu-Vazquez M and Fox TD: Dual functions of Mss51 couple synthesis of Cox1 to assembly of cytochrome c oxidase in Saccharomyces cerevisiae mitochondria. Mol Biol Cell. 20:4371–4380. 2009. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Chen G, Guo H, Song Y, Chang H, Wang S, Zhang M and Liu C: Long non‑coding RNA AK055347 is upregulated in patients with atrial fibrillation and regulates mitochondrial energy production in myocardiocytes. Mol Med Rep 14: 5311-5317, 2016.
APA
Chen, G., Guo, H., Song, Y., Chang, H., Wang, S., Zhang, M., & Liu, C. (2016). Long non‑coding RNA AK055347 is upregulated in patients with atrial fibrillation and regulates mitochondrial energy production in myocardiocytes. Molecular Medicine Reports, 14, 5311-5317. https://doi.org/10.3892/mmr.2016.5893
MLA
Chen, G., Guo, H., Song, Y., Chang, H., Wang, S., Zhang, M., Liu, C."Long non‑coding RNA AK055347 is upregulated in patients with atrial fibrillation and regulates mitochondrial energy production in myocardiocytes". Molecular Medicine Reports 14.6 (2016): 5311-5317.
Chicago
Chen, G., Guo, H., Song, Y., Chang, H., Wang, S., Zhang, M., Liu, C."Long non‑coding RNA AK055347 is upregulated in patients with atrial fibrillation and regulates mitochondrial energy production in myocardiocytes". Molecular Medicine Reports 14, no. 6 (2016): 5311-5317. https://doi.org/10.3892/mmr.2016.5893
Copy and paste a formatted citation
x
Spandidos Publications style
Chen G, Guo H, Song Y, Chang H, Wang S, Zhang M and Liu C: Long non‑coding RNA AK055347 is upregulated in patients with atrial fibrillation and regulates mitochondrial energy production in myocardiocytes. Mol Med Rep 14: 5311-5317, 2016.
APA
Chen, G., Guo, H., Song, Y., Chang, H., Wang, S., Zhang, M., & Liu, C. (2016). Long non‑coding RNA AK055347 is upregulated in patients with atrial fibrillation and regulates mitochondrial energy production in myocardiocytes. Molecular Medicine Reports, 14, 5311-5317. https://doi.org/10.3892/mmr.2016.5893
MLA
Chen, G., Guo, H., Song, Y., Chang, H., Wang, S., Zhang, M., Liu, C."Long non‑coding RNA AK055347 is upregulated in patients with atrial fibrillation and regulates mitochondrial energy production in myocardiocytes". Molecular Medicine Reports 14.6 (2016): 5311-5317.
Chicago
Chen, G., Guo, H., Song, Y., Chang, H., Wang, S., Zhang, M., Liu, C."Long non‑coding RNA AK055347 is upregulated in patients with atrial fibrillation and regulates mitochondrial energy production in myocardiocytes". Molecular Medicine Reports 14, no. 6 (2016): 5311-5317. https://doi.org/10.3892/mmr.2016.5893
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team