Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
December-2016 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2016 Volume 14 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Association of SCNN1B promoter methylation with essential hypertension

  • Authors:
    • Qilong Zhong
    • Chunyan Liu
    • Rui Fan
    • Shiwei Duan
    • Xuting Xu
    • Jinshun Zhao
    • Shuqi Mao
    • Wen Zhu
    • Lingmei Hao
    • Fengying Yin
    • Lina Zhang
  • View Affiliations / Copyright

    Affiliations: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China, Clinical Laboratory, Ningbo Baizhang Street Community Health Service Center, Ningbo, Zhejiang 315200, P.R. China, Clinical laboratory, The Seventh Hospital of Ningbo, Ningbo, Zhejiang 315202, P.R. China, Clinical Laboratory, The First Hospital of Ningbo, Ningbo, Zhejiang 315010, P.R. China
  • Pages: 5422-5428
    |
    Published online on: October 31, 2016
       https://doi.org/10.3892/mmr.2016.5905
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The amiloride-sensitive sodium channel beta subunit (SCNN1B) gene encodes the beta subunit of the epithelial sodium channel, which is involved in blood pressure homeostasis. The aim of the present study was to investigate the association between SCNN1B gene promoter methylation and essential hypertension (EH), and to explore whether SCNN1B methylation was altered by antihypertensive therapy. The present study recruited 282 individuals: 94 controls, 94 incident cases and 94 prevalent cases. Subsequently, the methylation status of six CpG sites in the SCNN1B promoter region was measured using bisulfite pyrosequencing technology. Among the six CpG sites, a significant difference in CpG1 and CpG2 methylation levels were detected between controls and incident cases (CpG1: β‑standardized=0.17, adjusted P=0.015; CpG2: β‑standardized=‑0.41, adjusted P=0.001). In addition, a significant difference was detected in CpG1 methylation levels between incident cases and prevalent cases (β‑standardized=‑0.252, adjusted P=3.77E‑04). The present study also demonstrated that CpG1 and CpG2 methylation levels were significantly lower in males compared with in females (CpG1: t=‑3.180, P=0.002; CpG2: t=‑2.148, P=0.033). CpG1 methylation was also shown to be positively correlated with age (controls: r=0.285, P=0.008; incident cases: r=0.401, P=0.0001; prevalent cases: r=0.367, P=0.001). These results indicated a significant association between EH and SCNN1B methylation, which was affected by age, gender and antihypertensive therapy.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Pratt JH: Central role for ENaC in development of hypertension. J Am Soc Nephrol. 16:3154–3159. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Garty H: Molecular properties of epithelial, amiloride-blockable Na+ channels. FASEB J. 8:522–528. 1994.PubMed/NCBI

3 

Loffing J and Schild L: Functional domains of the epithelial sodium channel. J Am Soc Nephrol. 16:3175–3181. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Wang LP, Gao LG, Zhou XL, Wu HY, Zhang L, Wen D, Li YH, Liu YX, Tian T, Fan XH, et al: Genetic diagnosis of liddle's syndrome by mutation analysis of SCNN1B and SCNN1G in a Chinese family. Chin Med J (Engl). 125:1401–1404. 2012.PubMed/NCBI

5 

Sawathiparnich P, Sumboonnanonda A, Weerakulwattana P and Limwongse C: A novel mutation in the beta-subunit of the epithelial sodium channel gene (SCNN1B) in a Thai family with liddle's syndrome. J Pediatr Endocrinol Metab. 22:85–89. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Wang W, Zhou W, Jiang L, Cui B, Ye L, Su T, Wang J, Li X and Ning G: Mutation analysis of SCNN1B in a family with liddle's syndrome. Endocrine. 29:385–390. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Noda Y: Liddle's syndrome. Nihon Jinzo Gakkai Shi. 53:160–162. 2011.(In Japanese). PubMed/NCBI

8 

Choy MK, Movassagh M, Goh HG, Bennett MR, Down TA and Foo RS: Genome-wide conserved consensus transcription factor binding motifs are hyper-methylated. BMC Genomics. 11:5192010. View Article : Google Scholar : PubMed/NCBI

9 

Zhang LN, Liu PP, Wang L, Yuan F, Xu L, Xin Y, Fei LJ, Zhong QL, Huang Y, Xu L, et al: Lower ADD1 gene promoter DNA methylation increases the risk of essential hypertension. PLoS One. 8:e634552013. View Article : Google Scholar : PubMed/NCBI

10 

Wang X, Falkner B, Zhu H, Shi H, Su S, Xu X, Sharma AK, Dong Y, Treiber F, Gutin B, et al: A genome-wide methylation study on essential hypertension in young african american males. PLoS One. 8:e539382013. View Article : Google Scholar : PubMed/NCBI

11 

Xu L, Zheng D, Wang L, Jiang D, Liu H, Xu L, Liao Q, Zhang L, Liu P, Shi X, et al: GCK gene-body hypomethylation is associated with the risk of coronary heart disease. Biomed Res Int. 2014:1517232014. View Article : Google Scholar : PubMed/NCBI

12 

Jiang D, Zheng D, Wang L, Huang Y, Liu H, Xu L, Liao Q, Liu P, Shi X, Wang Z, et al: Elevated PLA2G7 gene promoter methylation as a gender-specific marker of aging increases the risk of coronary heart disease in females. PLoS One. 8:e597522013. View Article : Google Scholar : PubMed/NCBI

13 

Cheng J, Tang L, Hong Q, Ye H, Xu X, Xu L, Bu S, Wang Q, Dai D, Jiang D and Duan S: Investigation into the promoter DNA methylation of three genes (CAMK1D, CRY2 and CALM2) in the peripheral blood of patients with type 2 diabetes. Exp Ther Med. 8:579–584. 2014.PubMed/NCBI

14 

Tang L, Wang L, Ye H, Xu X, Hong Q, Wang H, Xu L, Bu S, Zhang L, Cheng J, et al: BCL11A gene DNA methylation contributes to the risk of type 2 diabetes in males. Exp Ther Med. 8:459–463. 2014.PubMed/NCBI

15 

Tang L, Ye H, Hong Q, Wang L, Wang Q, Wang H, Xu L, Bu S, Zhang L, Cheng J, et al: Elevated CpG island methylation of GCK gene predicts the risk of type 2 diabetes in chinese males. Gene. 547:329–333. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Tang LL, Liu Q, Bu SZ, Xu LT, Wang QW, Mai YF and Duan SW: The effect of environmental factors and DNA methylation on type 2 diabetes mellitus. Yi Chuan. 35:1143–1152. 2013.(In Chinese). View Article : Google Scholar : PubMed/NCBI

17 

Holliday R: The inheritance of epigenetic defects. Science. 238:163–170. 1987. View Article : Google Scholar : PubMed/NCBI

18 

Cheng J, Wang Y, Zhou K, Wang L, Li J, Zhuang Q, Xu X, Xu L, Zhang K and Dai D: Male-specific association between dopamine receptor D4 gene methylation and schizophrenia. PLoS One. 9:e891282014. View Article : Google Scholar : PubMed/NCBI

19 

European Society of Hypertension-European Society of Cardiology Guidelines Committee, . 2003 European society of hypertension-european society of cardiology guidelines for the management of arterial hypertension. J Hypertens. 21:1011–1053. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Dai D, Cheng J, Zhou K, Lv Y, Zhuang Q, Zheng R, Zhang K, Jiang D, Gao S and Duan S: Significant association between DRD3 gene body methylation and schizophrenia. Psychiatry Res. 220:772–777. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Altobelli E, Petrocelli R, Maccarone M, Altomare G, Argenziano G, Giannetti A, Peserico A, Vena GA, Tiberti S, Chimenti S and Peris K: Risk factors of hypertension, diabetes and obesity in italian psoriasis patients: A survey on socio-demographic characteristics, smoking habits and alcohol consumption. Eur J Dermatol. 19:252–256. 2009.PubMed/NCBI

22 

Mathers JC: Nutritional modulation of ageing: Genomic and epigenetic approaches. Mech Ageing Dev. 127:584–589. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Hughes T, Ture-Ozdemir F, Alibaz-Oner F, Coit P, Direskeneli H and Sawalha AH: Epigenome-wide scan identifies a treatment-responsive pattern of altered DNA methylation among cytoskeletal remodeling genes in monocytes and CD4+ T cells from patients with behcet's disease. Arthritis Rheumatol. 66:1648–1658. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Polidoro S, Broccoletti R, Campanella G, Di Gaetano C, Menegatti E, Scoletta M, Lerda E, Matullo G, Vineis P, Berardi D, et al: Effects of bisphosphonate treatment on DNA methylation in osteonecrosis of the jaw. Mutat Res. 757:104–113. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Laytragoon-Lewin N, Rutqvist LE and Lewin F: DNA methylation in tumour and normal mucosal tissue of head and neck squamous cell carcinoma (HNSCC) patients: New diagnostic approaches and treatment. Med Oncol. 30:6542013. View Article : Google Scholar : PubMed/NCBI

26 

Crudo A, Petropoulos S, Moisiadis VG, Iqbal M, Kostaki A, Machnes Z, Szyf M and Matthews SG: Prenatal synthetic glucocorticoid treatment changes DNA methylation states in male organ systems: Multigenerational effects. Endocrinology. 153:3269–3283. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Guay SP, Brisson D, Lamarche B, Biron S, Lescelleur O, Biertho L, Marceau S, Vohl MC, Gaudet D and Bouchard L: ADRB3 gene promoter DNA methylation in blood and visceral adipose tissue is associated with metabolic disturbances in men. Epigenomics. 6:33–43. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Bellavia A, Urch B, Speck M, Brook RD, Scott JA, Albetti B, Behbod B, North M, Valeri L, Bertazzi PA, et al: DNA hypomethylation, ambient particulate matter and increased blood pressure: Findings from controlled human exposure experiments. J Am Heart Assoc. 2:e0002122013. View Article : Google Scholar : PubMed/NCBI

29 

Alexeeff SE, Baccarelli AA, Halonen J, Coull BA, Wright RO, Tarantini L, Bollati V, Sparrow D, Vokonas P and Schwartz J: Association between blood pressure and DNA methylation of retrotransposons and pro-inflammatory genes. Int J Epidemiol. 42:270–280. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Bell JT, Tsai PC, Yang TP, Pidsley R, Nisbet J, Glass D, Mangino M, Zhai G, Zhang F, Valdes A, et al: Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet. 8:e10026292012. View Article : Google Scholar : PubMed/NCBI

31 

Teschendorff AE, Menon U, Gentry-Maharaj A, Ramus SJ, Weisenberger DJ, Shen H, Campan M, Noushmehr H, Bell CG, Maxwell AP, et al: Age-dependent DNA methylation of genes that are suppressed in stem cells is a hallmark of cancer. Genome Res. 20:440–446. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Maegawa S, Hinkal G, Kim HS, Shen L, Zhang L, Zhang J, Zhang N, Liang S, Donehower LA and Issa JP: Widespread and tissue specific age-related DNA methylation changes in mice. Genome Res. 20:332–340. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Issa JP, Ottaviano YL, Celano P, Hamilton SR, Davidson NE and Baylin SB: Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet. 7:536–540. 1994. View Article : Google Scholar : PubMed/NCBI

34 

Wilson VL and Jones PA: DNA methylation decreases in aging but not in immortal cells. Science. 220:1055–75. 1983. View Article : Google Scholar : PubMed/NCBI

35 

Khattar RS, Swales JD, Dore C, Senior R and Lahiri A: Effect of aging on the prognostic significance of ambulatory systolic, diastolic and pulse pressure in essential hypertension. Circulation. 104:783–789. 2001. View Article : Google Scholar : PubMed/NCBI

36 

Grodzicki T, Michalewicz L and Messerli FH: Aging and essential hypertension: Effect of left ventricular hypertrophy on cardiac function. Am J Hypertens. 11:425–429. 1998. View Article : Google Scholar : PubMed/NCBI

37 

Kaz AM, Wong CJ, Dzieciatkowski S, Luo Y, Schoen RE and Grady WM: Patterns of DNA methylation in the normal colon vary by anatomical location, gender, and age. Epigenetics. 9:492–502. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Tapp HS, Commane DM, Bradburn DM, Arasaradnam R, Mathers JC, Johnson IT and Belshaw NJ: Nutritional factors and gender influence age-related DNA methylation in the human rectal mucosa. Aging Cell. 12:148–155. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Burghardt KJ, Pilsner JR, Bly MJ and Ellingrod VL: DNA methylation in schizophrenia subjects: Gender and MTHFR 677C/T genotype differences. Epigenomics. 4:261–268. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Zhang FF, Cardarelli R, Carroll J, Fulda KG, Kaur M, Gonzalez K, Vishwanatha JK, Santella RM and Morabia A: Significant differences in global genomic DNA methylation by gender and race/ethnicity in peripheral blood. Epigenetics. 6:623–629. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Hao Y, Huang W, Nielsen DA and Kosten TA: Litter gender composition and sex affect maternal behavior and DNA methylation levels of the oprm1 gene in rat offspring. Front Psychiatry. 2:212011. View Article : Google Scholar : PubMed/NCBI

42 

Boks MP, Derks EM, Weisenberger DJ, Strengman E, Janson E, Sommer IE, Kahn RS and Ophoff RA: The relationship of DNA methylation with age, gender and genotype in twins and healthy controls. PLoS One. 4:e67672009. View Article : Google Scholar : PubMed/NCBI

43 

Vaissiere T, Hung RJ, Zaridze D, Moukeria A, Cuenin C, Fasolo V, Ferro G, Paliwal A, Hainaut P, Brennan P, et al: Quantitative analysis of DNA methylation profiles in lung cancer identifies aberrant DNA methylation of specific genes and its association with gender and cancer risk factors. Cancer Res. 69:243–252. 2009. View Article : Google Scholar : PubMed/NCBI

44 

El-Maarri O, Becker T, Junen J, Manzoor SS, Diaz-Lacava A, Schwaab R, Wienker T and Oldenburg J: Gender specific differences in levels of DNA methylation at selected loci from human total blood: A tendency toward higher methylation levels in males. Hum Genet. 122:505–514. 2007. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhong Q, Liu C, Fan R, Duan S, Xu X, Zhao J, Mao S, Zhu W, Hao L, Yin F, Yin F, et al: Association of SCNN1B promoter methylation with essential hypertension. Mol Med Rep 14: 5422-5428, 2016.
APA
Zhong, Q., Liu, C., Fan, R., Duan, S., Xu, X., Zhao, J. ... Zhang, L. (2016). Association of SCNN1B promoter methylation with essential hypertension. Molecular Medicine Reports, 14, 5422-5428. https://doi.org/10.3892/mmr.2016.5905
MLA
Zhong, Q., Liu, C., Fan, R., Duan, S., Xu, X., Zhao, J., Mao, S., Zhu, W., Hao, L., Yin, F., Zhang, L."Association of SCNN1B promoter methylation with essential hypertension". Molecular Medicine Reports 14.6 (2016): 5422-5428.
Chicago
Zhong, Q., Liu, C., Fan, R., Duan, S., Xu, X., Zhao, J., Mao, S., Zhu, W., Hao, L., Yin, F., Zhang, L."Association of SCNN1B promoter methylation with essential hypertension". Molecular Medicine Reports 14, no. 6 (2016): 5422-5428. https://doi.org/10.3892/mmr.2016.5905
Copy and paste a formatted citation
x
Spandidos Publications style
Zhong Q, Liu C, Fan R, Duan S, Xu X, Zhao J, Mao S, Zhu W, Hao L, Yin F, Yin F, et al: Association of SCNN1B promoter methylation with essential hypertension. Mol Med Rep 14: 5422-5428, 2016.
APA
Zhong, Q., Liu, C., Fan, R., Duan, S., Xu, X., Zhao, J. ... Zhang, L. (2016). Association of SCNN1B promoter methylation with essential hypertension. Molecular Medicine Reports, 14, 5422-5428. https://doi.org/10.3892/mmr.2016.5905
MLA
Zhong, Q., Liu, C., Fan, R., Duan, S., Xu, X., Zhao, J., Mao, S., Zhu, W., Hao, L., Yin, F., Zhang, L."Association of SCNN1B promoter methylation with essential hypertension". Molecular Medicine Reports 14.6 (2016): 5422-5428.
Chicago
Zhong, Q., Liu, C., Fan, R., Duan, S., Xu, X., Zhao, J., Mao, S., Zhu, W., Hao, L., Yin, F., Zhang, L."Association of SCNN1B promoter methylation with essential hypertension". Molecular Medicine Reports 14, no. 6 (2016): 5422-5428. https://doi.org/10.3892/mmr.2016.5905
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team