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Article Open Access

Tanshinone II A stabilizes vulnerable plaques by suppressing RAGE signaling and NF-κB activation in apolipoprotein-E-deficient mice

Retraction in: /10.3892/mmr.2024.13410
  • Authors:
    • Dong Zhao
    • Lufang Tong
    • Lixin Zhang
    • Hong Li
    • Yingxin Wan
    • Tiezhong Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Geriatric Medicine, China‑Japan Friendship Hospital, Beijing 100029, P.R. China, Department of Pharmacy, China‑Japan Friendship Hospital, Beijing 100029, P.R. China, Department of Dermatology, China‑Japan Friendship Hospital, Beijing 100029, P.R. China, Institute of Clinical Medical Sciences, China‑Japan Friendship Hospital, Beijing 100029, P.R. China, Third Department of Internal Medicine, Changping Chinese and Western Medicine Hospital, Beijing 102208, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4983-4990
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    Published online on: November 1, 2016
       https://doi.org/10.3892/mmr.2016.5916
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Abstract

Tanshinone II A (TSIIA) is a diterpene quinone extracted from the roots of Salvia miltiorrhiza with anti-inflammatory and anti‑oxidant properties that is used to treat atherosclerosis. In the current study, morphological analyses were conducted to evaluate the effects of TSIIA on atherosclerotic vulnerable plaque stability. Additionally, receptor of advanced glycation end products (RAGE), adhesion molecule, and matrix‑metalloproteinases (MMPs) expression, and nuclear factor-κB (NF‑κB) activation were examined in apolipoprotein E (apoE)‑deficient mice treated with TSIIA. Eight‑week‑old apoE-/- mice were administered TSIIA and fed an atherogenic diet for 8 weeks. TSIIA exhibited no effects on plaque size. Analysis of the vulnerable plaque composition demonstrated decreased numbers of macrophages and smooth muscle cells, and increased collagen content in apoE‑deficient mice treated with TSIIA compared with untreated mice. Western blotting revealed that TSIIA downregulated the expression levels of vascular cellular adhesion molecule-1 (VCAM-1), intercellular adhesion molecule‑1 (ICAM‑1), and MMP‑2, ‑3, and ‑9, suppressed RAGE, and inhibited NF‑κB, JNK and p38 activation. The present study demonstrated that the underlying mechanism of TSIIA stabilization of vulnerable plaques involves interfering with RAGE and NF‑κB activation, and downregulation of downstream inflammatory factors, including ICAM‑1, VCAM‑1, and MMP‑2, ‑3 and ‑9 in apoE-/- mice.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao D, Tong L, Zhang L, Li H, Wan Y and Zhang T: Tanshinone II A stabilizes vulnerable plaques by suppressing RAGE signaling and NF-κB activation in apolipoprotein-E-deficient mice Retraction in /10.3892/mmr.2024.13410. Mol Med Rep 14: 4983-4990, 2016.
APA
Zhao, D., Tong, L., Zhang, L., Li, H., Wan, Y., & Zhang, T. (2016). Tanshinone II A stabilizes vulnerable plaques by suppressing RAGE signaling and NF-κB activation in apolipoprotein-E-deficient mice Retraction in /10.3892/mmr.2024.13410. Molecular Medicine Reports, 14, 4983-4990. https://doi.org/10.3892/mmr.2016.5916
MLA
Zhao, D., Tong, L., Zhang, L., Li, H., Wan, Y., Zhang, T."Tanshinone II A stabilizes vulnerable plaques by suppressing RAGE signaling and NF-κB activation in apolipoprotein-E-deficient mice Retraction in /10.3892/mmr.2024.13410". Molecular Medicine Reports 14.6 (2016): 4983-4990.
Chicago
Zhao, D., Tong, L., Zhang, L., Li, H., Wan, Y., Zhang, T."Tanshinone II A stabilizes vulnerable plaques by suppressing RAGE signaling and NF-κB activation in apolipoprotein-E-deficient mice Retraction in /10.3892/mmr.2024.13410". Molecular Medicine Reports 14, no. 6 (2016): 4983-4990. https://doi.org/10.3892/mmr.2016.5916
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao D, Tong L, Zhang L, Li H, Wan Y and Zhang T: Tanshinone II A stabilizes vulnerable plaques by suppressing RAGE signaling and NF-κB activation in apolipoprotein-E-deficient mice Retraction in /10.3892/mmr.2024.13410. Mol Med Rep 14: 4983-4990, 2016.
APA
Zhao, D., Tong, L., Zhang, L., Li, H., Wan, Y., & Zhang, T. (2016). Tanshinone II A stabilizes vulnerable plaques by suppressing RAGE signaling and NF-κB activation in apolipoprotein-E-deficient mice Retraction in /10.3892/mmr.2024.13410. Molecular Medicine Reports, 14, 4983-4990. https://doi.org/10.3892/mmr.2016.5916
MLA
Zhao, D., Tong, L., Zhang, L., Li, H., Wan, Y., Zhang, T."Tanshinone II A stabilizes vulnerable plaques by suppressing RAGE signaling and NF-κB activation in apolipoprotein-E-deficient mice Retraction in /10.3892/mmr.2024.13410". Molecular Medicine Reports 14.6 (2016): 4983-4990.
Chicago
Zhao, D., Tong, L., Zhang, L., Li, H., Wan, Y., Zhang, T."Tanshinone II A stabilizes vulnerable plaques by suppressing RAGE signaling and NF-κB activation in apolipoprotein-E-deficient mice Retraction in /10.3892/mmr.2024.13410". Molecular Medicine Reports 14, no. 6 (2016): 4983-4990. https://doi.org/10.3892/mmr.2016.5916
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