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Article

Nobiletin ameliorates isoflurane-induced cognitive impairment via antioxidant, anti-inflammatory and anti-apoptotic effects in aging rats

  • Authors:
    • Junying Bi
    • Haiyan Zhang
    • Jing Lu
    • Weifu Lei
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China, Gynaecology Ward‑1, Linyi People's Hospital, Linyi, Shandong 276000, P.R. China, Department of Anesthesiology, Linyi People's Hospital, Linyi, Shandong 276000, P.R. China
  • Pages: 5408-5414
    |
    Published online on: November 1, 2016
       https://doi.org/10.3892/mmr.2016.5919
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Abstract

A recent study reported that nobiletin is an active ingredient in Fructus Aurantii immaturus and Pericarpium Citri Reticulatae, which may be capable of preventing ischemic stroke. Therefore, the present study aimed to determine the neuroprotective effects of nobiletin, and to evaluate whether it could ameliorate isoflurane‑induced cognitive impairment via antioxidant, anti‑inflammatory and anti‑apoptotic effects in aging rats. Male Sprague‑Dawley rats (age, 18 months) were used to analyze the neuroprotective effects of nobiletin. Morris water maze test was used to determine cognitive competence. Enzyme‑linked immunosorbent assay and western blot analysis were also used to quantify nuclear factor‑κB, tumor necrosis factor (TNF)‑α, IL‑1β, IL‑6, glutathione, (GSH), GSH‑peroxidase, superoxide dismutase and malondialdehyde concentration and relevant protein expression levels Cognitive competence was increased in isoflurane-treated rats following treatment with nobiletin. In addition, as expected, nobiletin exerted antioxidant, anti-inflammatory and anti‑apoptotic effects on isoflurane‑induced cognitive impairment in aging rats. Treatment with nobiletin induced the activation of phosphorylated (p)‑Akt, p‑cAMP response element binding protein (CREB) and brain‑derived neurotrophic factor (BDNF) protein expression and reduced the levels of B‑cell lymphoma 2‑associated X protein (Bax) in isoflurane‑induced rats. In conclusion, the present study demonstrated that nobiletin may ameliorate isoflurane-induced cognitive impairment through antioxidant, anti‑inflammatory and anti‑apoptotic effects via modulation of Akt, Bax, p‑CREB and BDNF in aging rats. These findings provide support for the molecular mechanisms underlying the effects of nobiletin treatment on isoflurane-induced damage.
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1 

Zhang Y, Dong Y, Xu Z and Xie Z: Propofol and magnesium attenuate isoflurane-induced caspase-3 activation via inhibiting mitochondrial permeability transition pore. Med Gas Res. 2:202012. View Article : Google Scholar : PubMed/NCBI

2 

Wiese AJ, Brosnan RJ and Barter LS: Effects of acetylcholinesterase inhibition on quality of recovery from isoflurane-induced anesthesia in horses. Am J Vet Res. 75:223–230. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Cheng B, Zhang Y, Wang A, Dong Y and Xie Z: Vitamin C attenuates Isoflurane-Induced Caspase-3 activation and cognitive impairment. Mol Neurobiol. 52:1580–1589. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Ni C, Li Z, Qian M, Zhou Y, Wang J and Guo X: Isoflurane induced cognitive impairment in aged rats through hippocampal calcineurin/NFAT signaling. Biochem Biophys Res Commun. 460:889–895. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Sanders RD, Xu J, Shu Y, Januszewski A, Halder S, Fidalgo A, Sun P, Hossain M, Ma D and Maze M: Dexmedetomidine attenuates isoflurane-induced neurocognitive impairment in neonatal rats. Anesthesiology. 110:1077–1085. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Scuteri A and Wang H: Pulse wave velocity as a marker of cognitive impairment in the elderly. J Alzheimers Dis. 42:(Suppl 4). S401–S410. 2014.PubMed/NCBI

7 

Shu Y, Zhou Z, Wan Y, Sanders RD, Li M, Pac-Soo CK, Maze M and Ma D: Nociceptive stimuli enhance anesthetic-induced neuroapoptosis in the rat developing brain. Neurobiol Dis. 45:743–750. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Cao L, Li L, Lin D and Zuo Z: Isoflurane induces learning impairment that is mediated by interleukin 1β in rodents. PLoS One. 7:e514312012. View Article : Google Scholar : PubMed/NCBI

9 

Nakajima A, Ohizumi Y and Yamada K: Anti-dementia activity of Nobiletin, a Citrus Flavonoid: A review of animal studies. Clin Psychopharmacol Neurosci. 12:75–82. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Yamakuni T, Nakajima A and Ohizumi Y: Pharmacological action of nobiletin, a component of AURANTII NOBILIS PERICARPIUM with anti-dementia activity and its application for development of functional foods. Nihon Yakurigaku Zasshi. 132:155–159. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Lo YH, Pan MH, Li S, Yen JH, Kou MC, Ho CT and Wu MJ: Nobiletin metabolite, 3′,4′-dihydroxy-5,6,7,8-tetramethoxyflavone, inhibits LDL oxidation and down-regulates scavenger receptor expression and activity in THP-1 cells. Biochim Biophys Acta. 1801:114–126. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Jang SE, Ryu KR, Park SH, Chung S, Teruya Y, Han MJ, Woo JT and Kim DH: Nobiletin and tangeretin ameliorate scratching behavior in mice by inhibiting the action of histamine and the activation of NF-κB, AP-1 and p38. Int Immunopharmacol. 17:502–507. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Al Rahim M, Nakajima A, Saigusa D, Tetsu N, Maruyama Y, Shibuya M, Yamakoshi H, Tomioka Y, Iwabuchi Y, Ohizumi Y and Yamakuni T: 4′-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade. Biochemistry. 48:7713–7721. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Kupershmidt L, Amit T, Bar-Am O, Weinreb O and Youdim MB: Multi-target, neuroprotective and neurorestorative M30 improves cognitive impairment and reduces Alzheimer's-like neuropathology and age-related alterations in mice. Mol Neurobiol. 46:217–220. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Liang G, Ward C, Peng J, Zhao Y, Huang B and Wei H: Isoflurane causes greater neurodegeneration than an equivalent exposure of sevoflurane in the developing brain of neonatal mice. Anesthesiology. 112:1325–1334. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Yang N, Liang Y, Yang P, Wang W, Zhang X and Wang J: TNF-alpha receptor antagonist attenuates isoflurane-induced cognitive impairment in aged rats. Exp Ther Med. 12:463–468. 2016.PubMed/NCBI

17 

Wang X, Zhao B and Li X: Dexmedetomidine attenuates isoflurane-induced cognitive impairment through antioxidant, anti-inflammatory and anti-apoptosis in aging rat. Int J Clin Exp Med. 8:17281–17288. 2015.PubMed/NCBI

18 

Kim YK, Na KS, Myint AM and Leonard BE: The role of pro-inflammatory cytokines in neuroinflammation, neurogenesis and the neuroendocrine system in major depression. Prog Neuropsychopharmacol Biol Psychiatry. 64:277–284. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Castanon N, Lasselin J and Capuron L: Neuropsychiatric comorbidity in obesity: Role of inflammatory processes. Front Endocrinol (Lausanne). 5:742014.PubMed/NCBI

20 

Guan S, Tang Q, Liu W, Zhu R and Li B: Nobiletin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration and attenuates neointimal hyperplasia in a rat carotid artery injury model. Drug Dev Res. 75:489–496. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Golechha M, Sarangal V, Bhatia J, Chaudhry U, Saluja D and Arya DS: Naringin ameliorates pentylenetetrazol-induced seizures and associated oxidative stress, inflammation and cognitive impairment in rats: Possible mechanisms of neuroprotection. Epilepsy Behav. 41:98–102. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Liu GS, Zhang ZS, Yang B and He W: Resveratrol attenuates oxidative damage and ameliorates cognitive impairment in the brain of senescence-accelerated mice. Life Sci. 91:872–877. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Leite MR, Wilhelm EA, Jesse CR, Brandao R and Nogueira CW: Protective effect of caffeine and a selective A2A receptor antagonist on impairment of memory and oxidative stress of aged rats. Exp Gerontol. 46:309–315. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Haider S, Saleem S, Perveen T, et al: Age-related learning and memory deficits in rats: role of altered brain neurotransmitters, acetylcholinesterase activity and changes in antioxidant defense system. Age (Dordr). 36:96532014. View Article : Google Scholar : PubMed/NCBI

25 

Wang C, He L, Yan M, Zheng GY and Liu XY: Effects of polyprenols from pine needles of Pinus massoniana on ameliorating cognitive impairment in a D-galactose-induced mouse model. Age (Dordr). 36:96762014. View Article : Google Scholar : PubMed/NCBI

26 

Li T and Wang G: Computer-aided targeting of the PI3K/Akt/mTOR pathway: Toxicity reduction and therapeutic opportunities. Int J Mol Sci. 15:18856–18891. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Lu W, Xu Z, Zhang M and Zuo Y: MiR-19a promotes epithelial-mesenchymal transition through PI3K/AKT pathway in gastric cancer. Int J Clin Exp Pathol. 7:7286–7296. 2014.PubMed/NCBI

28 

Zhang L, Zhao H, Zhang X, Chen L, Zhao X, Bai X and Zhang J: Nobiletin protects against cerebral ischemia via activating the p-Akt, p-CREB, BDNF and Bcl-2 pathway and ameliorating BBB permeability in rat. Brain Res Bull. 96:45–53. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Malik S, Bhatia J, Suchal K, Gamad N, Dinda AK, Gupta YK and Arya DS: Nobiletin ameliorates cisplatin-induced acute kidney injury due to its anti-oxidant, anti-inflammatory and anti-apoptotic effects. Exp Toxicol Pathol. 67:427–433. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Alijanpour S, Rezayof A, Sepehri H and Delphi L: Alterations in the hippocampal phosphorylated CREB expression in drug state-dependent learning. Behav Brain Res. 292:109–115. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Ortega-Martinez S: A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis. Front Mol Neurosci. 8:462015. View Article : Google Scholar : PubMed/NCBI

32 

Wu L, Zhao QS, Li TW, et al: Yifei Xuanfei Jiangzhuo formula, a Chinese herbal decoction, improves memory impairment through inhibiting apoptosis and enhancing PKA/CREB signal transduction in rats with cerebral ischemia/reperfusion. Mol Med Rep. 12:4273–4283. 2015.PubMed/NCBI

33 

Aguiar AS Jr, Castro AA, Moreira EL, Glaser V, Santos AR, Tasca CI, Latini A and Prediger RD: Short bouts of mild-intensity physical exercise improve spatial learning and memory in aging rats: Involvement of hippocampal plasticity via AKT, CREB and BDNF signaling. Mech Ageing Dev. 132:560–567. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Zhang Y, Lan R, Wang J, Li XY, Zhu DN, Ma YZ, Wu JT and Liu ZH: Acupuncture reduced apoptosis and up-regulated BDNF and GDNF expression in hippocampus following hypoxia-ischemia in neonatal rats. J Ethnopharmacol. 172:124–132. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Zhang F, Zhu ZQ, Liu DX, Zhang C, Gong QH and Zhu YH: Emulsified isoflurane anesthesia decreases brain-derived neurotrophic factor expression and induces cognitive dysfunction in adult rats. Exp Ther Med. 8:471–477. 2014.PubMed/NCBI

36 

Rak K, Völker J, Frenz S, Scherzad A, Schendzielorz P, Radeloff A, Jablonka S, Hagen R and Mlynski R: Effects of the neurotrophic factors BDNF, NT-3, and FGF2 on dissociated neurons of the cochlear nucleus. Neuroreport. 25:960–964. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Li J, Zhou Y, Liu BB, Liu Q, Geng D, Weng LJ and Yi LT: Nobiletin ameliorates the deficits in Hippocampal BDNF, TrkB and Synapsin I induced by chronic unpredictable mild stress. Evid Based Complement Alternat Med. 2013:3596822013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Bi J, Zhang H, Lu J and Lei W: Nobiletin ameliorates isoflurane-induced cognitive impairment via antioxidant, anti-inflammatory and anti-apoptotic effects in aging rats. Mol Med Rep 14: 5408-5414, 2016.
APA
Bi, J., Zhang, H., Lu, J., & Lei, W. (2016). Nobiletin ameliorates isoflurane-induced cognitive impairment via antioxidant, anti-inflammatory and anti-apoptotic effects in aging rats. Molecular Medicine Reports, 14, 5408-5414. https://doi.org/10.3892/mmr.2016.5919
MLA
Bi, J., Zhang, H., Lu, J., Lei, W."Nobiletin ameliorates isoflurane-induced cognitive impairment via antioxidant, anti-inflammatory and anti-apoptotic effects in aging rats". Molecular Medicine Reports 14.6 (2016): 5408-5414.
Chicago
Bi, J., Zhang, H., Lu, J., Lei, W."Nobiletin ameliorates isoflurane-induced cognitive impairment via antioxidant, anti-inflammatory and anti-apoptotic effects in aging rats". Molecular Medicine Reports 14, no. 6 (2016): 5408-5414. https://doi.org/10.3892/mmr.2016.5919
Copy and paste a formatted citation
x
Spandidos Publications style
Bi J, Zhang H, Lu J and Lei W: Nobiletin ameliorates isoflurane-induced cognitive impairment via antioxidant, anti-inflammatory and anti-apoptotic effects in aging rats. Mol Med Rep 14: 5408-5414, 2016.
APA
Bi, J., Zhang, H., Lu, J., & Lei, W. (2016). Nobiletin ameliorates isoflurane-induced cognitive impairment via antioxidant, anti-inflammatory and anti-apoptotic effects in aging rats. Molecular Medicine Reports, 14, 5408-5414. https://doi.org/10.3892/mmr.2016.5919
MLA
Bi, J., Zhang, H., Lu, J., Lei, W."Nobiletin ameliorates isoflurane-induced cognitive impairment via antioxidant, anti-inflammatory and anti-apoptotic effects in aging rats". Molecular Medicine Reports 14.6 (2016): 5408-5414.
Chicago
Bi, J., Zhang, H., Lu, J., Lei, W."Nobiletin ameliorates isoflurane-induced cognitive impairment via antioxidant, anti-inflammatory and anti-apoptotic effects in aging rats". Molecular Medicine Reports 14, no. 6 (2016): 5408-5414. https://doi.org/10.3892/mmr.2016.5919
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