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Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR‑γ/HO‑1 pathways

  • Authors:
    • Xiaohua Shen
    • Meihui Wang
    • Xukun Bi
    • Jiefang Zhang
    • Shaoxiang Wen
    • Guosheng Fu
    • Liang Xia
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Biomedical Research (Therapy) Center, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, P.R. China
    Copyright: © Shen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5528-5534
    |
    Published online on: November 7, 2016
       https://doi.org/10.3892/mmr.2016.5929
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Abstract

Increasing evidence suggests endothelial progenitor cells (EPCs) improve neovascularization and endothelium regeneration. Resveratrol (RSV) is a natural polyphenolic compound, which has been demonstrated to exert multiple protective effects on the cardiovascular system, including inhibition of platelet adhesion and aggregation, reduction of myocardial ischemia‑reperfusion injury, and suppression of neointimal hyperplasia of injured vascular tissue. The present study investigated the role of RSV on levels of oxidative stress and senescence of EPCs, and the effects of RSV on vascular‑promoting and/or vascular‑healing capacity of EPCs. It was demonstrated that EPCs could promote the repair of endothelium of the injured artery. RSV reduced the oxidative reaction of EPCs and inhibited EPC senescence, and these effects may occur via the peroxisome proliferator‑activated receptor‑γ/heme oxygenase‑1 signaling pathways.
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Copy and paste a formatted citation
Spandidos Publications style
Shen X, Wang M, Bi X, Zhang J, Wen S, Fu G and Xia L: Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR‑γ/HO‑1 pathways. Mol Med Rep 14: 5528-5534, 2016.
APA
Shen, X., Wang, M., Bi, X., Zhang, J., Wen, S., Fu, G., & Xia, L. (2016). Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR‑γ/HO‑1 pathways. Molecular Medicine Reports, 14, 5528-5534. https://doi.org/10.3892/mmr.2016.5929
MLA
Shen, X., Wang, M., Bi, X., Zhang, J., Wen, S., Fu, G., Xia, L."Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR‑γ/HO‑1 pathways". Molecular Medicine Reports 14.6 (2016): 5528-5534.
Chicago
Shen, X., Wang, M., Bi, X., Zhang, J., Wen, S., Fu, G., Xia, L."Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR‑γ/HO‑1 pathways". Molecular Medicine Reports 14, no. 6 (2016): 5528-5534. https://doi.org/10.3892/mmr.2016.5929
Copy and paste a formatted citation
x
Spandidos Publications style
Shen X, Wang M, Bi X, Zhang J, Wen S, Fu G and Xia L: Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR‑γ/HO‑1 pathways. Mol Med Rep 14: 5528-5534, 2016.
APA
Shen, X., Wang, M., Bi, X., Zhang, J., Wen, S., Fu, G., & Xia, L. (2016). Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR‑γ/HO‑1 pathways. Molecular Medicine Reports, 14, 5528-5534. https://doi.org/10.3892/mmr.2016.5929
MLA
Shen, X., Wang, M., Bi, X., Zhang, J., Wen, S., Fu, G., Xia, L."Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR‑γ/HO‑1 pathways". Molecular Medicine Reports 14.6 (2016): 5528-5534.
Chicago
Shen, X., Wang, M., Bi, X., Zhang, J., Wen, S., Fu, G., Xia, L."Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR‑γ/HO‑1 pathways". Molecular Medicine Reports 14, no. 6 (2016): 5528-5534. https://doi.org/10.3892/mmr.2016.5929
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