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Article

Effects of hyperbaric oxygen therapy on RAGE and MCP-1 expression in rats with spinal cord injury

  • Authors:
    • Yong Wang
    • Chunsheng Li
    • Chunjin Gao
    • Zhuo Li
    • Jing Yang
    • Xuehua Liu
    • Fang Liang
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China, Department of Hyperbaric Oxygen, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, P.R. China
  • Pages: 5619-5625
    |
    Published online on: November 9, 2016
       https://doi.org/10.3892/mmr.2016.5935
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Abstract

The inflammatory response is an important source of secondary damage to neuronal tissue in the spinal cord following spinal cord injury (SCI). Hyperbaric oxygen (HBO) therapy reduces inflammation and promotes the restoration of locomotor function following SCI, however, the mechanisms underlying this effect remain to be determined. The aim of the current study was to investigate the mechanisms by which HBO therapy promotes recovery in a rat model of SCI by measuring expression levels of receptor for advanced glycation end products (RAGE) and monocyte chemoattractant protein‑1 (MCP‑1) in spinal cord tissue. Experimental animals (n=90) were divided into three groups: Sham‑operated (SH), SCI (T‑10 laminectomy) and SCI + HBO. Each group was further divided into five subgroups (n=6) that were examined at 12 h, and at 1, 3, 7 and 14 days post‑injury. Recovery of locomotor function was evaluated using the Basso, Beattie and Bresnahan (BBB) scoring system. Neutrophil infiltration was analyzed using myeloperoxidase (MPO) activity assays. The expression of RAGE and MCP‑1 was measured by immunohistochemistry, reverse transcription‑quantitative polymerase chain reaction and western blotting. RAGE and MCP‑1 expression and MPO activity were higher in the SCI groups than in the SH groups at each time point. HBO therapy reduced RAGE and MCP‑1 expression and MPO activity compared with untreated, injured animals at early post‑injury stages. In addition, HBO therapy improved BBB scores at post‑operative day 7 and 14. HBO therapy was, therefore, demonstrated to relieve secondary inflammatory responses, potentially by inhibiting the expression of RAGE and MCP‑1, resulting in significant recovery of locomotor function. The results of the present study may, therefore, be useful in improving the clinical application of HBO therapy for patients with SCI.
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1 

Beattie MS, Hermann GE, Rogers RC and Bresnahan JC: Cell death in models of spinal cord injury. Prog Brain Res. 137:37–47. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Nie H, Xiong L, Lao N, Chen S, Xu N and Zhu Z: Hyperbaric oxygen preconditioning induces tolerance against spinal cord ischemia by upregulation of antioxidant enzymes in rabbits. J Cereb Blood Flow Metab. 26:666–674. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Dayan K, Keser A, Konyalioglu S, Erturk M, Aydin F, Sengul G and Dagci T: The effect of hyperbaric oxygen on neuroregeneration following acute thoracic spinal cord injury. Life Sci. 90:360–364. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Nakamura M, Houghtling RA, MacArthur L, Bayer BM and Bregman BS: Differences in cytokine gene expression profile between acute and secondary injury in adult rat spinal cord. Exp Neurol. 184:313–325. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Fritz G: RAGE: A single receptor fits multiple ligands. Trends Biochem Sci. 36:625–632. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Xie J, Mendez JD, Méndez-Valenzuela V and Aguilar-Hernández MM: Cellular signalling of the receptor for advanced glycation end products (RAGE). Cell Signal. 25:2185–2197. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Lin L, Park S and Lakatta EG: RAGE signaling in inflammation and arterial aging. Front Biosci (Landmark Ed). 14:1403–1413. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Gao TL, Yuan XT, Yang D, Dai HL, Wang WJ, Peng X, Shao HJ, Jin ZF and Fu ZJ: Expression of HMGB1 and RAGE in rat and human brains after traumatic brain injury. J Trauma Acute Care Surg. 72:643–649. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Muhammad S, Barakat W, Stoyanov S, Murikinati S, Yang H, Tracey KJ, Bendszus M, Rossetti G, Nawroth PP, Bierhaus A and Schwaninger M: The HMGB1 receptor RAGE mediates ischemic brain damage. J Neurosci. 28:12023–12031. 2008. View Article : Google Scholar : PubMed/NCBI

10 

Chen KB, Uchida K, Nakajima H, Yayama T, Hirai T, Guerrero A Rodriguez, Kobayashi S, Ma WY, Liu SY, Zhu P and Baba H: High-mobility group box-1 and its receptors contribute to proinflammatory response in the acute phase of spinal cord injury in rats. Spine (Phila Pa 1976). 36:2122–2129. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Kwon BK, Stammers AM, Belanger LM, Bernardo A, Chan D, Bishop CM, Slobogean GP, Zhang H, Umedaly H, Giffin M, et al: Cerebrospinal fluid inflammatory cytokines and biomarkers of injury severity in acute human spinal cord injury. J Neurotrauma. 27:669–682. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Liu SQ, Ma YG, Peng H and Fan L: Monocyte chemoattractant protein-1 level in serum of patients with acute spinal cord injury. Chin J Traumatol. 8:216–219. 2005.PubMed/NCBI

13 

Galasso JM, Liu Y, Szaflarski J, Warren JS and Silverstein FS: Monocyte chemoattractant protein-1 is a mediator of acute excitotoxic injury in neonatal rat brain. Neuroscience. 101:737–744. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Allen EA, Erhardt EB and Calhoun VD: Data visualization in the neurosciences: Overcoming the curse of dimensionality. Neuron. 74:603–608. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Basso DM, Beattie MS and Bresnahan JC: A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma. 12:1–21. 1995. View Article : Google Scholar : PubMed/NCBI

16 

Yang L, Jones NR, Blumbergs PC, Van Den Heuvel C, Moore EJ, Manavis J, Sarvestani GT and Ghabriel MN: Severity-dependent expression of pro-inflammatory cytokines in traumatic spinal cord injury in the rat. J Clin Neurosci. 12:276–284. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Anik I, Kokturk S, Genc H, Cabuk B, Koc K, Yavuz S, Ceylan S, Ceylan S, Kamaci L and Anik Y: Immunohistochemical analysis of TIMP-2 and collagen types I and IV in experimental spinal cord ischemia-reperfusion injury in rats. J Spinal Cord Med. 34:257–264. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Kwon BK, Tetzlaff W, Grauer JN, Beiner J and Vaccaro AR: Pathophysiology and pharmacologic treatment of acute spinal cord injury. Spine J. 4:451–464. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Sinescu C, Popa F, Grigorean VT, Onose G, Sandu AM, Popescu M, Burnei G, Strambu V and Popa C: Molecular basis of vascular events following spinal cord injury. J Med Life. 3:254–261. 2010.PubMed/NCBI

21 

Miron VE, Boyd A, Zhao JW, Yuen TJ, Ruckh JM, Shadrach JL, van Wijngaarden P, Wagers AJ, Williams A, Franklin RJ and ffrench-Constant C: M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination. Nat Neurosci. 16:1211–1218. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Xue H, Zhang XY, Liu JM, Song Y, Liu TT and Chen D: NDGA reduces secondary damage after spinal cord injury in rats via anti-inflammatory effects. Brain Res. 1516:83–92. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Tibbles PM and Edelsberg JS: Hyperbaric-oxygen therapy. N Engl J Med. 334:1642–1648. 1996. View Article : Google Scholar : PubMed/NCBI

24 

Topuz K, Colak A, Cemil B, Kutlay M, Demircan MN, Simsek H, Ipcioglu O, Kucukodaci Z and Uzun G: Combined hyperbaric oxygen and hypothermia treatment on oxidative stress parameters after spinal cord injury: An experimental study. Arch Med Res. 41:506–512. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Liu X, Zhou Y, Wang Z, Yang J, Gao C and Su Q: Effect of VEGF and CX43 on the promotion of neurological recovery by hyperbaric oxygen treatment in spinal cord-injured rats. Spine J. 14:119–127. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Lu PG, Feng H, Yuan SJ, Zhang RW, Li M, Hu R, Liu ZS and Yin J: Effect of preconditioning with hyperbaric oxygen on neural cell apoptosis after spinal cord injury in rats. J Neurosurg Sci. 57:253–258. 2013.PubMed/NCBI

27 

Yang J, Liu X, Zhou Y, Wang G, Gao C and Su Q: Hyperbaric oxygen alleviates experimental (spinal cord) injury by downregulating HMGB1/NF-κB expression. Spine (Phila Pa 1976). 38:E1641–E1648. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Tan J, Zhang F, Liang F, Wang Y, Li Z, Yang J and Liu X: Protective effects of hyperbaric oxygen treatment against spinal cord injury in rats via toll-like receptor 2/nuclear factor-κB signaling. Int J Clin Exp Pathol. 7:1911–1919. 2014.PubMed/NCBI

29 

Chen X, Duan XS, Xu LJ, Zhao JJ, She ZF, Chen WW, Zheng ZJ and Jiang GD: Interleukin-10 mediates the neuroprotection of hyperbaric oxygen therapy against traumatic brain injury in mice. Neuroscience. 266:235–243. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Leskovar A, Moriarty LJ, Turek JJ, Schoenlein IA and Borgens RB: The macrophage in acute neural injury: Changes in cell numbers over time and levels of cytokine production in mammalian central and peripheral nervous systems. J Exp Biol. 203:1783–1795. 2000.PubMed/NCBI

31 

Tjoa T, Strausbaugh HJ, Maida N, Dazin PF, Rosen SD and Noble-Haeusslein LJ: The use of flow cytometry to assess neutrophil infiltration in the injured murine spinal cord. J Neurosci Methods. 129:49–59. 2003. View Article : Google Scholar : PubMed/NCBI

32 

Carlson SL, Parrish ME, Springer JE, Doty K and Dossett L: Acute inflammatory response in spinal cord following impact injury. Exp Neurol. 151:77–88. 1998. View Article : Google Scholar : PubMed/NCBI

33 

Stern D, Yan SD, Yan SF and Schmidt AM: Receptor for advanced glycation endproducts: A multiligand receptor magnifying cell stress in diverse pathologic settings. Adv Drug Deliv Rev. 54:1615–1625. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Kawabata H, Setoguchi T, Yone K, Souda M, Yoshida H, Kawahara K, Maruyama I and Komiya S: High mobility group box 1 is upregulated after spinal cord injury and is associated with neuronal cell apoptosis. Spine (Phila Pa 1976). 35:1109–1115. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Guo JD, Li L, Shi YM, Wang HD, Yuan YL, Shi XX and Hou SX: Genetic ablation of receptor for advanced glycation end products promotes functional recovery in mouse model of spinal cord injury. Mol Cell Biochem. 390:215–223. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Li H, Wu W, Sun Q, Liu M, Li W, Zhang XS, Zhou ML and Hang CH: Expression and cell distribution of receptor for advanced glycation end-products in the rat cortex following experimental subarachnoid hemorrhage. Brain Res. 1543:315–323. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Schmidt AM, Yan SD, Yan SF and Stern DM: The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses. J Clin Invest. 108:949–955. 2001. View Article : Google Scholar : PubMed/NCBI

38 

Che X, Ye W, Panga L, Wu DC and Yang GY: Monocyte chemoattractant protein-1 expressed in neurons and astrocytes during focal ischemia in mice. Brain Res. 902:171–177. 2001. View Article : Google Scholar : PubMed/NCBI

39 

Stammers AT, Liu J and Kwon BK: Expression of inflammatory cytokines following acute spinal cord injury in a rodent model. J Neurosci Res. 90:782–790. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Sandhir R, Gregory E, He YY and Berman NE: Upregulation of inflammatory mediators in a model of chronic pain after spinal cord injury. Neurochem Res. 36:856–862. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Zhang X, Chen C, Ma S, Wang Y and Su X: Inhibition of monocyte chemoattractant peptide-1 decreases secondary spinal cord injury. Mol Med Rep. 11:4262–4266. 2015.PubMed/NCBI

42 

McTigue DM, Tani M, Krivacic K, Chernosky A, Kelner GS, Maciejewski D, Maki R, Ransohoff RM and Stokes BT: Selective chemokine mRNA accumulation in the rat spinal cord after contusion injury. J Neurosci Res. 53:368–376. 1998. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Li C, Gao C, Li Z, Yang J, Liu X and Liang F: Effects of hyperbaric oxygen therapy on RAGE and MCP-1 expression in rats with spinal cord injury. Mol Med Rep 14: 5619-5625, 2016.
APA
Wang, Y., Li, C., Gao, C., Li, Z., Yang, J., Liu, X., & Liang, F. (2016). Effects of hyperbaric oxygen therapy on RAGE and MCP-1 expression in rats with spinal cord injury. Molecular Medicine Reports, 14, 5619-5625. https://doi.org/10.3892/mmr.2016.5935
MLA
Wang, Y., Li, C., Gao, C., Li, Z., Yang, J., Liu, X., Liang, F."Effects of hyperbaric oxygen therapy on RAGE and MCP-1 expression in rats with spinal cord injury". Molecular Medicine Reports 14.6 (2016): 5619-5625.
Chicago
Wang, Y., Li, C., Gao, C., Li, Z., Yang, J., Liu, X., Liang, F."Effects of hyperbaric oxygen therapy on RAGE and MCP-1 expression in rats with spinal cord injury". Molecular Medicine Reports 14, no. 6 (2016): 5619-5625. https://doi.org/10.3892/mmr.2016.5935
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Li C, Gao C, Li Z, Yang J, Liu X and Liang F: Effects of hyperbaric oxygen therapy on RAGE and MCP-1 expression in rats with spinal cord injury. Mol Med Rep 14: 5619-5625, 2016.
APA
Wang, Y., Li, C., Gao, C., Li, Z., Yang, J., Liu, X., & Liang, F. (2016). Effects of hyperbaric oxygen therapy on RAGE and MCP-1 expression in rats with spinal cord injury. Molecular Medicine Reports, 14, 5619-5625. https://doi.org/10.3892/mmr.2016.5935
MLA
Wang, Y., Li, C., Gao, C., Li, Z., Yang, J., Liu, X., Liang, F."Effects of hyperbaric oxygen therapy on RAGE and MCP-1 expression in rats with spinal cord injury". Molecular Medicine Reports 14.6 (2016): 5619-5625.
Chicago
Wang, Y., Li, C., Gao, C., Li, Z., Yang, J., Liu, X., Liang, F."Effects of hyperbaric oxygen therapy on RAGE and MCP-1 expression in rats with spinal cord injury". Molecular Medicine Reports 14, no. 6 (2016): 5619-5625. https://doi.org/10.3892/mmr.2016.5935
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