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Article

Translocation of BBAP from the cytoplasm to the nucleus reduces the metastatic ability of vemurafenib-resistant SKMEL28 cells

  • Authors:
    • Nguyen Dinh Thang
    • Nguyen Van Minh
    • Pham Thu Huong
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Plant Physiology, Faculty of Biology, VNU University of Science, Vietnam National University, Hanoi 120564, Vietnam, Key Laboratory of Enzyme and Protein Technology, VNU University of Science, Vietnam National University, Hanoi 120564, Vietnam
  • Pages: 317-322
    |
    Published online on: December 2, 2016
       https://doi.org/10.3892/mmr.2016.5976
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Abstract

To the best of our knowledge, the present study is the first to demonstrate that treatment of vemurafenib-resistant SKMEL28 (SKMEL28-R) cells with paclitaxel leads to a shift in localization of the E3-ligase BBAP from the cytoplasm to the nucleus, consequently decreasing the metastatic ability of this cell line. The present study revealed that the movement of BBAP from the cytoplasm to nucleus initiated a change in cell morphology. In addition, the translocation of BBAP led to a decrease of metastatic characteristics in SKMEL28‑R cells, including migration and invasion via downregulation of the phosphorylated form of focal adhesion kinase and N‑cadherin, as well as an upregulation of p21 and E-cadherin. The results of the present study suggested that BBAP may not only be a novel biomarker for melanoma, but also a novel therapeutic target for treatment of metastatic melanoma.
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1 

Aguiar RC, Yakushijin Y, Kharbanda S, Salgia R, Fletcher JA and Shipp MA: BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration. Blood. 96:4328–4334. 2000.PubMed/NCBI

2 

Takeyama K, Aguiar RC, Gu L, He C, Freeman GJ, Kutok JL, Aster JC and Shipp MA: The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity. J Biol Chem. 278:21930–21937. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Hakmé A, Huber A, Dolle P and Schreiber V: The macroPARP Genes Parp-9 and Parp-14 are developmentally and differentially regulated in mouse tissues. Dev Dyn. 237:209–215. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Yan Q, Dutt S, Xu R, Graves K, Juszczynski P, Manis JP and Shipp MA: BBAP monoubiquitylates Histone H4 at Lysine 91 and Selectively modulates the DNA damage response. Mol Cell. 36:110–120. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Thang ND, Yajima I, Kumasaka MY, Iida M, Suzuki T and Kato M: Deltex-3-like (DTX3L) stimulates metastasis of melanoma through FAK/PI3K/AKT but not MEK/ERK pathway. Oncotarget. 6:14290–14299. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Gupta GP and Massagué J: Cancer metastasis: Building a framework. Cell. 127:679–695. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Zhang Y, Sturgis EM, Zafereo ME, Wei Q and Li G: p14ARF genetic polymorphisms and susceptibility to second primary malignancy in patients with index squamous cell carcinoma of the head and neck. Cancer. 117:1227–1235. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Cheng TH, Hsu PK, Li AF, Hung IC, Huang MH and Hsu HS: Correlation of p53, MDM2 and p14(ARF) protein expression in human esophageal squamous cell carcinoma. J Cancer Res Clin Oncol. 135:1577–1582. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Lin TH, Kuo HC, Chou HP and Lu FJ: Berberine enhances inhibition of glioma tumor cell migration and invasiveness mediated by arsenic trioxide. BMC Cancer. 8:582008. View Article : Google Scholar : PubMed/NCBI

10 

Hsia DA, Mitra SK, Hauck CR, Streblow DN, Nelson JA, Ilic D, Huang S, Li E, Nemerow GR, Leng J, et al: Differential regulation of cell motility and invasion by FAK. J Cell Biol. 160:753–767. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Aplin AE, Howe AK and Juliano RL: Cell adhesion molecules, signal transduction and cell growth. Curr Opin Cell Biol. 11:737–744. 1999. View Article : Google Scholar : PubMed/NCBI

12 

Johnson JP: Cell adhesion molecules in the development and progression of malignant melanoma. Cancer Metastasis Rev. 18:345–357. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Hazan RB, Phillips GR, Qiao RF, Norton L and Aaronson SA: Exogenous expression of N-cadherin in breast cancer cell induces cell migration, invasion, and metastasis. J Cell Biol. 148:779–790. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Derycke LD and Bracke ME: N-cadherin in the spotlight of cell-cell adhesion, differentiation, embryogenesis, invasion and signaling. Int J Dev Biol. 48:463–476. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Bottazzi ME, Zhu X, Böhmer RM and Assoian RK: Regulation of p21(cip1) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase. J Cell Biol. 146:1255–1264. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Roovers K and Assoian RK: Integrating the MAP kinase signal into the G1 phase cell cycle machinery. Bioessays. 22:818–826. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Sherr CJ and Roberts JM: Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev. 9:1149–1163. 1995. View Article : Google Scholar : PubMed/NCBI

18 

Torii S, Yamamoto T, Tsuchiya Y and Nishida E: ERK MAP kinase in G cell cycle progression and cancer. Cancer Sci. 97:697–702. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Zhang M, Li J, Wang L, Tian Z, Zhang P, Xu Q, Zhang C, Wei F and Chen W: Prognostic significance of p21, p27 and survivin protein expression in patients with oral squamous cell carcinoma. Oncol Lett. 6:381–386. 2013.PubMed/NCBI

20 

Chiang KC, Yeh CN, Hsu JT, Chen LW, Kuo SF, Sun CC, Huang CC, Pang JH, Flanagan JN, Takano M, et al: MART-10, a novel vitamin D analog, inhibits head and neck squamous carcinoma cells growth through cell cycle arrest at G0/G1 with upregulation of p21 and p27 and downregulation of telomerase. J Steroid Biochem Mol Biol. 138:427–434. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Ling Y and Zhang C, Shen R, Xu Y, Zhu C, Lu M, Liu Y and Zhang C: p14ARF repression induced by promoter methylation associated with metastasis in esophageal squamous cell carcinoma. Dis Esophagus. 27:182–187. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Reed JA, Bales E, Xu W, Okan NA, Bandyopadhyay D and Medrano EE: Cytoplasmic localization of the oncogenic protein Ski in human cutaneous melanomas in vivo: Functional implications for transforming growth factor beta signaling. Cancer Res. 61:8074–8078. 2001.PubMed/NCBI

23 

Reed JA, Lin Q, Chen D, Mian IS and Medrano EE: SKI pathways inducing progression of human melanoma. Cancer Metastasis Rev. 24:265–272. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Akkiprik M, Hu L, Sahin A, Hao X and Zhang W: The subcellular localization of IGFBP5 affects its cell growth and migration functions in breast cancer. BMC Cancer. 9:1032009. View Article : Google Scholar : PubMed/NCBI

25 

Thang ND, Nghia PT, Kumasaka MY, Yajima I and Kato M: Treatment of vemurafenib-resistant SKMEL-28 melanoma cells with paclitaxel. Asian Pac J Cancer Prev. 16:699–705. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Juszczynski P, Kutok JL, Li C, Mitra J, Aguiar RC and Shipp MA: BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate. Mol Cell Biol. 26:5348–5359. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Yan Q, Xu R, Zhu L, Cheng X, Wang Z, Manis J and Shipp MA: BAL1 and Its Partner E3 ligase, BBAP, link Poly (ADP-Ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8. Mol Cell Biol. 33:845–857. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Johnson DP, Spitz GS, Tharkar S, Quayle SN, Shearstone JR, Jones S, McDowell ME, Wellman H, Tyler JK, Cairns BR, et al: HDAC1,2 inhibition impairs EZH2- and BBAP- mediated DNA repair to overcome chemoresistance in EZH2 gain-of-function mutant diffuse large B-cell lymphoma. Oncotarget. 6:4863–4887. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Bachmann SB, Frommel SC, Camicia R, Winkler HC, Santoro R and Hassa PO: DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells. Mol Cancer. 13:1252014. View Article : Google Scholar : PubMed/NCBI

30 

Zhang L and Zou W: Inhibition of integrin β1 decreases the malignancy of ovarian cancer cells and potentiates anticancer therapy via the FAK/STAT1 signaling pathway. Mol Med Rep. 12:7869–7876. 2015.PubMed/NCBI

31 

Zhang L, Wang D, Jiang W, Edwards D, Qiu W, Barroilhet LM, Rho JH, Jin L, Seethappan V, Vitonis A, et al: Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium. Reprod Biol Endocrinol. 8:742010. View Article : Google Scholar : PubMed/NCBI

32 

Lee MH, Kachroo P, Pagano PC, Yanagawa J, Wang G, Walser TC, Krysan K, Sharma S, John MS, Dubinett SM and Lee JM: Combination treatment with Apricoxib and IL-27 enhances inhibition of epithelial-mesenchymal transition in human lung cancer cells through a STAT1 dominant pathway. J Cancer Sci Ther. 6:468–477. 2014.PubMed/NCBI

33 

Kachroo P, Lee MH, Zhang L, Baratelli F, Lee G, Srivastava MK, Wang G, Walser TC, Krysan K, Sharma S, et al: IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production in a STAT1-dominant pathway in human non-small cell lung cancer. J Exp Clin Cancer Res. 32:972013. View Article : Google Scholar : PubMed/NCBI

34 

Zhang Y, Zhang Y, Yun H, Lai R and Su M: Correlation of STAT1 with apoptosis and cell-cycle markers in esophageal squamous cell carcinoma. PLoS One. 9:e1139282014. View Article : Google Scholar : PubMed/NCBI

35 

Sun Y, Yang S, Sun N and Chen J: Differential expression of STAT1 and p21 proteins predicts pancreatic cancer progression and prognosis. Pancreas. 43:619–623. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Liu W, Dong M, Bo L, Li C, Liu Q, Li Z and Jin F: Epigallocatechin-3-gallate suppresses alveolar epithelial cell apoptosis in seawater aspiration-induced acute lung injury via inhibiting STAT1-caspase-3/p21 associated pathway. Mol Med Rep. 13:829–836. 2016.PubMed/NCBI

37 

Li W, Fan J, Banerjee D and Bertino JR: Overexpression of p21(waf1) decreases G2-M arrest and apoptosis induced by paclitaxel in human sarcoma cells lacking both p53 and functional Rb protein. Mol Pharmacol. 55:1088–1093. 1999.PubMed/NCBI

38 

Héliez C, Baricault L, Barboule N and Valette A: Paclitaxel increases p21 synthesis and accumulation of its AKT-phosphorylated form in the cytoplasm of cancer cells. Oncogene. 22:3260–3268. 2003. View Article : Google Scholar : PubMed/NCBI

39 

Ferreira P, Oliveira MJ, Beraldi E, Mateus AR, Nakajima T, Gleave M, Yokota J, Carneiro F, Huntsman D, Seruca R and Suriano G: Loss of functional E-cadherin renders cells more resistant to the apoptotic agent taxol in vitro. Exp Cell Res. 310:99–104. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Kang Y, Hu W, Ivan C, Dalton HJ, Miyake T, Pecot CV, Zand B, Liu T, Huang J, Jennings NB, et al: Role of focal adhesion kinase in regulating YB-1-mediated paclitaxel resistance in ovarian cancer. J Natl Cancer Inst. 105:1485–1495. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Smalley KS: PLX-4032, a small-molecule B-Raf inhibitor for the potential treatment of malignant melanoma. Curr Opin Investig Drugs. 11:699–706. 2010.PubMed/NCBI

42 

Flaherty KT, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, O'Dwyer PJ, Lee RJ, Grippo JF, Nolop K and Chapman PB: Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med. 363:809–819. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Bollag G, Tsai J, Zhang J, Zhang C, Ibrahim P, Nolop K and Hirth P: Vemurafenib: The first drug approved for BRAF-mutant cancer. Nat Rev Drug Discov. 11:873–886. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, Chen Z, Lee MK, Attar N, Sazegar H, et al: Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature. 468:973–977. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Thang ND, Minh NV and Huong PT: Translocation of BBAP from the cytoplasm to the nucleus reduces the metastatic ability of vemurafenib-resistant SKMEL28 cells. Mol Med Rep 15: 317-322, 2017.
APA
Thang, N.D., Minh, N.V., & Huong, P.T. (2017). Translocation of BBAP from the cytoplasm to the nucleus reduces the metastatic ability of vemurafenib-resistant SKMEL28 cells. Molecular Medicine Reports, 15, 317-322. https://doi.org/10.3892/mmr.2016.5976
MLA
Thang, N. D., Minh, N. V., Huong, P. T."Translocation of BBAP from the cytoplasm to the nucleus reduces the metastatic ability of vemurafenib-resistant SKMEL28 cells". Molecular Medicine Reports 15.1 (2017): 317-322.
Chicago
Thang, N. D., Minh, N. V., Huong, P. T."Translocation of BBAP from the cytoplasm to the nucleus reduces the metastatic ability of vemurafenib-resistant SKMEL28 cells". Molecular Medicine Reports 15, no. 1 (2017): 317-322. https://doi.org/10.3892/mmr.2016.5976
Copy and paste a formatted citation
x
Spandidos Publications style
Thang ND, Minh NV and Huong PT: Translocation of BBAP from the cytoplasm to the nucleus reduces the metastatic ability of vemurafenib-resistant SKMEL28 cells. Mol Med Rep 15: 317-322, 2017.
APA
Thang, N.D., Minh, N.V., & Huong, P.T. (2017). Translocation of BBAP from the cytoplasm to the nucleus reduces the metastatic ability of vemurafenib-resistant SKMEL28 cells. Molecular Medicine Reports, 15, 317-322. https://doi.org/10.3892/mmr.2016.5976
MLA
Thang, N. D., Minh, N. V., Huong, P. T."Translocation of BBAP from the cytoplasm to the nucleus reduces the metastatic ability of vemurafenib-resistant SKMEL28 cells". Molecular Medicine Reports 15.1 (2017): 317-322.
Chicago
Thang, N. D., Minh, N. V., Huong, P. T."Translocation of BBAP from the cytoplasm to the nucleus reduces the metastatic ability of vemurafenib-resistant SKMEL28 cells". Molecular Medicine Reports 15, no. 1 (2017): 317-322. https://doi.org/10.3892/mmr.2016.5976
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