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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January-2017 Volume 15 Issue 1

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review

Novel copper complexes as potential proteasome inhibitors for cancer treatment (Review)

Zhen Zhang, Huiyun Wang, Maocai Yan, Huannan Wang, Chunyan Zhang
Pages: 3-11
Published online on: 09 December 2016

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Article Open Access

Abnormalities in endocrine and immune cells are correlated in dextran‑sulfate‑sodium‑induced colitis in rats

Magdy El‑Salhy, Jan Gunnar Hatlebakk, Odd Helge Gilja
Pages: 12-20
Published online on: 12 December 2016

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Article Open Access

A novel PDGF receptor inhibitor-eluting stent attenuates in-stent neointima formation in a rabbit carotid model

Chen Huang, Haijun Mei, Min Zhou, Xiaobing Zheng
Pages: 21-28
Published online on: 05 December 2016

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Article Open Access

Differential microRNA expression is associated with androgen receptor expression in breast cancer

Yaqin Shi, Fang Yang, Zijia Sun, Wenwen Zhang, Jun Gu, Xiaoxiang Guan
Pages: 29-36
Published online on: 09 December 2016

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Article Open Access

EphA4 may contribute to microvessel remodeling in the hippocampal CA1 and CA3 areas in a mouse model of temporal lobe epilepsy

Li Feng, Yi Shu, Qian Wu, Tiantian Liu, Hongyu Long, Huan Yang, Yi Li, Bo Xiao
Pages: 37-46
Published online on: 09 December 2016

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Article Open Access

Restorative effects of hydroxysafflor yellow A on hepatic function in an experimental regression model of hepatic fibrosis induced by carbon tetrachloride

Yanuo Li, Yan Shi, Yan Sun, Luying Liu, Xianyong Bai, Dong Wang, Hongxing Li
Pages: 47-56
Published online on: 24 November 2016

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Article Open Access

Early VEGF inhibition attenuates blood-brain barrier disruption in ischemic rat brains by regulating the expression of MMPs

Hai‑Tao Zhang, Ping Zhang, Yi Gao, Chen‑Long Li, Hong‑Jun Wang, Ling‑Chao Chen, Yan Feng, Rui‑Yan Li, Yong‑Li Li, Chuan‑Lu Jiang
Pages: 57-64
Published online on: 29 November 2016

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Article Open Access

Adhesion and invasion of Streptococcus pneumoniae to primary and secondary respiratory epithelial cells

Sara Novick, Marilous Shagan, Karin Blau, Sarit Lifshitz, Noga Givon‑Lavi, Nili Grossman, Lipa Bodner, Ron Dagan, Yaffa Mizrachi Nebenzahl
Pages: 65-74
Published online on: 06 December 2016

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Article

Effects of miR-145 on the inhibition of chondrocyte proliferation and fibrosis by targeting TNFRSF11B in human osteoarthritis

Guo‑Dong Wang, Xiao‑Wei Zhao, Yu‑Ge Zhang, Ying Kong, Shuai‑Shuai Niu, Long‑Fei Ma, Yuan‑Min Zhang
Pages: 75-80
Published online on: 05 December 2016

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Article Open Access

Identification of key genes induced by platelet-rich plasma in human dermal papilla cells using bioinformatics methods

Haiyan Shen, Hanxiao Cheng, Haihua Chen, Jufang Zhang
Pages: 81-88
Published online on: 06 December 2016

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Article Open Access

IL-17 contributed to the neuropathic pain following peripheral nerve injury by promoting astrocyte proliferation and secretion of proinflammatory cytokines

Caixia Sun, Jin Zhang, Li Chen, Tanghua Liu, Gaobing Xu, Chunye Li, Wen Yuan, Huaxi Xu, Zhaoliang Su
Pages: 89-96
Published online on: 09 December 2016

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Article Open Access

Berberine exerts an anti-inflammatory role in ocular Behcet's disease

Yan Yang, Qin Wang, Manyun Xie, Ping Liu, Xin Qi, Xiao Liu, Zhuo Li
Pages: 97-102
Published online on: 05 December 2016

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Article Open Access

Anti‑proliferative activity of epigallocatechin‑3‑gallate and silibinin on soft tissue sarcoma cells

Kamran Harati, Björn Behr, Christoph Wallner, Adrien Daigeler, Tobias Hirsch, Frank Jacobsen, Marcus Renner, Ali Harati, Marcus Lehnhardt, Mustafa Becerikli
Pages: 103-110
Published online on: 28 November 2016

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Article Open Access

Ganoderma lucidum polysaccharides protect fibroblasts against UVB-induced photoaging

Qinghai Zeng, Fang Zhou, Li Lei, Jing Chen, Jianyun Lu, Jianda Zhou, Ke Cao, Lihua Gao, Fang Xia, Shu Ding, Lihua Huang, Hong Xiang, Jingjing Wang, Yangfan Xiao, Rong Xiao, Jinhua Huang
Pages: 111-116
Published online on: 12 December 2016

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Article Open Access

Traditional medicine, Sobokchukeo‑Tang, modulates the inflammatory response in adipocytes and macrophages

Hoyoung Lee, Eun Hyoung Shim, Myeong Soo Lee, Chang‑Seon Myung
Pages: 117-124
Published online on: 07 December 2016

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Article Open Access

Effects of herbal Epimedium on the improvement of bone metabolic disorder through the induction of osteogenic differentiation from bone marrow-derived mesenchymal stem cells

Do Rim Kim, Ji Eun Lee, Kyung Jun Shim, Jin Hyoung Cho, Ho Chul Lee, Seong Kyu Park, Mun Seog Chang
Pages: 125-130
Published online on: 09 December 2016

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Article Open Access

Dexmedetomidine attenuates lipopolysaccharide-induced acute lung injury by inhibiting oxidative stress, mitochondrial dysfunction and apoptosis in rats

Chunlai Fu, Xingui Dai, You Yang, Mengxiang Lin, Yeping Cai, Shaoxi Cai
Pages: 131-138
Published online on: 09 December 2016

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Article Open Access

Identification of functional pathways associated with the conditional ablation of serum response factor in Dstncorn1 mice

Yanan Huo, Xin Xie, Bo Jiang
Pages: 139-145
Published online on: 05 December 2016

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Article Open Access

Differentially expressed miRNAs in oxygen‑induced retinopathy newborn mouse models

Yunpeng Wang, Suying Wu, Yang Yang, Fen Peng, Qintao Li, Peng Tian, Erying Xiang, Honglu Liang, Beibei Wang, Xiaoyu Zhou, Hua Huang, Xiaoguang Zhou
Pages: 146-152
Published online on: 06 December 2016

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Article Open Access

5‑bromo‑3‑(3‑hydroxyprop‑1‑ynyl)‑2H‑pyran‑2‑one induces apoptosis in T24 human bladder cancer cells through mitochondria-dependent signaling pathways Corrigendum in /10.3892/mmr.2016.6076

Guo‑Qiang Yu, Zhong‑Ling Dou, Zhao‑Hui Jia
Pages: 153-159
Published online on: 06 December 2016

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Article Open Access

Galectin-3 inhibition ameliorates hypoxia-induced pulmonary artery hypertension

Mingwen Hao, Miaomiao Li, Wenjun Li
Pages: 160-168
Published online on: 09 December 2016

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Article Open Access

Midazolam anesthesia protects neuronal cells from oxidative stress-induced death via activation of the JNK-ERK pathway

Jing‑Yu Liu, Feng Guo, Hong‑Ling Wu, Ying Wang, Jin‑Shan Liu
Pages: 169-179
Published online on: 12 December 2016

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Article Open Access

Inhibition of JNK suppresses autophagy and attenuates insulin resistance in a rat model of nonalcoholic fatty liver disease

Hua Yan, Yanqiong Gao, Ying Zhang
Pages: 180-186
Published online on: 24 November 2016

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Article Open Access

MicroRNA‑21 promotes migration and invasion of glioma cells via activation of Sox2 and β‑catenin signaling Retraction in /10.3892/mmr.2023.12982

Guoxuan Luo, Wentao Luo, Xiaohui Sun, Jinzhi Lin, Mo Wang, Yang Zhang, Weishi Luo, Yong Zhang
Pages: 187-193
Published online on: 28 November 2016

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Article

miR-195 inhibits the proliferation and migration of chondrocytes by targeting GIT1

Yang‑Lin Gu, Xiao‑Xu Rong, Li‑Ting Wen, Guo‑Xing Zhu, Ming‑Quan Qian
Pages: 194-200
Published online on: 05 December 2016

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Article Open Access

Calcineurin/nuclear factor-κB signaling mediates isoflurane-induced hippocampal neuroinflammation and subsequent cognitive impairment in aged rats

Zhengqian Li, Cheng Ni, Chun Xia, Joey Jaw, Yujie Wang, Yiyun Cao, Mao Xu, Xiangyang Guo
Pages: 201-209
Published online on: 24 November 2016

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Article Open Access

Norspermidine changes the basic structure of S. mutans biofilm

Meizhen Ou, Junqi Ling
Pages: 210-220
Published online on: 05 December 2016

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Article Open Access

cPKCγ membrane translocation is involved in herkinorin‑induced neuroprotection against cerebral ischemia/reperfusion injury in mice

Xiaochen Gui, Xu Cui, Haiping Wei, Guang Feng, Xuezheng Zhang, Yongjin He, Junfa Li, Tianzuo Li
Pages: 221-227
Published online on: 06 December 2016

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Article Open Access

Age-associated expression of erythropoietin and its receptor in rat spiral ganglion neurons and its association with neuronal apoptosis and hearing alterations

Cheng Zhong, Xueyuan Zhang
Pages: 228-234
Published online on: 09 December 2016

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Article Open Access

Clinical diagnosis and mutation analysis of a Chinese family with Camurati-Engelmann disease

Yong Chen, Wanqin Xie, Feng Hu, Jia Chen, Hexin Zheng, Haiyan Zhou, Bin Ni, Wanmeng Li, Jianda Zhou
Pages: 235-239
Published online on: 12 December 2016

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Article Open Access

Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells

Jinjing Jia, Yan Zheng, Wei Wang, Yongping Shao, Zhengxiao Li, Qiong Wang, Yuan Wang, Huling Yan
Pages: 240-248
Published online on: 02 December 2016

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Article Open Access

MicroRNA expression profiles and networks in CXCL12‑stimulated human endometrial stromal cells

Jie Mei, Ming‑Qing Li, Da‑Jin Li, Hai‑Xiang Sun
Pages: 249-255
Published online on: 07 December 2016

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Article Open Access

Lipoprotein redox status evaluation as a marker of cardiovascular disease risk in patients with inflammatory disease

Anca Ungurianu, Denisa Margină, Daniela Grădinaru, Claudia Băcanu, Mihaela Ilie, Christina Tsitsimpikou, Konstantinos Tsarouhas, Demetrios A. Spandidos, Aristides M. Tsatsakis
Pages: 256-262
Published online on: 28 November 2016

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Article

Down syndrome critical region 1 positively correlates with angiogenesis in hypopharyngeal cancer

Chao Lv, Dayu Liu, Xiaona Wei
Pages: 263-270
Published online on: 06 December 2016

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Article

Repetitive extragenic palindromic DNA sequences from Brucella melitensis stimulate Toll-like receptor 9 signaling in macrophages

Hui Yu, Liyun Bai, Yaxian Zhang, Zhanli Wang, Yongchun Yu
Pages: 271-276
Published online on: 06 December 2016

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Article

Vitamin K4 inhibits the proliferation and induces apoptosis of U2OS osteosarcoma cells via mitochondrial dysfunction

Weihua Di, Muhammad Khan, Yong Gao, Jing Cui, Deqiang Wang, Mingfen Qu, Liangtao Feng, Amara Maryam, Hongwen Gao
Pages: 277-284
Published online on: 07 December 2016

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Article

κ‑carrageenan‑derived pentasaccharide attenuates Aβ25‑35‑induced apoptosis in SH‑SY5Y cells via suppression of the JNK signaling pathway

Yang Liu, Liumi Jiang, Xiaofeng Li
Pages: 285-290
Published online on: 07 December 2016

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Article

A novel therapy for ovarian cancer using real‑time imaging

Zhen Zhang, Zhaojie Chen, Beibei Xie, Haiyan Zhang
Pages: 291-296
Published online on: 07 December 2016

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Article

Bcl11b regulates enamel matrix protein expression and dental epithelial cell differentiation during rat tooth development

Ziyue Li, Guoqing Chen, Yaling Yang, Weihua Guo, Weidong Tian
Pages: 297-304
Published online on: 12 December 2016

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Article

Novel CC2D2A compound heterozygous mutations cause Joubert syndrome

Daimin Xiao, Chunli Lv, Zhimin Zhang, Mingsong Wu, Xiang Zheng, Lei Yang, Xueying Li, Guan Wu, Jindong Chen
Pages: 305-308
Published online on: 07 December 2016

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Article

Molecular inhibition mechanisms of cell migration and invasion by coix polysaccharides in A549 NSCLC cells via targeting S100A4

Cheng Luo, Xin Wang, Can An, Chin‑Fa Hwang, Wenhua Miao, Lu Yang, Maonian Xu, Aiping Bai, Shanggui Deng
Pages: 309-316
Published online on: 05 December 2016

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Article

Translocation of BBAP from the cytoplasm to the nucleus reduces the metastatic ability of vemurafenib-resistant SKMEL28 cells

Nguyen Dinh Thang, Nguyen Van Minh, Pham Thu Huong
Pages: 317-322
Published online on: 02 December 2016

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Article

An epirubicin-peptide conjugate with anticancer activity is dependent upon the expression level of the surface transferrin receptor

Jiadan Yang, Qiyu Yang, Lu Xu, Jie Lou, Zhi Dong
Pages: 323-330
Published online on: 07 December 2016

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Article

Endoplasmic reticulum stress mediates sulforaphane-induced apoptosis of HepG2 human hepatocellular carcinoma cells

Xiang Zou, Zhongyuan Qu, Yueni Fang, Xin Shi, Yubin Ji
Pages: 331-338
Published online on: 09 December 2016

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Case Report Open Access

17α‑hydroxylase/17,20‑lyase deficiency in congenital adrenal hyperplasia: A case report

Simiao Xu, Shuhong Hu, Xuefeng Yu, Muxun Zhang, Yan Yang
Pages: 339-344
Published online on: 12 December 2016

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Article

Prx1 promotes the proliferation and migration of vascular smooth muscle cells in a TLR4-dependent manner

Zhicheng Zhu, Xiaomei Zheng, Dan Li, Tiance Wang, Rihao Xu, Hulin Piao, Kexiang Liu
Pages: 345-351
Published online on: 06 December 2016

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Article

Alanine and arginine rich domain containing protein, Aard, is directly regulated by androgen receptor in mouse Sertoli cells

Qiang Geng, Li‑Wei Ni, Bin Ouyang, Yan‑Hua Hu, Yu Zhao, Jun Guo
Pages: 352-358
Published online on: 12 December 2016

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Article

Expression of Bcl-2 and microRNAs in cardiac tissues of patients with dilated cardiomyopathy

Yong Wang, Min Li, Li Xu, Ju Liu, Dong Wang, Quan Li, Lili Wang, Peijie Li, Shanliang Chen, Tianqi Liu
Pages: 359-365
Published online on: 02 December 2016

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Article

Upregulation of endoplasmic reticulum stress is associated with diaphragm contractile dysfunction in a rat model of sepsis

Guangyu Jiao, Liying Hao, Mengmeng Wang, Bin Zhong, Miao Yu, Shuang Zhao, Pingping Wang, Rui Feng, Shutao Tan, Liu Chen
Pages: 366-374
Published online on: 09 December 2016

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Article

Oridonin promotes G2/M arrest in A549 cells by facilitating ATM activation

Mingxing Zheng, Zhibing Zhu, Yongzhao Zhao, Da Yao, Maoqing Wu, Gengyun Sun
Pages: 375-379
Published online on: 08 December 2016

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Article Open Access

Comparative analysis of hepatocellular carcinoma and cirrhosis gene expression profiles

Mingming Jiang, Qingfang Zeng, Suiping Dai, Huixia Liang, Fengying Dai, Xueling Xie, Kunlin Lu, Chunfang Gao
Pages: 380-386
Published online on: 09 December 2016

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Article

Involvement of xanthine oxidase and paraoxonase 1 in the process of oxidative stress in nonalcoholic fatty liver disease

Bing Wang, Rui‑Ning Yang, Yue‑Rong Zhu, Ji‑Cheng Xing, Xiao‑Wei Lou, Yu‑Jie He, Qi‑Long Ding, Ming‑Yue Zhang, Hong Qiu
Pages: 387-395
Published online on: 12 December 2016

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Article

Nitrogen gas plasma treatment of bacterial spores induces oxidative stress that damages the genomic DNA

Akikazu Sakudo, Yoichi Toyokawa, Tetsuji Nakamura, Yoshihito Yagyu, Yuichiro Imanishi
Pages: 396-402
Published online on: 29 November 2016

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Article

Anti‑aging effects of melatonin on the myocardial mitochondria of rats and associated mechanisms

Xin‑Hong Guo, Yan‑Hua Li, Yu‑Sheng Zhao, Yong‑Zhi Zhai, Li‑Cheng Zhang
Pages: 403-410
Published online on: 07 December 2016

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Article

A sensitive and specific indirect competitive enzyme‑linked immunosorbent assay for the detection of icariin

Jinjun Cheng, Yue Zhang, Shuchen Liu, Baoping Qu, Meiling Zhang, Xiaoman Liu, Yan Zhao, Huihua Qu
Pages: 411-416
Published online on: 30 November 2016

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Article

Engineering of the human vessel wall with hair follicle stem cells in vitro

Zhi‑Cheng Xu, Qun Zhang, Hong Li
Pages: 417-422
Published online on: 09 December 2016

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Article

Excess mechanical stress and hydrogen peroxide remodel extracellular matrix of cultured human uterosacral ligament fibroblasts by disturbing the balance of MMPs/TIMPs via the regulation of TGF‑β1 signaling pathway

Qifan Zhang, Cheng Liu, Shasha Hong, Jie Min, Qing Yang, Ming Hu, Yang Zhao, Li Hong
Pages: 423-430
Published online on: 06 December 2016

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Article

Effects of five candidate laxatives derived from Liriope platyphylla on the 5-HT receptor signaling pathway in three cell types present in the transverse colon

Ji Eun Kim, Eun Kyoung Koh, Sung Hwa Song, Ji Eun Sung, Hyun Ah Lee, Hong Gu Lee, Young Whan Choi, Dae Youn Hwang
Pages: 431-441
Published online on: 05 December 2016

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Article

Matrine‑induced apoptosis in Hep3B cells via the inhibition of MDM2

Ning Zhou, Jiequn Li, Ting Li, Guangshun Chen, Zhongqiang Zhang, Zhongzhou Si
Pages: 442-450
Published online on: 07 December 2016

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Article

Protective effects of Cambodian medicinal plants on tert‑butyl hydroperoxide‑induced hepatotoxicity via Nrf2‑mediated heme oxygenase‑1

Dong‑Sung Lee, Samell Keo, Sun‑Kaing Cheng, Hyuncheol Oh, Youn‑Chul Kim
Pages: 451-459
Published online on: 09 December 2016

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Article

Expression of soluble programmed death-1 protein in peripheral blood regulatory T cells and its effects on rheumatoid arthritis progression

Chun‑Feng Ren, Ya‑Xin Zhao, Chun‑Feng Hou, Luan Luan, Guo‑Qing Duan, Shu‑Jie Li, Jian‑Hong Zhao
Pages: 460-466
Published online on: 28 November 2016

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Article

Gene expression profiles of CYP24A1 and CYP27B1 in malignant and normal breast tissues

Naghmeh Zhalehjoo, Yadollah Shakiba, Mojtaba Panjehpour
Pages: 467-473
Published online on: 06 December 2016

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Article

Age-associated differences in transporter gene expression in kidneys of male rats

Yong‑Ji Xu, Yang Wang, Yuan‑Fu Lu, Shang‑Fu Xu, Qin Wu, Jie Liu
Pages: 474-482
Published online on: 28 November 2016

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Article

Tissue inhibitor of metalloproteinases 1, a novel biomarker of tuberculosis

Yingyu Chen, Jieru Wang, Pan Ge, Dejun Cao, Beiping Miao, Ian Robertson, Xia Zhou, Li Zhang, Huanchun Chen, Aizhen Guo
Pages: 483-487
Published online on: 07 December 2016

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Article

Inhibiting the cytoplasmic location of HMGB1 reverses cisplatin resistance in human cervical cancer cells

Jiyi Xia, Xiaolan Yu, Xueqin Song, Gang Li, Xiguang Mao, Yujiao Zhang
Pages: 488-494
Published online on: 07 December 2016

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Effect of RGD coupled MDA-7/IL-24 on apoptosis induction in a hepatocellular carcinoma cell line

Ebrahim Hosseini, Seyed Younes Hosseini, Tayebeh Hashempour, Mohammad‑Reza Fattahi, Majid Sadeghizadeh
Pages: 495-501
Published online on: 08 December 2016

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Resistin aggravates the expression of proinflammatory cytokines in cerulein‑stimulated AR42J pancreatic acinar cells

Chong‑Yi Jiang, Wei Wang
Pages: 502-506
Published online on: 12 December 2016

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January-2026 Volume 33 Issue 1

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Non‑coding RNAs in epithelial‑mesenchymal transition of renal cell carcinoma (Review)

Ziqiao Liu, Hanshen Zhou, Junxiao Shen, Yiming Qi, Xuke Gong, Cheng Zhang
Article Number: 51
Published online on: 24 November 2025

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FOXJ3 drives mesenchymal stem cell osteogenic differentiation via the Wnt/β‑catenin pathway: A novel regulator implicated in osteoporosis

Hongwei Xiao, Jianfeng Li, Wei Huang, Yi Qin
Article Number: 50
Published online on: 21 November 2025

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NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
Published online on: 21 November 2025

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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
Article Number: 48
Published online on: 21 November 2025

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Research progress on molecular therapy for glaucoma (Review)

Weiwei Wang, Gangwei Cheng, Qi Zhou, Sheng Wang, Linyi Zhang
Article Number: 47
Published online on: 21 November 2025

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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

Wenjie Hu, Rui Li, Zhongming Zhang
Article Number: 46
Published online on: 20 November 2025

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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

Pan Guo, Mengke Sun, Jingyu Zhang, Qianshu Yuan, Hong Cui, Junkai Huang, Jing Luo, Qianyu Zhu, Bingxin Zhang, Lizhi Hu
Article Number: 45
Published online on: 20 November 2025

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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
Article Number: 44
Published online on: 20 November 2025

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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
Article Number: 43
Published online on: 18 November 2025

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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
Article Number: 42
Published online on: 17 November 2025

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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
Article Number: 41
Published online on: 12 November 2025

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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
Article Number: 40
Published online on: 12 November 2025

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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

Shuang He, Lei Wang, Zhe Wang, Shiyong Yu, Qi Zhu, Yijun Xu, Yuhang Jiang, Yingxia Wu, Honggang Xiang
Article Number: 39
Published online on: 12 November 2025

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
Article Number: 35
Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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Retraction Open Access

[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
Article Number: 22
Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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Correction Open Access

[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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Review

RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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Retraction Open Access

[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Article

Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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Retraction Open Access

[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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Journal Cover
February-2026 Volume 33 Issue 2

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review Open Access

Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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