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Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells

  • Authors:
    • Jinjing Jia
    • Yan Zheng
    • Wei Wang
    • Yongping Shao
    • Zhengxiao Li
    • Qiong Wang
    • Yuan Wang
    • Huling Yan
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, School of Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China, Key Laboratory of Biomedical Information Engineering of the Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P.R. China
    Copyright: © Jia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 240-248
    |
    Published online on: December 2, 2016
       https://doi.org/10.3892/mmr.2016.5978
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Abstract

The cathelicidin antimicrobial peptide, LL-37, is a multifunctional peptide with a broad spectrum of antimicrobial activities, such as chemotaxis and neutralizing endotoxins. Previous studies have demonstrated that it LL‑37 serves a functional role in the development of numerous types of cancer including ovarian, breast, prostate and lung cancer. However, its role in the development of malignant melanoma (MM) remains unclear. To determine the role of LL‑37 and the potential interaction with Y-box binding protein 1 (YB‑1) in MM, RNA interference, western blot, reverse transcription-quantitative polymerase chain reaction, MTT and Transwell assays were performed. The current study demonstrated that LL‑37 induced YB‑1 expression, and increased tumor cell proliferation, migration and invasion of A375 and A875 MM cell lines. In addition, inhibition of nuclear factor‑κB (NF‑κB) attenuated LL‑37‑induced YB‑1 expression. These results demonstrate that, through the upregulation of YB‑1 expression and the activation of the NF‑κB signaling pathway, LL‑37 may promote the malignant progression of MM cells in vitro.
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Copy and paste a formatted citation
Spandidos Publications style
Jia J, Zheng Y, Wang W, Shao Y, Li Z, Wang Q, Wang Y and Yan H: Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells. Mol Med Rep 15: 240-248, 2017.
APA
Jia, J., Zheng, Y., Wang, W., Shao, Y., Li, Z., Wang, Q. ... Yan, H. (2017). Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells. Molecular Medicine Reports, 15, 240-248. https://doi.org/10.3892/mmr.2016.5978
MLA
Jia, J., Zheng, Y., Wang, W., Shao, Y., Li, Z., Wang, Q., Wang, Y., Yan, H."Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells". Molecular Medicine Reports 15.1 (2017): 240-248.
Chicago
Jia, J., Zheng, Y., Wang, W., Shao, Y., Li, Z., Wang, Q., Wang, Y., Yan, H."Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells". Molecular Medicine Reports 15, no. 1 (2017): 240-248. https://doi.org/10.3892/mmr.2016.5978
Copy and paste a formatted citation
x
Spandidos Publications style
Jia J, Zheng Y, Wang W, Shao Y, Li Z, Wang Q, Wang Y and Yan H: Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells. Mol Med Rep 15: 240-248, 2017.
APA
Jia, J., Zheng, Y., Wang, W., Shao, Y., Li, Z., Wang, Q. ... Yan, H. (2017). Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells. Molecular Medicine Reports, 15, 240-248. https://doi.org/10.3892/mmr.2016.5978
MLA
Jia, J., Zheng, Y., Wang, W., Shao, Y., Li, Z., Wang, Q., Wang, Y., Yan, H."Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells". Molecular Medicine Reports 15.1 (2017): 240-248.
Chicago
Jia, J., Zheng, Y., Wang, W., Shao, Y., Li, Z., Wang, Q., Wang, Y., Yan, H."Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells". Molecular Medicine Reports 15, no. 1 (2017): 240-248. https://doi.org/10.3892/mmr.2016.5978
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