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A novel PDGF receptor inhibitor-eluting stent attenuates in-stent neointima formation in a rabbit carotid model

  • Authors:
    • Chen Huang
    • Haijun Mei
    • Min Zhou
    • Xiaobing Zheng
  • View Affiliations / Copyright

    Affiliations: Division of Vascular Surgery, Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China, Department of Vascular Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 21-28
    |
    Published online on: December 5, 2016
       https://doi.org/10.3892/mmr.2016.5986
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Abstract

A novel drug-eluting stent (DES) is required to target vascular smooth muscle cells (SMCs) without harming endothelial cells (ECs). Platelet-derived growth factor (PDGF) is critical for the proliferation and migration of SMCs. Sunitinib [a PDGF receptor (PDGFR) tyrosine kinase inhibitor]‑eluting stents may therefore inhibit neointimal formation. The aim of the present study was to examine the stent‑based delivery of sunitinib in a rabbit carotid model; in addition, the effects of sunitinib were evaluated in vitro. Local administration of sunitinib markedly reduced neointimal formation without delaying re-endothelialization in the carotid artery model. In vitro, sunitinib inhibited SMC proliferation; however, no effects were observed on ECs. Sunitinib caused necrosis of SMCs. In addition, sunitinib attenuated PDGF-stimulated SMC migration in a scratch wound assay and inhibited α‑SMA cytoskeleton polymerization. Furthermore, sunitinib inhibited PDGF-induced phosphorylation of extracellular signal-regulated kinase in vitro and in vivo. Therefore, this novel DES may be a potential strategy for the treatment of vascular disorders.
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Copy and paste a formatted citation
Spandidos Publications style
Huang C, Mei H, Zhou M and Zheng X: A novel PDGF receptor inhibitor-eluting stent attenuates in-stent neointima formation in a rabbit carotid model. Mol Med Rep 15: 21-28, 2017.
APA
Huang, C., Mei, H., Zhou, M., & Zheng, X. (2017). A novel PDGF receptor inhibitor-eluting stent attenuates in-stent neointima formation in a rabbit carotid model. Molecular Medicine Reports, 15, 21-28. https://doi.org/10.3892/mmr.2016.5986
MLA
Huang, C., Mei, H., Zhou, M., Zheng, X."A novel PDGF receptor inhibitor-eluting stent attenuates in-stent neointima formation in a rabbit carotid model". Molecular Medicine Reports 15.1 (2017): 21-28.
Chicago
Huang, C., Mei, H., Zhou, M., Zheng, X."A novel PDGF receptor inhibitor-eluting stent attenuates in-stent neointima formation in a rabbit carotid model". Molecular Medicine Reports 15, no. 1 (2017): 21-28. https://doi.org/10.3892/mmr.2016.5986
Copy and paste a formatted citation
x
Spandidos Publications style
Huang C, Mei H, Zhou M and Zheng X: A novel PDGF receptor inhibitor-eluting stent attenuates in-stent neointima formation in a rabbit carotid model. Mol Med Rep 15: 21-28, 2017.
APA
Huang, C., Mei, H., Zhou, M., & Zheng, X. (2017). A novel PDGF receptor inhibitor-eluting stent attenuates in-stent neointima formation in a rabbit carotid model. Molecular Medicine Reports, 15, 21-28. https://doi.org/10.3892/mmr.2016.5986
MLA
Huang, C., Mei, H., Zhou, M., Zheng, X."A novel PDGF receptor inhibitor-eluting stent attenuates in-stent neointima formation in a rabbit carotid model". Molecular Medicine Reports 15.1 (2017): 21-28.
Chicago
Huang, C., Mei, H., Zhou, M., Zheng, X."A novel PDGF receptor inhibitor-eluting stent attenuates in-stent neointima formation in a rabbit carotid model". Molecular Medicine Reports 15, no. 1 (2017): 21-28. https://doi.org/10.3892/mmr.2016.5986
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