Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
January-2017 Volume 15 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2017 Volume 15 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

MicroRNA expression profiles and networks in CXCL12‑stimulated human endometrial stromal cells

  • Authors:
    • Jie Mei
    • Ming‑Qing Li
    • Da‑Jin Li
    • Hai‑Xiang Sun
  • View Affiliations / Copyright

    Affiliations: Reproductive Medicine Center, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China, Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai 200011, P.R. China
    Copyright: © Mei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 249-255
    |
    Published online on: December 7, 2016
       https://doi.org/10.3892/mmr.2016.5997
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The chemokine stromal cell-derived factor-1 (C-X-C motif chemokine ligand 12; CXCL12) is important in the recruitment of leukocytes to the peritoneal cavity and the regulation of endometriotic tissue growth in endometriosis patients. However, the alterations in microRNA (miRNA) expression induced by CXCL12 remain to be fully elucidated. The present study evaluated key miRNAs in CXCL12‑stimulated endometrial stromal cells (ESCs), and investigated the underlying cellular regulatory mechanisms of CXCL12 in endometriosis by building networks between miRNAs, genes and gene ontologies (GOs). Differential expression of miRNAs and mRNAs induced by CXCL12 stimulation in ESCs was measured using miRNA and gene chips, and it was observed that 35 miRNAs and 1,671 mRNAs were differentially expressed. Using potential target genes of the 35 miRNAs, intersections of these genes were examined and 63 intersection genes were identified. A total of 39 GOs were obtained for these intersection genes, based on information from GO databases, including immune cell chemoattractants, inflammatory and immune responses, and pathological processes of endometriotic lesions in endometriosis. In addition, miRNA‑gene networks were built according to the GO and Kyoto Encyclopedia of Genes and Genomes databases. The present study, to the best of our knowledge, provides the most complete miRNAome and mRNAome profiles, and the most detailed investigation of the underlying cellular regulatory mechanisms, of the effects of CXCL12 in endometriosis. These results may facilitate the complete elucidation of the role of CXCL12 in endometriosis, and its underlying epigenetic mechanisms.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Bulun SE: Endometriosis. N Engl J Med. 360:268–279. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Li MQ, Wang Y, Chang KK, Meng YH, Liu LB, Mei J, Wang Y, Wang XQ, Jin LP and Li DJ: CD4+Foxp3+ regulatory T cell differentiation mediated by endometrial stromal cell-derived TECK promotes the growth and invasion of endometriotic lesion. Cell Death Dis. 5:e14362014. View Article : Google Scholar : PubMed/NCBI

3 

Borrelli GM, Carvalho KI, Kallas EG, Mechsner S, Baracat EC and Abrão MS: Chemokines in the pathogenesis of endometriosis and infertility. J Reprod Immunol. 981–9. (2013)2013.PubMed/NCBI

4 

Balkwill F: Cancer and the chemokine network. Nat Rev Cancer. 4:540–550. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Ruiz A, Salvo VA, Ruiz LA, Báez P, García M and Flores I: Basal and steroid hormone-regulated expression of CXCR4 in humanendometrium and endometriosis. Reprod Sci. 17:894–903. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Leconte M, Chouzenoux S, Nicco C, Chéreau C, Arkwright S, Santulli P, Weill B, Chapron C, Dousset B and Batteux F: Role of the CXCL12-CXCR4 axis in the development of deep rectal endometriosis. J Reprod Immunol. 103:45–52. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Mei J, Zhu XY, Jin LP, Duan ZL, Li DJ and Li MQ: Estrogen promotes the survival of human secretory phase endometrial stromal cells via CXCL12/CXCR4 upregulation-mediated autophagy inhibition. Hum Reprod. 30:1677–1689. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Burney RO, Hamilton AE, Aghajanova L, Vo KC, Nezhat CN, Lessey BA and Giudice LC: MicroRNA expression profiling of eutopic secretory endometrium in women with versus without endometriosis. Mol Hum Reprod. 15:625–631. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Bao Y, Gao Y, Jin Y, Cong W, Pan X and Cui X: MicroRNA expression profiles and networks in mouse lung infected with H1N1 influenza virus. Mol Genet Genomics. 290:1885–1897. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Clarke R, Ressom HW, Wang A, Xuan J, Liu MC, Gehan EA and Wang Y: The properties of high-dimensional data spaces: Implications for exploring gene and protein expression data. Nat Rev Cancer. 8:37–49. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Gene Ontology Consortium, . The gene ontology (GO) project in 2006. Nucleic Acids Res. 34:(Database issue). D322–D326. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Joung JG, Hwang KB, Nam JW, Kim SJ and Zhang BT: Discovery of microRNA-mRNA modules via population-based probabilistic learning. Bioinformatics. 23:1141–1147. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Ramey JW and Archer DF: Peritoneal fluid: Its relevance to the development of endometriosis. Fertil Steril. 60:1–14. 1993.PubMed/NCBI

14 

Ahn SH, Edwards AK, Singh SS, Young SL, Lessey BA and Tayade C: IL-17A Contributes to the pathogenesis of endometriosis by triggering proinflammatory cytokines and angiogenic growth factors. J Immunol. 195:2591–2600. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Nasu K, Nishida M, Kawano Y, Tsuno A, Abe W, Yuge A, Takai N and Narahara H: Aberrant expression of apoptosis-related molecules in endometriosis: A possible mechanism underlying the pathogenesis of endometriosis. Reprod Sci. 18:206–218. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Guo SW: Epigenetics of endometriosis. Mol Hum Reprod. 15:587–607. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Abe W, Nasu K, Nakada C, Kawano Y, Moriyama M and Narahara H: miR-196b targets c-myc and Bcl-2 expression, inhibits proliferation and induces apoptosis in endometriotic stromal cells. Hum Reprod. 28:750–761. 2013. View Article : Google Scholar : PubMed/NCBI

18 

Barrier BF: Immunology of endometriosis. Clin Obstet Gynecol. 53:397–402. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Berbic M, Hey-Cunningham AJ, Ng C, Tokushige N, Ganewatta S, Markham R, Russell P and Fraser IS: The role of Foxp3+ regulatory T-cells in endometriosis: A potential controlling mechanism for a complex, chronic immunological condition. Hum Reprod. 25:900–907. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Zhou C, Liu J, Tang Y and Liang X: Inflammation linking EMT and cancer stem cells. Oral Oncol. 48:1068–1075. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Tellez CS, Juri DE, Do K, Bernauer AM, Thomas CL, Damiani LA, Tessema M, Leng S and Belinsky SA: EMT and stem cell-like properties associated with miR-205 and miR-200 epigenetic silencing are early manifestations during carcinogen-induced transformation of human lung epithelial cells. Cancer Res. 71:3087–3097. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Lu X, Luo F, Liu Y, Zhang A, Li J, Wang B, Xu W, Shi L, Liu X, Lu L and Liu Q: The IL-6/STAT3 pathway via miR-21 is involved in the neoplastic and metastatic properties of arsenite-transformed human keratinocytes. Toxicol Lett. 237:191–199. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Engels BM and Hutvagner G: Principles and effects of microRNA-mediated post-transcriptional gene regulation. Oncogene. 25:6163–6169. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Teague EM Ohlsson, Print CG and Hull ML: The role of microRNAs in endometriosis and associated reproductive conditions. Hum Reprod Update. 16:142–165. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Braza-Boïls A, Marí-Alexandre J, Gilabert J, Sánchez-Izquierdo D, España F, Estellés A and Gilabert-Estellés J: MicroRNA expression profile in endometriosis: Its relation to angiogenesis and fibrinolytic factors. Hum Reprod. 29:978–988. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Filigheddu N, Gregnanin I, Porporato PE, Surico D, Perego B, Galli L, Patrignani C, Graziani A and Surico N: Differential expression of microRNAs between eutopic and ectopic endometrium in ovarian endometriosis. J Biomed Biotech. 2010:3695492010.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Mei J, Li MQ, Li DJ and Sun HX: MicroRNA expression profiles and networks in CXCL12‑stimulated human endometrial stromal cells. Mol Med Rep 15: 249-255, 2017.
APA
Mei, J., Li, M., Li, D., & Sun, H. (2017). MicroRNA expression profiles and networks in CXCL12‑stimulated human endometrial stromal cells. Molecular Medicine Reports, 15, 249-255. https://doi.org/10.3892/mmr.2016.5997
MLA
Mei, J., Li, M., Li, D., Sun, H."MicroRNA expression profiles and networks in CXCL12‑stimulated human endometrial stromal cells". Molecular Medicine Reports 15.1 (2017): 249-255.
Chicago
Mei, J., Li, M., Li, D., Sun, H."MicroRNA expression profiles and networks in CXCL12‑stimulated human endometrial stromal cells". Molecular Medicine Reports 15, no. 1 (2017): 249-255. https://doi.org/10.3892/mmr.2016.5997
Copy and paste a formatted citation
x
Spandidos Publications style
Mei J, Li MQ, Li DJ and Sun HX: MicroRNA expression profiles and networks in CXCL12‑stimulated human endometrial stromal cells. Mol Med Rep 15: 249-255, 2017.
APA
Mei, J., Li, M., Li, D., & Sun, H. (2017). MicroRNA expression profiles and networks in CXCL12‑stimulated human endometrial stromal cells. Molecular Medicine Reports, 15, 249-255. https://doi.org/10.3892/mmr.2016.5997
MLA
Mei, J., Li, M., Li, D., Sun, H."MicroRNA expression profiles and networks in CXCL12‑stimulated human endometrial stromal cells". Molecular Medicine Reports 15.1 (2017): 249-255.
Chicago
Mei, J., Li, M., Li, D., Sun, H."MicroRNA expression profiles and networks in CXCL12‑stimulated human endometrial stromal cells". Molecular Medicine Reports 15, no. 1 (2017): 249-255. https://doi.org/10.3892/mmr.2016.5997
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team