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Article Open Access

IL-17 contributed to the neuropathic pain following peripheral nerve injury by promoting astrocyte proliferation and secretion of proinflammatory cytokines

  • Authors:
    • Caixia Sun
    • Jin Zhang
    • Li Chen
    • Tanghua Liu
    • Gaobing Xu
    • Chunye Li
    • Wen Yuan
    • Huaxi Xu
    • Zhaoliang Su
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China, Central Laboratory, The Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China, Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 89-96
    |
    Published online on: December 9, 2016
       https://doi.org/10.3892/mmr.2016.6018
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Abstract

Central neuroinflammation is important in the pathophysiological processes of neuropathic pain following peripheral nerve injury. Recently, interleukin-17 (IL-17) has been detected in different inflammatory conditions of the central nervous system and contributes to neuropathic pain associated with multiple sclerosis, experimental autoimmune encephalomyelitis. The present study, based on the rat model of spinal nerve ligation, analyzed the infiltration of cluster of differentiation (CD)4+ T cells and the expression of IL‑17 in the spinal cord during the maintenance phase of neuropathic pain, and investigated central inflammatory reaction and astrocyte activation. The results demonstrated that the infiltrated CD4+ T cells in the spinal cord increased in the rat model of spinal nerve ligation, and immunofluorescence staining demonstrated that the CD4+/IL‑17+ cells were located at superficial laminae of spinal dorsal horn. This was accompanied by significant upregulation of IL‑17. Furthermore, the mRNA expression levels of IL‑1β and IL‑6 were also significantly enhanced in model rats compared with the sham and control groups in the spinal dorsal horn. In vitro, the proliferation ability and secretion of proinflammatory cytokines notably increased in the IL‑17‑stimulated astrocytes. Results from the present study indicate that IL‑17 may contribute to neuropathic pain by promoting the proliferation of astrocytes and secretion of proinflammatory cytokines in spinal nerve ligation‑induced neuropathic pain.
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1 

Geber C, Baumgärtner U, Schwab R, Müller H, Stoeter P, Dieterich M, Sommer C, Birklein F and Treede RD: Revised definition of neuropathic pain and its grading system: An open case series illustrating its use in clinical practice. Am J Med. 122:(Supp 10). S3–S12. 2009.

2 

Kim CF and Moalem-Taylor G: Interleukin-17 contributes to neuroinflammation and neuropathic pain following peripheral nerve injury in mice. J Pain. 12:370–383. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Saadé NE and Jabbur SJ: Nociceptive behavior in animal models for peripheral neuropathy: Spinal and supraspinal mechanisms. Prog Neurobiol. 86:22–47. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Ellis A and Bennett DL: Neuroinflammation and the generation of neuropathic pain. Br J Anaesth. 111:26–37. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Ramesh G: Novel Therapeutic Targets in Neuroinflammation and Neuropathic Pain. Inflamm Cell Signal. 1:pii–e111. 2014.

6 

Liu F and Yuan H: Role of glia in neuropathic pain. Front Biosci (Landmark Ed). 19:798–807. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Chiang CY, Wang J, Xie YF, Zhang S, Hu JW, Dostrovsky JO and Sessle BJ: Astroglial glutamate-glutamine shuttle is involved in central sensitization of nociceptive neurons in rat medullary dorsal horn. J Neurosci. 27:9068–9076. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Liu L, Rudin M and Kozlova EN: Glial cell proliferation in the spinal cord after dorsal rhizotomy or sciatic nerve transection in the adult rat. Exp Brain Res. 131:64–73. 2000. View Article : Google Scholar : PubMed/NCBI

9 

Chiang CY, Sessle BJ and Dostrovsky JO: Role of astrocytes in pain. Neurochem Res. 37:2419–2431. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Gao YJ and Ji RR: Targeting astrocyte signaling for chronic pain. Neurotherapeutics. 7:482–493. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Kimelberg HK and Nedergaard M: Functions of astrocytes and their potential as therapeutic targets. Neurotherapeutics. 7:338–353. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Kang Z, Altuntas CZ, Gulen MF, Liu C, Giltiay N, Qin H, Liu L, Qian W, Ransohoff RM, Bergmann C, et al: Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis. Immunity. 32:414–425. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Lin YC, Huang SY, Jean YH, Chen WF, Sung CS, Kao ES, Wang HM, Chakraborty C, Duh CY and Wen ZH: Intrathecal lemnalol, a natural marine compound obtained from Formosan soft coral, attenuates nociceptive responses and the activity of spinal glial cells in neuropathic rats. Behav Pharmacol. 22:739–750. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Tsuda M, Kohro Y, Yano T, Tsujikawa T, Kitano J, Tozaki-Saitoh H, Koyanagi S, Ohdo S, Ji RR, Salter MW and Inoue K: JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats. Brain. 134:1127–1139. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Isailovic N, Daigo K, Mantovani A and Selmi C: Interleukin-17 and innate immunity in infections and chronic inflammation. J Autoimmun. 60:1–11. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Lubberts E: IL-17/Th17 targeting: On the road to prevent chronic destructive arthritis? Cytokine. 41:84–91. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Noma N, Khan J, Chen IF, Markman S, Benoliel R, Hadlaq E, Imamura Y and Eliav E: Interleukin-17 levels in rat models of nerve damage and neuropathic pain. Neurosci Lett. 493:86–91. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Day YJ, Liou JT, Lee CM, Lin YC, Mao CC, Chou AH, Liao CC and Lee HC: Lack of interleukin-17 leads to a modulated micro-environment and amelioration of mechanical hypersensitivity after peripheral nerve injury in mice. Pain. 155:1293–1302. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Zheng H, Zhang Z, Luo N, Liu Y, Chen Q and Yan H: Increased Th17 cells and IL17 in rats with traumatic optic neuropathy. Mol Med Rep. 10:1954–1958. 2014.PubMed/NCBI

20 

Meng X, Zhang Y, Lao L, Saito R, Li A, Bäckman CM, Berman BM, Ren K, Wei PK and Zhang RX: Spinal interleukin-17 promotes thermal hyperalgesia and NMDA NR1 phosphorylation in an inflammatory pain rat model. Pain. 154:294–305. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Cao L and DeLeo JA: CNS-infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain. Eur J Immunol. 38:448–458. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Costigan M, Moss A, Latremoliere A, Johnston C, Verma-Gandhu M, Herbert TA, Barrett L, Brenner GJ, Vardeh D, Woolf CJ and Fitzgerald M: T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity. J Neurosci. 29:14415–14422. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Olechowski CJ, Truong JJ and Kerr BJ: Neuropathic pain behaviours in a chronic-relapsing model of experimental autoimmune encephalomyelitis (EAE). Pain. 141:156–164. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Kim SH and Chung JM: An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain. 50:355–363. 1992. View Article : Google Scholar : PubMed/NCBI

25 

Chaplan SR, Bach FW, Pogrel JW, Chung JM and Yaksh TL: Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 53:55–63. 1994. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Beeton C and Chandy KG: Isolation of mononuclear cells from the central nervous system of rats with EAE. J Vis Exp. 5272007.PubMed/NCBI

28 

Kerstetter AE and Miller RH: Isolation and culture of spinal cord astrocytes. Methods Mol Biol. 814:93–104. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Clark AK, Old EA and Malcangio M: Neuropathic pain and cytokines: Current perspectives. J Pain Res. 6:803–814. 2013.PubMed/NCBI

30 

Iwakura Y, Ishigame H, Saijo S and Nakae S: Functional specialization of interleukin-17 family members. Immunity. 34:149–162. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Hu P, Bembrick AL, Keay KA and McLachlan EM: Immune cell involvement in dorsal root ganglia and spinal cord after chronic constriction or transection of the rat sciatic nerve. Brain Behav Immun. 21:599–616. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Draleau K, Maddula S, Slaiby A, Nutile-McMenemy N, De Leo J and Cao L: Phenotypic identification of spinal cord-infiltrating CD4 T lymphocytes in a murine model of neuropathic pain. J Pain Relief. (Suppl 3). 0032014.PubMed/NCBI

33 

Zhang J, Takahashi HK, Liu K, Wake H, Liu R, Maruo T, Date I, Yoshino T, Ohtsuka A, Mori S and Nishibori M: Anti-high mobility group box-1 monoclonal antibody protects the blood-brain barrier from ischemia-induced disruption in rats. Stroke. 42:1420–1428. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Stokes JA, Cheung J, Eddinger K, Corr M and Yaksh TL: Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice. J Neuroinflammation. 10:1482013.PubMed/NCBI

35 

Knier B, Rothhammer V, Heink S, Puk O, Graw J, Hemmer B and Korn T: Neutralizing IL-17 protects the optic nerve from autoimmune pathology and prevents retinal nerve fiber layer atrophy during experimental autoimmune encephalomyelitis. J Autoimmun. 56:34–44. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Kleinschnitz C, Hofstetter HH, Meuth SG, Braeuninger S, Sommer C and Stoll G: T cell infiltration after chronic constriction injury of mouse sciatic nerve is associated with interleukin-17 expression. Exp Neurol. 200:480–485. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Xu S and Cao X: Interleukin-17 and its expanding biological functions. Cell Mol Immunol. 7:164–174. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Kawasaki Y, Zhang L, Cheng JK and Ji RR: Cytokine mechanisms of central sensitization: Distinct and overlapping role of interleukin-1beta, interleukin-6 and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. J Neurosci. 28:5189–5194. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Guo W, Wang H, Watanabe M, Shimizu K, Zou S, LaGraize SC, Wei F, Dubner R and Ren K: Glial-cytokine-neuronal interactions underlying the mechanisms of persistent pain. J Neurosci. 27:6006–6018. 2007. View Article : Google Scholar : PubMed/NCBI

40 

Gelderblom M, Weymar A, Bernreuther C, Velden J, Arunachalam P, Steinbach K, Orthey E, Arumugam TV, Leypoldt F, Simova O, et al: Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke. Blood. 120:3793–3802. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Kawanokuchi J, Shimizu K, Nitta A, Yamada K, Mizuno T, Takeuchi H and Suzumura A: Production and functions of IL-17 in microglia. J Neuroimmunol. 194:54–61. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun C, Zhang J, Chen L, Liu T, Xu G, Li C, Yuan W, Xu H and Su Z: IL-17 contributed to the neuropathic pain following peripheral nerve injury by promoting astrocyte proliferation and secretion of proinflammatory cytokines. Mol Med Rep 15: 89-96, 2017.
APA
Sun, C., Zhang, J., Chen, L., Liu, T., Xu, G., Li, C. ... Su, Z. (2017). IL-17 contributed to the neuropathic pain following peripheral nerve injury by promoting astrocyte proliferation and secretion of proinflammatory cytokines. Molecular Medicine Reports, 15, 89-96. https://doi.org/10.3892/mmr.2016.6018
MLA
Sun, C., Zhang, J., Chen, L., Liu, T., Xu, G., Li, C., Yuan, W., Xu, H., Su, Z."IL-17 contributed to the neuropathic pain following peripheral nerve injury by promoting astrocyte proliferation and secretion of proinflammatory cytokines". Molecular Medicine Reports 15.1 (2017): 89-96.
Chicago
Sun, C., Zhang, J., Chen, L., Liu, T., Xu, G., Li, C., Yuan, W., Xu, H., Su, Z."IL-17 contributed to the neuropathic pain following peripheral nerve injury by promoting astrocyte proliferation and secretion of proinflammatory cytokines". Molecular Medicine Reports 15, no. 1 (2017): 89-96. https://doi.org/10.3892/mmr.2016.6018
Copy and paste a formatted citation
x
Spandidos Publications style
Sun C, Zhang J, Chen L, Liu T, Xu G, Li C, Yuan W, Xu H and Su Z: IL-17 contributed to the neuropathic pain following peripheral nerve injury by promoting astrocyte proliferation and secretion of proinflammatory cytokines. Mol Med Rep 15: 89-96, 2017.
APA
Sun, C., Zhang, J., Chen, L., Liu, T., Xu, G., Li, C. ... Su, Z. (2017). IL-17 contributed to the neuropathic pain following peripheral nerve injury by promoting astrocyte proliferation and secretion of proinflammatory cytokines. Molecular Medicine Reports, 15, 89-96. https://doi.org/10.3892/mmr.2016.6018
MLA
Sun, C., Zhang, J., Chen, L., Liu, T., Xu, G., Li, C., Yuan, W., Xu, H., Su, Z."IL-17 contributed to the neuropathic pain following peripheral nerve injury by promoting astrocyte proliferation and secretion of proinflammatory cytokines". Molecular Medicine Reports 15.1 (2017): 89-96.
Chicago
Sun, C., Zhang, J., Chen, L., Liu, T., Xu, G., Li, C., Yuan, W., Xu, H., Su, Z."IL-17 contributed to the neuropathic pain following peripheral nerve injury by promoting astrocyte proliferation and secretion of proinflammatory cytokines". Molecular Medicine Reports 15, no. 1 (2017): 89-96. https://doi.org/10.3892/mmr.2016.6018
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