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Review

Novel copper complexes as potential proteasome inhibitors for cancer treatment (Review)

  • Authors:
    • Zhen Zhang
    • Huiyun Wang
    • Maocai Yan
    • Huannan Wang
    • Chunyan Zhang
  • View Affiliations / Copyright

    Affiliations: Institute of Antitumor Drug Research, School of Pharmacy, Jining Medical University, Rizhao, Shandong 276826, P.R. China, Neurobiology Institute, Jining Medical University, Jining, Shandong 272100, P.R. China
  • Pages: 3-11
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    Published online on: December 9, 2016
       https://doi.org/10.3892/mmr.2016.6022
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Abstract

The use of metal complexes in the pharmaceutical industry has recently increased and as a result, novel metal‑based complexes have initiated an interest as potential anticancer agents. Copper (Cu), which is an essential trace element in all living organisms, is important in maintaining the function of numerous proteins and enzymes. It has recently been demonstrated that Cu complexes may be used as tumor‑specific proteasome inhibitors and apoptosis inducers, by targeting the ubiquitin‑proteasome pathway (UPP). Cu complexes have demonstrated promising results in preclinical studies. The UPP is important in controlling the expression, activity and location of various proteins. Therefore, selective proteasome inhibition and apoptotic induction in cancer cells have been regarded as potential anticancer strategies. The present short review discusses recent progress in the development of Cu complexes, including clioquinol, dithiocarbamates and Schiff bases, as proteasome inhibitors for cancer treatment. A discussion of recent research regarding the understanding of metal inhibitors based on Cu and ligand platforms is presented.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Z, Wang H, Yan M, Wang H and Zhang C: Novel copper complexes as potential proteasome inhibitors for cancer treatment (Review). Mol Med Rep 15: 3-11, 2017.
APA
Zhang, Z., Wang, H., Yan, M., Wang, H., & Zhang, C. (2017). Novel copper complexes as potential proteasome inhibitors for cancer treatment (Review). Molecular Medicine Reports, 15, 3-11. https://doi.org/10.3892/mmr.2016.6022
MLA
Zhang, Z., Wang, H., Yan, M., Wang, H., Zhang, C."Novel copper complexes as potential proteasome inhibitors for cancer treatment (Review)". Molecular Medicine Reports 15.1 (2017): 3-11.
Chicago
Zhang, Z., Wang, H., Yan, M., Wang, H., Zhang, C."Novel copper complexes as potential proteasome inhibitors for cancer treatment (Review)". Molecular Medicine Reports 15, no. 1 (2017): 3-11. https://doi.org/10.3892/mmr.2016.6022
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Wang H, Yan M, Wang H and Zhang C: Novel copper complexes as potential proteasome inhibitors for cancer treatment (Review). Mol Med Rep 15: 3-11, 2017.
APA
Zhang, Z., Wang, H., Yan, M., Wang, H., & Zhang, C. (2017). Novel copper complexes as potential proteasome inhibitors for cancer treatment (Review). Molecular Medicine Reports, 15, 3-11. https://doi.org/10.3892/mmr.2016.6022
MLA
Zhang, Z., Wang, H., Yan, M., Wang, H., Zhang, C."Novel copper complexes as potential proteasome inhibitors for cancer treatment (Review)". Molecular Medicine Reports 15.1 (2017): 3-11.
Chicago
Zhang, Z., Wang, H., Yan, M., Wang, H., Zhang, C."Novel copper complexes as potential proteasome inhibitors for cancer treatment (Review)". Molecular Medicine Reports 15, no. 1 (2017): 3-11. https://doi.org/10.3892/mmr.2016.6022
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