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Article

MicroRNA‑375 inhibits oral squamous cell carcinoma cell migration and invasion by targeting platelet‑derived growth factor‑A

  • Authors:
    • Zheng‑Hao Cao
    • Jing‑Liang Cheng
    • Yong Zhang
    • Chun‑Xiao Bo
    • Yan‑Liang Li
  • View Affiliations / Copyright

    Affiliations: Department of MRI, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China
  • Pages: 922-928
    |
    Published online on: December 19, 2016
       https://doi.org/10.3892/mmr.2016.6057
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Abstract

MicroRNA‑375 (miR‑375) serves an important role in cancer development and growth. However, little is known about the role of miR‑375 in the regulation of oral squamous cell carcinoma (OSCC) metastasis and invasion. The present study measured the expression levels of miR‑375 in Tca8113, UM2, UM1 and CAL‑27 cell lines, using reverse transcription‑quantitative polymerase chain reaction. The results demonstrated that miR‑375 expression levels were significantly reduced in UM1 and CAL‑27 (highly metastatic) compared with Tca8113 and UM2 (less aggressive) OSCC cell lines. Furthermore, it was revealed that overexpression of miR‑375 suppressed the migration and invasion of UM1 cells. Based on a luciferase reporter assay, platelet‑derived growth factor‑A (PDGF‑A) was identified as a direct target gene of miR‑375. Additionally, overexpression of PDGF‑A significantly reversed the effect of miR‑375 on cell migration and invasion in UM1 cells. These data demonstrated that miR‑375 suppressed OSCC cell migration and invasion by targeting PDGF‑A, which may be a potential therapeutic target for the treatment of OSCC.
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Copy and paste a formatted citation
Spandidos Publications style
Cao ZH, Cheng JL, Zhang Y, Bo CX and Li YL: MicroRNA‑375 inhibits oral squamous cell carcinoma cell migration and invasion by targeting platelet‑derived growth factor‑A. Mol Med Rep 15: 922-928, 2017.
APA
Cao, Z., Cheng, J., Zhang, Y., Bo, C., & Li, Y. (2017). MicroRNA‑375 inhibits oral squamous cell carcinoma cell migration and invasion by targeting platelet‑derived growth factor‑A. Molecular Medicine Reports, 15, 922-928. https://doi.org/10.3892/mmr.2016.6057
MLA
Cao, Z., Cheng, J., Zhang, Y., Bo, C., Li, Y."MicroRNA‑375 inhibits oral squamous cell carcinoma cell migration and invasion by targeting platelet‑derived growth factor‑A". Molecular Medicine Reports 15.2 (2017): 922-928.
Chicago
Cao, Z., Cheng, J., Zhang, Y., Bo, C., Li, Y."MicroRNA‑375 inhibits oral squamous cell carcinoma cell migration and invasion by targeting platelet‑derived growth factor‑A". Molecular Medicine Reports 15, no. 2 (2017): 922-928. https://doi.org/10.3892/mmr.2016.6057
Copy and paste a formatted citation
x
Spandidos Publications style
Cao ZH, Cheng JL, Zhang Y, Bo CX and Li YL: MicroRNA‑375 inhibits oral squamous cell carcinoma cell migration and invasion by targeting platelet‑derived growth factor‑A. Mol Med Rep 15: 922-928, 2017.
APA
Cao, Z., Cheng, J., Zhang, Y., Bo, C., & Li, Y. (2017). MicroRNA‑375 inhibits oral squamous cell carcinoma cell migration and invasion by targeting platelet‑derived growth factor‑A. Molecular Medicine Reports, 15, 922-928. https://doi.org/10.3892/mmr.2016.6057
MLA
Cao, Z., Cheng, J., Zhang, Y., Bo, C., Li, Y."MicroRNA‑375 inhibits oral squamous cell carcinoma cell migration and invasion by targeting platelet‑derived growth factor‑A". Molecular Medicine Reports 15.2 (2017): 922-928.
Chicago
Cao, Z., Cheng, J., Zhang, Y., Bo, C., Li, Y."MicroRNA‑375 inhibits oral squamous cell carcinoma cell migration and invasion by targeting platelet‑derived growth factor‑A". Molecular Medicine Reports 15, no. 2 (2017): 922-928. https://doi.org/10.3892/mmr.2016.6057
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