Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
February-2017 Volume 15 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2017 Volume 15 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

TGF-β1 mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating core 1 β1, 3-galactosyltransferase and Cosmc

  • Authors:
    • Jun Xiao
    • Manting Wang
    • Dawei Xiong
    • Ying Wang
    • Qiuyue Li
    • Jing Zhou
    • Qinkai Chen
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Nephrology, Affiliated Jiujiang Hospital of Nanchang University, Jiujiang, Jiangxi 332000, P.R. China, Institute of Microbiology, Jiangxi Academy of Sciences, Nanchang, Jiangxi 330096, P.R. China
  • Pages: 969-974
    |
    Published online on: December 29, 2016
       https://doi.org/10.3892/mmr.2016.6084
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aberrant glycosylation of IgA1 is pivotal in the pathogenesis of IgA nephropathy (IgAN). The aim of the present study was to investigate the effect of transforming growth factor‑β1 (TGF‑β1) on the glycosylation of IgA1 and the associated mechanism. The mRNA levels of core1 β1, 3-galactosyltransferase (C1GalT1) and its molecular chaperone, Cosmc, were analyzed, as was the subsequent O-glycosylation of IgA1, in a human B‑cell line stimulated with TGF‑β1. The IgA1‑positive human B‑cell line was cultured with different concentrations of recombinant human TGF‑β1 (5, 10, 15 and 30 ng/ml). The production and glycosylation of IgA1 were assayed using sandwich ELISA and enzyme‑linked lectin binding assays, respectively, and the mRNA levels of C1GalT1 and Cosmc were quantified using reverse transcription‑quantitative polymerase chain reaction analysis. The results showed that the production of IgA1 was stimulated by low concentrations of TGF‑β1 (5 or 10 ng/ml) and was suppressed by high concentrations (15 or 30 ng/ml). The terminal glycosylation of secreted IgA1 was altered in response to TGF‑β1. TGF‑β1 stimulation significantly decreased the mRNA levels of C1GalT1 and Cosmc. TGF‑β1 may be key in controlling the glycosylation of IgA1, in part via the downregulation of C1GalT1 and Cosmc.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

D'Amico G: Natural history of idiopathic IgA nephropathy and factors predictive of disease outcome. Semin Nephrol. 24:179–196. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Barratt J, Feehally J and Smith AC: Pathogenesis of IgA nephropathy. Semin Nephrol. 24:197–217. 2004. View Article : Google Scholar : PubMed/NCBI

3 

Tarelli E, Smith AC, Hendry BM, Challacombe SJ and Pouria S: Human serum IgA1 is substituted with up to six O-glycans as shown by matrix assisted laser desorption ionisation time-of-flight mass spectrometry. Carbohydr Res. 339:2329–2335. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Renfrow MB, Cooper HJ, Tomana M, Kulhavy R, Hiki Y, Toma K, Emmett MR, Mestecky J, Marshall AG and Novak J: Determination of aberrant O-glycosylation in the IgA1 hinge region by electron capture dissociation Fourier transform-ion cyclotron resonance mass spectrometry. J Biol Chem. 280:19136–19145. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Moldoveanu Z, Wyatt RJ, Lee JY, Tomana M, Julian BA, Mestecky J, Huang WQ, Anreddy SR, Hall S, Hastings MC, et al: Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels. Kidney Int. 71:1148–1154. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Kokubo T, Hiki Y, Iwase H, Horii A, Tanaka A, Nishikido J, Hotta K and Kobayashi Y: Evidence for involvement of IgA1 hinge glycopeptide in the IgA1-IgA1 interaction in IgA nephropathy. J Am Soc Nephrol. 8:915–919. 1997.PubMed/NCBI

7 

Yan Y, Xu LX, Zhang JJ, Zhang Y and Zhao MH: Self-aggregated deglycosylated IgA1 with or without IgG were associated with the development of IgA nephropathy. Clin Exp Immunol. 144:17–24. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Barratt J, Smith AC and Feehally J: The pathogenic role of IgA1 O-linked glycosylation in the pathogenesis of IgA nephropathy. Nephrology. 12:275–284. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Floege J: The pathogenesis of IgA nephropathy: What is new and how does it change therapeutic approaches? Am J Kidney Dis. 58:992–1004. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Ju T, Brewer K, D'Souza A, Cummings RD and Canfield WM: Cloning and expression of human core 1 beta1,3-galactosyltransferase. J Biol Chem. 277:178–186. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Ju T and Cummings RD: A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase. Proc Natl Acad Sci USA. 99:16613–16618. 2002. View Article : Google Scholar : PubMed/NCBI

12 

Allen AC, Topham PS, Harper SJ and Feehally J: Leucocyte beta 1,3 galactosyltransferase activity in IgA nephropathy. Nephrol Dial Transplant. 12:701–706. 1997. View Article : Google Scholar : PubMed/NCBI

13 

Suzuki H, Moldoveanu Z, Hall S, Brown R, Vu HL, Novak L, Julian BA, Tomana M, Wyatt RJ, Edberg JC, et al: IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1. J Clin Invest. 118:629–639. 2008.PubMed/NCBI

14 

Takahashi K, Raska M, Horynova M Stuchlova, Hall SD, Poulsen K, Kilian M, Hiki Y, Yuzawa Y, Moldoveanu Z, Julian BA, et al: Enzymatic sialylation of IgA1 O-Glycans: Implications for studies of IgA nephropathy. PLoS One. 9:e990262014. View Article : Google Scholar : PubMed/NCBI

15 

Nagasawa R, Maruyama N, Imasawa T and Mitarai T: Role of T cells in murine IgA nephropathy. Nephrol Dial Transplant. 14 Suppl 1:S12–S13. 1999. View Article : Google Scholar

16 

Lycke N: T cell and cytokine regulation of the IgA response. Chem Immunol. 71:209–234. 1998. View Article : Google Scholar : PubMed/NCBI

17 

Chintalacharuvu SR and Emancipator SN: The glycosylation of IgA produced by murine B cells is altered by Th2 cytokines. J Immunol. 159:2327–2333. 1997.PubMed/NCBI

18 

Yamada K, Kobayashi N, Ikeda T, Suzuki Y, Tsuge T, Horikoshi S, Emancipator SN and Tomino Y: Down-regulation of core 1 beta 1,3-galactosyltransferase and Cosmc by Th2 cytokine alters O-glycosylation of IgA1. Nephrol Dial Transplant. 25:3890–3897. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Suzuki H, Raska M, Yamada K, Moldoveanu Z, Julian BA, Wyatt RJ, Tomino Y, Gharavi AG and Novak J: Cytokines Alter IgA1 O-Glycosylation by Dysregulating C1GalT1 and ST6GalNAc-II Enzymes. J Biol Chem. 289:5330–5339. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Yu HH, Chu KH, Yang YH, Lee JH, Wang LC, Lin YT and Chiang BL: Genetics and Immunopathogenesis of IgA Nephropathy. Clinic Rev Allerg Immunol. 41:198–213. 2011. View Article : Google Scholar

21 

Toyabe S, Harada W and Uchiyama M: Oligoclonally expanding gammadelta T lymphocytes induce IgA switching in IgA nephropathy. Clin Exp Immunol. 124:110–117. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Meng H, Zhang L, E XQ, Ye F, Li H, Han C, Yamakawa M and Jin X: Application of Oxford classification, and overexpression of transforming growth factor-β1 and immunoglobulins in immunoglobulin A nephropathy: Correlation with World Health Organization classification of immunoglobulin A nephropathy in a Chinese patient cohort. Transl Res. 163:8–18. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Yang YH, Huang MT, Lin SC, Lin YT, Tsai MJ and Chiang BL: Increased transfroming growth factor-beta (TGF-beta)-secreting T cells and IgA anti-cardiolipin antibody levels during acute stage of childhood Henoch-Schönlein purpura. Clin Exp Immunol. 122:285–290. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Xiao J, Cao CY, Zhou J and Wang WH: Changes in levels of Th1, Th2 and Th3 cells in peripheral blood in patients with IgA nephropathy and their significance. Prac Clin Med. 13:28–31. 2012.(In Chinese).

25 

Qin W, Zhou Q, Yang LC, Li Z, Su BH, Luo H and Fan JM: Peripheral B lymphocyte beta1, 3-galactosyltransferase and chaperone expression in immunoglobulin A nephropathy. J Intern Med. 258:467–477. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Xie LS, Qin W, Fan JM, Huang J, Xie XS and Li Z: The role of C1GALT1C1 in lipopolysaccharide-induced IgA1 aberrant O-glycosylation in IgA nephropathy. Clin Invest Med. 33:E5–E13. 2010.PubMed/NCBI

27 

De Wolff JF, Dickinson SJ, Smith AC, Molyneux K, Feehally J, Simon A and Barratt J: Abnormal IgD and IgA1 O-glycosylation in hyperimmunoglobulinaemia D and periodic fever syndrome. Clin Exp Med. 9:291–296. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Prud'homme GJ and Piccirillo CA: The inhibitory effects of transforming growth factor-beta-1(TGF-beta1) in autoimmune diseases. J Autoimmun. 14:23–42. 2000. View Article : Google Scholar : PubMed/NCBI

30 

Del Prete D, Gambaro G, Lupo A, Anglani F, Brezzi B, Magistroni R, Graziotto R, Furci L, Modena F, Bernich P, et al: Precocious activation of genes of the renin-angiotensin system and the fibrogenic cascade in IgA glomerulonephritis. Kidney Int. 64:149–159. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Leung JC, Chan LY, Tsang AW, Liu EW, Lam MF, Tang SC and Lai KN: Anti-macrophagemigration inhibitory factor reduces transforming growth factor-beta 1 expression in experimental IgA nephropathy. Nephrol Dial Transplant. 19:1976–1985. 2004. View Article : Google Scholar : PubMed/NCBI

32 

Zhong Q, Leung JC, Chan LY, Tsang AW, Chen X and Lai KN: The study of Chinese medicinal herbal formula Shen San Fang in the treatment of experimental IgA nephropathy. Am J Chin Med. 33:613–626. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Chihara Y, Ono H, Ishimitsu T, Ono Y, Ishikawa K, Rakugi H, Ogihara T and Matsuoka H: Roles of TGF-beta 1 and apoptosis in the progression of glomerulosclerosis in human IgA nephropathy. Clin Nephrol. 65:385–392. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Kim PH and Kagnoff MF: Transforming growth factor beta 1 increases IgA isotype switching at the clonal level. J Immunol. 145:3773–3778. 1990.PubMed/NCBI

35 

Cazac BB and Roes J: TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo. Immunity. 13:443–451. 2000. View Article : Google Scholar : PubMed/NCBI

36 

Boratyńska M: Urine excretion of transforming growth factor-beta 1 in chronic allograft nephropathy. Ann Transplant. 4:23–28. 1999.

37 

Ibelgaufts H: Cytokines and Cells Online Pathfinder Encyclopaedia (COPE). http://www.copewithcytokines.de/cope.cgi2007.

38 

Kajdaniuk D, Marek B, Borgiel-Marek H and Kos-Kudła B: Transforming growth factor β1 (TGF-β1) in physiology and pathology. Endokrynol Pol. 64:384–396. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Barratt J and Feehally J: IgA nephropathy. J Am Soc Nephrol. 16:2088–2097. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Coppo R and Amore A: Aberrant glycosylation in IgA nephropathy (IgAN). Kidney Int. 65:1544–1547. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Julian BA and Novak J: IgA nephropathy: An update. Curr Opin Nephrol Hypertens. 13:171–179. 2004. View Article : Google Scholar : PubMed/NCBI

42 

Lai KN: Pathogenesis of IgA nephropathy. Nat Rev Nephrol. 8:275–283. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Ju T, Brewer K, D'Souza A, Cummings RD and Canfield WM: Cloning and expression of human core 1 beta1, 3-galactosyltransferase. J Biol Chem. 277:178–186. 2002. View Article : Google Scholar : PubMed/NCBI

44 

Serino G, Sallustio F, Cox SN, Pesce F and Schena FP: Abnormal miR-148b expression promotes aberrant glycosylation of IgA1 in IgA nephropathy. J Am Soc Nephrol. 23:814–824. 2012. View Article : Google Scholar : PubMed/NCBI

45 

He L, Peng Y, Liu H, Yin W, Chen X, Peng X, Shao J, Liu Y and Liu F: Activation of the interleukin-4/signal transducer and activator of transcription 6 signaling pathway and homeodomain-interacting protein kinase 2 production by tonsillar mononuclear cells in IgA nephropathy. Am J Nephrol. 38:321–332. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Inoue T, Sugiyama H, Hiki Y, Takiue K, Morinaga H, Kitagawa M, Maeshima Y, Fukushima K, Nishizaki K, Akagi H, et al: Differential expression of glycogenes in tonsillar B lymphocytes in association with proteinuria and renal dysfunction in IgA nephropathy. Clin Immunol. 136:447–455. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xiao J, Wang M, Xiong D, Wang Y, Li Q, Zhou J and Chen Q: TGF-β1 mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating core 1 β1, 3-galactosyltransferase and Cosmc. Mol Med Rep 15: 969-974, 2017.
APA
Xiao, J., Wang, M., Xiong, D., Wang, Y., Li, Q., Zhou, J., & Chen, Q. (2017). TGF-β1 mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating core 1 β1, 3-galactosyltransferase and Cosmc. Molecular Medicine Reports, 15, 969-974. https://doi.org/10.3892/mmr.2016.6084
MLA
Xiao, J., Wang, M., Xiong, D., Wang, Y., Li, Q., Zhou, J., Chen, Q."TGF-β1 mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating core 1 β1, 3-galactosyltransferase and Cosmc". Molecular Medicine Reports 15.2 (2017): 969-974.
Chicago
Xiao, J., Wang, M., Xiong, D., Wang, Y., Li, Q., Zhou, J., Chen, Q."TGF-β1 mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating core 1 β1, 3-galactosyltransferase and Cosmc". Molecular Medicine Reports 15, no. 2 (2017): 969-974. https://doi.org/10.3892/mmr.2016.6084
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao J, Wang M, Xiong D, Wang Y, Li Q, Zhou J and Chen Q: TGF-β1 mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating core 1 β1, 3-galactosyltransferase and Cosmc. Mol Med Rep 15: 969-974, 2017.
APA
Xiao, J., Wang, M., Xiong, D., Wang, Y., Li, Q., Zhou, J., & Chen, Q. (2017). TGF-β1 mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating core 1 β1, 3-galactosyltransferase and Cosmc. Molecular Medicine Reports, 15, 969-974. https://doi.org/10.3892/mmr.2016.6084
MLA
Xiao, J., Wang, M., Xiong, D., Wang, Y., Li, Q., Zhou, J., Chen, Q."TGF-β1 mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating core 1 β1, 3-galactosyltransferase and Cosmc". Molecular Medicine Reports 15.2 (2017): 969-974.
Chicago
Xiao, J., Wang, M., Xiong, D., Wang, Y., Li, Q., Zhou, J., Chen, Q."TGF-β1 mimics the effect of IL-4 on the glycosylation of IgA1 by downregulating core 1 β1, 3-galactosyltransferase and Cosmc". Molecular Medicine Reports 15, no. 2 (2017): 969-974. https://doi.org/10.3892/mmr.2016.6084
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team