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Article Open Access

The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma

  • Authors:
    • Moyu Ming
    • Chaoqian Li
    • Zhixi Luo
    • Shengqiu Lv
    • Qixiang Sun
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
    Copyright: © Ming et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 777-783
    |
    Published online on: December 29, 2016
       https://doi.org/10.3892/mmr.2016.6087
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Abstract

Allergic asthma is a chronic airway disorder characterized by airway inflammation, mucus hypersecretion, and airway hyperresponsiveness (AHR). A murine model of asthma was used to examine the antiasthmatic effect of inhaled inactived Mycobacterium phlei (M. phlei). AHR, neutrophil levels, eosinophil levels and levels of interleukin (IL)‑17 and IL‑23 receptor (IL‑23R) were monitored. The results demonstrated that inactivated M. phlei alleviates the IL‑17+γδT cell‑mediated immune response and attenuates airway inflammation and airway hyperresponsiveness in the asthmatic murine lung, partially through inhibiting the expression of IL‑23R. In conclusion, inactivated M. phlei may be an effective antiasthmatic treatment, regulating IL‑17‑producing γδT (IL‑17+γδT) cell‑mediated airway inflammation and airway hyperresponsiveness to relieve the symptoms of mice with asthma.
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1 

Galli SJ, Tsai M and Piliponsky AM: The development of allergic inflammation. Nature. 454:445–454. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Ming M, Luo Z, Lv S and Li C: Inhalation of inactivated-Mycobacterium phlei prevents asthma-mediated airway hyperresponsiveness and airway eosinophilia in mice by reducing IL-5 and IL-13 levels. Mol Med Rep. 14:5343–5349. 2016.PubMed/NCBI

3 

Cockcroft DW and Davis BE: Mechanisms of airway hyperresponsiveness. J Allergy Clin Immunol. 118:551–559; quiz 560–1. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Hofmann MA, Kiecker F and Zuberbier T: A systematic review of the role of interleukin-17 and the interleukin-20 family in inflammatory allergic skin diseases. Curr Opin Allergy Clin Immunol. 16:451–457. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Kawaguchi M, Onuchic LF, Li XD, Essayan DM, Schroeder J, Xiao HQ, Liu MC, Krishnaswamy G, Germino G and Huang SK: Identification of a novel cytokine, ML-1, and its expression in subjects with asthma. J Immunol. 167:4430–4435. 2001. View Article : Google Scholar : PubMed/NCBI

6 

Hellings PW, Kasran A, Liu Z, Vandekerckhove P, Wuyts A, Overbergh L, Mathieu C and Ceuppens JL: Interleukin-17 orchestrates the granulocyte influx into airways after allergen inhalation in a mouse model of allergic asthma. Am J Respir Cell Mol Biol. 28:42–50. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Molet S, Hamid Q, Davoineb F, Nutku E, Taha R, Pagé N, Olivenstein R, Elias J and Chakir J: IL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines. J Allergy Clin Immunol. 108:430–438. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Shen F, Zhao MW, He B, Wang YZ and Yao WZ: The levels and clinical implications of induced sputum interleukin-17 in chronic obstructive pulmonary disease and asthma. Zhonghua Nei Ke Za Zhi. 43:888–890. 2004.(In Chinese). PubMed/NCBI

9 

Liang SC, Long AJ, Bennett F, Whitters MJ, Karim R, Collins M, Goldman SJ, Dunussi-Joannopoulos K, Williams CM, Wright JF and Fouser LA: An IL-17F/A heterodimer protein is produced by mouse Th17 cells and induces airway neutrophil recruitment. J Immunol. 179:7791–7799. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Barczyk A, Pierzchala W and Sozañska E: Interleukin-17 in sputum correlates with airway hyperresponsiveness to methacholine. Respir Med. 97:726–733. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Lockhart E, Green AM and Flynn JL: IL-17 production is dominated by gammadelta T cells rather than CD4 T cells during Mycobacterium tuberculosis infection. J Immunol. 177:4662–4669. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Lu H, Li DJ and Jin LP: γδT Cells and Related Diseases. Am J Reprod Immunol. 75:609–618. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Shibata K and Yoshikai Y: Functions of IL-17-producing γδ T Cells. Open Immunology Journal. 2:151–155. 2009. View Article : Google Scholar

14 

Stark MA, Huo Y, Burcin TL, Morris MA, Olson TS and Ley K: Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity. 22:285–294. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Nakamura R, Shibata K, Yamada H, Shimoda K, Nakayama K and Yoshikai Y: Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by gammadelta T cells. J Immunol. 181:2071–2075. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Saunus JM, Wagner SA, Matias MA, Hu Y, Zaini ZM and Farah CS: Early activation of the interleukin-23-17 axis in a murine model of oropharyngeal candidiasis. Mol Oral Microbiol. 25:343–356. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Aggarwal S, Ghilardi N, Xie MH, de Sauvage FJ and Gurney AL: Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. J Biol Chem. 278:1910–1914. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Sutton CE, Lalor SJ, Sweeney CM, Brereton CF, Lavelle EC and Mills KH: Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity. Immunity. 31:331–341. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Zhong Q, Zhou K, Liang QL, Lin S, Wang YC, Xiong XY, Meng ZY, Zhao T, Zhu WY, Yang YR, et al: Interleukin-23 secreted by activated macrophages drives γδT cell production of interleukin-17 to aggravate secondary injury after intracerebral hemorrhage. J Am Heart Assoc. 5:pii: e0043402016. View Article : Google Scholar

20 

Sutton CE, Mielke LA and Mills KH: IL-17producing γδ T cells and innate lymphoid cells. Eur J Immunol. 42:2221–2231. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Martin B, Hirota K, Cua DJ, Stockinger B and Veldhoen M: Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. Immunity. 31:321–330. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Robinson DS, Hamid Q, Ying S, Tsicopoulos A, Barkans J, Bentley AM, Corrigan C, Durham SR and Kay AB: Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med. 326:298–304. 1992. View Article : Google Scholar : PubMed/NCBI

23 

Kon OM and Kay AB: T cells and chronic asthma. Int Arch Allergy Immunol. 118:133–135. 1999. View Article : Google Scholar : PubMed/NCBI

24 

Nagai H, Teramachi H and Tuchiya T: Recent advances in the development of anti-allergic drugs. Allergol Int. 55:35–42. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Ye YL, Chuang YH and Chiang BL: Strategies of mucosal immunotherapy for allergic diseases. Cell Mol Immunol. 8:453–461. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Zhang J, Li C and Guo S: Effects of inhaled inactivated Mycobacterium phlei on airway inflammation in mouse asthmatic models. J Aerosol Med Pulm Drug Deliv. 25:96–103. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Sinkora M, Sinkorová J and Holtmeier W: Development of gammadelta thymocyte subsets during prenatal and postnatal ontogeny. Immunology. 115:544–555. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Poole JA, Wyatt TA, Romberger DJ, Staab E, Simet S, Reynolds SJ, Sisson JH and Kielian T: MyD88 in lung resident cells governs airway inflammatory and pulmonary function responses to organic dust treatment. Respir Res. 16:1112015. View Article : Google Scholar : PubMed/NCBI

29 

Nakasone C, Yamamoto N, Nakamatsu M, Kinjo T, Miyagi K, Uezu K, Nakamura K, Higa F, Ishikawa H, O'brien RL, et al: Accumulation of gamma/delta T cells in the lungs and their roles in neutrophil-mediated host defense against pneumococcal infection. Microbes Infect. 9:251–258. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Zhang J, Guo S, Li C and Jiang X: Therapeutic effects of inhaled inactivated Mycobacterium phlei in adult patients with moderate persistent asthma. Immunotherapy. 4:383–387. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Ming M, Li C, Luo Z and Lv S: Effect of inhaled inactivated Mycobacterium phlei in children with moderate asthma. Immunotherapy. 5:191–197. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Nakada EM, Shan J, Kinyanjui MW and Fixman ED: Adjuvant-dependent regulation of interleukin-17 expressing γδ T cells and inhibition of Th2 responses in allergic airways disease. Respir Res. 15:902014. View Article : Google Scholar : PubMed/NCBI

33 

O'Brien RL, Roark CL and Born WK: IL-17-producing gammadelta T cells. Eur J Immunol. 39:662–666. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Roark CL, Simonian PL, Fontenot AP, Born WK and O'Brien RL: gammadelta T cells: An important source of IL-17. Curr Opin Immunol. 20:353–357. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Lochner M, Peduto L, Cherrier M, Sawa S, Langa F, Varona R, Riethmacher D, Si-Tahar M, Di Santo JP and Eberl G: In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J Exp Med. 205:1381–1393. 2008. View Article : Google Scholar : PubMed/NCBI

36 

Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, Schluns K, Tian Q, Watowich SS, Jetten AM and Dong C: Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature. 448:480–483. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ming M, Li C, Luo Z, Lv S and Sun Q: The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma. Mol Med Rep 15: 777-783, 2017.
APA
Ming, M., Li, C., Luo, Z., Lv, S., & Sun, Q. (2017). The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma. Molecular Medicine Reports, 15, 777-783. https://doi.org/10.3892/mmr.2016.6087
MLA
Ming, M., Li, C., Luo, Z., Lv, S., Sun, Q."The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma". Molecular Medicine Reports 15.2 (2017): 777-783.
Chicago
Ming, M., Li, C., Luo, Z., Lv, S., Sun, Q."The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma". Molecular Medicine Reports 15, no. 2 (2017): 777-783. https://doi.org/10.3892/mmr.2016.6087
Copy and paste a formatted citation
x
Spandidos Publications style
Ming M, Li C, Luo Z, Lv S and Sun Q: The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma. Mol Med Rep 15: 777-783, 2017.
APA
Ming, M., Li, C., Luo, Z., Lv, S., & Sun, Q. (2017). The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma. Molecular Medicine Reports, 15, 777-783. https://doi.org/10.3892/mmr.2016.6087
MLA
Ming, M., Li, C., Luo, Z., Lv, S., Sun, Q."The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma". Molecular Medicine Reports 15.2 (2017): 777-783.
Chicago
Ming, M., Li, C., Luo, Z., Lv, S., Sun, Q."The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma". Molecular Medicine Reports 15, no. 2 (2017): 777-783. https://doi.org/10.3892/mmr.2016.6087
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