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Immunomodulatory effects of Pseudostellaria heterophylla (Miquel) Pax on regulation of Th1/Th2 levels in mice with atopic dermatitis

  • Authors:
    • You Yeon Choi
    • Mi Hye Kim
    • Kwang Seok Ahn
    • Jae‑Young Um
    • Seok‑Geun Lee
    • Woong Mo Yang
  • View Affiliations / Copyright

    Affiliations: Department of Convergence Korean Medical Science, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea, Department of Korean Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea, Department of Korean Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea, Cancer Preventive Material Development Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea
    Copyright: © Choi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 649-656
    |
    Published online on: December 29, 2016
       https://doi.org/10.3892/mmr.2016.6093
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Abstract

Pseudostellaria heterophylla (PH) has various pharmacological effects that include immunologic enhancement and anti‑oxidation. However, it remains unclear whether PH exerts beneficial effects in dermatological diseases. The present study examined the effects of PH on a 2,4-dinitrochlorobenzene (DNCB)‑induced atopic dermatitis (AD) mouse model and elucidated its underlying mechanism of action. PH extract (1 and 100 mg/ml) was applied topically to DNCB-treated dorsal skin of mice every day for 11 days. The immunomodulatory effects of PH were evaluated by measuring skin thickness, mast cell infiltration, serum levels of immunoglobulin E (IgE), and mRNA expression levels of T helper (h)1/Th2 and pro‑inflammatory cytokines in dorsal skin. In addition, cluster of differentiation (CD)4+ T cells were detected in dorsal skin by immunohistochemistry. Topical application of PH significantly reduced the thickness of dermis, epidermis and serum IgE production compared with the DNCB group. PH treatment inhibited infiltration of inflammatory cells, including mast cells and CD4+ T cells, and suppressed the mRNA expression levels of cytokines (interferon‑γ, interleukin‑4, ‑6, ‑8 and ‑1β, and tumor necrosis factor‑α) associated with the immune response. Furthermore, PH treatment significantly downregulated the protein expression levels of nuclear factor‑κB, phosphorylated inhibitor of κBα and mitogen‑activated protein kinases. The results suggested that PH may be a potential therapeutic strategy for the treatment of AD via the modulation of Th1 and Th2 levels.
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1 

Levy ML: Atopic dermatitis: Understanding the disease and its management. Curr Med Res Opin. 23:3091–3103. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Minnicozzi M, Sawyer RT and Fenton MJ: Innate immunity in allergic disease. Immunol Rev. 242:106–127. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Mosmann TR and Coffman RL: Th1 and th2 cells: Different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol. 7:145–173. 1989. View Article : Google Scholar : PubMed/NCBI

4 

Leung DY, Boguniewicz M, Howell MD, Nomura I and Hamid QA: New insights into atopic dermatitis. J Clin Invest. 113:651–657. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Nakamura K: Pathogenesis and treatment of allergic skin disease-atopic dermatitis. Arerugi. 64:703–706. 2015.(In Japanese). PubMed/NCBI

6 

Liu J, Pei M, Zheng C, Li Y, Wang Y, Lu A and Yang L: A systems-pharmacology analysis of herbal medicines used in health improvement treatment: Predicting potential new drugs and targets. Evid Based Complement Alternat Med. 2013:9387642013. View Article : Google Scholar : PubMed/NCBI

7 

Ng TB, Liu F and Wang HX: The antioxidant effects of aqueous and organic extracts of panax quinquefolium, panax notoginseng, codonopsis pilosula, pseudostellaria heterophylla and glehnia littoralis. J Ethnopharmacol. 93:285–288. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Pang W, Lin S, Dai Q, Zhang H and Hu J: Antitussive activity of pseudostellaria heterophylla (miq.) pax extracts and improvement in lung function via adjustment of multi-cytokine levels. Molecules. 16:3360–3370. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Li X, Chen Y, Lai Y, Yang Q, Hu H and Wang Y: Sustainable utilization of traditional chinese medicine resources: Systematic evaluation on different production modes. Evid Based Complement Alternat Med. 2015:2189012015.PubMed/NCBI

10 

Li Y and Yang XW: Studies on chemical constituents of root tuber of cultivated pseudostellaria heterophylla (Zheshen No1). Zhongguo Zhong Yao Za Zhi. 33:2353–2355. 2008.(In Chinese). PubMed/NCBI

11 

Wong CK, Leung KN, Fung MC, Fung KP and Choy YM: The induction of cytokine gene expression in murine peritoneal macrophages by pseudostellaria heterophylla. Immunopharmacol Immunotoxicol. 16:347–357. 1994. View Article : Google Scholar : PubMed/NCBI

12 

Choi YY, Kim MH, Hong J, Kim K and Yang WM: Effect of Dangguibohyul-Tang, a mixed extract of astragalus membranaceus and angelica sinensis, on allergic and inflammatory skin reaction compared with single extracts of astragalus membranaceus or angelica sinensis. Evid Based Complement Alternat Med. 2016:59363542016. View Article : Google Scholar : PubMed/NCBI

13 

Shin HS, See HJ, Jung SY, Choi DW, Kwon DA, Bae MJ, Sung KS and Shon DH: Turmeric (curcuma longa) attenuates food allergy symptoms by regulating type 1/type 2 helper t cells (th1/th2) balance in a mouse model of food allergy. J Ethnopharmacol. 175:21–29. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Kang H, Lee CH, Kim JR, Kwon JY, Seo SG, Han JG, Kim BG, Kim JE and Lee KW: Chlorella vulgaris attenuates dermatophagoides farinae-induced atopic dermatitis-like symptoms in nc/nga mice. Int J Mol Sci. 16:21021–21034. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Park S, Kim da S, Kang S and Shin BK: Synergistic topical application of salt-processed phellodendron amurense and sanguisorba officinalis linne alleviates atopic dermatitis symptoms by reducing levels of immunoglobulin e and pro-inflammatory cytokines in nc/nga mice. Mol Med Rep. 12:7657–7664. 2015.PubMed/NCBI

16 

Vocanson M, Hennino A, Chavagnac C, Saint-Mezard P, Dubois B, Kaiserlian D and Nicolas JF: Contribution of cd4(+)and cd8(+) T-cells in contact hypersensitivity and allergic contact dermatitis. Expert Rev Clin Immunol. 1:75–86. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Zhang EY, Chen AY and Zhu BT: Mechanism of dinitrochlorobenzene-induced dermatitis in mice: Role of specific antibodies in pathogenesis. PLoS One. 4:e77032009. View Article : Google Scholar : PubMed/NCBI

18 

Lee HS, Kim SK, Han JB, Choi HM, Park JH, Kim EC, Choi MS, An HJ, Um JY, Kim HM and Min BI: Inhibitory effects of Rumex japonicus Houtt. On the development of atopic dermatitis-like skin lesions in Nc/Nga mice. Br J Dermatol. 155:33–38. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Chen L, Martinez O, Overbergh L, Mathieu C, Prabhakar BS and Chan LS: Early up-regulation of Th2 cytokines and late surge of Th1 cytokines in an atopic dermatitis model. Clin Exp Immunol. 138:375–387. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Lee HJ, Lee HP, Ha SJ, Byun DG and Kim JW: Spontaneous expression of mrna for iL-10, GM-CSF, TGF-beta, TGF-alpha, and IL-6 in peripheral blood mononuclear cells from atopic dermatitis. Ann Allergy Asthma Immunol. 84:553–558. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Szegedi K, Lutter R, Res PC, Bos JD, Luiten RM, Kezic S and Middelkamp-Hup MA: Cytokine profiles in interstitial fluid from chronic atopic dermatitis skin. J Eur Acad Dermatol Venereol. 29:2136–2144. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Li W, Zhao Y, Xu X, Ma W, Gao P, Wang Y, Liang K and Li R: Rebamipide suppresses TNF-α mediated inflammation in vitro and attenuates the severity of dermatitis in mice. FEBS J. 282:2317–2326. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Lee J, Choi YY, Kim MH, Han JM, Lee JE, Kim EH, Hong J, Kim J and Yang WM: Topical application of angelica sinensis improves pruritus and skin inflammation in mice with atopic dermatitis-like symptoms. J Med Food. 19:98–105. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Mishra S, Tripathi A, Chaudhari BP, Dwivedi PD, Pandey HP and Das M: Deoxynivalenol induced mouse skin cell proliferation and inflammation via MAPK pathway. Toxicol Appl Pharmacol. 279:186–197. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Choi YY, Kim MH, Ahn KS, Um JY, Lee SG and Yang WM: Immunomodulatory effects of Pseudostellaria heterophylla (Miquel) Pax on regulation of Th1/Th2 levels in mice with atopic dermatitis. Mol Med Rep 15: 649-656, 2017.
APA
Choi, Y.Y., Kim, M.H., Ahn, K.S., Um, J., Lee, S., & Yang, W.M. (2017). Immunomodulatory effects of Pseudostellaria heterophylla (Miquel) Pax on regulation of Th1/Th2 levels in mice with atopic dermatitis. Molecular Medicine Reports, 15, 649-656. https://doi.org/10.3892/mmr.2016.6093
MLA
Choi, Y. Y., Kim, M. H., Ahn, K. S., Um, J., Lee, S., Yang, W. M."Immunomodulatory effects of Pseudostellaria heterophylla (Miquel) Pax on regulation of Th1/Th2 levels in mice with atopic dermatitis". Molecular Medicine Reports 15.2 (2017): 649-656.
Chicago
Choi, Y. Y., Kim, M. H., Ahn, K. S., Um, J., Lee, S., Yang, W. M."Immunomodulatory effects of Pseudostellaria heterophylla (Miquel) Pax on regulation of Th1/Th2 levels in mice with atopic dermatitis". Molecular Medicine Reports 15, no. 2 (2017): 649-656. https://doi.org/10.3892/mmr.2016.6093
Copy and paste a formatted citation
x
Spandidos Publications style
Choi YY, Kim MH, Ahn KS, Um JY, Lee SG and Yang WM: Immunomodulatory effects of Pseudostellaria heterophylla (Miquel) Pax on regulation of Th1/Th2 levels in mice with atopic dermatitis. Mol Med Rep 15: 649-656, 2017.
APA
Choi, Y.Y., Kim, M.H., Ahn, K.S., Um, J., Lee, S., & Yang, W.M. (2017). Immunomodulatory effects of Pseudostellaria heterophylla (Miquel) Pax on regulation of Th1/Th2 levels in mice with atopic dermatitis. Molecular Medicine Reports, 15, 649-656. https://doi.org/10.3892/mmr.2016.6093
MLA
Choi, Y. Y., Kim, M. H., Ahn, K. S., Um, J., Lee, S., Yang, W. M."Immunomodulatory effects of Pseudostellaria heterophylla (Miquel) Pax on regulation of Th1/Th2 levels in mice with atopic dermatitis". Molecular Medicine Reports 15.2 (2017): 649-656.
Chicago
Choi, Y. Y., Kim, M. H., Ahn, K. S., Um, J., Lee, S., Yang, W. M."Immunomodulatory effects of Pseudostellaria heterophylla (Miquel) Pax on regulation of Th1/Th2 levels in mice with atopic dermatitis". Molecular Medicine Reports 15, no. 2 (2017): 649-656. https://doi.org/10.3892/mmr.2016.6093
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