Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
March-2017 Volume 15 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2017 Volume 15 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

TNF‑α regulates apoptosis of human vascular smooth muscle cells through gap junctions

  • Authors:
    • Mei Tang
    • Jun Fang
  • View Affiliations / Copyright

    Affiliations: Infusion Preparation Center of Pharmacy Department, Xianning Central Hospital & The First Clinical Hospital of Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China, Division of Nephrology, Department of Internal Medicine, Xianning Central Hospital & The First Clinical Hospital of Hubei University of Science and Technology, Xianning, Hubei 437100, P.R. China
  • Pages: 1407-1411
    |
    Published online on: January 5, 2017
       https://doi.org/10.3892/mmr.2017.6106
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Inflammatory cytokines are released by immune cells and are able to induce vascular smooth muscle cells (VSMCs) to undergo apoptosis, causing atherosclerotic plaque rupture. Changes in the expression levels of connexins (Cxs) have been demonstrated in VSMCs to be involved in the pathogenesis of atherosclerotic progression. The present study examined the effect of tumor necrosis factor‑α (TNF‑α) on Cx43 expression levels and apoptosis in human VSMCs. Overexpression of Cx43 plasmids notably stimulated VSMC proliferation. TNF‑α directly inhibited Cx43 expression levels in a dose‑ and time‑dependent manner in VSMCs, however this was blocked by c‑Jun N‑terminal kinase inhibitor. TNF‑α also increased caspase‑3 activity and apoptosis of VSMCs through the inhibition of Cx43. These data suggested that TNF‑α induced the apoptosis of VMSCs and prompted the destabilization of atherosclerotic plaques by downregulating Cx43.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Menegazzo L, Poncina N, Albiero M, Menegolo M, Grego F, Avogaro A and Fadini GP: Diabetes modifies the relationships among carotid plaque calcification, composition and inflammation. Atherosclerosis. 241:533–538. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Small TW and Pickering JG: Nuclear degradation of Wilms tumor 1-associating protein and survivin splice variant switching underlie IGF-1-mediated survival. J Biol Chem. 284:24684–24695. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Martinez-Hervás S, Vinué A, Núñez L, Andrés-Blasco I, Piqueras L, Real JT, Ascaso JF, Burks DJ, Sanz MJ and González-Navarro H: Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and increasing CX3CL1/CX3CR1 axis. Cardiovasc Res. 103:324–336. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Anwar A, Zahid AA, Scheidegger KJ, Brink M and Delafontaine P: Tumor necrosis factor-alpha regulates insulin-like growth factor-1 and insulin-like growth factor binding protein-3 expression in vascular smooth muscle. Circulation. 105:1220–1225. 2002. View Article : Google Scholar : PubMed/NCBI

5 

Pfenniger A, Chanson M and Kwak BR: Connexins in atherosclerosis. Biochim Biophys Acta. 1828:157–166. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Tran CH, Vigmond EJ, Goldman D, Plane F and Welsh DG: Electrical communication in branching arterial networks. Am J Physiol Heart Circ Physiol. 303:H680–H692. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Peng WJ, Liu Y, Yu YR, Fu YQ, Zhao Y, Kuang HB, Huang QR, He M and Luo D: Rutaecarpine prevented dysfunction of endothelial gap junction induced by Ox-LDL via activation of TRPV1. Eur J Pharmacol. 756:8–14. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Kwak BR, Mulhaupt F, Veillard N, Gros DB and Mach F: Altered pattern of vascular connexin expression in atherosclerotic plaques. Arterioscler Thromb Vasc Biol. 22:225–230. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Chanson M, Derouette JP, Roth I, Foglia B, Scerri I, Dudez T and Kwak BR: Gap junctional communication in tissue inflammation and repair. Biochim Biophys Acta. 1711:197–207. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Deglise S, Martin D, Probst H, Saucy F, Hayoz D, Waeber G, Nicod P, Ris HB, Corpataux JM and Haefliger JA: Increased connexin43 expression in human saphenous veins in culture is associated with intimal hyperplasia. J Vasc Surg. 41:1043–1052. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Mitra AK, Jia G, Gangahar DM and Agrawal DK: Temporal PTEN inactivation causes proliferation of saphenous vein smooth muscle cells of human CABG conduits. J Cell Mol Med. 13:177–187. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Kim J and Ko J: Human sLZIP promotes atherosclerosis via MMP-9 transcription and vascular smooth muscle cell migration. FASEB J. 28:5010–5021. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Zhuang J, Peng W, Li H, Lu Y, Wang K, Fan F, Li S and Xu Y: Inhibitory effects of vinpocetine on the progression of atherosclerosis are mediated by Akt/NF-κB dependent mechanisms in apoE-/− mice. PLoS One. 8:e825092013. View Article : Google Scholar : PubMed/NCBI

14 

McSpadden LC, Kirkton RD and Bursac N: Electrotonic loading of anisotropic cardiac monolayers by unexcitable cells depends on connexin type and expression level. Am J Physiol Cell Physiol. 297:C339–C351. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Zhang Y, Kanter EM and Yamada KA: Remodeling of cardiac fibroblasts following myocardial infarction results in increased gap junction intercellular communication. Cardiovasc Pathol. 19:e233–e240. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Oviedo-Orta E and Evans Howard W: Gap junctions and connexin-mediated communication in the immune system. Biochim Biophys Acta. 1662:102–112. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Chadjichristos CE, Matter CM, Roth I, Sutter E, Pelli G, Luscher TF, Chanson M and Kwak BR: Reduced connexin43 expression limits neointima formation after balloon distension injury in hypercholesterolemic mice. Circulation. 113:2835–2843. 2006. View Article : Google Scholar : PubMed/NCBI

18 

Chadjichristos CE, Morel S, Derouette JP, Sutter E, Roth I, Brisset AC, Bochaton-Piallat ML and Kwak BR: Targeting connexin 43 prevents platelet-derived growth factor-BB-induced phenotypic change in porcine coronary artery smooth muscle cells. Circ Res. 102:653–660. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Rotllan N, Wanschel AC, Fernández-Hernando A, Salerno AG, Offermanns S, Sessa WC and Fernández-Hernando C: Genetic evidence supports a major role for Akt1 in VSMCs during atherogenesis. Circ Res. 116:1744–1752. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Moran EP and Agrawal DK: Increased expression of inhibitor of apoptosis proteins in atherosclerotic plaques of symptomatic patients with carotid stenosis. Exp Mol Pathol. 83:11–16. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Gray K, Kumar S, Figg N, Harrison J, Baker L, Mercer J, Littlewood T and Bennett M: Effects of DNA damage in smooth muscle cells in atherosclerosis. Circ Res. 116:816–826. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Clarke MC, Figg N, Maguire JJ, Davenport AP, Goddard M, Littlewood TD and Bennett MR: Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis. Nat Med. 12:1075–1080. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Wu X, Huang W, Luo G and Alain LA: Hypoxia induces connexin 43 dysregulation by modulating matrix metalloproteinases via MAPK signaling. Mol Cell Biochem. 384:155–162. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Kimura K, Orita T, Morishige N, Nishida T and Sonoda KH: Role of the JNK signaling pathway in downregulation of connexin43 by TNF-α in human corneal fibroblasts. Curr Eye Res. 38:926–932. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Shyu KG, Wang BW, Yang YH, Tsai SC, Lin S and Lee CC: Amphetamine activates connexin43 gene expression in cultured neonatal rat cardiomyocytes through JNK and AP-1 pathway. Cardiovasc Res. 63:98–108. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Fernandez-Cobo M, Gingalewski C, Drujan D and De Maio A: Downregulation of connexin 43 gene expression in rat heart during inflammation. The role of tumour necrosis factor. Cytokine. 11:216–224. 1999. View Article : Google Scholar : PubMed/NCBI

27 

Saez PJ, Shoji KF, Aguirre A and Sáez JC: Regulation of hemichannels and gap junction channels by cytokines in antigen-presenting cells. Mediators Inflamm. 2014:7427342014. View Article : Google Scholar : PubMed/NCBI

28 

Huang S, Dudez T, Scerri I, Thomas MA, Giepmans BN, Suter S and Chanson M: Defective activation of c-Src in cystic fibrosis airway epithelial cells results in loss of tumor necrosis factor-alpha-induced gap junction regulation. J Biol Chem. 278:8326–8332. 2003. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Tang M and Fang J: TNF‑α regulates apoptosis of human vascular smooth muscle cells through gap junctions. Mol Med Rep 15: 1407-1411, 2017.
APA
Tang, M., & Fang, J. (2017). TNF‑α regulates apoptosis of human vascular smooth muscle cells through gap junctions. Molecular Medicine Reports, 15, 1407-1411. https://doi.org/10.3892/mmr.2017.6106
MLA
Tang, M., Fang, J."TNF‑α regulates apoptosis of human vascular smooth muscle cells through gap junctions". Molecular Medicine Reports 15.3 (2017): 1407-1411.
Chicago
Tang, M., Fang, J."TNF‑α regulates apoptosis of human vascular smooth muscle cells through gap junctions". Molecular Medicine Reports 15, no. 3 (2017): 1407-1411. https://doi.org/10.3892/mmr.2017.6106
Copy and paste a formatted citation
x
Spandidos Publications style
Tang M and Fang J: TNF‑α regulates apoptosis of human vascular smooth muscle cells through gap junctions. Mol Med Rep 15: 1407-1411, 2017.
APA
Tang, M., & Fang, J. (2017). TNF‑α regulates apoptosis of human vascular smooth muscle cells through gap junctions. Molecular Medicine Reports, 15, 1407-1411. https://doi.org/10.3892/mmr.2017.6106
MLA
Tang, M., Fang, J."TNF‑α regulates apoptosis of human vascular smooth muscle cells through gap junctions". Molecular Medicine Reports 15.3 (2017): 1407-1411.
Chicago
Tang, M., Fang, J."TNF‑α regulates apoptosis of human vascular smooth muscle cells through gap junctions". Molecular Medicine Reports 15, no. 3 (2017): 1407-1411. https://doi.org/10.3892/mmr.2017.6106
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team