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Article Open Access

IsomiR expression patterns in canonical and Dicer‑independent microRNAs

  • Authors:
    • Tingming Liang
    • Jiafeng Yu
    • Chang Liu
    • Li Guo
  • View Affiliations / Copyright

    Affiliations: Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Science, Nanjing Normal University, Nanjing, Jiangsu 210023, P.R. China, Shandong Provincial Key Laboratory of Functional Macromolecular Biophysics, Institute of Biophysics, Dezhou University, Dezhou, Shandong 253023, P.R. China, Department of Bioinformatics, School of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing, Jiangsu 210023, P.R. China
    Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1071-1078
    |
    Published online on: January 13, 2017
       https://doi.org/10.3892/mmr.2017.6117
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Abstract

Multiple microRNA (miRNA) variants, known as isomiRs, are extensively distributed in miRNA loci and predominantly derive from the alternative cleavage of Drosha/Dicer and 3'addition events. The present study aimed to investigate the expression patterns of multiple isomiRs in typical miRNA and Dicer‑independent miRNA loci by conducting evolutionary and expression analysis using public datasets. Although different miRNA maturation processes exist, multiple isomiRs can be detected by similar expression distributions. However, isomiR expression in Dicer‑independent miRNA loci tends to be at a moderate level, particularly for random distribution in the ends that are split by Dicer in the typical miRNA loci. Compared with the mature miRNA locus (dominant miRNA locus), the non‑dominant miRNA locus indicates an expression distribution similar to that of the Dicer‑independent miRNA locus. These results increase the understanding of multiple isomiRs in the progression of diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Liang T, Yu J, Liu C and Guo L: IsomiR expression patterns in canonical and Dicer‑independent microRNAs. Mol Med Rep 15: 1071-1078, 2017.
APA
Liang, T., Yu, J., Liu, C., & Guo, L. (2017). IsomiR expression patterns in canonical and Dicer‑independent microRNAs. Molecular Medicine Reports, 15, 1071-1078. https://doi.org/10.3892/mmr.2017.6117
MLA
Liang, T., Yu, J., Liu, C., Guo, L."IsomiR expression patterns in canonical and Dicer‑independent microRNAs". Molecular Medicine Reports 15.3 (2017): 1071-1078.
Chicago
Liang, T., Yu, J., Liu, C., Guo, L."IsomiR expression patterns in canonical and Dicer‑independent microRNAs". Molecular Medicine Reports 15, no. 3 (2017): 1071-1078. https://doi.org/10.3892/mmr.2017.6117
Copy and paste a formatted citation
x
Spandidos Publications style
Liang T, Yu J, Liu C and Guo L: IsomiR expression patterns in canonical and Dicer‑independent microRNAs. Mol Med Rep 15: 1071-1078, 2017.
APA
Liang, T., Yu, J., Liu, C., & Guo, L. (2017). IsomiR expression patterns in canonical and Dicer‑independent microRNAs. Molecular Medicine Reports, 15, 1071-1078. https://doi.org/10.3892/mmr.2017.6117
MLA
Liang, T., Yu, J., Liu, C., Guo, L."IsomiR expression patterns in canonical and Dicer‑independent microRNAs". Molecular Medicine Reports 15.3 (2017): 1071-1078.
Chicago
Liang, T., Yu, J., Liu, C., Guo, L."IsomiR expression patterns in canonical and Dicer‑independent microRNAs". Molecular Medicine Reports 15, no. 3 (2017): 1071-1078. https://doi.org/10.3892/mmr.2017.6117
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