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Article Open Access

MicroRNA-141 inhibits tumor growth and minimizes therapy resistance in colorectal cancer

  • Authors:
    • Jun Ye
    • Zhen Wang
    • Jing Zhao
    • Wuzhen Chen
    • Dang Wu
    • Pin Wu
    • Jian Huang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang), Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Thoracic Surgury, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China, Department of Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China
    Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1037-1042
    |
    Published online on: January 23, 2017
       https://doi.org/10.3892/mmr.2017.6135
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Abstract

Colorectal cancer (CRC) is one of most common cancers and causes of cancer-associated mortality worldwide, due to its recurrence, metastasis and therapy resistance. Cancer stem cells (CSC) have been demonstrated to be vital for tumor initiation and recurrence. microRNAs may act as an oncogenes or tumor suppressors in numerous cancers. The present study demonstrated that microRNA-141 (miR‑141) was downregulated in CSC compared with differentiated cancer cells, and in tumor compared with healthy tissue. miR‑141 may inhibit CRC cell proliferation and the maintenance of CSC stemness, thereby enhancing drug susceptibility. In addition, the present study identified cyclin D2 as a novel target gene of miR‑141. In conclusion, the antitumor role of miR‑141 and its target cyclin D2 may suggest the development of miR‑141 as a potential therapeutic agent.
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Copy and paste a formatted citation
Spandidos Publications style
Ye J, Wang Z, Zhao J, Chen W, Wu D, Wu P and Huang J: MicroRNA-141 inhibits tumor growth and minimizes therapy resistance in colorectal cancer. Mol Med Rep 15: 1037-1042, 2017.
APA
Ye, J., Wang, Z., Zhao, J., Chen, W., Wu, D., Wu, P., & Huang, J. (2017). MicroRNA-141 inhibits tumor growth and minimizes therapy resistance in colorectal cancer. Molecular Medicine Reports, 15, 1037-1042. https://doi.org/10.3892/mmr.2017.6135
MLA
Ye, J., Wang, Z., Zhao, J., Chen, W., Wu, D., Wu, P., Huang, J."MicroRNA-141 inhibits tumor growth and minimizes therapy resistance in colorectal cancer". Molecular Medicine Reports 15.3 (2017): 1037-1042.
Chicago
Ye, J., Wang, Z., Zhao, J., Chen, W., Wu, D., Wu, P., Huang, J."MicroRNA-141 inhibits tumor growth and minimizes therapy resistance in colorectal cancer". Molecular Medicine Reports 15, no. 3 (2017): 1037-1042. https://doi.org/10.3892/mmr.2017.6135
Copy and paste a formatted citation
x
Spandidos Publications style
Ye J, Wang Z, Zhao J, Chen W, Wu D, Wu P and Huang J: MicroRNA-141 inhibits tumor growth and minimizes therapy resistance in colorectal cancer. Mol Med Rep 15: 1037-1042, 2017.
APA
Ye, J., Wang, Z., Zhao, J., Chen, W., Wu, D., Wu, P., & Huang, J. (2017). MicroRNA-141 inhibits tumor growth and minimizes therapy resistance in colorectal cancer. Molecular Medicine Reports, 15, 1037-1042. https://doi.org/10.3892/mmr.2017.6135
MLA
Ye, J., Wang, Z., Zhao, J., Chen, W., Wu, D., Wu, P., Huang, J."MicroRNA-141 inhibits tumor growth and minimizes therapy resistance in colorectal cancer". Molecular Medicine Reports 15.3 (2017): 1037-1042.
Chicago
Ye, J., Wang, Z., Zhao, J., Chen, W., Wu, D., Wu, P., Huang, J."MicroRNA-141 inhibits tumor growth and minimizes therapy resistance in colorectal cancer". Molecular Medicine Reports 15, no. 3 (2017): 1037-1042. https://doi.org/10.3892/mmr.2017.6135
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