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Article

Lnc‑IL7R promotes the growth of fibroblast‑like synoviocytes through interaction with enhancer of zeste homolog 2 in rheumatoid arthritis

  • Authors:
    • Zhao Ye
    • Juan Xu
    • Shukui Li
    • Cheng Cai
    • Tiejun Li
    • Lishan Sun
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China, Department of Ultrasound, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China, Department of Teaching, Cangzhou Central Hospital, Cangzhou, Hebei 061000, P.R. China
  • Pages: 1412-1418
    |
    Published online on: January 26, 2017
       https://doi.org/10.3892/mmr.2017.6150
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Abstract

Rheumatoid arthritis (RA) is an inflammatory and autoimmune disease that affects ~1% of the world's population. Although the precise mechanism of RA has yet to be elucidated, accumulating evidence suggests that fibroblast‑like synoviocytes (FLSs) serve critical roles in the initiation and progression of RA. However, the underlying molecular mechanisms of FLS proliferation have yet to be elucidated. Long noncoding‑interleukin‑7 receptor (lnc‑IL7R) has been recently identified, which is activated by lipopolysaccharide (LPS) stimulation and diminishes the LPS‑induced inflammatory response. In the present study, gain‑ and loss‑of‑function assays were performed in order to investigate the role of lnc‑IL7R in FLS. It is demonstrated, to the best of the authors' knowledge for the first time, that lnc‑IL7R promotes cell proliferation, cell cycle progression and inhibits apoptosis in FLS. Further investigation identified that lnc‑IL7 interacts with enhancer of zeste homolog 2 (EZH2) and is required for polycomb repressive complex 2 (PRC2)‑mediated suppression, including cyclin‑dependent kinase inhibitor 1A and cyclin‑dependent kinase inhibitor 2A. Lnc‑IL7R may be a promising therapeutic target for the treatment of RA.
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1 

Gibofsky A: Epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis: A Synopsis. Am J Manag Care. 20:S128–S135. 2014.PubMed/NCBI

2 

Huber LC, Distler O, Tarner I, Gay RE, Gay S and Pap T: Synovial fibroblasts: Key players in rheumatoid arthritis. Rheumatology (Oxford). 45:669–675. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Yang CL, Or TC, Ho MH and Lau AS: Scientific basis of botanical medicine as alternative remedies for rheumatoid arthritis. Clin Rev Allergy Immunol. 44:284–300. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Mor A, Abramson SB and Pillinger MH: The fibroblast-like synovial cell in rheumatoid arthritis: A key player in inflammation and joint destruction. Clin Immunol. 115:118–128. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Bottini N and Firestein GS: Duality of fibroblast-like synoviocytes in RA: Passive responders and imprinted aggressors. Nat Rev Rheumatol. 9:24–33. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Bartok B and Firestein GS: Fibroblast-like synoviocytes: Key effector cells in rheumatoid arthritis. Immunol Rev. 233:233–255. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Smith MD and Walker JG: Apoptosis a relevant therapeutic target in rheumatoid arthritis? Rheumatology (Oxford). 43:405–407. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Bai S, Liu H, Chen KH, Eksarko P, Perlman H, Moore TL and Pope RM: NF-kappaB-regulated expression of cellular FLIP protects rheumatoid arthritis synovial fibroblasts from tumor necrosis factor alpha-mediated apoptosis. Arthritis Rheum. 50:3844–3855. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Wilusz JE, Sunwoo H and Spector DL: Long noncoding RNAs: Functional surprises from the RNA world. Genes Dev. 23:1494–1504. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Liu G, Mattick JS and Taft RJ: A meta-analysis of the genomic and transcriptomic composition of complex life. Cell Cycle. 12:2061–2072. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Huang JL, Zheng L, Hu YW and Wang Q: Characteristics of long non-coding RNA and its relation to hepatocellular carcinoma. Carcinogenesis. 35:507–514. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Lam MT, Li W, Rosenfeld MG and Glass CK: Enhancer RNAs and regulated transcriptional programs. Trends Biochem Sci. 39:170–182. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Li Y, Chen H, Pan T, Jiang C, Zhao Z, Wang Z, Zhang J, Xu J and Li X: LncRNA ontology: Inferring lncRNA functions based on chromatin states and expression patterns. Oncotarget. 24:39793–39805. 2015.

14 

Keenan CR, Schuliga MJ and Stewart AG: Pro-inflammatory mediators increase levels of the noncoding RNA GAS5 in airway smooth muscle and epithelial cells. Can J Physiol Pharmacol. 93:203–206. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Cheng HS, Njock MS, Khyzha N, Dang LT and Fish JE: Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation. Front Genet. 5:4222014. View Article : Google Scholar : PubMed/NCBI

16 

Jiang H, Modise T, Helm R, Jensen RV and Good DJ: Characterization of the hypothalamic transcriptome in response to food deprivation reveals global changes in long noncoding RNA and cell cycle response genes. Genes Nutr. 10:482015. View Article : Google Scholar : PubMed/NCBI

17 

Xiao H, Tang K, Liu P, Chen K, Hu J, Zeng J, Xiao W, Yu G, Yao W, Zhou H, et al: LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma. Oncotarget. 6:38005–38015. 2015.PubMed/NCBI

18 

Spurlock CF III, Tossberg JT, Matlock BK, Olsen NJ and Aune TM: Methotrexate inhibits NF-κB activity via long intergenic (noncoding) RNA-p21 induction. Arthritis Rheumatol. 66:2947–2957. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Cui H, Xie N, Tan Z, Banerjee S, Thannickal VJ, Abraham E and Liu G: The human long noncoding RNA lnc-IL7R regulates the inflammatory response. Eur J Immunol. 44:2085–2095. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Messemaker TC, Frank-Bertoncelj M, Marques RB, Adriaans A, Bakker AM, Daha N, Gay S, Huizinga TW, Toes RE, Mikkers HM and Kurreeman F: A novel long non-coding RNA in the rheumatoid arthritis risk locus TRAF1-C5 influences C5 mRNA levels. Genes Immun. 17:85–92. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Sun J, Yan P, Chen Y, Chen Y, Yang J, Xu G, Mao H and Qiu Y: MicroRNA-26b inhibits cell proliferation and cytokine secretion in human RASF cells via the Wnt/GSK-3β/β-catenin pathway. Diagn Pathol. 10:722015. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Braconi C, Valeri N, Kogure T, Gasparini P, Huang N, Nuovo GJ, Terracciano L, Croce CM and Patel T: Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma. Proc Natl Acad Sci USA. 108:786–791. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Cao C, Sun J, Zhang D, Guo X, Xie L, Li X, Wu D and Liu L: The long intergenic noncoding RNA UFC1, a target of MicroRNA 34a, interacts with the mRNA stabilizing protein HuR to increase levels of β-catenin in HCC cells. Gastroenterology. 148:415–426, e18. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Khalil AM, Guttman M, Huarte M, Garber M, Raj A, Morales Rivea D, Thomas K, Presser A, Bernstein BE, van Oudenaarden A, et al: Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci USA. 106:11667–11672. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Sweeney SE and Firestein GS: Rheumatoid arthritis: Regulation of synovial inflammation. Int J Biochem Cell Biol. 36:372–378. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Umar S, Hedaya O, Singh AK and Ahmed S: Thymoquinone inhibits TNF-α-induced inflammation and cell adhesion in rheumatoid arthritis synovial fibroblasts by ASK1 regulation. Toxicol Appl Pharmacol. 287:299–305. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Wang H, Fang Y, Wang Y, Wang Z, Zou Q, Shi Y, Chen J and Peng D: Inhibitory effect of curcumol on Jak2-STAT signal pathway molecules of fibroblast-like synoviocytes in patients with rheumatoid arthritis. Evid Based Complement Alternat Med. 2012:7464262012.PubMed/NCBI

29 

Carrion M, Juarranz Y, Martínez C, González-Álvaro I, Pablos JL, Gutiérrez-Cañas I and Gomariz RP: IL-22/IL-22R1 axis and S100A8/A9 alarmins in human osteoarthritic and rheumatoid arthritis synovial fibroblasts. Rheumatology (Oxford). 52:2177–2186. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Miao CG, Yang YY, He X, Huang C, Huang Y, Qin D, Du CL and Li J: MicroRNA-152 modulates the canonical Wnt pathway activation by targeting DNA methyltransferase 1 in arthritic rat model. Biochimie. 106:149–156. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Picascia A, Grimaldi V, Pignalosa O, De Pascale MR, Schiano C and Napoli C: Epigenetic control of autoimmune diseases: From bench to bedside. Clin Immunol. 157:1–15. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Gonzalez S, Aguilera S, Urzúa U, Quest AF, Molina C, Alliende C, Hermoso M and González MJ: Mechanotransduction and epigenetic control in autoimmune diseases. Autoimmun Rev. 10:175–179. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Karouzakis E, Rengel Y, Jüngel A, Kolling C, Gay RE, Michel BA, Tak PP, Gay S, Neidhart M and Ospelt C: DNA methylation regulates the expression of CXCL12 in rheumatoid arthritis synovial fibroblasts. Genes Immun. 12:643–652. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Lin SY, Hsieh SC, Lin YC, Lee CN, Tsai MH, Lai LC, Chuang EY, Chen PC, Hung CC, Chen LY, et al: A whole genome methylation analysis of systemic lupus erythematosus: Hypomethylation of the IL10 and IL1R2 promoters is associated with disease activity. Genes Immun. 13:214–220. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Wilkinson J: Study reveals a DNA methylome signature in rheumatoid arthritis. Epigenomics. 4:4812012.PubMed/NCBI

36 

Nakano K, Whitaker JW, Boyle DL, Wang W and Firestein GS: DNA methylome signature in rheumatoid arthritis. Ann Rheum Dis. 72:110–117. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Viatte S, Plant D and Raychaudhuri S: Genetics and epigenetics of rheumatoid arthritis. Nat Rev Rheumatol. 9:141–153. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Huber LC, Brock M, Hemmatazad H, Giger OT, Moritz F, Trenkmann M, Distler JH, Gay RE, Kolling C, Moch H, et al: Histone deacetylase/acetylase activity in total synovial tissue derived from rheumatoid arthritis and osteoarthritis patients. Arthritis Rheum. 56:1087–1093. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Trenkmann M, Brock M, Gay RE, Kolling C, Speich R, Michel BA, Gay S and Huber LC: Expression and function of EZH2 in synovial fibroblasts: Epigenetic repression of the Wnt inhibitor SFRP1 in rheumatoid arthritis. Ann Rheum Dis. 70:1482–1488. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Yang F, Zhang L, Huo XS, Yuan JH, Xu D, Yuan SX, Zhu N, Zhou WP, Yang GS, Wang YZ, et al: Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans. Hepatology. 54:1679–1689. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, Tanaka F, Shibata K, Suzuki A, Komune S, et al: Long noncoding RNA HOTAIR regulates polycomb-dependent chromatin modification and is associated with poor prognosis in colorectal cancers. Cancer Res. 71:6320–6326. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ye Z, Xu J, Li S, Cai C, Li T and Sun L: Lnc‑IL7R promotes the growth of fibroblast‑like synoviocytes through interaction with enhancer of zeste homolog 2 in rheumatoid arthritis. Mol Med Rep 15: 1412-1418, 2017.
APA
Ye, Z., Xu, J., Li, S., Cai, C., Li, T., & Sun, L. (2017). Lnc‑IL7R promotes the growth of fibroblast‑like synoviocytes through interaction with enhancer of zeste homolog 2 in rheumatoid arthritis. Molecular Medicine Reports, 15, 1412-1418. https://doi.org/10.3892/mmr.2017.6150
MLA
Ye, Z., Xu, J., Li, S., Cai, C., Li, T., Sun, L."Lnc‑IL7R promotes the growth of fibroblast‑like synoviocytes through interaction with enhancer of zeste homolog 2 in rheumatoid arthritis". Molecular Medicine Reports 15.3 (2017): 1412-1418.
Chicago
Ye, Z., Xu, J., Li, S., Cai, C., Li, T., Sun, L."Lnc‑IL7R promotes the growth of fibroblast‑like synoviocytes through interaction with enhancer of zeste homolog 2 in rheumatoid arthritis". Molecular Medicine Reports 15, no. 3 (2017): 1412-1418. https://doi.org/10.3892/mmr.2017.6150
Copy and paste a formatted citation
x
Spandidos Publications style
Ye Z, Xu J, Li S, Cai C, Li T and Sun L: Lnc‑IL7R promotes the growth of fibroblast‑like synoviocytes through interaction with enhancer of zeste homolog 2 in rheumatoid arthritis. Mol Med Rep 15: 1412-1418, 2017.
APA
Ye, Z., Xu, J., Li, S., Cai, C., Li, T., & Sun, L. (2017). Lnc‑IL7R promotes the growth of fibroblast‑like synoviocytes through interaction with enhancer of zeste homolog 2 in rheumatoid arthritis. Molecular Medicine Reports, 15, 1412-1418. https://doi.org/10.3892/mmr.2017.6150
MLA
Ye, Z., Xu, J., Li, S., Cai, C., Li, T., Sun, L."Lnc‑IL7R promotes the growth of fibroblast‑like synoviocytes through interaction with enhancer of zeste homolog 2 in rheumatoid arthritis". Molecular Medicine Reports 15.3 (2017): 1412-1418.
Chicago
Ye, Z., Xu, J., Li, S., Cai, C., Li, T., Sun, L."Lnc‑IL7R promotes the growth of fibroblast‑like synoviocytes through interaction with enhancer of zeste homolog 2 in rheumatoid arthritis". Molecular Medicine Reports 15, no. 3 (2017): 1412-1418. https://doi.org/10.3892/mmr.2017.6150
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