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Article

Periostin is essential for periodontal ligament remodeling during orthodontic treatment

  • Authors:
    • Hui‑Yong Xu
    • Er‑Min Nie
    • Gang Deng
    • Ling‑Zhi Lai
    • Feng‑Yang Sun
    • Hua Tian
    • Fu‑Chun Fang
    • Ya‑Guang Zou
    • Bu‑Ling Wu
    • Jun Ou‑Yang
  • View Affiliations / Copyright

    Affiliations: Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Stomatology, The First Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China, Department of Stomatology, The People's Hospital of Jiaozuo, Jiaozuo, Henan 454002, P.R. China, Guangdong Provincial Medical Biomechanical Key Laboratory, Department of Anatomy, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
  • Pages: 1800-1806
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    Published online on: February 13, 2017
       https://doi.org/10.3892/mmr.2017.6200
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Abstract

Orthodontic tooth movement is a process stimulated and maintained by external tensile stress; periodontal ligament remodeling serves an important role during this process. However, the function and underlying mechanism of periostin (PN) during orthodontic periodontal ligament remodeling remain unclear. The present study established in vitro and in vivo models of orthodontic treatment to investigate the expression levels of PN under conditions of external tensile stress load. These results indicated that tensile stress load increased the expression levels of PN in mouse peridontal ligaments and human periodontal ligament cells (hPDLCs), during orthodontic tooth movement. Furthermore, the present study demonstrated that the expression levels of PN were regulated by transforming grown factor β, and that PN promotes type I collagen and α‑smooth muscle actin expression levels in hPDLCs. Therefore, PN may be essential for periodontal ligament remodeling during orthodontic treatment, and therefore may represent a potential therapeutic target.
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Copy and paste a formatted citation
Spandidos Publications style
Xu HY, Nie EM, Deng G, Lai LZ, Sun FY, Tian H, Fang FC, Zou YG, Wu BL, Ou‑Yang J, Ou‑Yang J, et al: Periostin is essential for periodontal ligament remodeling during orthodontic treatment. Mol Med Rep 15: 1800-1806, 2017.
APA
Xu, H., Nie, E., Deng, G., Lai, L., Sun, F., Tian, H. ... Ou‑Yang, J. (2017). Periostin is essential for periodontal ligament remodeling during orthodontic treatment. Molecular Medicine Reports, 15, 1800-1806. https://doi.org/10.3892/mmr.2017.6200
MLA
Xu, H., Nie, E., Deng, G., Lai, L., Sun, F., Tian, H., Fang, F., Zou, Y., Wu, B., Ou‑Yang, J."Periostin is essential for periodontal ligament remodeling during orthodontic treatment". Molecular Medicine Reports 15.4 (2017): 1800-1806.
Chicago
Xu, H., Nie, E., Deng, G., Lai, L., Sun, F., Tian, H., Fang, F., Zou, Y., Wu, B., Ou‑Yang, J."Periostin is essential for periodontal ligament remodeling during orthodontic treatment". Molecular Medicine Reports 15, no. 4 (2017): 1800-1806. https://doi.org/10.3892/mmr.2017.6200
Copy and paste a formatted citation
x
Spandidos Publications style
Xu HY, Nie EM, Deng G, Lai LZ, Sun FY, Tian H, Fang FC, Zou YG, Wu BL, Ou‑Yang J, Ou‑Yang J, et al: Periostin is essential for periodontal ligament remodeling during orthodontic treatment. Mol Med Rep 15: 1800-1806, 2017.
APA
Xu, H., Nie, E., Deng, G., Lai, L., Sun, F., Tian, H. ... Ou‑Yang, J. (2017). Periostin is essential for periodontal ligament remodeling during orthodontic treatment. Molecular Medicine Reports, 15, 1800-1806. https://doi.org/10.3892/mmr.2017.6200
MLA
Xu, H., Nie, E., Deng, G., Lai, L., Sun, F., Tian, H., Fang, F., Zou, Y., Wu, B., Ou‑Yang, J."Periostin is essential for periodontal ligament remodeling during orthodontic treatment". Molecular Medicine Reports 15.4 (2017): 1800-1806.
Chicago
Xu, H., Nie, E., Deng, G., Lai, L., Sun, F., Tian, H., Fang, F., Zou, Y., Wu, B., Ou‑Yang, J."Periostin is essential for periodontal ligament remodeling during orthodontic treatment". Molecular Medicine Reports 15, no. 4 (2017): 1800-1806. https://doi.org/10.3892/mmr.2017.6200
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