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Article

Protection against Staphylococcus aureus and tetanus infections by a combined vaccine containing SasA and TeNT‑Hc in mice

  • Authors:
    • Yilong Yang
    • Rui Yu
    • Xiuxu Yang
    • Shuling Liu
    • Ting Fang
    • Xiaohong Song
    • Lihua Hou
    • Changming Yu
    • Junjie Xu
    • Ling Fu
    • Shaoqiong Yi
    • Wei Chen
  • View Affiliations / Copyright

    Affiliations: Laboratory of Vaccine and Antibody Engineering, Beijing Institute of Biotechnology, Fengtai, Beijing 100071, P.R. China
  • Pages: 2369-2373
    |
    Published online on: February 21, 2017
       https://doi.org/10.3892/mmr.2017.6227
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Abstract

In developing countries, trauma patients and neonates are vulnerable to Staphylococcus aureus (S. aureus) and Clostridium tetani infections. It has been suggested that a combined vaccine against the two infections may be a reliable and cost‑effective strategy. Previous studies have indicated that the S. aureus surface protein A (SasA) and the C fragment of tetanus neurotoxin (TeNT‑Hc) may be suitable candidates for a vaccine against S. aureus and tetanus infections, respectively. In the present study, mice were immunized with a combined vaccine containing SasA and TeNT‑Hc, which induced a robust immune response to both antigens, and mutual interference between SasA and TeNT‑Hc was not observed. In the S.aureus challenge model, the combined vaccine fully protected BALB/c mice against lethal intraperitoneal challenges with 3x109 colony‑forming units of a methicillin‑resistant S. aureus USA300 strain. In the TeNT challenge model, the combined vaccine conferred complete protection against a lethal dose of (2x103) xLD50 tetanus toxin. These results implied that SasA and TeNT‑Hc promising components for a combined vaccine against S. aureus and tetanus infections.
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Copy and paste a formatted citation
Spandidos Publications style
Yang Y, Yu R, Yang X, Liu S, Fang T, Song X, Hou L, Yu C, Xu J, Fu L, Fu L, et al: Protection against Staphylococcus aureus and tetanus infections by a combined vaccine containing SasA and TeNT‑Hc in mice. Mol Med Rep 15: 2369-2373, 2017.
APA
Yang, Y., Yu, R., Yang, X., Liu, S., Fang, T., Song, X. ... Chen, W. (2017). Protection against Staphylococcus aureus and tetanus infections by a combined vaccine containing SasA and TeNT‑Hc in mice. Molecular Medicine Reports, 15, 2369-2373. https://doi.org/10.3892/mmr.2017.6227
MLA
Yang, Y., Yu, R., Yang, X., Liu, S., Fang, T., Song, X., Hou, L., Yu, C., Xu, J., Fu, L., Yi, S., Chen, W."Protection against Staphylococcus aureus and tetanus infections by a combined vaccine containing SasA and TeNT‑Hc in mice". Molecular Medicine Reports 15.4 (2017): 2369-2373.
Chicago
Yang, Y., Yu, R., Yang, X., Liu, S., Fang, T., Song, X., Hou, L., Yu, C., Xu, J., Fu, L., Yi, S., Chen, W."Protection against Staphylococcus aureus and tetanus infections by a combined vaccine containing SasA and TeNT‑Hc in mice". Molecular Medicine Reports 15, no. 4 (2017): 2369-2373. https://doi.org/10.3892/mmr.2017.6227
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y, Yu R, Yang X, Liu S, Fang T, Song X, Hou L, Yu C, Xu J, Fu L, Fu L, et al: Protection against Staphylococcus aureus and tetanus infections by a combined vaccine containing SasA and TeNT‑Hc in mice. Mol Med Rep 15: 2369-2373, 2017.
APA
Yang, Y., Yu, R., Yang, X., Liu, S., Fang, T., Song, X. ... Chen, W. (2017). Protection against Staphylococcus aureus and tetanus infections by a combined vaccine containing SasA and TeNT‑Hc in mice. Molecular Medicine Reports, 15, 2369-2373. https://doi.org/10.3892/mmr.2017.6227
MLA
Yang, Y., Yu, R., Yang, X., Liu, S., Fang, T., Song, X., Hou, L., Yu, C., Xu, J., Fu, L., Yi, S., Chen, W."Protection against Staphylococcus aureus and tetanus infections by a combined vaccine containing SasA and TeNT‑Hc in mice". Molecular Medicine Reports 15.4 (2017): 2369-2373.
Chicago
Yang, Y., Yu, R., Yang, X., Liu, S., Fang, T., Song, X., Hou, L., Yu, C., Xu, J., Fu, L., Yi, S., Chen, W."Protection against Staphylococcus aureus and tetanus infections by a combined vaccine containing SasA and TeNT‑Hc in mice". Molecular Medicine Reports 15, no. 4 (2017): 2369-2373. https://doi.org/10.3892/mmr.2017.6227
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