Open Access

Role of HLA-B27 in the pathogenesis of ankylosing spondylitis (Review)

  • Authors:
    • Bin Chen
    • Jia Li
    • Chongru He
    • Dahe Li
    • Wenwen Tong
    • Yuming Zou
    • Weidong Xu
  • View Affiliations

  • Published online on: February 24, 2017     https://doi.org/10.3892/mmr.2017.6248
  • Pages: 1943-1951
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The study of ankylosing spondylitis (AS) has made significant progress over the last decade. Genome-wide association studies have identified and further substantiated the role of susceptibility genes outside the major histocompatibility complex locus. However, human leukocyte antigen (HLA)‑B27 has been suggested to be important in the pathogenesis of AS, contributing to ~20.1% of AS heritability. The current review will present the classical and non‑classical forms of HLA-B27, as well as their pathogenic roles, and further discuss the hypotheses regarding the potential pathogenesis of AS. In addition, the association between the pathogenic role of HLA‑B27 and inflammatory indexes, including the interleukin-23/‑17 axis will be investigated to provide novel insights into the pathogenesis of AS. The aim of the present review is to provide an update of the current research into the pathogenesis of AS, and provide a comprehensive description of the pathogenic role of HLA-B27 in AS.
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April-2017
Volume 15 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Chen B, Li J, He C, Li D, Tong W, Zou Y and Xu W: Role of HLA-B27 in the pathogenesis of ankylosing spondylitis (Review). Mol Med Rep 15: 1943-1951, 2017
APA
Chen, B., Li, J., He, C., Li, D., Tong, W., Zou, Y., & Xu, W. (2017). Role of HLA-B27 in the pathogenesis of ankylosing spondylitis (Review). Molecular Medicine Reports, 15, 1943-1951. https://doi.org/10.3892/mmr.2017.6248
MLA
Chen, B., Li, J., He, C., Li, D., Tong, W., Zou, Y., Xu, W."Role of HLA-B27 in the pathogenesis of ankylosing spondylitis (Review)". Molecular Medicine Reports 15.4 (2017): 1943-1951.
Chicago
Chen, B., Li, J., He, C., Li, D., Tong, W., Zou, Y., Xu, W."Role of HLA-B27 in the pathogenesis of ankylosing spondylitis (Review)". Molecular Medicine Reports 15, no. 4 (2017): 1943-1951. https://doi.org/10.3892/mmr.2017.6248