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Article

Deep sea water improves hypercholesterolemia and hepatic lipid accumulation through the regulation of hepatic lipid metabolic gene expression

  • Authors:
    • Kyu‑Shik Lee
    • So‑Young Chun
    • Yun‑Suk Kwon
    • Soyoung Kim
    • Kyung‑Soo Nam
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology and Intractable Disease Research Center, School of Medicine, Dongguk University, Gyeongju, Gyeongsangbuk‑do 38066, Republic of Korea
  • Pages: 2814-2822
    |
    Published online on: March 13, 2017
       https://doi.org/10.3892/mmr.2017.6317
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Abstract

A high‑fat diet or high‑cholesterol diet (HCD) is a major cause of metabolic diseases, including obesity and diabetes; vascular diseases, including hypertension, stroke and arteriosclerosis; and liver diseases, including hepatic steatosis and cirrhosis. The present study aimed to evaluate the effects of deep sea water (DSW) on rats fed a HCD. DSW decreased HCD‑induced increases in total cholesterol and low‑density lipoprotein (LDL) cholesterol in the blood, and recovered high‑density lipoprotein cholesterol. In addition, DSW decreased levels of liver injury markers, which were increased in response to HCD, including glutamate‑oxaloacetate transaminase, glutamate‑pyruvate transferase and alkaline phosphatase. Lower lipid droplet levels were observed in the livers of rats fed a HCD and treated with DSW at a hardness of 1,500, as compared with those in the HCD only group. Semi‑quantitative reverse transcription‑polymerase chain reaction (RT‑PCR) revealed that mRNA expression levels of fatty acid synthase and sterol regulatory element binding protein‑1c (SREBP‑1c) in rats fed a HCD with DSW were lower compared with the HCD only group. Furthermore, quantitative RT‑PCR revealed that DSW enhanced LDL receptor (LDLR) mRNA expression in a hardness‑dependent manner. Combined, the results of the present study indicated that DSW may reduce HCD‑induced increases in blood and liver lipid levels, indicating that DSW may protect against hypercholesterolemia and non‑alcoholic hepatic steatosis. In addition, the present study demonstrated that DSW‑induced downregulation of lipids in the blood and hepatic lipid accumulation was mediated by enhancement of LDLR expression and suppression of fatty acid synthase and SREBP‑1c.
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View References

1 

Ma Y, Wang W, Zhang J, Lu Y, Wu W, Yan H and Wang Y: Hyperlipidemia and atherosclerotic lesion development in Ldlr-deficient mice on a long-term high-fat diet. PLoS One. 7:e358352012. View Article : Google Scholar : PubMed/NCBI

2 

Zhang X, Wu C, Wu H, Sheng L, Su Y, Zhang X, Luan H, Sun G, Sun X, Tian Y, et al: Anti-hyperlipidemic effects and potential mechanisms of action of the caffeoylquinic acid-rich Pandanus tectorius fruit extract in hamsters fed a high fat-diet. PLoS One. 8:e619222013. View Article : Google Scholar : PubMed/NCBI

3 

Daniels SR: Management of hyperlipidemia in pediatrics. Curr Opin Cardiol. 27:92–97. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Cholesterol Treatment Trialists' (CTT) Collaboration. Baigent C, Blackwell L, Emberson J, Holland LE, Reith C, Bhala N, Peto R, Barnes EH, Keech A, et al: Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet. 376:1670–1681. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Berry JD, Dyer A, Cai X, Garside DB, Ning H, Thomas A, Greenland P, Van Horn L, Tracy RP and Lloyd-Jones DM: Lifetime risks of cardiovascular disease. N Engl J Med. 366:321–329. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Harchaoui KE, Visser ME, Kastelein JJ, Stroes ES and Dallinga-Thie GM: Triglycerides and cardiovascular risk. Curr Cardiol Rev. 5:216–222. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Yang ZH, Miyahara H, Takeo J, Hatanaka A and Katayama M: Pollock oil supplementation modulates hyperlipidemia and ameliorates hepatic steatosis in mice fed a high-fat diet. Lipids Health Dis. 10:1892011. View Article : Google Scholar : PubMed/NCBI

8 

Yao Z, Liu XC and Gu YE: Schisandra chinensis Baill, a Chinese medicinal herb, alleviates high-fat-diet-inducing non-alcoholic steatohepatitis in rats. Afr J Tradit Complement Altern Med. 11:222–227. 2013.PubMed/NCBI

9 

Carrier B, Wen S, Zigouras S, Browne RW, Li Z, Patel MS, Williamson DL and Rideout TC: Alpha-lipoic acid reduces LDL-particle number and PCSK9 concentrations in high-fat fed obese Zucker rats. PLoS One. 9:e908632014. View Article : Google Scholar : PubMed/NCBI

10 

Singh AB, Kan CF, Shende V, Dong B and Liu J: A novel posttranscriptional mechanism for dietary cholesterol-mediated suppression of liver LDL receptor expression. J Lipid Res. 55:1397–1407. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Kim H, Bartley GE, Arvik T, Lipson R, Nah SY, Seo K and Yokoyama W: Dietary supplementation of chardonnay grape seed flour reduces plasma cholesterol concentration, hepatic steatosis, and abdominal fat content in high-fat diet-induced obese hamsters. J Agric Food Chem. 62:1919–1925. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Kim S, Chun SY, Lee DH, Lee KS and Nam KS: Mineral-enriched deep-sea water inhibits the metastatic potential of human breast cancer cell lines. Int J Oncol. 43:1691–1700. 2013.PubMed/NCBI

13 

Katsuda S, Yasukawa T, Nakagawa K, Miyake M, Yamasaki M, Katahira K, Mohri M, Shimizu T and Hazama A: Deep-sea water improves cardiovascular hemodynamics in Kurosawa and Kusanagi-Hypercholesterolemic (KHC) rabbits. Biol Pharm Bull. 31:38–44. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Lee KS, Shin JS, Kwon YS, Moon DS and Nam KS: Suppression of cancer progression and metastasis in HT-29 human colorectal adenocarcinomas by deep sea water. Biotechnol Bioproc Eng. 18:194–200. 2013. View Article : Google Scholar

15 

Fu ZY, Yang FL, Hsu HW and Lu YF: Drinking deep seawater decreases serum total and low-density lipoprotein-cholesterol in hypercholesterolemic subjects. J Med Food. 15:535–541. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Ha BG, Shin EJ, Park JE and Shon YH: Anti-diabetic effect of balanced deep-sea water and its mode of action in high-fat diet induced diabetic mice. Mar Drugs. 11:4193–4212. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Hataguchi Y, Tai H, Nakajima H and Kimata H: Drinking deep-sea water restores mineral imbalance in atopic eczema/dermatitis syndrome. Eur J Clin Nutr. 59:1093–1096. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Hsu CL, Chang YY, Chiu CH, Yang KT, Wang Y, Fu SG and Chen YC: Cardiovascular protection of deep-seawater drinking water in high-fat/cholesterol fed hamsters. Food Chem. 127:1146–1152. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Hwang HS, Kim HA, Lee SH and Yun JW: Anti-obesity and antidiabetic effects of deep sea water on ob/ob mice. Mar Biotechnol (NY). 11:531–539. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Hwang HS, Kim SH, Yoo YG, Chu YS, Shon YH, Nam KS and Yun JW: Inhibitory effect of deep-sea water on differentiation of 3T3-L1 adipocytes. Mar Biotechnol (NY). 11:161–168. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Li PC, Pan CH, Sheu MJ, Wu CC, Ma WF and Wu CH: Deep sea water prevents balloon angioplasty-induced hyperplasia through MMP-2: An in vitro and in vivo study. PLoS One. 9:e969272014. View Article : Google Scholar : PubMed/NCBI

22 

Miyamura M, Yoshioka S, Hamada A, Takuma D, Yokota J, Kusunose M, Kyotani S, Kawakita H, Odani K, Tsutsui Y and Nishioka Y: Difference between deep seawater and surface seawater in the preventive effect of atherosclerosis. Biol Pharm Bull. 27:1784–1787. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Sheu MJ, Chou PY, Lin WH, Pan CH, Chien YC, Chung YL, Liu FC and Wu CH: Deep sea water modulates blood pressure and exhibits hypolipidemic effects via the AMPK-ACC pathway: An in vivo study. Mar Drugs. 11:2183–2202. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Yoshioka S, Hamada A, Cui T, Yokota J, Yamamoto S, Kusunose M, Miyamura M, Kyotani S, Kaneda R, Tsutsui Y, et al: Pharmacological activity of deep-sea water: Examination of hyperlipemia prevention and medical treatment effect. Biol Pharm Bull. 26:1552–1559. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Reitman S and Frankel S: A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol. 28:56–63. 1957. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

27 

Vuppalanchi R and Chalasani N: Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management. Hepatology. 49:306–317. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Inoue M, Ohtake T, Motomura W, Takahashi N, Hosoki Y, Miyoshi S, Suzuki Y, Saito H, Kohgo Y and Okumura T: Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice. Biochem Biophys Res Commun. 336:215–222. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Chen IS, Chang YY, Hsu CL, Lin HW, Chang MH, Chen JW, Chen SS and Chen YC: Alleviative effects of deep-seawater drinking water on hepatic lipid accumulation and oxidation induced by a high-fat diet. J Chin Med Assoc. 76:95–101. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Ma PT, Gil G, Südhof TC, Bilheimer DW, Goldstein JL and Brown MS: Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits. Proc Natl Acad Sci USA. 83:8370–8374. 1986. View Article : Google Scholar : PubMed/NCBI

31 

Yasunobu Y, Hayashi K, Shingu T, Nomura K, Ohkura Y, Tanaka K, Kuga Y, Nomura S, Ohtani H, Nishimura T, et al: Reduction of plasma cholesterol levels and induction of hepatic LDL receptor by cerivastatin sodium (CAS 143201-11-0, BAY w 6228), a new inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase, in dogs. Cardiovasc Drugs Ther. 11:567–574. 1997. View Article : Google Scholar : PubMed/NCBI

32 

Abad C, Vargas FR, Zoltan T, Proverbio T, Piñero S, Proverbio F and Marín R: Magnesium sulfate affords protection against oxidative damage during severe preeclampsia. Placenta. 36:179–185. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Olatunji LA and Soladoye AO: Increased magnesium intake prevents hyperlipidemia and insulin resistance and reduces lipid peroxidation in fructose-fed rats. Pathophysiology. 14:11–15. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Gupta M, Solanki MH, Chatterjee PK, Xue X, Roman A, Desai N, Rochelson B and Metz CN: Maternal magnesium deficiency in mice leads to maternal metabolic dysfunction and altered lipid metabolism with fetal growth restriction. Mol Med. 20:332–340. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Niranjan G, Anitha D, Srinivasan AR, Velu VK, Venkatesh C, Babu MS, Ramesh R and Saha S: Association of inflammatory sialoproteins, lipid peroxides and serum magnesium levels with cardiometabolic risk factors in obese children of South Indian population. Int J Biomed Sci. 10:118–123. 2014.PubMed/NCBI

36 

Jacqmain M, Doucet E, Després JP, Bouchard C and Tremblay A: Calcium intake, body composition, and lipoprotein-lipid concentrations in adults. Am J Clin Nutr. 77:1448–1452. 2003.PubMed/NCBI

37 

Miyake S: The mechanism of release of hepatic enzymes in various liver diseases. II. Altered activity ratios of GOT to GPT in serum and liver of patients with liver diseases. Acta Med Okayama. 33:343–358. 1979.PubMed/NCBI

38 

Cremers J, Drent M, Driessen A, Nieman F, Wijnen P, Baughman R and Koek G: Liver-test abnormalities in sarcoidosis. Eur J Gastroenterol Hepatol. 24:17–24. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Morán-Salvador E, López-Parra M, García-Alonso V, Titos E, Martínez-Clemente M, González-Périz A, López-Vicario C, Barak Y, Arroyo V and Clària J: Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts. FASEB J. 25:2538–2550. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Deng Q, Li X, Fu S, Yin L, Zhang Y, Wang T, Wang J, Liu L, Yuan X, Sun G, et al: SREBP-1c gene silencing can decrease lipid deposits in bovine hepatocytes cultured in vitro. Cell Physiol Biochem. 33:1568–1578. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Chang XX, Yan HM, Xu Q, Xia MF, Bian H, Zhu TF and Gao X: The effects of berberine on hyperhomocysteinemia and hyperlipidemia in rats fed with a long-term high-fat diet. Lipids Health Dis. 11:862012. View Article : Google Scholar : PubMed/NCBI

42 

Benn T, Kim B, Park YK, Yang Y, Pham TX, Ku CS, Farruggia C, Harness E, Smyth JA and Lee JY: Polyphenol-rich blackcurrant extract exerts hypocholesterolaemic and hypoglycaemic effects in mice fed a diet containing high fat and cholesterol. Br J Nutr. 113:1697–1703. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Zhao Y, Peng L, Yang LC, Xu XD, Li WJ, Luo XM and Jin X: Wedelolactone regulates lipid metabolism and improves hepatic steatosis partly by AMPK Activation and Up-regulation of expression of PPARα/LPL and LDLR. PLoS One. 10:e01327202015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lee KS, Chun SY, Kwon YS, Kim S and Nam KS: Deep sea water improves hypercholesterolemia and hepatic lipid accumulation through the regulation of hepatic lipid metabolic gene expression. Mol Med Rep 15: 2814-2822, 2017.
APA
Lee, K., Chun, S., Kwon, Y., Kim, S., & Nam, K. (2017). Deep sea water improves hypercholesterolemia and hepatic lipid accumulation through the regulation of hepatic lipid metabolic gene expression. Molecular Medicine Reports, 15, 2814-2822. https://doi.org/10.3892/mmr.2017.6317
MLA
Lee, K., Chun, S., Kwon, Y., Kim, S., Nam, K."Deep sea water improves hypercholesterolemia and hepatic lipid accumulation through the regulation of hepatic lipid metabolic gene expression". Molecular Medicine Reports 15.5 (2017): 2814-2822.
Chicago
Lee, K., Chun, S., Kwon, Y., Kim, S., Nam, K."Deep sea water improves hypercholesterolemia and hepatic lipid accumulation through the regulation of hepatic lipid metabolic gene expression". Molecular Medicine Reports 15, no. 5 (2017): 2814-2822. https://doi.org/10.3892/mmr.2017.6317
Copy and paste a formatted citation
x
Spandidos Publications style
Lee KS, Chun SY, Kwon YS, Kim S and Nam KS: Deep sea water improves hypercholesterolemia and hepatic lipid accumulation through the regulation of hepatic lipid metabolic gene expression. Mol Med Rep 15: 2814-2822, 2017.
APA
Lee, K., Chun, S., Kwon, Y., Kim, S., & Nam, K. (2017). Deep sea water improves hypercholesterolemia and hepatic lipid accumulation through the regulation of hepatic lipid metabolic gene expression. Molecular Medicine Reports, 15, 2814-2822. https://doi.org/10.3892/mmr.2017.6317
MLA
Lee, K., Chun, S., Kwon, Y., Kim, S., Nam, K."Deep sea water improves hypercholesterolemia and hepatic lipid accumulation through the regulation of hepatic lipid metabolic gene expression". Molecular Medicine Reports 15.5 (2017): 2814-2822.
Chicago
Lee, K., Chun, S., Kwon, Y., Kim, S., Nam, K."Deep sea water improves hypercholesterolemia and hepatic lipid accumulation through the regulation of hepatic lipid metabolic gene expression". Molecular Medicine Reports 15, no. 5 (2017): 2814-2822. https://doi.org/10.3892/mmr.2017.6317
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