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Mice endometrium receptivity in early pregnancy is impaired by maternal hyperinsulinemia

  • Authors:
    • Runqin Li
    • Juan Wu
    • Junlin He
    • Yingxiong Wang
    • Xueqing Liu
    • Xuemei Chen
    • Chao Tong
    • Yubin Ding
    • Yan Su
    • Wenqi Chen
    • Chen Zhang
    • Rufei Gao
  • View Affiliations / Copyright

    Affiliations: Laboratory of Reproductive Biology, School of Public Health, Chongqing Medical University, Chongqing 400014, P.R. China, Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2503-2510
    |
    Published online on: March 14, 2017
       https://doi.org/10.3892/mmr.2017.6322
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Abstract

Previous studies have investigated the lower embryo implantation rates in women with polycystic ovary syndrome, obesity and type 2 diabetes, and specifically the association between the abnormal oocyte and embryo and hyperinsulinemia. The importance of hyperinsulinemia on maternal endometrium receptivity remains to be elucidated. The present study used a hyperinsulinemic mouse model to determine whether hyperinsulinemia may affect endometrial receptivity. An insulin intervention mouse model was first established. The serum levels of insulin, progesterone and estradiol were subsequently detected by ELISA assay analysis. The number of implantation sites was recorded using Trypan blue dye and the morphology of mice uteri was investigated using hematoxylin and eosin staining. The expression levels of molecular markers associated with endometrial receptivity were detected by reverse transcription‑quantitative polymerase chain reaction, western blotting and immunohistochemistry analyses. Finally, the importance of mechanistic target of rapamycin (mTOR) expression following insulin treatment was determined. Mice treated with insulin developed insulin resistance and hyperinsulinemia. The number of implantation sites following insulin treatment did not differ between the control and insulin‑treated groups. Additionally, no significant morphological alterations in mice uteri between control and insulin‑treated groups were observed. However, the expression levels of estrogen receptor (Esr) 1, Esr2, progesterone receptor and homeobox A10 associated with endometrial receptivity, were imbalanced during endometrium receptivity when maternal hyperinsulinemia was induced. Western blot analysis revealed that expression levels of endometrial phosphorylated (p)‑mTOR and p‑ribosomal protein S6 kinase β‑1 were significantly greater in the insulin‑treated group. These results demonstrated that although an embryo may implant into endometrium, mice endometrium receptivity in early pregnancy may be impaired by maternal hyperinsulinemia. In addition, mTOR signaling may be involved in this process. The present study provides preliminary results demonstrating that female reproduction may be compromised during hyperinsulinemia, which requires further investigation in future studies.
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1 

Nagashima T, Li Q, Clementi C, Lydon JP, DeMayo FJ and Matzuk MM: BMPR2 is required for postimplantation uterine function and pregnancy maintenance. J Clin Invest. 123:2539–2550. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Mori M, Kitazume M, Ose R, Kurokawa J, Koga K, Osuga Y, Arai S and Miyazaki T: Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice. J Clin Invest. 121:318–327. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Dale PO, Tanbo T, Haug E and Abyholm T: The impact of insulin resistance on the outcome of ovulation induction with low-dose follicle stimulating hormone in women with polycystic ovary syndrome. Hum Reprod. 13:567–570. 1998. View Article : Google Scholar : PubMed/NCBI

4 

Svendsen PF, Nilas L, Nørgaard K, Jensen JE and Madsbad S: Obesity, body composition and metabolic disturbances in polycystic ovary syndrome. Hum Reprod. 23:2113–2121. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Igosheva N, Abramov AY, Poston L, Eckert JJ, Fleming TP, Duchen MR and McConnell J: Maternal diet-induced obesity alters mitochondrial activity and redox status in mouse oocytes and zygotes. PLoS One. 5:e100742010. View Article : Google Scholar : PubMed/NCBI

6 

Lintsen AM, Pasker-de Jong PC, de Boer EJ, Burger CW, Jansen CA, Braat DD and van Leeuwen FE: Effects of subfertility cause, smoking and body weight on the success rate of IVF. Hum Reprod. 20:1867–1875. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Cano F, García-Velasco JA, Millet A, Remohí J, Simón C and Pellicer A: Oocyte quality in polycystic ovaries revisited: Identification of a particular subgroup of women. J Assist Reprod Genet. 14:254–261. 1997. View Article : Google Scholar : PubMed/NCBI

8 

Steiner DF, Park SY, Støy J, Philipson LH and Bell GI: A brief perspective on insulin production. Diabetes Obes Metab. 11:(Suppl 4). 189–196. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Homburg R: Should patients with polycystic ovarian syndrome be treated with metformin? A note of cautious optimism. Hum Reprod. 17:853–856. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Kasumov T, Solomon TP, Hwang C, Huang H, Haus JM, Zhang R and Kirwan JP: Improved insulin sensitivity after exercise training is linked to reduced plasma C14: 0 ceramide in obesity and type 2 diabetes. Obesity (Silver Spring). 23:1414–1421. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Ou XH, Li S, Wang ZB, Li M, Quan S, Xing F, Guo L, Chao SB, Chen Z, Liang XW, et al: Maternal insulin resistance causes oxidative stress and mitochondrial dysfunction in mouse oocytes. Hum Reprod. 27:2130–2145. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Schulte MM, Tsai JH and Moley KH: Obesity and PCOS: The effect of metabolic derangements on endometrial receptivity at the time of implantation. Reprod Sci. 22:6–141. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Mioni R, Mozzanega B, Granzotto M, Pierobon A, Zuliani L, Maffei P, Blandamura S, Grassi S, Sicolo N and Vettor R: Insulin receptor and glucose transporters mRNA expression throughout the menstrual cycle in human endometrium: A physiological and cyclical condition of tissue insulin resistance. Gynecol Endocrinol. 28:1014–1018. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Williamson DL, Dungan CM, Mahmoud AM, Mey JT, Blackburn BK and Haus JM: Aberrant REDD1-mTORC1 responses to insulin in skeletal muscle from Type 2 diabetics. Am J Physiol Regul Integr Comp Physiol. 309:R855–R863. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Caron A, Richard D and Laplante M: The Roles of mTOR complexes in lipid metabolism. Annu Rev Nutr. 35:321–348. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Sharawy MH, El-Awady MS, Megahed N and Gameil NM: Attenuation of insulin resistance in rats by agmatine: Role of SREBP-1c, mTOR and GLUT-2. Naunyn Schmiedebergs Arch Pharmacol. 389:45–56. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Xiao F, Yu J, Guo Y, Deng J, Li K, Du Y, Chen S, Zhu J, Sheng H and Guo F: Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice. Metabolism. 63:841–850. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Chen X, He J, Ding Y, Zeng L, Gao R, Cheng S, Liu X and Wang Y: The role of MTOR in mouse uterus during embryo implantation. Reproduction. 138:351–356. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Wang A, Ji L, Shang W, Li M, Chen L, White RE and Han G: Expression of GPR30, ERα and ERβ in endometrium during window of implantation in patients with polycystic ovary syndrome: A pilot study. Gynecol Endocrinol. 27:251–255. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Poretsky L, Clemons J and Bogovich K: Hyperinsulinemia and human chorionic gonadotropin synergistically promote the growth of ovarian follicular cysts in rats. Metabolism. 41:903–910. 1992. View Article : Google Scholar : PubMed/NCBI

21 

Lima MH, Souza LC, Caperuto LC, Bevilacqua E, Gasparetti AL, Zanuto R, Saad MJ and Carvalho CR: Up-regulation of the phosphatidylinositol 3-kinase/protein kinase B pathway in the ovary of rats by chronic treatment with hCG and insulin. J Endocrinol. 190:451–459. 2006. View Article : Google Scholar : PubMed/NCBI

22 

Paria BC, Huet-Hudson YM and Dey SK: Blastocyst's state of activity determines the ‘window’ of implantation in the receptive mouse uterus. Proc Natl Acad Sci USA. 90:10159–10162. 1993. View Article : Google Scholar : PubMed/NCBI

23 

Tan Y, Tan D, He M, Gu M, Wang Z, Zeng G and Duan E: A model for implantation: Coculture of blastocysts and uterine endometrium in mice. Biol Reprod. 72:556–561. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Zorn TM, Soto-Suazo M, Pellegrini CR, Oliveira JG and Stumpf WE: Estradiol receptor binding to the epithelium of uterine lumen and glands: Region- and time-related changes during preimplantation and periimplantation periods studied by autoradiography. Histochem Cell Biol. 120:1–12. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Liu G, Zhang X, Lin H, Wang H, Li Q, Ni J and Zhu C: Effects of E-cadherin on mouse embryo implantation and expression of matrix metalloproteinase-2 and −9. Biochem Biophys Res Commun. 343:832–838. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Chan SY: Effects of prostaglandin E2 and F2 alpha on peri-implantation development of mouse embryos in vitro. Prostaglandins. 42:321–336. 1991. View Article : Google Scholar : PubMed/NCBI

28 

Palaniappan M, Menon B and Menon KM: Stimulatory effect of insulin on theca-interstitial cell proliferation and cell cycle regulatory proteins through MTORC1 dependent pathway. Mol Cell Endocrinol. 366:81–89. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Li Z, Miard S, Laplante M, Sonenberg N and Picard F: Insulin stimulates IGFBP-2 expression in 3T3-L1 adipocytes through the PI3K/mTOR pathway. Mol Cell Endocrinol. 358:63–68. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Catalano PM and Shankar K: Obesity and pregnancy: Mechanisms of short term and long term adverse consequences for mother and child. BMJ. 356:j12017. View Article : Google Scholar : PubMed/NCBI

31 

Moran L and Teede H: Metabolic features of the reproductive phenotypes of polycystic ovary syndrome. Hum Reprod Update. 15:477–488. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Diamanti-Kandarakis E and Dunaif A: Insulin resistance and the polycystic ovary syndrome revisited: An update on mechanisms and implications. Endocr Rev. 33:981–1030. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Templeman NM, Skovsø S, Page MM, Lim GE and Johnson JD: A causal role for hyperinsulinemia in obesity. J Endocrinol. 232:R173–R183. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Wang H and Dey SK: Roadmap to embryo implantation: Clues from mouse models. Nat Rev Genet. 7:185–199. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Quenby S, Anim-Somuah M, Kalumbi C, Farquharson R and Aplin JD: Different types of recurrent miscarriage are associated with varying patterns of adhesion molecule expression in endometrium. Reprod Biomed Online. 14:224–234. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Sabatini DM: mTOR and cancer: Insights into a complex relationship. Nat Rev Cancer. 6:729–734. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Vahidnezhad H, Youssefian L and Uitto J: Molecular genetics of the PI3K-AKT-mTOR pathway in genodermatoses: Diagnostic implications and treatment opportunities. J Invest Dermatol. 136:15–23. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Wataya-Kaneda M: Mammalian target of rapamycin and tuberous sclerosis complex. J Dermatol Sci. 79:93–100. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Somers MJ and Paul E: Safety considerations of mammalian target of rapamycin inhibitors in tuberous sclerosis complex and renal transplantation. J Clin Pharmacol. 55:368–376. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Huo F, Zhang C, He H and Wang Y: MicroRNA-144-3p inhibits proliferation and induces apoptosis of human salivary adenoid carcinoma cells via targeting of mTOR. Biotechnol Lett. 38:409–416. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Neil J, Shannon C, Mohan A, Laurent D, Murali R and Jhanwar-Uniyal M: ATP-site binding inhibitor effectively targets mTORC1 and mTORC2 complexes in glioblastoma. Int J Oncol. 48:1045–1052. 2016.PubMed/NCBI

42 

Fritzen AM, Madsen AB, Kleinert M, Treebak JT, Lundsgaard AM, Jensen TE, Richter EA, Wojtaszewski J, Kiens B and Frøsig C: Regulation of autophagy in human skeletal muscle: Effects of exercise, exercise training and insulin stimulation. J Physiol. 594:745–761. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Martin PM and Sutherland AE: Exogenous amino acids regulate trophectoderm differentiation in the mouse blastocyst through an mTOR-dependent pathway. Dev Biol. 240:182–193. 2001. View Article : Google Scholar : PubMed/NCBI

44 

Gangloff YG, Mueller M, Dann SG, Svoboda P, Sticker M, Spetz JF, Um SH, Brown EJ, Cereghini S, Thomas G and Kozma SC: Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol. 24:9508–9516. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Kim J, Song G, Wu G, Gao H, Johnson GA and Bazer FW: Arginine, leucine, and glutamine stimulate proliferation of porcine trophectoderm cells through the MTOR-RPS6K-RPS6-EIF4EBP1 signal transduction pathway. Biol Reprod. 88:1132013. View Article : Google Scholar : PubMed/NCBI

46 

Wollenhaupt K, Brüssow KP, Albrecht D and Tomek W: The Akt/mTor signaling cascade is modified during placentation in the porcine uterine tissue. Reprod Biol. 13:184–194. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Mahdi H, Xiu J, Reddy SK and DeBernardo R: Alteration in PI3K/mTOR, MAPK pathways and Her2 expression/amplification is more frequent in uterine serous carcinoma than ovarian serous carcinoma. J Surg Oncol. 112:188–194. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Guntas G, Hallett RA, Zimmerman SP, Williams T, Yumerefendi H, Bear JE and Kuhlman B: Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins. Proc Natl Acad Sci USA. 112:112–117. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li R, Wu J, He J, Wang Y, Liu X, Chen X, Tong C, Ding Y, Su Y, Chen W, Chen W, et al: Mice endometrium receptivity in early pregnancy is impaired by maternal hyperinsulinemia. Mol Med Rep 15: 2503-2510, 2017.
APA
Li, R., Wu, J., He, J., Wang, Y., Liu, X., Chen, X. ... Gao, R. (2017). Mice endometrium receptivity in early pregnancy is impaired by maternal hyperinsulinemia. Molecular Medicine Reports, 15, 2503-2510. https://doi.org/10.3892/mmr.2017.6322
MLA
Li, R., Wu, J., He, J., Wang, Y., Liu, X., Chen, X., Tong, C., Ding, Y., Su, Y., Chen, W., Zhang, C., Gao, R."Mice endometrium receptivity in early pregnancy is impaired by maternal hyperinsulinemia". Molecular Medicine Reports 15.5 (2017): 2503-2510.
Chicago
Li, R., Wu, J., He, J., Wang, Y., Liu, X., Chen, X., Tong, C., Ding, Y., Su, Y., Chen, W., Zhang, C., Gao, R."Mice endometrium receptivity in early pregnancy is impaired by maternal hyperinsulinemia". Molecular Medicine Reports 15, no. 5 (2017): 2503-2510. https://doi.org/10.3892/mmr.2017.6322
Copy and paste a formatted citation
x
Spandidos Publications style
Li R, Wu J, He J, Wang Y, Liu X, Chen X, Tong C, Ding Y, Su Y, Chen W, Chen W, et al: Mice endometrium receptivity in early pregnancy is impaired by maternal hyperinsulinemia. Mol Med Rep 15: 2503-2510, 2017.
APA
Li, R., Wu, J., He, J., Wang, Y., Liu, X., Chen, X. ... Gao, R. (2017). Mice endometrium receptivity in early pregnancy is impaired by maternal hyperinsulinemia. Molecular Medicine Reports, 15, 2503-2510. https://doi.org/10.3892/mmr.2017.6322
MLA
Li, R., Wu, J., He, J., Wang, Y., Liu, X., Chen, X., Tong, C., Ding, Y., Su, Y., Chen, W., Zhang, C., Gao, R."Mice endometrium receptivity in early pregnancy is impaired by maternal hyperinsulinemia". Molecular Medicine Reports 15.5 (2017): 2503-2510.
Chicago
Li, R., Wu, J., He, J., Wang, Y., Liu, X., Chen, X., Tong, C., Ding, Y., Su, Y., Chen, W., Zhang, C., Gao, R."Mice endometrium receptivity in early pregnancy is impaired by maternal hyperinsulinemia". Molecular Medicine Reports 15, no. 5 (2017): 2503-2510. https://doi.org/10.3892/mmr.2017.6322
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