Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-2017 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2017 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Plasma microRNA-451 as a novel hemolytic marker for β0-thalassemia/HbE disease

  • Authors:
    • Kamonlak Leecharoenkiat
    • Yuka Tanaka
    • Yasuko Harada
    • Porntip Chaichompoo
    • Orawan Sarakul
    • Yasunobu Abe
    • Duncan Richard Smith
    • Suthat Fucharoen
    • Saovaros Svasti
    • Tsukuru Umemura
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Microscopy, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand, Division of Medical Technology, Department of Health Sciences, Faculty of Medical Sciences, Kyushu University, Fukuoka 812‑8582, Japan, Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand, Department of Medical Technology, School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80160, Thailand, Department of Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812‑8582, Japan, Molecular Pathology Laboratory, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhon Pathom 73170, Thailand, Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Salaya, Nakhon Pathom 73170, Thailand
    Copyright: © Leecharoenkiat et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2495-2502
    |
    Published online on: March 15, 2017
       https://doi.org/10.3892/mmr.2017.6326
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

In Southeast Asia, particularly in Thailand, β0-thalassemia/hemoglobin E (HbE) disease is a common hereditary hematological disease. It is associated with pathophysiological processes, such as the intramedullary destruction of immature erythroid cells and peripheral hemolysis of mature red blood cells. MicroRNA (miR) sequences, which are short non-coding RNA that regulate gene expression in a suppressive manner, serve a crucial role in human erythropoiesis. In the present study, the plasma levels of the erythroid-expressed miRNAs, miR‑451 and miR‑155, were analyzed in 23 patients with β0-thalassemia/HbE and 16 control subjects. Reverse transcription‑quantitative polymerase chain reaction analysis revealed significantly higher levels of plasma miR‑451 and miR‑155 in β0‑thalassemia/HbE patients when compared to the control subjects. Notably, among the β0‑thalassemia/HbE patients, a significant increase in miR‑451 levels was detected in severe cases when compared with mild cases. The levels of plasma miR‑451 correlated with reticulocyte and platelet counts. The results suggest that increased plasma miR‑451 levels may be associated with the degree of hemolysis and accelerated erythropoiesis in β0‑thalassemia/HbE patients. In conclusion, miR‑451 may represent a relevant biomarker for pathological erythropoiesis associated with β0-thalassemia/HbE.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Olivieri NF: The beta-thalassemias. N Engl J Med. 341:99–109. 1999. View Article : Google Scholar : PubMed/NCBI

2 

Fucharoen S and Winichagoon P: Clinical and hematologic aspects of hemoglobin E beta-thalassemia. Curr Opin Hematol. 7:106–112. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Vichinsky E: Hemoglobin e syndromes. Hematology Am Soc Hematol Educ Program. 79–83. 2007.PubMed/NCBI

4 

Fucharoen S and Winichagoon P: Hemoglobinopathies in southeast Asia. Hemoglobin. 11:65–88. 1987. View Article : Google Scholar : PubMed/NCBI

5 

Rund D and Rachmilewitz E: Beta-thalassemia. N Engl J Med. 353:1135–1146. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Olivieri NF, Pakbaz Z and Vichinsky E: Hb E/beta-thalassaemia: A common & clinically diverse disorder. Indian J Med Res. 134:522–531. 2011.PubMed/NCBI

7 

Thein SL: Pathophysiology of beta thalassemia-a guide to molecular therapies. Hematology Am Soc Hematol Educ Program. 31–37. 2005.PubMed/NCBI

8 

Weatherall DJCJ: The thalassemia syndromes. Malden MA Blackwell Science. 2001.

9 

Conran N: Intravascular hemolysis: A disease mechanism not to be ignored. Acta Haematol. 132:97–99. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Atichartakarn V, Chuncharunee S, Archararit N, Udomsubpayakul U and Aryurachai K: Intravascular hemolysis, vascular endothelial cell activation and thrombophilia in splenectomized patients with hemoglobin E/β-thalassemia disease. Acta Haematol. 132:100–107. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Filipowicz W, Bhattacharyya SN and Sonenberg N: Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight? Nat Rev Genet. 9:102–114. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Miska EA: How microRNAs control cell division, differentiation and death. Curr Opin Genet Dev. 15:563–568. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Roth C, Rack B, Müller V, Janni W, Pantel K and Schwarzenbach H: Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer. Breast Cancer Res. 12:R902010. View Article : Google Scholar : PubMed/NCBI

15 

Lawrie CH, Gal S, Dunlop HM, Pushkaran B, Liggins AP, Pulford K, Banham AH, Pezzella F, Boultwood J, Wainscoat JS, et al: Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br J Haematol. 141:672–675. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Chen Y, Gelfond JA, McManus LM and Shireman PK: Reproducibility of quantitative RT-PCR array in miRNA expression profiling and comparison with microarray analysis. BMC Genomics. 10:4072009. View Article : Google Scholar : PubMed/NCBI

17 

Reid G, Kirschner MB and van Zandwijk N: Circulating microRNAs: Association with disease and potential use as biomarkers. Crit Rev Oncol Hematol. 80:193–208. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, Peterson A, Noteboom J, O'Briant KC, Allen A, et al: Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA. 105:10513–10518. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Masaki S, Ohtsuka R, Abe Y, Muta K and Umemura T: Expression patterns of microRNAs 155 and 451 during normal human erythropoiesis. Biochem Biophys Res Commun. 364:509–514. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Pase L, Layton JE, Kloosterman WP, Carradice D, Waterhouse PM and Lieschke GJ: miR-451 regulates zebrafish erythroid maturation in vivo via its target gata2. Blood. 113:1794–1804. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Kim M, Tan YS, Cheng WC, Kingsbury TJ, Heimfeld S and Civin CI: MIR144 and MIR451 regulate human erythropoiesis via RAB14. Br J Haematol. 168:583–597. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Bruchova-Votavova H, Yoon D and Prchal JT: miR-451 enhances erythroid differentiation in K562 cells. Leuk Lymphoma. 51:686–693. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Zhan M, Miller CP, Papayannopoulou T, Stamatoyannopoulos G and Song CZ: MicroRNA expression dynamics during murine and human erythroid differentiation. Exp Hematol. 35:1015–1025. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Svasti S, Masaki S, Penglong T, Abe Y, Winichagoon P, Fucharoen S and Umemura T: Expression of microRNA-451 in normal and thalassemic erythropoiesis. Ann Hematol. 89:953–958. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Faraoni I, Antonetti FR, Cardone J and Bonmassar E: miR-155 gene: A typical multifunctional microRNA. Biochim Biophys Acta. 1792:497–505. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Zhu W, Qin W, Atasoy U and Sauter ER: Circulating microRNAs in breast cancer and healthy subjects. BMC Res Notes. 2:892009. View Article : Google Scholar : PubMed/NCBI

27 

Eis PS, Tam W, Sun L, Chadburn A, Li Z, Gomez MF, Lund E and Dahlberg JE: Accumulation of miR-155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci USA. 102:3627–3632. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Winichagoon P, Saechan V, Sripanich R, Nopparatana C, Kanokpongsakdi S, Maggio A and Fucharoen S: Prenatal diagnosis of beta-thalassaemia by reverse dot-blot hybridization. Prenat Diagn. 19:428–435. 1999. View Article : Google Scholar : PubMed/NCBI

29 

Sripichai O, Makarasara W, Munkongdee T, Kumkhaek C, Nuchprayoon I, Chuansumrit A, Chuncharunee S, Chantrakoon N, Boonmongkol P, Winichagoon P and Fucharoen S: A scoring system for the classification of beta-thalassemia/HbE disease severity. Am J Hematol. 83:482–484. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Arce-Bejarano R, Lomonte B and Gutiérrez JM: Intravascular hemolysis induced by the venom of the Eastern coral snake, Micrurus fulvius, in a mouse model: Identification of directly hemolytic phospholipases A2. Toxicon. 90:26–35. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Ragab SM, Safan MA and Badr EA: Study of serum haptoglobin level and its relation to erythropoietic activity in Beta thalassemia children. Mediterr J Hematol Infect Dis. 7:e20150192015. View Article : Google Scholar : PubMed/NCBI

32 

Okumiya T, Ishikawa-Nishi M, Doi T, Kamioka M, Takeuchi H, Doi Y and Sugiura T: Evaluation of intravascular hemolysis with erythrocyte creatine in patients with cardiac valve prostheses. Chest. 125:2115–2120. 2004. View Article : Google Scholar : PubMed/NCBI

33 

Rother RP, Bell L, Hillmen P and Gladwin MT: The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: A novel mechanism of human disease. JAMA. 293:1653–1662. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Mock DM, Matthews NI, Zhu S, Strauss RG, Schmidt RL, Nalbant D, Cress GA and Widness JA: Red blood cell (RBC) survival determined in humans using RBCs labeled at multiple biotin densities. Transfusion. 51:1047–1057. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Painter PC, Van Meter S, Dabbs RL and Clement GE: Analytical evaluation and comparison of Dupont aca lactate dehydrogenase-1 (LD1) isoenzyme assay diagnostic efficiency for acute myocardial infarction detection with other LD1 methods and aca CK-MB. A two-site study. Angiology. 45:585–595. 1994. View Article : Google Scholar : PubMed/NCBI

36 

Rasmussen KD, Simmini S, Abreu-Goodger C, Bartonicek N, Di Giacomo M, Bilbao-Cortes D, Horos R, Von Lindern M, Enright AJ and O'Carroll D: The miR-144/451 locus is required for erythroid homeostasis. J Exp Med. 207:1351–1358. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Leecharoenkiat K, Tanaka Y, Harada Y, Chaichompoo P, Sarakul O, Abe Y, Smith DR, Fucharoen S, Svasti S, Umemura T, Umemura T, et al: Plasma microRNA-451 as a novel hemolytic marker for β0-thalassemia/HbE disease. Mol Med Rep 15: 2495-2502, 2017.
APA
Leecharoenkiat, K., Tanaka, Y., Harada, Y., Chaichompoo, P., Sarakul, O., Abe, Y. ... Umemura, T. (2017). Plasma microRNA-451 as a novel hemolytic marker for β0-thalassemia/HbE disease. Molecular Medicine Reports, 15, 2495-2502. https://doi.org/10.3892/mmr.2017.6326
MLA
Leecharoenkiat, K., Tanaka, Y., Harada, Y., Chaichompoo, P., Sarakul, O., Abe, Y., Smith, D. R., Fucharoen, S., Svasti, S., Umemura, T."Plasma microRNA-451 as a novel hemolytic marker for β0-thalassemia/HbE disease". Molecular Medicine Reports 15.5 (2017): 2495-2502.
Chicago
Leecharoenkiat, K., Tanaka, Y., Harada, Y., Chaichompoo, P., Sarakul, O., Abe, Y., Smith, D. R., Fucharoen, S., Svasti, S., Umemura, T."Plasma microRNA-451 as a novel hemolytic marker for β0-thalassemia/HbE disease". Molecular Medicine Reports 15, no. 5 (2017): 2495-2502. https://doi.org/10.3892/mmr.2017.6326
Copy and paste a formatted citation
x
Spandidos Publications style
Leecharoenkiat K, Tanaka Y, Harada Y, Chaichompoo P, Sarakul O, Abe Y, Smith DR, Fucharoen S, Svasti S, Umemura T, Umemura T, et al: Plasma microRNA-451 as a novel hemolytic marker for β0-thalassemia/HbE disease. Mol Med Rep 15: 2495-2502, 2017.
APA
Leecharoenkiat, K., Tanaka, Y., Harada, Y., Chaichompoo, P., Sarakul, O., Abe, Y. ... Umemura, T. (2017). Plasma microRNA-451 as a novel hemolytic marker for β0-thalassemia/HbE disease. Molecular Medicine Reports, 15, 2495-2502. https://doi.org/10.3892/mmr.2017.6326
MLA
Leecharoenkiat, K., Tanaka, Y., Harada, Y., Chaichompoo, P., Sarakul, O., Abe, Y., Smith, D. R., Fucharoen, S., Svasti, S., Umemura, T."Plasma microRNA-451 as a novel hemolytic marker for β0-thalassemia/HbE disease". Molecular Medicine Reports 15.5 (2017): 2495-2502.
Chicago
Leecharoenkiat, K., Tanaka, Y., Harada, Y., Chaichompoo, P., Sarakul, O., Abe, Y., Smith, D. R., Fucharoen, S., Svasti, S., Umemura, T."Plasma microRNA-451 as a novel hemolytic marker for β0-thalassemia/HbE disease". Molecular Medicine Reports 15, no. 5 (2017): 2495-2502. https://doi.org/10.3892/mmr.2017.6326
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team