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Review

Viral and host factors associated with outcomes of hepatitis C virus infection (Review)

  • Authors:
    • Zehui Yan
    • Yuming Wang
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Diseases, Southwest Hospital, Third Military Medical University, Shapingba, Chongqing 400038, P.R. China
  • Pages: 2909-2924
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    Published online on: March 22, 2017
       https://doi.org/10.3892/mmr.2017.6351
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Abstract

Hepatitis C virus (HCV) infection is a major health issue globally. Owing to the progress made in host genetics and HCV molecular virology, emerging data have suggested that the natural course and treatment response in patients with HCV infection are largely determined by complex host‑viral interactions. HCV genotype is the most important viral factor predicting the response to pegylated interferon‑α plus ribavirin therapy. The subtype of HCV genotype 1 is the key viral factor that predicts the efficacy of direct‑acting antiviral therapy. HCV genome heterogeneity and baseline viral load are additionally associated with the treatment response. Multiple host genetic variants localized in genes associated with the immune response have been identified as predictors of spontaneous disease course and therapy outcome in chronic HCV. However, most findings from candidate gene association studies have not been proven universal for all investigated populations and independent studies. Previous findings in independent large genome wide association studies confirmed that interferon‑λ3 gene polymorphisms are associated with spontaneous clearance and treatment responsiveness. A polymorphism of the inosine triphosphatase gene has been identified as a protective factor against ribavirin‑induced anemia and dose reductions. Another genetic variant in the patatin‑like phospholipase domain containing 3 genes is associated with hepatic steatosis and fibrosis in patients with HCV. The present review focused on the identified viral and host factors associated with outcomes of patients with HCV, and assessed the involvement of viral and host genetics in the natural history and treatment outcomes of HCV infection. This will provide novel ideas concerning personalized prevention and individualized clinical management.
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1 

Webster DP, Klenerman P and Dusheiko GM: Hepatitis C. Lancet. 385:1124–1135. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Micallef JM, Kaldor JM and Dore GJ: Spontaneous viral clearance following acute hepatitis C infection: A systematic review of longitudinal studies. J Viral Hepat. 13:34–41. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Shepard CW, Finelli L and Alter MJ: Global epidemiology of hepatitis C virus infection. Lancet Infect Dis. 5:558–567. 2005. View Article : Google Scholar : PubMed/NCBI

4 

McHutchison JG, Lawitz EJ, Shiffman ML, Muir AJ, Galler GW, McCone J, Nyberg LM, Lee WM, Ghalib RH, Schiff ER, et al: Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection. N Engl J Med. 361:580–593. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Ghany MG, Strader DB, Thomas DL and Seeff LB: American Association for the Study of Liver Diseases: Diagnosis, management, and treatment of hepatitis C: An update. Hepatology. 49:1335–1374. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Fried MW, Shiffman ML, Reddy KR, Smith C, Marinos G, Gonçales FL Jr, Häussinger D, Diago M, Carosi G, Dhumeaux D, et al: Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med. 347:975–982. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Aghemo A and De Francesco R: New horizons in hepatitis C antiviral therapy with direct-acting antivirals. Hepatology. 58:428–438. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Rauch A, Gaudieri S, Thio C and Bochud PY: Host genetic determinants of spontaneous hepatitis C clearance. Pharmacogenomics. 10:1819–1837. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Bowen DG and Walker CM: Adaptive immune responses in acute and chronic hepatitis C virus infection. Nature. 436:946–952. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Doyle JS, Hellard ME and Thompson AJ: The role of viral and host genetics in natural history and treatment of chronic HCV infection. Best Pract Res Clin Gastroenterol. 26:413–427. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Bull RA, Luciani F, McElroy K, Gaudieri S, Pham ST, Chopra A, Cameron B, Maher L, Dore GJ, White PA and Lloyd AR: Sequential bottlenecks drive viral evolution in early acute hepatitis C virus infection. PLoS Pathog. 7:e10022432011. View Article : Google Scholar : PubMed/NCBI

12 

Bochud PY, Cai T, Overbeck K, Bochud M, Dufour JF, Müllhaupt B, Borovicka J, Heim M, Moradpour D, Cerny A, et al: Genotype 3 is associated with accelerated fibrosis progression in chronic hepatitis C. J Hepatol. 51:655–666. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Pearlman BL and Traub N: Sustained virologic response to antiviral therapy for chronic hepatitis C virus infection: A cure and so much more. Clin Infect Dis. 52:889–900. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Zhu Y and Chen S: Antiviral treatment of hepatitis C virus infection and factors affecting efficacy. World J Gastroenterol. 19:8963–8973. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Hadziyannis SJ, Sette H Jr, Morgan TR, Balan V, Diago M, Marcellin P, Ramadori G, Bodenheimer H Jr, Bernstein D, Rizzetto M, et al: Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: A randomized study of treatment duration and ribavirin dose. Ann Intern Med. 140:346–355. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Khuroo MS, Khuroo MS and Dahab ST: Meta-analysis: A randomized trial of peginterferon plus ribavirin for the initial treatment of chronic hepatitis C genotype 4. Aliment Pharmacol Ther. 20:931–938. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Nguyen MH, Trinh HN, Garcia R, Nguyen G, Lam KD and Keeffe EB: Higher rate of sustained virologic response in chronic hepatitis C genotype 6 treated with 48 weeks versus 24 weeks of peginterferon plus ribavirin. Am J Gastroenterol. 103:1131–1135. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Foster GR, Hézode C, Bronowicki JP, Carosi G, Weiland O, Verlinden L, van Heeswijk R, van Baelen B, Picchio G and Beumont M: Telaprevir alone or with peginterferon and ribavirin reduces HCV RNA in patients with chronic genotype 2 but not genotype 3 infections. Gastroenterology. 141:881–889, e1. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Howe J, Graham D, McMonagle P, Curry S, Chase R, Lahser F, Ogert RA, Strizki J, Barnard RJBO, Zhang R, et al: 844In vitro characterization of the pan-genotyope activity of the HCV NS3/4A protease inhibitors Boceprevir and Telapreevir. J Hepatology. 56:S3292012. View Article : Google Scholar

20 

Jacobson IM, McHutchison JG, Dusheiko G, Di Bisceglie AM, Reddy KR, Bzowej NH, Marcellin P, Muir AJ, Ferenci P, Flisiak R, et al: Telaprevir for previously untreated chronic hepatitis C virus infection. N Engl J Med. 364:2405–2416. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Zeuzem S, Andreone P, Pol S, Lawitz E, Diago M, Roberts S, Focaccia R, Younossi Z, Foster GR, Horban A, et al: Telaprevir for retreatment of HCV infection. N Engl J Med. 364:2417–2428. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Poordad F, McCone J Jr, Bacon BR, Bruno S, Manns MP, Sulkowski MS, Jacobson IM, Reddy KR, Goodman ZD, Boparai N, et al: Boceprevir for untreated chronic HCV genotype 1 infection. N Engl J Med. 364:1195–1206. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Bacon BR, Gordon SC, Lawitz E, Marcellin P, Vierling JM, Zeuzem S, Poordad F, Goodman ZD, Sings HL, Boparai N, et al: Boceprevir for previously treated chronic HCV genotype 1 infection. N Engl J Med. 364:1207–1217. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Vierling J, Flamm S, Gordon S, Lawitz E, Bronowicki JP, Davis M, Yoshida E, Pedicone LD, Deng W, Treitel M, et al: Efficacy of boceprevir in prior null responders to peginterferon/ribavirin: The PROVIDE study. Hepatology. 54:796A2011.

25 

Sulkowski M, Gardiner D, Lawitz E, Hinestrosa F, Nelson D, Thuluvath P, Rodriguez-Torres M, Lok A, Schwartz H, Reddy KR, et al: 1422 Potent Viral Suppression with all-Oral Combination of Daclatasvir (NS5A Inhibitor) and GS-7977 (NS5B Inhibitor), +/− ribavirin, in treatment-naive patients with chronic HCV GT1, 2, OR 3. J Hepatology. 56:S5602012. View Article : Google Scholar

26 

Gane EJ, Stedman CA, Hyland RH, Sorensen RD, Symonds WT, Hindes RG and Berrey MM: 1113 electron: Once daily PSI-7977 Plus RBV in HCV GT1/2/3. J Hepatology. 56:S438–S439. 2012. View Article : Google Scholar

27 

Gane EJ, Stedman CA, Hyland RH, Ding X, Svarovskaia E, Symonds WT, Hindes RG and Berrey MM: Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C. N Engl J Med. 368:34–44. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Moreno C, Hezode C, Marcellin P, Bourgeois S, Francque S, Samuel D, Zoulim F, Grange JD, Shukla U, Lenz O, et al: Efficacy and safety of simeprevir with Peg-IFN/ribavirin in naive or experienced patients infected with chronic HCV genotype 4. J Hepatol. 62:1047–1055. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Zeuzem S, Soriano V, Asselah T, et al: SVR4 and SVR12 with an interferon-free regimen of BI-201335 and BI-207127, +/−ribavirin, in treatment-naıve patients with chronic genotype-1 HCV infection: Interim results of SOUND-C2. J Hepatol (EASL 47th Annual Meeting abstracts). 56:542012.

30 

Lok AS, Gardiner DF, Lawitz E, Martorell C, Everson GT, Ghalib R, Reindollar R, Rustgi V, McPhee F, Wind-Rotolo M, et al: Preliminary study of two antiviral agents for hepatitis C genotype 1. N Engl J Med. 366:216–224. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Jacobson IM, Brown RS Jr, Freilich B, Afdhal N, Kwo PY, Santoro J, Becker S, Wakil AE, Pound D, Godofsky E, et al: Peginterferon alfa-2b and weight-based or flat-dose ribavirin in chronic hepatitis C patients: A randomized trial. Hepatology. 46:971–981. 2007. View Article : Google Scholar : PubMed/NCBI

32 

Shiffman ML, Suter F, Bacon BR, Nelson D, Harley H, Solá R, Shafran SD, Barange K, Lin A, Soman A and Zeuzem S: ACCELERATE Investigators: Peginterferon alfa-2a and ribavirin for 16 or 24 weeks in HCV genotype 2 or 3. N Engl J Med. 357:124–134. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Zeuzem S, Buti M, Ferenci P, Sperl J, Horsmans Y, Cianciara J, Ibranyi E, Weiland O, Noviello S, Brass C and Albrecht J: Efficacy of 24 weeks treatment with peginterferon alfa-2b plus ribavirin in patients with chronic hepatitis C infected with genotype 1 and low pretreatment viremia. J Hepatol. 44:97–103. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Hopkins S, Bobardt M, Chatterji U, Garcia-Rivera JA, Lim P and Gallay PA: The cyclophilin inhibitor SCY-635 disrupts hepatitis C virus NS5A-cyclophilin A complexes. Antimicrob Agents Chemother. 56:3888–3897. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Zeuzem S, Fried MW, Reddy KR, et al: Improving the clinical relevance of pretreatment viral load as a predictor of sustained virological response (SVR) in patients infected with hepatitis C genotype 1 treated with peginterferon alfa-2a (40KD) (PEGASYS (R)) plus ribavirin (COPEGUS (R)). Hepatology. 44:(S1). 267A–268A. 2006.

36 

European Association for the Study of the Liver: EASL Clinical Practice Guidelines: Management of hepatitis C virus infection. J Hepatol. 55:245–264. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Rocco A, Compare D, Coccoli P, Esposito C, Di Spirito A, Barbato A, Strazzullo P and Nardone G: Vitamin B12 supplementation improves rates of sustained viral response in patients chronically infected with hepatitis C virus. Gut. 62:766–773. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Kurosaki M, Sakamoto N, Iwasaki M, Sakamoto M, Suzuki Y, Hiramatsu N, Sugauchi F, Tamori A, Nakagawa M and Izumi N: Sequences in the interferon sensitivity-determining region and core region of hepatitis C virus impact pretreatment prediction of response to PEG-interferon plus ribavirin: Data mining analysis. J Med Virol. 83:445–452. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Yen YH, Hung CH, Hu TH, Chen CH, Wu CM, Wang JH, Lu SN and Lee CM: Mutations in the interferon sensitivity-determining region (nonstructural 5A amino acid 2209–2248) in patients with hepatitis C-1b infection and correlating response to combined therapy of pegylated interferon and ribavirin. Aliment Pharmacol Ther. 27:72–79. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Zeuzem S, Lee JH and Roth WK: Mutations in the nonstructural 5A gene of European hepatitis C virus isolates and response to interferon alfa. Hepatology. 25:740–744. 1997. View Article : Google Scholar : PubMed/NCBI

41 

Duverlie G, Khorsi H, Castelain S, Jaillon O, Izopet J, Lunel F, Eb F, Penin F and Wychowski C: Sequence analysis of the NS5A protein of European hepatitis C virus 1b isolates and relation to interferon sensitivity. J Gen Virol. 79:1373–1381. 1998. View Article : Google Scholar : PubMed/NCBI

42 

El-Shamy A, Nagano-Fujii M, Sasase N, Imoto S, Kim SR and Hotta H: Sequence variation in hepatitis C virus nonstructural protein 5A predicts clinical outcome of pegylated interferon/ribavirin combination therapy. Hepatology. 48:38–47. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Akuta N, Suzuki F, Sezaki H, Suzuki Y, Hosaka T, Someya T, Kobayashi M, Saitoh S, Watahiki S, Sato J, et al: Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 1b high viral load and non-virological response to interferon-ribavirin combination therapy. Intervirology. 48:372–380. 2005. View Article : Google Scholar : PubMed/NCBI

44 

Akuta N, Suzuki F, Kawamura Y, Yatsuji H, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, Arase Y, et al: Predictive factors of early and sustained responses to peginterferon plus ribavirin combination therapy in Japanese patients infected with hepatitis C virus genotype 1b: Amino acid substitutions in the core region and low-density lipoprotein cholesterol levels. J Hepatol. 46:403–410. 2007. View Article : Google Scholar : PubMed/NCBI

45 

Akuta N, Suzuki F, Hirakawa M, Kawamura Y, Yatsuji H, Sezaki H, Suzuki Y, Hosaka T, Kobayashi M, Kobayashi M, et al: Amino acid substitution in hepatitis C virus core region and genetic variation near the interleukin 28B gene predict viral response to telaprevir with peginterferon and ribavirin. Hepatology. 52:421–429. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Donlin MJ, Cannon NA, Aurora R, Li J, Wahed AS, Di Bisceglie AM and Tavis JE: Virahep-C Study Group: Contribution of genome-wide HCV genetic differences to outcome of interferon-based therapy in Caucasian American and African American patients. PLoS One. 5:e90322010. View Article : Google Scholar : PubMed/NCBI

47 

Aurora R, Donlin MJ, Cannon NA and Tavis JE: Genome-wide hepatitis C virus amino acid covariance networks can predict response to antiviral therapy in humans. J Clin Invest. 119:225–236. 2009.PubMed/NCBI

48 

Halfon P and Locarnini S: Hepatitis C virus resistance to protease inhibitors. J Hepatol. 55:192–206. 2011. View Article : Google Scholar : PubMed/NCBI

49 

McHutchison JG, Manns MP, Muir AJ, Terrault NA, Jacobson IM, Afdhal NH, Heathcote EJ, Zeuzem S, Reesink HW, Garg J, et al: Telaprevir for previously treated chronic HCV infection. N Engl J Med. 362:1292–1303. 2010. View Article : Google Scholar : PubMed/NCBI

50 

Bartels DJ, Zhou Y, Zhang EZ, Marcial M, Byrn RA, Pfeiffer T, Tigges AM, Adiwijaya BS, Lin C, Kwong AD and Kieffer TL: Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3.4A protease inhibitors in treatment-naive subjects. J Infect Dis. 198:800–807. 2008. View Article : Google Scholar : PubMed/NCBI

51 

Kieffer TL, Sarrazin C, Miller JS, Welker MW, Forestier N, Reesink HW, Kwong AD and Zeuzem S: Telaprevir and pegylated interferon-alpha-2a inhibit wild-type and resistant genotype 1 hepatitis C virus replication in patients. Hepatology. 46:631–639. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Sarrazin C and Zeuzem S: Resistance to direct antiviral agents in patients with hepatitis C virus infection. Gastroenterology. 138:447–462. 2010. View Article : Google Scholar : PubMed/NCBI

53 

Thomas DL, Thio CL, Martin MP, Qi Y, Ge D, O'Huigin C, Kidd J, Kidd K, Khakoo SI, Alexander G, et al: Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature. 461:798–801. 2009. View Article : Google Scholar : PubMed/NCBI

54 

Rauch A, Kutalik Z, Descombes P, Cai T, Di Iulio J, Mueller T, Bochud M, Battegay M, Bernasconi E, Borovicka J, et al: Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: A genome-wide association study. Gastroenterology. 138:1338–1345. 2010. View Article : Google Scholar : PubMed/NCBI

55 

Kenny-Walsh E: Clinical outcomes after hepatitis C infection from contaminated anti-D immune globulin. Irish Hepatology Research Group. N Engl J Med. 340:1228–1233. 1999. View Article : Google Scholar : PubMed/NCBI

56 

Grebely J, Petoumenos K, Hellard M, Matthews GV, Suppiah V, Applegate T, Yeung B, Marks P, Rawlinson W, Lloyd AR, et al: Potential role for interleukin-28B genotype in treatment decision-making in recent hepatitis C virus infection. Hepatology. 52:1216–1224. 2010. View Article : Google Scholar : PubMed/NCBI

57 

Tillmann HL, Thompson AJ, Patel K, Wiese M, Tenckhoff H, Nischalke HD, Lokhnygina Y, Kullig U, Göbel U, Capka E, et al: A polymorphism near IL28B is associated with spontaneous clearance of acute hepatitis C virus and jaundice. Gastroenterology. 139:1586–1592. 2010. View Article : Google Scholar : PubMed/NCBI

58 

Ramadori G and Christ B: Cytokines and the hepatic acute-phase response. Semin Liver Dis. 19:141–155. 1999. View Article : Google Scholar : PubMed/NCBI

59 

Gao B: Cytokines, STATs and liver disease. Cell Mol Immunol. 2:92–100. 2005.PubMed/NCBI

60 

Fishman D, Faulds G, Jeffery R, Mohamed-Ali V, Yudkin JS, Humphries S and Woo P: The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest. 102:1369–1376. 1998. View Article : Google Scholar : PubMed/NCBI

61 

Barrett S, Collins M, Kenny C, Ryan E, Keane CO and Crowe J: Polymorphisms in tumour necrosis factor-alpha, transforming growth factor-beta, interleukin-10, interleukin-6, interferon-gamma, and outcome of hepatitis C virus infection. J Med Virol. 71:212–218. 2003. View Article : Google Scholar : PubMed/NCBI

62 

Minton EJ, Smillie D, Smith P, Shipley S, McKendrick MW, Gleeson DC, Underwood JC, Cannings C and Wilson AG: Trent Hepatitis C Study Group: Clearance of hepatitis C virus is not associated with single nucleotide polymorphisms in the IL-1, −6, or −10 genes. Hum Immunol. 66:127–132. 2005. View Article : Google Scholar : PubMed/NCBI

63 

Oleksyk TK, Thio CL, Truelove AL, Goedert JJ, Donfield SM, Kirk GD, Thomas DL, O'Brien SJ and Smith MW: Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance. Genes Immun. 6:347–357. 2005. View Article : Google Scholar : PubMed/NCBI

64 

Paladino N, Fainboim H, Theiler G, Schroder T, Muñoz AE, Flores AC, Galdame O and Fainboim L: Gender susceptibility to chronic hepatitis C virus infection associated with interleukin 10 promoter polymorphism. J Virol. 80:9144–9150. 2006. View Article : Google Scholar : PubMed/NCBI

65 

Lio D, Caruso C, Di Stefano R, Romano Colonna G, Ferraro D, Scola L, Crivello A, Licata A, Valenza LM, Candore G, et al: IL-10 and TNF-alpha polymorphisms and the recovery from HCV infection. Hum Immunol. 64:674–680. 2003. View Article : Google Scholar : PubMed/NCBI

66 

Mangia A, Santoro R, Piattelli M, Pazienza V, Grifa G, Iacobellis A and Andriulli A: IL-10 haplotypes as possible predictors of spontaneous clearance of HCV infection. Cytokine. 25:103–109. 2004. View Article : Google Scholar : PubMed/NCBI

67 

Kusumoto K, Uto H, Hayashi K, Takahama Y, Nakao H, Suruki R, Stuver SO, Ido A and Tsubouchi H: Interleukin-10 or tumor necrosis factor-alpha polymorphisms and the natural course of hepatitis C virus infection in a hyperendemic area of Japan. Cytokine. 34:24–31. 2006. View Article : Google Scholar : PubMed/NCBI

68 

Houldsworth A, Metzner M, Rossol S, Shaw S, Kaminski E, Demaine AG and Cramp ME: Polymorphisms in the IL-12B gene and outcome of HCV infection. J Interferon Cytokine Res. 25:271–276. 2005. View Article : Google Scholar : PubMed/NCBI

69 

Mueller T, Mas-Marques A, Sarrazin C, Wiese M, Halangk J, Witt H, Ahlenstiel G, Spengler U, Goebel U, Wiedenmann B, et al: Influence of interleukin 12B (IL12B) polymorphisms on spontaneous and treatment-induced recovery from hepatitis C virus infection. J Hepatol. 41:652–658. 2004. View Article : Google Scholar : PubMed/NCBI

70 

Yin LM, Zhu WF, Wei L, Xu XY, Sun DG, Wang YB, Fan WM, Yu M, Tian XL, Wang QX, et al: Association of interleukin-12 p40 gene 3′-untranslated region polymorphism and outcome of HCV infection. World J Gastroenterol. 10:2330–2333. 2004. View Article : Google Scholar : PubMed/NCBI

71 

An P, Thio CL, Kirk GD, Donfield S, Goedert JJ and Winkler CA: Regulatory polymorphisms in the interleukin-18 promoter are associated with hepatitis C virus clearance. J Infect Dis. 198:1159–1165. 2008. View Article : Google Scholar : PubMed/NCBI

72 

Hennig BJ, Frodsham AJ, Hellier S, Knapp S, Yee LJ, Wright M, Zhang L, Thomas HC, Thursz M and Hill AV: Influence of IL-10RA and IL-22 polymorphisms on outcome of hepatitis C virus infection. Liver Int. 27:1134–1143. 2007. View Article : Google Scholar : PubMed/NCBI

73 

Larrea E, Garcia N, Qian C, Civeira MP and Prieto J: Tumor necrosis factor alpha gene expression and the response to interferon in chronic hepatitis C. Hepatology. 23:210–217. 1996. View Article : Google Scholar : PubMed/NCBI

74 

D'Alfonso S and Richiardi PM: A polymorphic variation in a putative regulation box of the TNFA promoter region. Immunogenetics. 39:150–154. 1994. View Article : Google Scholar : PubMed/NCBI

75 

Wilson AG, de Vries N, Pociot F, di Giovine FS, van der Putte LB and Duff GW: An allelic polymorphism within the human tumor necrosis factor alpha promoter region is strongly associated with HLA A1, B8, and DR3 alleles. J Exp Med. 177:557–560. 1993. View Article : Google Scholar : PubMed/NCBI

76 

Wilson AG, Symons JA, McDowell TL, McDevitt HO and Duff GW: Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci USA. 94:3195–3199. 1997. View Article : Google Scholar : PubMed/NCBI

77 

Hohler T, Kruger A, Gerken G, Schneider PM, zum Büschenefelde Meyer KH and Rittner C: A tumor necrosis factor-alpha (TNF-alpha) promoter polymorphism is associated with chronic hepatitis B infection. Clin Exp Immunol. 111:579–582. 1998. View Article : Google Scholar : PubMed/NCBI

78 

Dai CY, Chuang WL, Chang WY, Chen SC, Lee LP, Hsieh MY, Hou NJ, Lin ZY, Huang JF, Hsieh MY, et al: Tumor necrosis factor- alpha promoter polymorphism at position −308 predicts response to combination therapy in hepatitis C virus infection. J Infect Dis. 193:98–101. 2006. View Article : Google Scholar : PubMed/NCBI

79 

Yee LJ, Tang J, Herrera J, Kaslow RA and van Leeuwen DJ: Tumor necrosis factor gene polymorphisms in patients with cirrhosis from chronic hepatitis C virus infection. Genes Immun. 1:386–390. 2000. View Article : Google Scholar : PubMed/NCBI

80 

Schiemann U, Glas J, Török P, Simperl C, Martin K, König A, Schmidt F, Schaefer M and Folwaczny C: Response to combination therapy with interferon alfa-2a and ribavirin in chronic hepatitis C according to a TNF-alpha promoter polymorphism. Digestion. 68:1–4. 2003. View Article : Google Scholar : PubMed/NCBI

81 

Kimura T, Saito T, Yoshimura M, Yixuan S, Baba M, Ji G, Muramatsu M and Kawata S: Association of transforming growth factor-beta 1 functional polymorphisms with natural clearance of hepatitis C virus. J Infect Dis. 193:1371–1374. 2006. View Article : Google Scholar : PubMed/NCBI

82 

Neumann-Haefelin C, Blum HE, Chisari FV and Thimme R: T cell response in hepatitis C virus infection. J Clin Virol. 32:75–85. 2005. View Article : Google Scholar : PubMed/NCBI

83 

Singh R, Kaul R, Kaul A and Khan K: A comparative review of HLA associations with hepatitis B and C viral infections across global populations. World J Gastroenterol. 13:1770–1787. 2007. View Article : Google Scholar : PubMed/NCBI

84 

Alric L, Fort M, Izopet J, Vinel JP, Bureau C, Sandre K, Charlet JP, Beraud M, Abbal M and Duffaut M: Study of host- and virus-related factors associated with spontaneous hepatitis C virus clearance. Tissue Antigens. 56:154–158. 2000. View Article : Google Scholar : PubMed/NCBI

85 

Thursz M, Yallop R, Goldin R, Trepo C and Thomas HC: Influence of MHC class II genotype on outcome of infection with hepatitis C virus. The HENCORE group. Hepatitis C European network for cooperative research. Lancet. 354:2119–2124. 1999. View Article : Google Scholar : PubMed/NCBI

86 

McKiernan SM, Hagan R, Curry M, McDonald GS, Kelly A, Nolan N, Walsh A, Hegarty J, Lawlor E and Kelleher D: Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source. Hepatology. 40:108–114. 2004. View Article : Google Scholar : PubMed/NCBI

87 

Chuang WC, Sarkodie F, Brown CJ, Owusu-Ofori S, Brown J, Li C, Navarrete C, Klenerman P and Allain JP: Protective effect of HLA-B57 on HCV genotype 2 infection in a West African population. J Med Virol. 79:724–733. 2007. View Article : Google Scholar : PubMed/NCBI

88 

Thio CL, Gao X, Goedert JJ, Vlahov D, Nelson KE, Hilgartner MW, O'Brien SJ, Karacki P, Astemborski J, Carrington M and Thomas DL: HLA-Cw*04 and hepatitis C virus persistence. J Virol. 76:4792–4797. 2002. View Article : Google Scholar : PubMed/NCBI

89 

Hraber P, Kuiken C and Yusim K: Evidence for human leukocyte antigen heterozygote advantage against hepatitis C virus infection. Hepatology. 46:1713–1721. 2007. View Article : Google Scholar : PubMed/NCBI

90 

Hong X, Yu RB, Sun NX, Wang B, Xu YC and Wu GL: Human leukocyte antigen class II DQB1*0301, DRB1*1101 alleles and spontaneous clearance of hepatitis C virus infection: A meta-analysis. World J Gastroenterol. 11:7302–7307. 2005. View Article : Google Scholar : PubMed/NCBI

91 

Schmidt J, Thimme R and Neumann-Haefelin C: Host genetics in immune-mediated hepatitis C virus clearance. Biomark Med. 5:155–169. 2011. View Article : Google Scholar : PubMed/NCBI

92 

Khakoo SI, Thio CL, Martin MP, Brooks CR, Gao X, Astemborski J, Cheng J, Goedert JJ, Vlahov D, Hilgartner M, et al: HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science. 305:872–874. 2004. View Article : Google Scholar : PubMed/NCBI

93 

Zúñiga J, Romero V, Azocar J, Terreros D, Vargas- MI, Torres-García D, Jiménez-Alvarez L, Vargas-Alarcón G, Granados-Montiel J, Husain Z, et al: Protective KIR-HLA interactions for HCV infection in intravenous drug users. Mol Immunol. 46:2723–2727. 2009. View Article : Google Scholar : PubMed/NCBI

94 

Lu Z, Zhang B, Chen S, Gai Z, Feng Z, Liu X, Liu Y, Wen X, Li L, Jiao Y, et al: Association of KIR genotypes and haplotypes with susceptibility to chronic hepatitis B virus infection in Chinese Han population. Cell Mol Immunol. 5:457–463. 2008. View Article : Google Scholar : PubMed/NCBI

95 

Dring MM, Morrison MH, McSharry BP, Guinan KJ and Hagan R: Irish HCV Research Consortium, O'Farrelly C and Gardiner CM: Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection. Proc Natl Acad Sci USA. 108:5736–5741. 2011. View Article : Google Scholar : PubMed/NCBI

96 

Knapp S, Warshow U, Hegazy D, Brackenbury L, Guha IN, Fowell A, Little AM, Alexander GJ, Rosenberg WM, Cramp ME and Khakoo SI: Consistent beneficial effects of killer cell immunoglobulin-like receptor 2DL3 and group 1 human leukocyte antigen-C following exposure to hepatitis C virus. Hepatology. 51:1168–1175. 2010. View Article : Google Scholar : PubMed/NCBI

97 

Romero V, Azocar J, Zúñiga J, Clavijo OP, Terreros D, Gu X, Husain Z, Chung RT, Amos C and Yunis EJ: Interaction of NK inhibitory receptor genes with HLA-C and MHC class II alleles in Hepatitis C virus infection outcome. Mol Immunol. 45:2429–2436. 2008. View Article : Google Scholar : PubMed/NCBI

98 

Montes-Cano MA, Caro-Oleas JL, Romero-Gómez M, Diago M, Andrade R, Carmona I, Reina Aguilar J, Núñez-Roldán A and González-Escribano MF: HLA-C and KIR genes in hepatitis C virus infection. Hum Immunol. 66:1106–1109. 2005. View Article : Google Scholar : PubMed/NCBI

99 

Rauch A, Laird R, McKinnon E, Telenti A, Furrer H, Weber R, Smillie D and Gaudieri S: Swiss HIV Cohort Study: Influence of inhibitory killer immunoglobulin-like receptors and their HLA-C ligands on resolving hepatitis C virus infection. Tissue Antigens. 69:(Suppl 1). S237–S240. 2007. View Article : Google Scholar

100 

Schott E, Witt H, Hinrichsen H, Neumann K, Weich V, Bergk A, Halangk J, Müller T, Tinjala S, Puhl G, Neuhaus P, et al: Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infection. J Hepatol. 46:372–380. 2007. View Article : Google Scholar : PubMed/NCBI

101 

Zhu C, Zhang R, Liu D, Mukhtar MM, Liu W, Peng G, Wang K, Hao Q, Xu Y, Liu F, et al: Association of functional polymorphism of ApoB promoter with hepatitis C virus infection. Clin Chim Acta. 401:124–127. 2009. View Article : Google Scholar : PubMed/NCBI

102 

Sarrazin C, Berg T, Ross RS, Schirmacher P, Wedemeyer H, Neumann U, Schmidt HH, Spengler U, Wirth S, Kessler HH, et al: Prophylaxis, diagnosis and therapy of hepatitis C virus (HCV) infection: The German guidelines on the management of HCV infection. Z Gastroenterol. 48:289–351. 2010.(In German). View Article : Google Scholar : PubMed/NCBI

103 

Ge D, Fellay J, Thompson AJ, Simon JS, Shianna KV, Urban TJ, Heinzen EL, Qiu P, Bertelsen AH, Muir AJ, et al: Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature. 461:399–401. 2009. View Article : Google Scholar : PubMed/NCBI

104 

Suppiah V, Moldovan M, Ahlenstiel G, Berg T, Weltman M, Abate ML, Bassendine M, Spengler U, Dore GJ, Powell E, et al: IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Genet. 41:1100–1104. 2009. View Article : Google Scholar : PubMed/NCBI

105 

Tanaka Y, Nishida N, Sugiyama M, Kurosaki M, Matsuura K, Sakamoto N, Nakagawa M, Korenaga M, Hino K, Hige S, et al: Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat Genet. 41:1105–1109. 2009. View Article : Google Scholar : PubMed/NCBI

106 

Antaki N, Bibert S, Kebbewar K, Asaad F, Baroudi O, Alideeb S, Hadad M, Abboud D, Sabah H, Bochud PY and Negro F: IL28B polymorphisms predict response to therapy among chronic hepatitis C patients with HCV genotype 4. J Viral Hepat. 20:59–64. 2013. View Article : Google Scholar : PubMed/NCBI

107 

Rallon NI, Naggie S, Benito JM, Medrano J, Restrepo C, Goldstein D, Shianna KV, Vispo E, Thompson A, McHutchison J and Soriano V: Association of a single nucleotide polymorphism near the interleukin-28B gene with response to hepatitis C therapy in HIV/hepatitis C virus-coinfected patients. AIDS. 24:F23–F29. 2010. View Article : Google Scholar : PubMed/NCBI

108 

Thompson AJ, Muir AJ, Sulkowski MS, Ge D, Fellay J, Shianna KV, Urban T, Afdhal NH, Jacobson IM, Esteban R, et al: Interleukin-28B polymorphism improves viral kinetics and is the strongest pretreatment predictor of sustained virologic response in genotype 1 hepatitis C virus. Gastroenterology. 139:120–129, e18. 2010. View Article : Google Scholar : PubMed/NCBI

109 

Bochud PY, Bibert S, Negro F, Haagmans B, Soulier A, Ferrari C, Missale G, Zeuzem S, Pawlotsky JM, Schalm S, et al: IL28B polymorphisms predict reduction of HCV RNA from the first day of therapy in chronic hepatitis C. J Hepatol. 55:980–988. 2011. View Article : Google Scholar : PubMed/NCBI

110 

Scherzer TM, Hofer H, Staettermayer AF, Rutter K, Beinhardt S, Steindl-Munda P, Kerschner H, Kessler HH and Ferenci P: Early virologic response and IL28B polymorphisms in patients with chronic hepatitis C genotype 3 treated with peginterferon alfa-2a and ribavirin. J Hepatol. 54:866–871. 2011. View Article : Google Scholar : PubMed/NCBI

111 

Yu ML, Huang CF, Huang JF, Chang NC, Yang JF, Lin ZY, Chen SC, Hsieh MY, Wang LY, Chang WY, et al: Role of interleukin-28B polymorphisms in the treatment of hepatitis C virus genotype 2 infection in Asian patients. Hepatology. 53:7–13. 2011. View Article : Google Scholar : PubMed/NCBI

112 

Stättermayer AF, Stauber R, Hofer H, Rutter K, Beinhardt S, Scherzer TM, Zinober K, Datz C, Maieron A, Dulic-Lakovic E, et al: Impact of IL28B genotype on the early and sustained virologic response in treatment-naïve patients with chronic hepatitis C. Clin Gastroenterol Hepatol. 9:344–350, e2. 2011. View Article : Google Scholar : PubMed/NCBI

113 

Jaeckel E, Cornberg M, Wedemeyer H, Santantonio T, Mayer J, Zankel M, Pastore G, Dietrich M, Trautwein C and Manns MP: German Acute Hepatitis C Therapy Group: Treatment of acute hepatitis C with interferon alfa-2b. N Engl J Med. 345:1452–1457. 2001. View Article : Google Scholar : PubMed/NCBI

114 

Wiegand J, Buggisch P, Boecher W, Zeuzem S, Gelbmann CM, Berg T, Kauffmann W, Kallinowski B, Cornberg M and Jaeckel E: Early monotherapy with pegylated interferon alpha-2b for acute hepatitis C infection: The HEP-NET acute-HCV-II study. Hepatology. 43:250–256. 2006. View Article : Google Scholar : PubMed/NCBI

115 

Kamal SM, Fouly AE, Kamel RR, Hockenjos B, Al Tawil A, Khalifa KE, He Q, Koziel MJ, El Naggar KM, Rasenack J and Afdhal NH: Peginterferon alfa-2b therapy in acute hepatitis C: Impact of onset of therapy on sustained virologic response. Gastroenterology. 130:632–638. 2006. View Article : Google Scholar : PubMed/NCBI

116 

Holmes JA, Sievert W and Thompson AJ: IL28B polymorphism and genetic biomarkers of viral clearance in hepatitis C virus infection. Biomark Med. 5:461–478. 2011. View Article : Google Scholar : PubMed/NCBI

117 

Halfon P, Bourliere M, Ouzan D, Maor Y, Renou C, Wartelle C, Pénaranda G, Tran A, Botta D, Oules V, et al: A single IL28B genotype SNP rs12979860 determination predicts treatment response in patients with chronic hepatitis C Genotype 1 virus. Eur J Gastroenterol Hepatol. 23:931–935. 2011. View Article : Google Scholar : PubMed/NCBI

118 

Ghany MG, Nelson DR, Strader DB, Thomas DL and Seeff LB: American Association for Study of Liver Diseases: An update on treatment of genotype 1 chronic hepatitis C virus infection: 2011 practice guideline by the American Association for the study of liver diseases. Hepatology. 54:1433–1444. 2011. View Article : Google Scholar : PubMed/NCBI

119 

Ank N, Iversen MB, Bartholdy C, Staeheli P, Hartmann R, Jensen UB, Dagnaes-Hansen F, Thomsen AR, Chen Z, Haugen H, et al: An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity. J Immunol. 180:2474–2485. 2008. View Article : Google Scholar : PubMed/NCBI

120 

Li M, Liu X, Zhou Y and Su SB: Interferon-lambdas: The modulators of antivirus, antitumor, and immune responses. J Leukoc Biol. 86:23–32. 2009. View Article : Google Scholar : PubMed/NCBI

121 

Honda M, Sakai A, Yamashita T, Nakamoto Y, Mizukoshi E, Sakai Y, Yamashita T, Nakamura M, Shirasaki T, Horimoto K, et al: Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C. Gastroenterology. 139:499–509. 2010. View Article : Google Scholar : PubMed/NCBI

122 

Urban TJ, Thompson AJ, Bradrick SS, Fellay J, Schuppan D, Cronin KD, Hong L, McKenzie A, Patel K, Shianna KV, et al: IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C. Hepatology. 52:1888–1896. 2010. View Article : Google Scholar : PubMed/NCBI

123 

Jacobson IM, Catlett I, Marcellin P, Bzowej NH, Muir AJ, Adda N, Bengtsson L, George S, Seepersaud S, Ramachandram R, et al: 1369 Telaprevir substantially improved SVR rates across all IL28B genotypes in the advance trial. J Hepatology. 54:S542–S543. 2011. View Article : Google Scholar

124 

Bronowicki JP, Hezode C, Bengtsson L, Pol S, Bourliere M, Serfaty L, de Ledinghen V, Tran A, Benhamou Y, Grang JD, et al: 1094 100% SVR in IL28B CC patients treated with 12 weeks of telaprevir, peginterferon and ribavirin in the PROVE2 trial. J Hepatology. 56:S430–S431. 2012. View Article : Google Scholar

125 

Penney MS, De Souza C, Seepersaud S, Alves K, Koziel MJ, Kauffman RS, Di Bisceglie AM and Botfield MC: 1203 All IL28B genotypes have high SVR rates in patients treated with VX-222 in combination with Telaprevir/Peginterferon/Ribavin in the ZENITH study. J Hepatology. 56:S476–S477. 2012. View Article : Google Scholar

126 

Poordad F, Bronowicki JP, Gordon SC, Zeuzem S, Jacobson IM, Sulkowski MS, Poynard TMorgan, TRBurroughs MSniukiene V, et al: 12 IL28B polymorphism predicts virologic response in patients with hepatitis C genotype 1 treated with boceprevir (BOC) combination therapy. J Hepatology. 54:S62011. View Article : Google Scholar

127 

Sulkowski MS, Asselah T, Lalezari J, Ferenci P, Fainboim H, Leggett B, Bessone F, Mauss S, Heo J, Datsenko Y, et al: Faldaprevir combined with pegylated interferon alfa-2a and ribavirin in treatment-naïve patients with chronic genotype 1 HCV: SILEN-C1 trial. Hepatology. 57:2143–2154. 2013. View Article : Google Scholar : PubMed/NCBI

128 

Chu TW, Kulkarni R, Gane EJ, Roberts SK, Stedman C, Angus PW, Ritchie B, Lu XY, Ipe D, Lopatin U, et al: Effect of IL28B genotype on early viral kinetics during interferon-free treatment of patients with chronic hepatitis C. Gastroenterology. 142:790–795. 2012. View Article : Google Scholar : PubMed/NCBI

129 

Liu S, Cipriano LE, Holodniy M, Owens DK and Goldhaber-Fiebert JD: New protease inhibitors for the treatment of chronic hepatitis C: A cost-effectiveness analysis. Ann Intern Med. 156:279–290. 2012. View Article : Google Scholar : PubMed/NCBI

130 

Hijikata M, Ohta Y and Mishiro S: Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt −88) correlated with the response of hepatitis C patients to interferon. Intervirology. 43:124–127. 2000. View Article : Google Scholar : PubMed/NCBI

131 

Knapp S, Yee LJ, Frodsham AJ, Hennig BJ, Hellier S, Zhang L, Wright M, Chiaramonte M, Graves M, Thomas HC, et al: Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: Roles of MxA, OAS-1 and PKR. Genes Immun. 4:411–419. 2003. View Article : Google Scholar : PubMed/NCBI

132 

Suzuki F, Arase Y, Suzuki Y, Tsubota A, Akuta N, Hosaka T, Someya T, Kobayashi M, Saitoh S, Ikeda K, et al: Single nucleotide polymorphism of the MxA gene promoter influences the response to interferon monotherapy in patients with hepatitis C viral infection. J Viral Hepat. 11:271–276. 2004. View Article : Google Scholar : PubMed/NCBI

133 

El Bader Din NG, Salum GM, Anany MA, Ibrahim MK, Dawood RM, Zayed N, El Abd YS, El-Shenawy R and El Awady MK: Association of myxovirus resistance gene promoter polymorphism with response to combined interferon treatment and progression of liver disease in chronic HCV egyptian patients. J Interferon Cytokine Res. 35:641–648. 2015. View Article : Google Scholar : PubMed/NCBI

134 

Persico M, Capasso M, Russo R, Persico E, Crocè L, Tiribelli C and Iolascon A: Elevated expression and polymorphisms of SOCS3 influence patient response to antiviral therapy in chronic hepatitis C. Gut. 57:507–515. 2008. View Article : Google Scholar : PubMed/NCBI

135 

Welzel TM, Morgan TR, Bonkovsky HL, Naishadham D, Pfeiffer RM, Wright EC, Hutchinson AA, Crenshaw AT, Bashirova A, Carrington M, et al: Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial. Hepatology. 49:1847–1858. 2009. View Article : Google Scholar : PubMed/NCBI

136 

Su X, Yee LJ, Im K, Rhodes SL, Tang Y, Tong X, Howell C, Ramcharran D, Rosen HR, Taylor MW, et al: Association of single nucleotide polymorphisms in interferon signaling pathway genes and interferon-stimulated genes with the response to interferon therapy for chronic hepatitis C. J Hepatol. 49:184–191. 2008. View Article : Google Scholar : PubMed/NCBI

137 

Constantini PK, Wawrzynowicz-Syczewska M, Clare M, Boron-Kaczmarska A, McFarlane IG, Cramp ME and Donaldson PT: Interleukin-1, interleukin-10 and tumour necrosis factor-alpha gene polymorphisms in hepatitis C virus infection: An investigation of the relationships with spontaneous viral clearance and response to alpha-interferon therapy. Liver. 22:404–412. 2002. View Article : Google Scholar : PubMed/NCBI

138 

Edwards-Smith CJ, Jonsson JR, Purdie DM, Bansal A, Shorthouse C and Powell EE: Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alfa. Hepatology. 30:526–530. 1999. View Article : Google Scholar : PubMed/NCBI

139 

Vidigal PG, Germer JJ and Zein NN: Polymorphisms in the interleukin-10, tumor necrosis factor-alpha and transforming growth factor-beta1 genes in chronic hepatitis C patients treated with interferon and ribavirin. J Hepatol. 36:271–277. 2002. View Article : Google Scholar : PubMed/NCBI

140 

Gracie JA, Robertson SE and McInnes IB: Interleukin-18. J Leukoc Biol. 73:213–224. 2003. View Article : Google Scholar : PubMed/NCBI

141 

Nakanishi K, Yoshimoto T, Tsutsui H and Okamura H: Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev. 12:53–72. 2001. View Article : Google Scholar : PubMed/NCBI

142 

Tsutsui H, Adachi K, Seki E and Nakanishi K: Cytokine-induced inflammatory liver injuries. Curr Mol Med. 3:545–559. 2003. View Article : Google Scholar : PubMed/NCBI

143 

Haas SL, Weiss C, Bugert P, Gundt J, Witt H, Singer MV, Berg T and Böcker U: Interleukin 18 promoter variants (−137G>C and −607C>A) in patients with chronic hepatitis C: Association with treatment response. J Clin Immunol. 29:620–628. 2009. View Article : Google Scholar : PubMed/NCBI

144 

Giedraitis V, He B, Huang WX and Hillert J: Cloning and mutation analysis of the human IL-18 promoter: A possible role of polymorphisms in expression regulation. J Neuroimmunol. 112:146–152. 2001. View Article : Google Scholar : PubMed/NCBI

145 

Rosen HR, McHutchison JG, Conrad AJ, Lentz JJ, Marousek G, Rose SL, Zaman A, Taylor K and Chou S: Tumor necrosis factor genetic polymorphisms and response to antiviral therapy in patients with chronic hepatitis C. Am J Gastroenterol. 97:714–720. 2002. View Article : Google Scholar : PubMed/NCBI

146 

Neuman MG, Benhamou JP, Martinot M, Boyer N, Shear NH, Malkiewicz I, Katz GG, Suneja A, Singh S and Marcellin P: Predictors of sustained response to alpha interferon therapy in chronic hepatitis C. Clin Biochem. 32:537–545. 1999. View Article : Google Scholar : PubMed/NCBI

147 

Wasmuth HE, Werth A, Mueller T, Berg T, Dietrich CG, Geier A, Gartung C, Lorenzen J, Matern S and Lammert F: Haplotype-tagging RANTES gene variants influence response to antiviral therapy in chronic hepatitis C. Hepatology. 40:327–334. 2004. View Article : Google Scholar : PubMed/NCBI

148 

Huang Y, Yang H, Borg BB, Su X, Rhodes SL, Yang K, Tong X, Tang G, Howell CD, Rosen HR, et al: A functional SNP of interferon-gamma gene is important for interferon-alpha-induced and spontaneous recovery from hepatitis C virus infection. Proc Natl Acad Sci USA. 104:985–990. 2007. View Article : Google Scholar : PubMed/NCBI

149 

Almarri A, El Dwick N, Al Kabi S, Sleem K, Rashed A, Ritter MA and Batchelor JR: Interferon-alpha therapy in HCV hepatitis: HLA phenotype and cirrhosis are independent predictors of clinical outcome. Hum Immunol. 59:239–242. 1998. View Article : Google Scholar : PubMed/NCBI

150 

Romero-Gomez M, González-Escribano MF, Torres B, Barroso N, Montes-Cano MA, Sánchez-Muñoz D, Núñez-Roldan A and Aguilar-Reina J: HLA class I B44 is associated with sustained response to interferon + ribavirin therapy in patients with chronic hepatitis C. Am J Gastroenterol. 98:1621–1626. 2003. View Article : Google Scholar : PubMed/NCBI

151 

Jiao J and Wang JB: Hepatitis C virus genotypes, HLA-DRB alleles and their response to interferon-alpha and ribavirin in patients with chronic hepatitis C. Hepatobiliary Pancreat Dis Int. 4:80–83. 2005.PubMed/NCBI

152 

Lindemann M, Virchow S, Ramann F, Barsegian V, Kreuzfelder E, Siffert W, Müller N and Grosse-Wilde H: The G protein beta3 subunit 825T allele is a genetic marker for enhanced T cell response. FEBS Lett. 495:82–86. 2001. View Article : Google Scholar : PubMed/NCBI

153 

Sarrazin C, Berg T, Weich V, Mueller T, Frey UH, Zeuzem S, Gerken G, Roggendorf M and Siffert W: GNB3 C825T polymorphism and response to interferon-alfa/ribavirin treatment in patients with hepatitis C virus genotype 1 (HCV-1) infection. J Hepatol. 43:388–393. 2005. View Article : Google Scholar : PubMed/NCBI

154 

Ahlenstiel G, Nischalke HD, Bueren K, Berg T, Vogel M, Biermer M, Grünhage F, Sauerbruch T, Rockstroh J, Spengler U and Nattermann J: The GNB3 C825T polymorphism affects response to HCV therapy with pegylated interferon in HCV/HIV co-infected but not in HCV mono-infected patients. J Hepatol. 47:348–355. 2007. View Article : Google Scholar : PubMed/NCBI

155 

Schott E, Witt H, Neumann K, Bergk A, Halangk J, Weich V, Müller T, Puhl G, Wiedenmann B and Berg T: Association of TLR7 single nucleotide polymorphisms with chronic HCV-infection and response to interferon-a-based therapy. J Viral Hepat. 15:71–78. 2008.PubMed/NCBI

156 

Lebray P, Zylberberg H, Hue S, Poulet B, Carnot F, Martin S, Chretien Y, Pol S, Caillat-Zuckman S, Bréchot C and Nalpas B: Influence of HFE gene polymorphism on the progression and treatment of chronic hepatitis C. J Viral Hepat. 11:175–182. 2004. View Article : Google Scholar : PubMed/NCBI

157 

Yee LJ, Perez KA, Tang J, van Leeuwen DJ and Kaslow RA: Association of CTLA4 polymorphisms with sustained response to interferon and ribavirin therapy for chronic hepatitis C virus infection. J Infect Dis. 187:1264–1271. 2003. View Article : Google Scholar : PubMed/NCBI

158 

Patton HM, Patel K, Behling C, Bylund D, Blatt LM, Vallée M, Heaton S, Conrad A, Pockros PJ and McHutchison JG: The impact of steatosis on disease progression and early and sustained treatment response in chronic hepatitis C patients. J Hepatol. 40:484–490. 2004. View Article : Google Scholar : PubMed/NCBI

159 

Westin J, Lagging M, Dhillon AP, Norkrans G, Romero AI, Pawlotsky JM, Zeuzem S, Schalm SW, Verheij-Hart E, Negro F, et al: Impact of hepatic steatosis on viral kinetics and treatment outcome during antiviral treatment of chronic HCV infection. J Viral Hepat. 14:29–35. 2007. View Article : Google Scholar : PubMed/NCBI

160 

Shah SR, Patel K, Marcellin P, Foster GR, Manns M, Kottilil S, Healey L, Pulkstenis E, Subramanian GM, McHutchison JG, et al: Steatosis is an independent predictor of relapse following rapid virologic response in patients with HCV genotype 3. Clin Gastroenterol Hepatol. 9:688–693. 2011. View Article : Google Scholar : PubMed/NCBI

161 

Restivo L, Zampino R, Guerrera B, Ruggiero L and Adinolfi LE: Steatosis is the predictor of relapse in HCV genotype 3- but not 2-infected patients treated with 12 weeks of pegylated interferon-α-2a plus ribavirin and RVR. J Viral Hepat. 19:346–352. 2012. View Article : Google Scholar : PubMed/NCBI

162 

Conjeevaram HS, Kleiner DE, Everhart JE, Hoofnagle JH, Zacks S, Afdhal NH and Wahed AS: Virahep-C Study Group: Race, insulin resistance and hepatic steatosis in chronic hepatitis C. Hepatology. 45:80–87. 2007. View Article : Google Scholar : PubMed/NCBI

163 

Tarantino G, Conca P, Sorrentino P and Ariello M: Metabolic factors involved in the therapeutic response of patients with hepatitis C virus-related chronic hepatitis. J Gastroenterol Hepatol. 21:1266–1268. 2006. View Article : Google Scholar : PubMed/NCBI

164 

Hanouneh IA, Feldstein AE, Lopez R, Yerian L, Pillai A, Zein CO and Zein NN: Clinical significance of metabolic syndrome in the setting of chronic hepatitis C virus infection. Clin Gastroenterol Hepatol. 6:584–589. 2008. View Article : Google Scholar : PubMed/NCBI

165 

Shirakawa H, Matsumoto A, Joshita S, Komatsu M, Tanaka N, Umemura T, Ichijo T, Yoshizawa K, Kiyosawa K and Tanaka E: Nagano Interferon Treatment Research Group: Pretreatment prediction of virological response to peginterferon plus ribavirin therapy in chronic hepatitis C patients using viral and host factors. Hepatology. 48:1753–1760. 2008. View Article : Google Scholar : PubMed/NCBI

166 

Zeuzem S: Heterogeneous virologic response rates to interferon-based therapy in patients with chronic hepatitis C: Who responds less well? Ann Intern Med. 140:370–381. 2004.PubMed/NCBI

167 

Fellay J, Thompson AJ, Ge D, Gumbs CE, Urban TJ, Shianna KV, Little LD, Qiu P, Bertelsen AH, Watson M, et al: ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. Nature. 464:405–408. 2010. View Article : Google Scholar : PubMed/NCBI

168 

Thompson AJ, Clark PJ, Singh A, Ge D, Fellay J, Zhu M, Zhu Q, Urban TJ, Patel K, Tillmann HL, et al: Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients. J Hepatol. 56:313–319. 2012. View Article : Google Scholar : PubMed/NCBI

169 

Thompson AJ, Fellay J, Patel K, Tillmann HL, Naggie S, Ge D, Urban TJ, Shianna KV, Muir AJ, Fried MW, et al: Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction. Gastroenterology. 139:1181–1189. 2010. View Article : Google Scholar : PubMed/NCBI

170 

Thompson AJ, Santoro R, Piazzolla V, Clark PJ, Naggie S, Tillmann HL, Patel K, Muir AJ, Shianna KV, Mottola L, et al: Inosine triphosphatase genetic variants are protective against anemia during antiviral therapy for HCV2/3 but do not decrease dose reductions of RBV or increase SVR. Hepatology. 53:389–395. 2011. View Article : Google Scholar : PubMed/NCBI

171 

Hitomi Y, Cirulli ET, Fellay J, McHutchison JG, Thompson AJ, Gumbs CE, Shianna KV, Urban TJ and Goldstein DB: Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function. Gastroenterology. 140:1314–1321. 2011. View Article : Google Scholar : PubMed/NCBI

172 

Gochee PA, Powell EE, Purdie DM, Pandeya N, Kelemen L, Shorthouse C, Jonsson JR and Kelly B: Association between apolipoprotein E epsilon4 and neuropsychiatric symptoms during interferon alpha treatment for chronic hepatitis C. Psychosomatics. 45:49–57. 2004. View Article : Google Scholar : PubMed/NCBI

173 

Horsburgh K, McCarron MO, White F and Nicoll JA: The role of apolipoprotein E in Alzheimer's disease, acute brain injury and cerebrovascular disease: Evidence of common mechanisms and utility of animal models. Neurobiol Aging. 21:245–255. 2000. View Article : Google Scholar : PubMed/NCBI

174 

Wada M, Marusawa H, Yamada R, Nasu A, Osaki Y, Kudo M, Nabeshima M, Fukuda Y, Chiba T and Matsuda F: Association of genetic polymorphisms with interferon-induced haematologic adverse effects in chronic hepatitis C patients. J Viral Hepat. 16:388–396. 2009. View Article : Google Scholar : PubMed/NCBI

175 

Poynard T, Bedossa P and Opolon P: Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups. Lancet. 349:825–832. 1997. View Article : Google Scholar : PubMed/NCBI

176 

Thomas DL, Astemborski J, Rai RM, Anania FA, Schaeffer M, Galai N, Nolt K, Nelson KE, Strathdee SA, Johnson L, et al: The natural history of hepatitis C virus infection: Host, viral, and environmental factors. JAMA. 284:450–456. 2000. View Article : Google Scholar : PubMed/NCBI

177 

Davis GL, Alter MJ, El-Serag H, Poynard T and Jennings LW: Aging of hepatitis C virus (HCV)-infected persons in the United States: A multiple cohort model of HCV prevalence and disease progression. Gastroenterology. 138:513–521. 2010. View Article : Google Scholar : PubMed/NCBI

178 

Missiha SB, Ostrowski M and Heathcote EJ: Disease progression in chronic hepatitis C: Modifiable and nonmodifiable factors. Gastroenterology. 134:1699–1714. 2008. View Article : Google Scholar : PubMed/NCBI

179 

Wright M, Goldin R, Fabre A, Lloyd J, Thomas H, Trepo C, Pradat P and Thursz M: HENCORE collaboration: Measurement and determinants of the natural history of liver fibrosis in hepatitis C virus infection: A cross sectional and longitudinal study. Gut. 52:574–579. 2003. View Article : Google Scholar : PubMed/NCBI

180 

Bataller R, North KE and Brenner DA: Genetic polymorphisms and the progression of liver fibrosis: A critical appraisal. Hepatology. 37:493–503. 2003. View Article : Google Scholar : PubMed/NCBI

181 

Huang H, Shiffman ML, Friedman S, Venkatesh R, Bzowej N, Abar OT, Rowland CM, Catanese JJ, Leong DU, Sninsky JJ, et al: A 7 gene signature identifies the risk of developing cirrhosis in patients with chronic hepatitis C. Hepatology. 46:297–306. 2007. View Article : Google Scholar : PubMed/NCBI

182 

Marcolongo M, Young B, Dal Pero F, Fattovich G, Peraro L, Guido M, Sebastiani G, Palù G and Alberti A: A seven-gene signature (cirrhosis risk score) predicts liver fibrosis progression in patients with initially mild chronic hepatitis C. Hepatology. 50:1038–1044. 2009. View Article : Google Scholar : PubMed/NCBI

183 

Trepo E, Potthoff A, Pradat P, Bakshi R, Young B, Lagier R, Moreno C, Verset L, Cross R, Degré D, et al: Role of a cirrhosis risk score for the early prediction of fibrosis progression in hepatitis C patients with minimal liver disease. J Hepatol. 55:38–44. 2011. View Article : Google Scholar : PubMed/NCBI

184 

Thompson AJ, Clark PJ, Zhu M, Ge D, Sulkowski MS, Muir AJ, Tillmann HL, Patel K, Naggie S, Afdhal NH, et al: Genome wide-association study identifies IL28B polymorphism to be associated with baseline ALT and hepatic necro-inflammatory activity in chronic hepatitis C patients enrolled in the IDEAL study. Journal. 52:1220A–1221A. 2010.

185 

Stickel F, Buch S, Lau K, zu Schwabedissen Meyer H, Berg T, Ridinger M, Rietschel M, Schafmayer C, Braun F, Hinrichsen H, et al: Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians. Hepatology. 53:86–95. 2011. View Article : Google Scholar : PubMed/NCBI

186 

Trépo E, Pradat P, Potthoff A, Momozawa Y, Quertinmont E, Gustot T, Lemmers A, Berthillon P, Amininejad L, Chevallier M, et al: Impact of patatin-like phospholipase-3 (rs738409 C>G) polymorphism on fibrosis progression and steatosis in chronic hepatitis C. Hepatology. 54:60–69. 2011. View Article : Google Scholar : PubMed/NCBI

187 

Dunn W, O'Neil M, Zhao J, Wu CH, Roberts B, Chakraborty S, Sherman C, Weaver B, Taylor R, Olson J, et al: Donor PNPLA3 rs738409 genotype affects fibrosis progression in liver transplantation for hepatitis C. Hepatology. 59:453–460. 2014. View Article : Google Scholar : PubMed/NCBI

188 

Valenti L, Aghemo A, Stättermayer AF, Maggioni P, De Nicola S, Motta BM, Rumi MG, Dongiovanni P, Ferenci P, Colombo M and Fargion S: Implications of PNPLA3 polymorphism in chronic hepatitis C patients receiving peginterferon plus ribavirin. Aliment Pharmacol Ther. 35:1434–1442. 2012. View Article : Google Scholar : PubMed/NCBI

189 

Nakamura M, Kanda T, Nakamoto S, Miyamura T, Jiang X, Wu S and Yokosuka O: No correlation between PNPLA3 rs738409 genotype and fatty liver and hepatic cirrhosis in Japanese patients with HCV. PLoS One. 8:e813122013. View Article : Google Scholar : PubMed/NCBI

190 

Patin E, Kutalik Z, Guergnon J, Bibert S, Nalpas B, Jouanguy E, Munteanu M, Bousquet L, Argiro L, Halfon P, et al: Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection. Gastroenterology. 143:1244–1252, e1-12. 2012. View Article : Google Scholar : PubMed/NCBI

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Spandidos Publications style
Yan Z and Wang Y: Viral and host factors associated with outcomes of hepatitis C virus infection (Review). Mol Med Rep 15: 2909-2924, 2017.
APA
Yan, Z., & Wang, Y. (2017). Viral and host factors associated with outcomes of hepatitis C virus infection (Review). Molecular Medicine Reports, 15, 2909-2924. https://doi.org/10.3892/mmr.2017.6351
MLA
Yan, Z., Wang, Y."Viral and host factors associated with outcomes of hepatitis C virus infection (Review)". Molecular Medicine Reports 15.5 (2017): 2909-2924.
Chicago
Yan, Z., Wang, Y."Viral and host factors associated with outcomes of hepatitis C virus infection (Review)". Molecular Medicine Reports 15, no. 5 (2017): 2909-2924. https://doi.org/10.3892/mmr.2017.6351
Copy and paste a formatted citation
x
Spandidos Publications style
Yan Z and Wang Y: Viral and host factors associated with outcomes of hepatitis C virus infection (Review). Mol Med Rep 15: 2909-2924, 2017.
APA
Yan, Z., & Wang, Y. (2017). Viral and host factors associated with outcomes of hepatitis C virus infection (Review). Molecular Medicine Reports, 15, 2909-2924. https://doi.org/10.3892/mmr.2017.6351
MLA
Yan, Z., Wang, Y."Viral and host factors associated with outcomes of hepatitis C virus infection (Review)". Molecular Medicine Reports 15.5 (2017): 2909-2924.
Chicago
Yan, Z., Wang, Y."Viral and host factors associated with outcomes of hepatitis C virus infection (Review)". Molecular Medicine Reports 15, no. 5 (2017): 2909-2924. https://doi.org/10.3892/mmr.2017.6351
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