Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-2017 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2017 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Suppression of nuclear factor erythroid‑2‑related factor 2‑mediated antioxidative defense in the lung injury induced by chronic exposure to methamphetamine in rats

  • Authors:
    • Yang Bai
    • Yun Wang
    • Ming Liu
    • Yu‑Han Gu
    • Bin Jiang
    • Xu Wu
    • Huai‑Liang Wang
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Pharmacology, School of Pharmacy, China Medical University, Shenyang, Liaoning 110122, P.R. China, Department of Drug Control, China Criminal Police University, Shenyang, Liaoning 110035, P.R. China, Department of Cardiovascular Ultrasound, The First Hospital, China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang, Liaoning 110122, P.R. China
  • Pages: 3135-3142
    |
    Published online on: March 22, 2017
       https://doi.org/10.3892/mmr.2017.6356
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The imbalance between oxidative stress and antioxidant defense is important in the pathogenesis of lung diseases. Nuclear factor erythroid‑2‑related factor 2 (Nrf2) is a key transcriptional factor that regulates the antioxidant response. The purpose of the present study was to investigate whether Nrf2‑mediated antioxidative defense is involved in methamphetamine (MA)‑induced lung injury in rats. Following establishment of chronic MA toxicity in rats, Doppler ultrasonic detection was used to measure the changes of physiological indexes, followed by hematoxylin and eosin staining, ELISA and western blot analysis. MA was demonstrated to increase the heart rate and peak blood flow velocity of pulmonary arterial valves and to decrease the survival rate of rats, and resulted in lung injury characterized by perivascular exudates, airspace edema, slight hemorrhage and inflammatory cell infiltration. MA significantly inhibited the expression of nuclear Nrf2 protein and its target genes (glutamate‑cysteine ligase catalytic subunit C and heme oxygenase‑1), and dose‑dependently reduced glutathione (GSH) levels and the ratio of GSH/oxidized glutathione, accompanied by increases in reactive oxygen species (ROS) levels in rat lungs. Linear regression analysis revealed that there was a positive correlation between lung ROS level and lung injury indexes. These findings suggested that chronic exposure to MA led to lung injury by suppression of Nrf2‑mediated antioxidative defense, suggesting that Nrf2 may be an important therapeutic target for MA‑induced chronic lung toxicity.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Patel D, Desai GM, Frases S, Cordero RJ, DeLeon-Rodriguez CM, Eugenin EA, Nosanchuk JD and Martinez LR: Methamphetamine enhances Cryptococcus neoformans pulmonary infection and dissemination to the brain. MBio. 4:pii: e00400. –13. 2013. View Article : Google Scholar

2 

Rothman RB and Baumann MH: Methamphetamine and idiopathic pulmonary arterial hypertension: Role of the serotonin transporter. Chest. 132:1412–1413. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Volkow ND, Fowler JS, Wang GJ, Shumay E, Telang F, Thanos PK and Alexoff D: Distribution and pharmacokinetics of methamphetamine in the human body: Clinical implications. PLoS One. 5:e152692010. View Article : Google Scholar : PubMed/NCBI

4 

Eba S, Hoshikawa Y, Moriguchi T, Mitsuishi Y, Satoh H, Ishida K, Watanabe T, Shimizu T, Shimokawa H, Okada Y, et al: The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice. Am J Respir Cell Mol Biol. 49:324–333. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Van Houten B: Pulmonary arterial hypertension is associated with oxidative stress-induced genome instability. Am J Respir Crit Care Med. 192:129–130. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Ushio-Fukai M: Localizing NADPH oxidase-derived ROS. Sci STKE. 2006:re82006.PubMed/NCBI

7 

Auten RL and Davis JM: Oxygen toxicity and reactive oxygen species: The devil is in the details. Pediatr Res. 66:121–127. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Chiou SY, Lee YS, Jeng MJ, Tsao PC and Soong WJ: Moderate hypothermia attenuates oxidative stress injuries in alveolar epithelial A549 cells. Exp Lung Res. 39:217–228. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Huang CH, Yang ML, Tsai CH, Li YC, Lin YJ and Kuan YH: Ginkgo biloba leaves extract (EGb 761) attenuates lipopolysaccharide-induced acute lung injury via inhibition of oxidative stress and NF-κB-dependent matrix metalloproteinase-9 pathway. Phytomedicine. 20:303–309. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Wang Y, Liu M, Wang HM, Bai Y, Zhang XH, Sun YX and Wang HL: Involvement of serotonin mechanism in methamphetamine-induced chronic pulmonary toxicity in rats. Hum Exp Toxicol. 32:736–746. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Montes S, Juárez-Rebollar D, Nava-Ruíz C, Sánchez-García A, Heras-Romero Y, Rios C and Méndez-Armenta M: Immunohistochemical study of Nrf2-antioxidant response element as indicator of oxidative stress induced by cadmium in developing rats. Oxid Med Cell Longev. 2015:5706502015. View Article : Google Scholar : PubMed/NCBI

12 

Komaravelli N and Casola A: Respiratory viral infections and subversion of cellular antioxidant defenses. J Pharmacogenomics Pharmacoproteomics. 5:pii: 1000141. 2014.PubMed/NCBI

13 

Kim SG, Lee WH and Kim YW: Nrf2 (NF-E2-Related Factor2)Encyclopedia of Signaling Molecules. Choi S: 1st. Springer; New York, NY: pp. 1262–1268. 2012

14 

Kim J, Cha YN and Surh YJ: A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders. Mutat Res. 690:12–23. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Atia AE and Abdullah AB: Modulation of Nrf2/Keap1 pathway by dietary phytochemicals. Int J Res Med Sci. 2:375–381. 2014. View Article : Google Scholar

16 

D'Oria V, Petrini S, Travaglini L, Priori C, Piermarini E, Petrillo S, Carletti B, Bertini E and Piemonte F: Frataxin deficiency leads to reduced expression and impaired translocation of NF-E2-related factor (Nrf2) in cultured motor neurons. Int J Mol Sci. 14:7853–7865. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Chiang HS and Maric M: Lysosomal thiol reductase negatively regulates autophagy by altering glutathione synthesis and oxidation. Free Radic Biol Med. 51:688–699. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Howden R: Nrf2 and cardiovascular defense. Oxid Med Cell Longev. 2013:1043082013. View Article : Google Scholar : PubMed/NCBI

19 

Liu M, Wang Y, Wang HM, Bai Y, Zhang XH, Sun YX and Wang HL: Fluoxetine attenuates chronic methamphetamine-induced pulmonary arterial remodelling: Possible involvement of serotonin transporter and serotonin 1B receptor. Basic Clin Pharmacol Toxicol. 112:77–82. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Zhao Z, Tang X, Zhao X, Zhang M, Zhang W, Hou S, Yuan W, Zhang H, Shi L, Jia H, et al: Tylvalosin exhibits anti-inflammatory property and attenuates acute lung injury in different models possibly through suppression of NF-κB activation. Biochem Pharmacol. 90:73–87. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Kudo K, Terae S, Ishii A, Omatsu T, Asano T, Tha KK and Miyasaka K: Physiologic change in flow velocity and direction of dural venous sinuses with respiration: MR venography and flow analysis. AJNR Am J Neuroradiol. 25:551–557. 2004.PubMed/NCBI

22 

Halimi KE, Negadi M, Bouguetof H, Zemour L, Boumendil D and Mentouri Chentouf Z: Respiratory variations in aortic blood flow velocity and inferior vena cava diameter as predictors of fluid responsiveness in mechanically ventilated children using transthoracic echocardiography in a pediatric PICU. Critical Care. 19:(Suppl 1). S1812015. View Article : Google Scholar

23 

Qin T, Yin Y, Yu Q and Yang Q: Bursopentin (BP5) protects dendritic cells from lipopolysaccharide-induced oxidative stress for immunosuppression. PLoS One. 10:e01174772015. View Article : Google Scholar : PubMed/NCBI

24 

Wells SM, Buford MC, Braseth SN, Hutchison JD and Holian A: Acute inhalation exposure to vaporized methamphetamine causes lung injury in mice. Inhal Toxicol. 20:829–838. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Baylor PA, Sobenes JR and Vallyathan V: Interstitial pulmonary fibrosis and progressive massive fibrosis related to smoking methamphetamine with talc as filler. Respir Care. 58:e53–e55. 2013.PubMed/NCBI

26 

Antus B, Drozdovszky O, Barta I and Kelemen K: Comparison of airway and systemic malondialdehyde levels for assessment of oxidative stress in cystic fibrosis. Lung. 193:597–604. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Sellamuthu PS, Arulselvan P, Kamalraj S, Fakurazi S and Kandasamy M: Protective nature of mangiferin on oxidative stress and antioxidant status in tissues of streptozotocin-induced diabetic rats. ISRN Pharmacol. 2013:7501092013. View Article : Google Scholar : PubMed/NCBI

28 

Singh S, Vrishni S, Singh BK, Rahman I and Kakkar P: Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases. Free Radic Res. 44:1267–1288. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Kovac S, Angelova PR, Holmström KM, Zhang Y, Dinkova-Kostova AT and Abramov AY: Nrf2 regulates ROS production by mitochondria and NADPH oxidase. Biochim Biophys Acta. 1850:794–801. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Messier EM, Day BJ, Bahmed K, Kleeberger SR, Tuder RM, Bowler RP, Chu HW, Mason RJ and Kosmider B: N-acetylcysteine protects murine alveolar type II cells from cigarette smoke injury in a nuclear erythroid 2-related factor-2-independent manner. Am J Respir Cell Mol Biol. 48:559–567. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Masuda Y, Vaziri ND, Li S, Le A, Hajighasemi-Ossareh M, Robles L, Foster CE, Stamos MJ, Al-Abodullah I, Ricordi C and Ichii H: The effect of Nrf2 pathway activation on human pancreatic islet cells. PLoS One. 10:e01310122015. View Article : Google Scholar : PubMed/NCBI

32 

Ishii T, Itoh K, Takahashi S, Sato H, Yanagawa T, Katoh Y, Bannai S and Yamamoto M: Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem. 275:16023–16029. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Richie JP Jr, Nichenametla S, Neidig W, Calcagnotto A, Haley JS, Schell TD and Muscat JE: Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr. 54:251–263. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Sinha-Hikim I, Shen R, Kovacheva E, Crum A, Vaziri ND and Norris KC: Inhibition of apoptotic signalling in spermine-treated vascular smooth muscle cells by a novel glutathione precursor. Cell Biol Int. 34:503–511. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Kim SH, Smith AJ, Tan J, Shytle RD and Giunta B: MSM ameliorates HIV-1 Tat induced neuronal oxidative stress via rebalance of the glutathione cycle. Am J Transl Res. 7:328–338. 2015.PubMed/NCBI

36 

Yang SR, Park JR and Kang KS: Reactive oxygen species in mesenchymal stem cell aging: Implication to lung diseases. Oxid Med Cell Longev. 2015:4862632015. View Article : Google Scholar : PubMed/NCBI

37 

Jayakumar S, Kunwar A, Sandur SK, Pandey BN and Chaubey RC: Differential response of DU145 and PC3 prostate cancer cells to ionizing radiation: Role of reactive oxygen species, GSH and Nrf2 in radiosensitivity. Biochim Biophys Acta. 1840:485–494. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Xia R, Xu J, Yin H, Wu H, Xia Z, Zhou D, Xia ZY, Zhang L, Li H and Xiao X: Intravenous infusion of dexmedetomidine combined isoflurane inhalation reduces oxidative stress and potentiates hypoxia pulmonary vasoconstriction during one-lung ventilation in patients. Mediators Inflamm. 2015:2380412015. View Article : Google Scholar : PubMed/NCBI

39 

Yang X, Yao H, Chen Y, Sun L, Li Y, Ma X, Duan S, Li X, Xiang R, Han J and Duan Y: Inhibition of glutathione production induces macrophage CD36 expression and enhances cellular-oxidized low density lipoprotein (oxLDL) uptake. J Biol Chem. 290:21788–21799. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Bai Y, Wang Y, Liu M, Gu YH, Jiang B, Wu X and Wang HL: Suppression of nuclear factor erythroid‑2‑related factor 2‑mediated antioxidative defense in the lung injury induced by chronic exposure to methamphetamine in rats. Mol Med Rep 15: 3135-3142, 2017.
APA
Bai, Y., Wang, Y., Liu, M., Gu, Y., Jiang, B., Wu, X., & Wang, H. (2017). Suppression of nuclear factor erythroid‑2‑related factor 2‑mediated antioxidative defense in the lung injury induced by chronic exposure to methamphetamine in rats. Molecular Medicine Reports, 15, 3135-3142. https://doi.org/10.3892/mmr.2017.6356
MLA
Bai, Y., Wang, Y., Liu, M., Gu, Y., Jiang, B., Wu, X., Wang, H."Suppression of nuclear factor erythroid‑2‑related factor 2‑mediated antioxidative defense in the lung injury induced by chronic exposure to methamphetamine in rats". Molecular Medicine Reports 15.5 (2017): 3135-3142.
Chicago
Bai, Y., Wang, Y., Liu, M., Gu, Y., Jiang, B., Wu, X., Wang, H."Suppression of nuclear factor erythroid‑2‑related factor 2‑mediated antioxidative defense in the lung injury induced by chronic exposure to methamphetamine in rats". Molecular Medicine Reports 15, no. 5 (2017): 3135-3142. https://doi.org/10.3892/mmr.2017.6356
Copy and paste a formatted citation
x
Spandidos Publications style
Bai Y, Wang Y, Liu M, Gu YH, Jiang B, Wu X and Wang HL: Suppression of nuclear factor erythroid‑2‑related factor 2‑mediated antioxidative defense in the lung injury induced by chronic exposure to methamphetamine in rats. Mol Med Rep 15: 3135-3142, 2017.
APA
Bai, Y., Wang, Y., Liu, M., Gu, Y., Jiang, B., Wu, X., & Wang, H. (2017). Suppression of nuclear factor erythroid‑2‑related factor 2‑mediated antioxidative defense in the lung injury induced by chronic exposure to methamphetamine in rats. Molecular Medicine Reports, 15, 3135-3142. https://doi.org/10.3892/mmr.2017.6356
MLA
Bai, Y., Wang, Y., Liu, M., Gu, Y., Jiang, B., Wu, X., Wang, H."Suppression of nuclear factor erythroid‑2‑related factor 2‑mediated antioxidative defense in the lung injury induced by chronic exposure to methamphetamine in rats". Molecular Medicine Reports 15.5 (2017): 3135-3142.
Chicago
Bai, Y., Wang, Y., Liu, M., Gu, Y., Jiang, B., Wu, X., Wang, H."Suppression of nuclear factor erythroid‑2‑related factor 2‑mediated antioxidative defense in the lung injury induced by chronic exposure to methamphetamine in rats". Molecular Medicine Reports 15, no. 5 (2017): 3135-3142. https://doi.org/10.3892/mmr.2017.6356
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team