Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-2017 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2017 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Health risk assessment of environmental selenium: Emerging evidence and challenges (Review)

  • Authors:
    • Marco Vinceti
    • Tommaso Filippini
    • Silvia Cilloni
    • Annalisa Bargellini
    • Anna Valeria Vergoni
    • Aristides Tsatsakis
    • Margherita Ferrante
  • View Affiliations / Copyright

    Affiliations: CREAGEN, Research Center of Environmental, Genetic and Nutritional Epidemiology, Section of Public Health, University of Modena and Reggio Emilia, Modena, Italy, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy, Department of Forensic Sciences and Toxicology, University of Crete, Heraklion, Crete, Greece, Department of Medical, Surgical Sciences and Advanced Technologies ‘G.F. Ingrassia’, University of Catania, Catania, Italy
    Copyright: © Vinceti et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3323-3335
    |
    Published online on: March 24, 2017
       https://doi.org/10.3892/mmr.2017.6377
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

New data have been accumulated in the scientific literature in recent years which allow a more adequate risk assessment of selenium with reference to human health. This new evidence comes from environmental studies, carried out in populations characterized by abnormally high or low selenium intakes, and from high-quality and large randomized controlled trials with selenium recently carried out in the US and in other countries. These trials have consistently shown no beneficial effect on cancer and cardiovascular risk, and have yielded indications of unexpected toxic effects of selenium exposure. Overall, these studies indicate that the minimal amount of environmental selenium which is source of risk to human health is much lower than anticipated on the basis of older studies, since toxic effects were shown at levels of intake as low as around 260 µg/day for organic selenium and around 16 µg/day for inorganic selenium. Conversely, populations with average selenium intake of less than 13-19 µg/day appear to be at risk of a severe cardiomyopathy, Keshan disease. Overall, there is the need to reconsider the selenium standards for dietary intake, drinking water, outdoor and indoor air levels, taking into account the recently discovered adverse health effects of low-dose selenium overexposure, and carefully assessing the significance of selenium-induced proteomic changes.
View Figures

Figure 1

Figure 2

View References

1 

Vinceti M, Dennert G, Crespi CM, Zwahlen M, Brinkman M, Zeegers MP, Horneber M, D'Amico R and Del Giovane C: Selenium for preventing cancer. Cochrane Database Syst Rev. 3:CD0051952014.

2 

Lance P, Alberts DS, Thompson PA, Fales L, Wang F, Jose San J, Jacobs ET, Goodman PJ, Darke AK, Yee M, et al: Colorectal adenomas in participants of the SELECT randomized trial of selenium and vitamin E for prostate cancer prevention. Cancer Prev Res (Phila). 10:45–54. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Thompson PA, Ashbeck EL, Roe DJ, Fales L, Buckmeier J, Wang F, Bhattacharyya A, Hsu CH, Chow HH, Ahnen DJ, et al: Selenium supplementation for prevention of colorectal adenomas and risk of associated type 2 diabetes. J Natl Cancer Inst. 108:pii: djw152. 2016. View Article : Google Scholar

4 

Institute of Medicine Food and Nutrition Board: Dietary references intakes for vitamin C, vitamin E, selenium, and carotenoids. National Academy Press; Washington, DC: 2000

5 

Vinceti M, Crespi CM, Bonvicini F, Malagoli C, Ferrante M, Marmiroli S and Stranges S: The need for a reassessment of the safe upper limit of selenium in drinking water. Sci Total Environ. 443:633–642. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Rothman KJ, Greenland S and Lash TL: Modern Epidemiology. Lippincott Williams & Wilkins; Philadelphia: 2012, View Article : Google Scholar

7 

Michalke B, Halbach S and Nischwitz V: JEM spotlight: Metal speciation related to neurotoxicity in humans. J Environ Monit. 11:939–954. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Gammelgaard B, Jackson MI and Gabel-Jensen C: Surveying selenium speciation from soil to cell--forms and transformations. Anal Bioanal Chem. 399:1743–1763. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Weekley CM and Harris HH: Which form is that? The importance of selenium speciation and metabolism in the prevention and treatment of disease. Chem Soc Rev. 42:8870–8894. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Vinceti M, Solovyev N, Mandrioli J, Crespi CM, Bonvicini F, Arcolin E, Georgoulopoulou E and Michalke B: Cerebrospinal fluid of newly diagnosed amyotrophic lateral sclerosis patients exhibits abnormal levels of selenium species including elevated selenite. Neurotoxicology. 38:25–32. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Vinceti M, Grill P, Malagoli C, Filippini T, Storani S, Malavolti M and Michalke B: Selenium speciation in human serum and its implications for epidemiologic research: A cross-sectional study. J Trace Elem Med Biol. 31:1–10. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Vinceti M, Wei ET, Malagoli C, Bergomi M and Vivoli G: Adverse health effects of selenium in humans. Rev Environ Health. 16:233–251. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Vinceti M, Mandrioli J, Borella P, Michalke B, Tsatsakis A and Finkelstein Y: Selenium neurotoxicity in humans: Bridging laboratory and epidemiologic studies. Toxicol Lett. 230:295–303. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Vinceti M, Crespi CM, Malagoli C, Del Giovane C and Krogh V: Friend or foe? The current epidemiologic evidence on selenium and human cancer risk. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 31:305–341. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Vinceti M, Burlingame B, Fillippini T, Naska A, Bargellini A and Borella P: The epidemiology of selenium and human healthSelenium: Its Molecular Biology and Role in Human Health. Hatfield D, Schweizer U and Gladyshev VN: 4th. Springer Science Business Media; New York: pp. 365–376. 2016, View Article : Google Scholar

16 

Joint FAO/WHO Expert Consultation on Human Vitamin and Mineral Requirements: Vitamin and mineral requirements in human nutrition. 2nd. World Health Organization and Food and Agriculture Organization of the United Nations; Geneva: 2004

17 

Keshan Disease Research Group of the Chinese Academy of Medical Sciences: Epidemiologic studies on the etiologic relationship of selenium and Keshan disease. Chin Med J (Engl). 92:477–482. 1979.PubMed/NCBI

18 

Keshan Disease Research Group of the Chinese Academy of Medical Sciences: Observations on effect of sodium selenite in prevention of Keshan disease. Chin Med J (Engl). 92:471–476. 1979.PubMed/NCBI

19 

Wang T and Li Q: Interpretation of selenium deficiency and Keshan disease with causal inference of modern epidemiologyThe 5th International Selenium Seminar. Organizing Committee of the International Selenium Seminar; Moscow: pp. 34–35. 2015

20 

Lei C, Niu X, Ma X and Wei J: Is selenium deficiency really the cause of Keshan disease? Environ Geochem Health. 33:183–188. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Winther KH, Bonnema SJ, Cold F, Debrabant B, Nybo M, Cold S and Hegedüs L: Does selenium supplementation affect thyroid function? Results from a randomized, controlled, double-blinded trial in a Danish population. Eur J Endocrinol. 172:657–667. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Stranges S, Marshall JR, Natarajan R, Donahue RP, Trevisan M, Combs GF, Cappuccio FP, Ceriello A and Reid ME: Effects of long-term selenium supplementation on the incidence of type 2 diabetes: A randomized trial. Ann Intern Med. 147:217–223. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Lippman SM, Klein EA, Goodman PJ, Lucia MS, Thompson IM, Ford LG, Parnes HL, Minasian LM, Gaziano JM, Hartline JA, et al: Effect of selenium and vitamin E on risk of prostate cancer and other cancers: The Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 301:39–51. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Vinceti M, Rovesti S, Gabrielli C, Marchesi C, Bergomi M, Martini M and Vivoli G: Cancer mortality in a residential cohort exposed to environmental selenium through drinking water. J Clin Epidemiol. 48:1091–1097. 1995. View Article : Google Scholar : PubMed/NCBI

25 

Vinceti M, Rothman KJ, Bergomi M, Borciani N, Serra L and Vivoli G: Excess melanoma incidence in a cohort exposed to high levels of environmental selenium. Cancer Epidemiol Biomarkers Prev. 7:853–856. 1998.PubMed/NCBI

26 

Vinceti M, Ballotari P, Steinmaus C, Malagoli C, Luberto F, Malavolti M and Rossi Giorgi P: Long-term mortality patterns in a residential cohort exposed to inorganic selenium in drinking water. Environ Res. 150:348–356. 2016. View Article : Google Scholar : PubMed/NCBI

27 

Saint-Amour D, Roy MS, Bastien C, Ayotte P, Dewailly E, Després C, Gingras S and Muckle G: Alterations of visual evoked potentials in preschool Inuit children exposed to methylmercury and polychlorinated biphenyls from a marine diet. Neurotoxicology. 27:567–578. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Vinceti M, Bonvicini F, Rothman KJ, Vescovi L and Wang F: The relation between amyotrophic lateral sclerosis and inorganic selenium in drinking water: A population-based case-control study. Environ Health. 9:772010. View Article : Google Scholar : PubMed/NCBI

29 

Vinceti M and Rothman KJ: More results but no clear conclusion on selenium and cancer. Am J Clin Nutr. 104:245–246. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Hughes DJ, Duarte-Salles T, Hybsier S, Trichopoulou A, Stepien M, Aleksandrova K, Overvad K, Tjønneland A, Olsen A, Affret A, et al: Prediagnostic selenium status and hepatobiliary cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort. Am J Clin Nutr. 104:406–414. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Ma X, Yang Y, Li HL, Zheng W, Gao J, Zhang W, Yang G, Shu XO and Xiang YB: Dietary trace element intake and liver cancer risk: Results from two population-based cohorts in China. Int J Cancer. 140:1050–1059. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Knekt P, Marniemi J, Teppo L, Heliövaara M and Aromaa A: Is low selenium status a risk factor for lung cancer? Am J Epidemiol. 148:975–982. 1998. View Article : Google Scholar : PubMed/NCBI

33 

van den Brandt PA, Goldbohm RA, van't Veer P, Bode P, Dorant E, Hermus RJ and Sturmans F: A prospective cohort study on selenium status and the risk of lung cancer. Cancer Res. 53:4860–4865. 1993.PubMed/NCBI

34 

Suadicani P, Hein HO and Gyntelberg F: Serum selenium level and risk of lung cancer mortality: A 16-year follow-up of the Copenhagen Male Study. Eur Respir J. 39:1443–1448. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Menkes MS, Comstock GW, Vuilleumier JP, Helsing KJ, Rider AA and Brookmeyer R: Serum beta-carotene, vitamins A and E, selenium, and the risk of lung cancer. N Engl J Med. 315:1250–1254. 1986. View Article : Google Scholar : PubMed/NCBI

36 

van Noord PA, Maas MJ, van der Tweel I and Collette C: Selenium and the risk of postmenopausal breast cancer in the DOM cohort. Breast Cancer Res Treat. 25:11–19. 1993. View Article : Google Scholar : PubMed/NCBI

37 

van den Brandt PA, Goldbohm RA, van't Veer P, Bode P, Dorant E, Hermus RJ and Sturmans F: Toenail selenium levels and the risk of breast cancer. Am J Epidemiol. 140:20–26. 1994. View Article : Google Scholar : PubMed/NCBI

38 

Garland M, Morris JS, Stampfer MJ, Colditz GA, Spate VL, Baskett CK, Rosner B, Speizer FE, Willett WC and Hunter DJ: Prospective study of toenail selenium levels and cancer among women. J Natl Cancer Inst. 87:497–505. 1995. View Article : Google Scholar : PubMed/NCBI

39 

Clark LC, Combs GFJ Jr, Turnbull BW, Slate EH, Chalker DK, Chow J, Davis LS, Glover RA, Graham GF, Gross EG, et al: Nutritional Prevention of Cancer Study Group: Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. JAMA. 276:1957–1963. 1996. View Article : Google Scholar : PubMed/NCBI

40 

Jablonska E and Vinceti M: Selenium and Human Health: Witnessing a Copernican Revolution? J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 33:328–368. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Higgins JP: A revised tool to assess risk of bias in randomized trials. (RoB 2.0). 2016.

42 

Rees K, Hartley L, Day C, Flowers N, Clarke A and Stranges S: Selenium supplementation for the primary prevention of cardiovascular disease. Cochrane Database Syst Rev. 1:CD0096712013.

43 

Stratton MS, Reid ME, Schwartzberg G, Minter FE, Monroe BK, Alberts DS, Marshall JR and Ahmann FR: Selenium and prevention of prostate cancer in high-risk men: The Negative Biopsy Study. Anticancer Drugs. 14:589–594. 2003. View Article : Google Scholar : PubMed/NCBI

44 

Algotar AM, Stratton MS, Ahmann FR, Ranger-Moore J, Nagle RB, Thompson PA, Slate E, Hsu CH, Dalkin BL, Sindhwani P, et al: Phase 3 clinical trial investigating the effect of selenium supplementation in men at high-risk for prostate cancer. Prostate. 73:328–335. 2013. View Article : Google Scholar : PubMed/NCBI

45 

Karp DD, Lee SJ, Keller SM, Wright GS, Aisner S, Belinsky SA, Johnson DH, Johnston MR, Goodman G, Clamon G, et al: Randomized, double-blind, placebo-controlled, phase III chemoprevention trial of selenium supplementation in patients with resected stage I non-small-cell lung cancer: ECOG 5597. J Clin Oncol. 31:4179–4187. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Kristal AR, Darke AK, Morris JS, Tangen CM, Goodman PJ, Thompson IM, Meyskens FL Jr, Goodman GE, Minasian LM, Parnes HL, et al: Baseline selenium status and effects of selenium and vitamin e supplementation on prostate cancer risk. J Natl Cancer Inst. 106:djt4562014. View Article : Google Scholar : PubMed/NCBI

47 

Albanes D, Till C, Klein EA, Goodman PJ, Mondul AM, Weinstein SJ, Taylor PR, Parnes HL, Gaziano JM, Song X, et al: Plasma tocopherols and risk of prostate cancer in the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Cancer Prev Res (Phila). 7:886–895. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Martinez EE, Darke AK, Tangen CM, Goodman PJ, Fowke JH, Klein EA and Abdulkadir SA: A functional variant in NKX3.1 associated with prostate cancer risk in the Selenium and Vitamin E Cancer Prevention Trial (SELECT). Cancer Prev Res (Phila). 7:950–957. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Duffield-Lillico AJ, Slate EH, Reid ME, Turnbull BW, Wilkins PA, Combs GF Jr, Park HK, Gross EG, Graham GF, Stratton MS, et al: Nutritional Prevention of Cancer Study Group: Selenium supplementation and secondary prevention of nonmelanoma skin cancer in a randomized trial. J Natl Cancer Inst. 95:1477–1481. 2003. View Article : Google Scholar : PubMed/NCBI

50 

Dréno B, Euvrard S, Frances C, Moyse D and Nandeuil A: Effect of selenium intake on the prevention of cutaneous epithelial lesions in organ transplant recipients. Eur J Dermatol. 17:140–145. 2007.PubMed/NCBI

51 

Lubinski J, Jaworska K, Durda K, Jakubowska A, Huzarski T, Byrski T, Stawicka M, Gronwald J, Górski B, Wasowicz W, et al: Selenium and the risk of cancer in BRCA1 carriers. Hered Cancer Clin Pract. 9:(Suppl 2). A52011. View Article : Google Scholar :

52 

Duffield-Lillico AJ, Reid ME, Turnbull BW, Combs GFJ Jr, Slate EH, Fischbach LA, Marshall JR and Clark LC: Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: A summary report of the Nutritional Prevention of Cancer Trial. Cancer Epidemiol Biomarkers Prev. 11:630–639. 2002.PubMed/NCBI

53 

Duffield-Lillico AJ, Dalkin BL, Reid ME, Turnbull BW, Slate EH, Jacobs ET, Marshall JR and Clark LC: Nutritional Prevention of Cancer Study Group: Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: An analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial. BJU Int. 91:608–612. 2003. View Article : Google Scholar : PubMed/NCBI

54 

Vinceti M, Maraldi T, Bergomi M and Malagoli C: Risk of chronic low-dose selenium overexposure in humans: Insights from epidemiology and biochemistry. Rev Environ Health. 24:231–248. 2009. View Article : Google Scholar : PubMed/NCBI

55 

Yang GQ, Wang SZ, Zhou RH and Sun SZ: Endemic selenium intoxication of humans in China. Am J Clin Nutr. 37:872–881. 1983.PubMed/NCBI

56 

Barron E, Migeot V, Rabouan S, Potin-Gautier M, Séby F, Hartemann P, Lévi Y and Legube B: The case for re-evaluating the upper limit value for selenium in drinking water in Europe. J Water Health. 7:630–641. 2009. View Article : Google Scholar : PubMed/NCBI

57 

Frisbie SH, Mitchell EJ and Sarkar B: Urgent need to reevaluate the latest World Health Organization guidelines for toxic inorganic substances in drinking water. Environ Health. 14:632015. View Article : Google Scholar : PubMed/NCBI

58 

Scientific Committee on Food: Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Level of SeleniumEuropean Commission. Brussels: 2000, https://ec.europa.eu/food/sites/food/files/safety/docs/sci-com_scf_out80g_en.pdf

59 

Tsubota-Utsugi M, Imai E, Nakade M, Tsuboyama-Kasaoka N, Morita A and Tokudome S: Dietary Reference Intakes for Japanese - 2010. The summary report from the Scientific Committee of ‘Dietary Reference intakes for Japanese’National Institute of Health and Nutrition. Japan: 2012

60 

Nordic Nutrition Recommendations 2012. 5th. Nordic Council of Ministers; Copenhagen: 2014, doi: org/10.6027/Nord2014-002.

61 

Società Italiana di Nutrizione Umana: LARN - Livelli di assunzione di riferimento di nutrienti e energia per la popolazione italiana - IV revisioneSICS. Milan: 2014, (In Italian).

62 

Marschall TA, Bornhorst J, Kuehnelt D and Schwerdtle T: Differing cytotoxicity and bioavailability of selenite, methylselenocysteine, selenomethionine, selenosugar 1 and trimethylselenonium ion and their underlying metabolic transformations in human cells. Mol Nutr Food Res. 60:2622–2632. 2016. View Article : Google Scholar : PubMed/NCBI

63 

Lazard M, Dauplais M, Blanquet S and Plateau P: Trans-sulfuration pathway seleno-amino acids are mediators of selenomethionine toxicity in Saccharomyces cerevisiae. J Biol Chem. 290:10741–10750. 2015. View Article : Google Scholar : PubMed/NCBI

64 

Raine JC, Lallemand L, Pettem CM and Janz DM: Effects of chronic dietary selenomethionine exposure on the visual system of adult and F1 generation zebrafish (Danio rerio). Bull Environ Contam Toxicol. 97:331–336. 2016. View Article : Google Scholar : PubMed/NCBI

65 

Dolgova NV, Hackett MJ, MacDonald TC, Nehzati S, James AK, Krone PH, George GN and Pickering IJ: Distribution of selenium in zebrafish larvae after exposure to organic and inorganic selenium forms. Metallomics. 8:305–312. 2016. View Article : Google Scholar : PubMed/NCBI

66 

Göen T, Schaller B, Jäger T, Bräu-Dümler Ch, Schaller KH and Drexler H: Biological monitoring of exposure and effects in workers employed in a selenium-processing plant. Int Arch Occup Environ Health. 88:623–630. 2015. View Article : Google Scholar : PubMed/NCBI

67 

Jäger T, Drexler H and Göen T: Human metabolism and renal excretion of selenium compounds after oral ingestion of sodium selenate dependent on trimethylselenium ion (TMSe) status. Arch Toxicol. 90:149–158. 2016. View Article : Google Scholar : PubMed/NCBI

68 

Ito K, Mathes R, Ross Z, Nádas A, Thurston G and Matte T: Fine particulate matter constituents associated with cardiovascular hospitalizations and mortality in New York City. Environ Health Perspect. 119:467–473. 2011. View Article : Google Scholar : PubMed/NCBI

69 

Heck JE, Park AS, Qiu J, Cockburn M and Ritz B: Risk of leukemia in relation to exposure to ambient air toxics in pregnancy and early childhood. Int J Hyg Environ Health. 217:662–668. 2014. View Article : Google Scholar : PubMed/NCBI

70 

Burk RF Jr: Selenium deficiency in search of a disease. Hepatology. 8:421–423. 1988. View Article : Google Scholar : PubMed/NCBI

71 

Yu FF, Liu H and Guo X: Integrative multivariate logistic regression analysis of risk factors for Kashin-Beck disease. Biol Trace Elem Res. 174:274–279. 2016. View Article : Google Scholar : PubMed/NCBI

72 

Yu FF, Zhang YX, Zhang LH, Li WR, Guo X and Lammi MJ: Identified molecular mechanism of interaction between environmental risk factors and differential expression genes in cartilage of Kashin-Beck disease. Medicine (Baltimore). 95:e56692016. View Article : Google Scholar : PubMed/NCBI

73 

Beck MA, Levander OA and Handy J: Selenium deficiency and viral infection. J Nutr. 133:(Suppl 1). 1463S–1467S. 2003.PubMed/NCBI

74 

Sheridan PA, Zhong N, Carlson BA, Perella CM, Hatfield DL and Beck MA: Decreased selenoprotein expression alters the immune response during influenza virus infection in mice. J Nutr. 137:1466–1471. 2007.PubMed/NCBI

75 

Gu BQ: Pathology of Keshan disease. A comprehensive review. Chin Med J (Engl). 96:251–261. 1983.PubMed/NCBI

76 

Levander OA and Beck MA: Interacting nutritional and infectious etiologies of Keshan disease. Insights from coxsackie virus B-induced myocarditis in mice deficient in selenium or vitamin E. Biol Trace Elem Res. 56:5–21. 1997. View Article : Google Scholar : PubMed/NCBI

77 

Xu GL, Wang SC, Gu BQ, Yang YX, Song HB, Xue WL, Liang WS and Zhang PY: Further investigation on the role of selenium deficiency in the aetiology and pathogenesis of Keshan disease. Biomed Environ Sci. 10:316–326. 1997.PubMed/NCBI

78 

Chen J: An original discovery: Selenium deficiency and Keshan disease (an endemic heart disease). Asia Pac J Clin Nutr. 21:320–326. 2012.PubMed/NCBI

79 

Guanqing H: On the etiology of Keshan disease: Two hypotheses. Chin Med J (Engl). 92:416–422. 1979.PubMed/NCBI

80 

Cermelli C, Vinceti M, Scaltriti E, Bazzani E, Beretti F, Vivoli G and Portolani M: Selenite inhibition of Coxsackie virus B5 replication: Implications on the etiology of Keshan disease. J Trace Elem Med Biol. 16:41–46. 2002. View Article : Google Scholar : PubMed/NCBI

81 

Schoenmakers E, Agostini M, Mitchell C, Schoenmakers N, Papp L, Rajanayagam O, Padidela R, Ceron-Gutierrez L, Doffinger R, Prevosto C, et al: Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans. J Clin Invest. 120:4220–4235. 2010. View Article : Google Scholar : PubMed/NCBI

82 

Scoto M, Cirak S, Mein R, Feng L, Manzur AY, Robb S, Childs AM, Quinlivan RM, Roper H, Jones DH, et al: SEPN1-related myopathies: Clinical course in a large cohort of patients. Neurology. 76:2073–2078. 2011. View Article : Google Scholar : PubMed/NCBI

83 

Ardissone A, Bragato C, Blasevich F, Maccagnano E, Salerno F, Gandioli C, Morandi L, Mora M and Moroni I: SEPN1-related myopathy in three patients: Novel mutations and diagnostic clues. Eur J Pediatr. 175:1113–1118. 2016. View Article : Google Scholar : PubMed/NCBI

84 

Schomburg L, Dumitrescu AM, Liao XH, Bin-Abbas B, Hoeflich J, Köhrle J and Refetoff S: Selenium supplementation fails to correct the selenoprotein synthesis defect in subjects with SBP2 gene mutations. Thyroid. 19:277–281. 2009. View Article : Google Scholar : PubMed/NCBI

85 

EFSA NDA Panel: Scientific opinion on dietary reference values for selenium. EFSA J. 12:38462014. View Article : Google Scholar

86 

Ge KY, Wang SQ, Bai J, Xue AN, Deng XJ, Su CQ and Wu SQ: The protective effect of selenium against viral myocarditis in miceSelenium in biology and medicine. Part B, Combs GF, Spallholz JE, Levander OA and Oldfield JE: Avi Book, Van Nostrand Reinhold Co.; New York: pp. 761–768. 1987

87 

Spallholz JE: Free radical generation by selenium compounds and their prooxidant toxicity. Biomed Environ Sci. 10:260–270. 1997.PubMed/NCBI

88 

Stewart MS, Spallholz JE, Neldner KH and Pence BC: Selenium compounds have disparate abilities to impose oxidative stress and induce apoptosis. Free Radic Biol Med. 26:42–48. 1999. View Article : Google Scholar : PubMed/NCBI

89 

Letavayová L, Vlasáková D, Spallholz JE, Brozmanová J and Chovanec M: Toxicity and mutagenicity of selenium compounds in Saccharomyces cerevisiae. Mutat Res. 638:1–10. 2008. View Article : Google Scholar : PubMed/NCBI

90 

Misra S, Boylan M, Selvam A, Spallholz JE and Björnstedt M: Redox-active selenium compounds - from toxicity and cell death to cancer treatment. Nutrients. 7:3536–3556. 2015. View Article : Google Scholar : PubMed/NCBI

91 

Lee KH and Jeong D: Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: The selenium paradox (Review). Mol Med Rep. 5:299–304. 2012.PubMed/NCBI

92 

Brozmanová J, Mániková D, Vlčková V and Chovanec M: Selenium: A double-edged sword for defense and offence in cancer. Arch Toxicol. 84:919–938. 2010. View Article : Google Scholar : PubMed/NCBI

93 

Schiar VP, Dos Santos DB, Paixão MW, Nogueira CW, Rocha JB and Zeni G: Human erythrocyte hemolysis induced by selenium and tellurium compounds increased by GSH or glucose: A possible involvement of reactive oxygen species. Chem Biol Interact. 177:28–33. 2009. View Article : Google Scholar : PubMed/NCBI

94 

Guo CH, Hsia S, Hsiung DY and Chen PC: Supplementation with selenium yeast on the prooxidant-antioxidant activities and anti-tumor effects in breast tumor xenograft-bearing mice. J Nutr Biochem. 26:1568–1579. 2015. View Article : Google Scholar : PubMed/NCBI

95 

Hafeman DG, Sunde RA and Hoekstra WG: Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat. J Nutr. 104:580–587. 1974.PubMed/NCBI

96 

Oh SH, Sunde RA, Pope AL and Hoekstra WG: Glutathione peroxidase response to selenium intake in lambs fed a Torula yeast-based, artificial milk. J Anim Sci. 42:977–983. 1976. View Article : Google Scholar : PubMed/NCBI

97 

Kramer GF and Ames BN: Mechanisms of mutagenicity and toxicity of sodium selenite (Na2SeO3) in Salmonella typhimurium. Mutat Res. 201:169–180. 1988. View Article : Google Scholar : PubMed/NCBI

98 

Macallan DC and Sedgwick P: Selenium supplementation and selenoenzyme activity. Clin Sci (Lond). 99:579–581. 2000. View Article : Google Scholar : PubMed/NCBI

99 

Tsongas TA and Ferguson SW: Selenium concentrations in human urine and drinking waterProceedings of ‘Trace Elements in Man and Animal-3’. Kirchgessner N: Institute for Nursing Physiology Technical University Munchen; Freising: pp. 320–321. 1978

100 

Tsongas TA and Ferguson SW: Human health effects of selenium in a rural Colorado drinking water supply. In: Proceedings of ‘Trace substances in environmental health-XIA symposium’. Hemphill DD: University of Missouri; Columbia: pp. 30–35. 1977

101 

Valentine JL: Environmental occurrence of selenium in waters and related health significance. Biomed Environ Sci. 10:292–299. 1997.PubMed/NCBI

102 

Valentine JL, Kang HK, Dang PM and Schluchter M: Selenium concentrations and glutathione peroxidase activities in a population exposed to selenium via drinking water. J Toxicol Environ Health. 6:731–736. 1980. View Article : Google Scholar : PubMed/NCBI

103 

Valentine JL, Faraji B and Kang HK: Human glutathione peroxidase activity in cases of high selenium exposures. Environ Res. 45:16–27. 1988. View Article : Google Scholar : PubMed/NCBI

104 

Valentine JL, Reisbord LS, Kang HK and Schluchter M: Effects on human health of exposure to selenium in drinking waterProceedings of ‘Selenium in Biology and Medicine - Part B’. Combs GF, Levander OA, Spallholz JE and Oldfield JE: Van Nostrand Reihold Co.; New York: pp. 675–687. 1987

105 

Longnecker MP, Taylor PR, Levander OA, Howe M, Veillon C, McAdam PA, Patterson KY, Holden JM, Stampfer MJ, Morris JS, et al: Selenium in diet, blood, and toenails in relation to human health in a seleniferous area. Am J Clin Nutr. 53:1288–1294. 1991.PubMed/NCBI

106 

Brätter P and de Negretti Brätter VE: Influence of high dietary selenium intake on the thyroid hormone level in human serum. J Trace Elem Med Biol. 10:163–166. 1996. View Article : Google Scholar : PubMed/NCBI

107 

Fordyce FM, Zhan G, Green K and Liu X: Soil, grain and water chemistry in relation to human selenium-responsive diseases in Enshi District, China. Applied Geochemistry. 15:117–132. 2000.doi: 10.1016/S0883-2927(99)00035-9. View Article : Google Scholar

108 

Zhu J, Wang N, Li S, Li L, Su H and Liu C: Distribution and transport of selenium in Yutangba, China: Impact of human activities. Sci Total Environ. 392:252–261. 2008. View Article : Google Scholar : PubMed/NCBI

109 

Hira CK, Partal K and Dhillon KS: Dietary selenium intake by men and women in high and low selenium areas of Punjab. Public Health Nutr. 7:39–43. 2004. View Article : Google Scholar : PubMed/NCBI

110 

Lemire M, Fillion M, Frenette B, Passos CJ, Guimarães JR, Barbosa F Jr and Mergler D: Selenium from dietary sources and motor functions in the Brazilian Amazon. Neurotoxicology. 32:944–953. 2011. View Article : Google Scholar : PubMed/NCBI

111 

Lemire M, Philibert A, Fillion M, Passos CJ, Guimarães JR, Barbosa F Jr and Mergler D: No evidence of selenosis from a selenium-rich diet in the Brazilian Amazon. Environ Int. 40:128–136. 2012. View Article : Google Scholar : PubMed/NCBI

112 

Qin HB, Zhu JM, Liang L, Wang MS and Su H: The bioavailability of selenium and risk assessment for human selenium poisoning in high-Se areas, China. Environ Int. 52:66–74. 2013. View Article : Google Scholar : PubMed/NCBI

113 

Martens IB, Cardoso BR, Hare DJ, Niedzwiecki MM, Lajolo FM, Martens A and Cozzolino SM: Selenium status in preschool children receiving a Brazil nut-enriched diet. Nutrition. 31:1339–1343. 2015. View Article : Google Scholar : PubMed/NCBI

114 

Chawla R, Loomba R, Chaudhary RJ, Singh S and Dhillon KS: Impact of high selenium exposure on organ function and biochemical profile of the rural population living in seleniferous soils in Punjab, IndiaGlobal advance in selenium research from theory to application. CRC Press; Sao Paulo: pp. 93–94. 2015, View Article : Google Scholar

115 

Yu SY, Zhu YJ and Li WG: Protective role of selenium against hepatitis B virus and primary liver cancer in Qidong. Biol Trace Elem Res. 56:117–124. 1997. View Article : Google Scholar : PubMed/NCBI

116 

Yu SY, Zhu YJ, Li WG, Huang QS, Huang CZ, Zhang QN and Hou C: A preliminary report on the intervention trials of primary liver cancer in high-risk populations with nutritional supplementation of selenium in China. Biol Trace Elem Res. 29:289–294. 1991. View Article : Google Scholar : PubMed/NCBI

117 

Li WG: Preliminary observations on effect of selenium yeast on high risk populations with primary liver cancer. Zhonghua Yu Fang Yi Xue Za Zhi. 26:268–271. 1992.(In Chinese). PubMed/NCBI

118 

Li W, Zhu Y, Yan X, Zhang Q, Li X, Ni Z, Shen Z, Yao H and Zhu J: The prevention of primary liver cancer by selenium in high risk populations. Zhonghua Yu Fang Yi Xue Za Zhi. 34:336–338. 2000.(In Chinese). PubMed/NCBI

119 

Lotan Y, Goodman PJ, Youssef RF, Svatek RS, Shariat SF, Tangen CM, Thompson IM Jr and Klein EA: Evaluation of vitamin E and selenium supplementation for the prevention of bladder cancer in SWOG coordinated SELECT. J Urol. 187:2005–2010. 2012. View Article : Google Scholar : PubMed/NCBI

120 

Klein EA, Thompson IM Jr, Tangen CM, Crowley JJ, Lucia MS, Goodman PJ, Minasian LM, Ford LG, Parnes HL, Gaziano JM, et al: Vitamin E and the risk of prostate cancer: The Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 306:1549–1556. 2011. View Article : Google Scholar : PubMed/NCBI

121 

Marshall JR, Tangen CM, Sakr WA, Wood DP Jr, Berry DL, Klein EA, Lippman SM, Parnes HL, Alberts DS, Jarrard DF, et al: Phase III trial of selenium to prevent prostate cancer in men with high-grade prostatic intraepithelial neoplasia: SWOG S9917. Cancer Prev Res (Phila). 4:1761–1769. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Vinceti M, Filippini T, Cilloni S, Bargellini A, Vergoni AV, Tsatsakis A and Ferrante M: Health risk assessment of environmental selenium: Emerging evidence and challenges (Review) . Mol Med Rep 15: 3323-3335, 2017.
APA
Vinceti, M., Filippini, T., Cilloni, S., Bargellini, A., Vergoni, A.V., Tsatsakis, A., & Ferrante, M. (2017). Health risk assessment of environmental selenium: Emerging evidence and challenges (Review) . Molecular Medicine Reports, 15, 3323-3335. https://doi.org/10.3892/mmr.2017.6377
MLA
Vinceti, M., Filippini, T., Cilloni, S., Bargellini, A., Vergoni, A. V., Tsatsakis, A., Ferrante, M."Health risk assessment of environmental selenium: Emerging evidence and challenges (Review) ". Molecular Medicine Reports 15.5 (2017): 3323-3335.
Chicago
Vinceti, M., Filippini, T., Cilloni, S., Bargellini, A., Vergoni, A. V., Tsatsakis, A., Ferrante, M."Health risk assessment of environmental selenium: Emerging evidence and challenges (Review) ". Molecular Medicine Reports 15, no. 5 (2017): 3323-3335. https://doi.org/10.3892/mmr.2017.6377
Copy and paste a formatted citation
x
Spandidos Publications style
Vinceti M, Filippini T, Cilloni S, Bargellini A, Vergoni AV, Tsatsakis A and Ferrante M: Health risk assessment of environmental selenium: Emerging evidence and challenges (Review) . Mol Med Rep 15: 3323-3335, 2017.
APA
Vinceti, M., Filippini, T., Cilloni, S., Bargellini, A., Vergoni, A.V., Tsatsakis, A., & Ferrante, M. (2017). Health risk assessment of environmental selenium: Emerging evidence and challenges (Review) . Molecular Medicine Reports, 15, 3323-3335. https://doi.org/10.3892/mmr.2017.6377
MLA
Vinceti, M., Filippini, T., Cilloni, S., Bargellini, A., Vergoni, A. V., Tsatsakis, A., Ferrante, M."Health risk assessment of environmental selenium: Emerging evidence and challenges (Review) ". Molecular Medicine Reports 15.5 (2017): 3323-3335.
Chicago
Vinceti, M., Filippini, T., Cilloni, S., Bargellini, A., Vergoni, A. V., Tsatsakis, A., Ferrante, M."Health risk assessment of environmental selenium: Emerging evidence and challenges (Review) ". Molecular Medicine Reports 15, no. 5 (2017): 3323-3335. https://doi.org/10.3892/mmr.2017.6377
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team