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Article

Determinants of serum manganese levels in an Italian population

  • Authors:
    • Tommaso Filippini
    • Bernhard Michalke
    • Peter Grill
    • Carlotta Malagoli
    • Marcella Malavolti
    • Luciano Vescovi
    • Sabina Sieri
    • Vittorio Krogh
    • Andrea Cherubini
    • Giuseppe Maffeis
    • Roberto Lucchini
    • Margherita Ferrante
    • Marco Vinceti
  • View Affiliations / Copyright

    Affiliations: CREAGEN, Environmental, Genetic and Nutritional Epidemiology Research Center, Section of Public Health, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, I‑41125 Modena, Italy, Helmholtz Zentrum München, Research Center for Environmental Health, Research Unit Analytical BioGeoChemistry, D‑85764 Neuherberg, Germany, Laboratory of Environmental Chemistry, IREN, I-42123 Reggio Emilia, Italy, Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori I‑20133 Milan, Italy, TerrAria s.r.l., I‑20125 Milan, Italy, Section of Occupational Medicine, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, I‑25125 Brescia, Italy, Department of Medical, Surgical Sciences and Advanced Technologies ‘G.F. Ingrassia’, University of Catania, I‑95123 Catania, Italy
  • Pages: 3340-3349
    |
    Published online on: March 24, 2017
       https://doi.org/10.3892/mmr.2017.6379
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Abstract

Manganese (Mn) is both essential and toxic for humans, mainly depending on the total levels and its species. Main sources of exposure include food and air pollution, particularly motorized traffic. We sought to determine the potential influence of these sources on serum total levels of Mn and Mn species. We selected a random sample of municipality residents from an Italian urban municipality, from whom we collected detailed personal information, dietary habits and a blood sample for serum Mn determination. We also assessed outdoor air Mn exposure, by modeling levels of particulate matter ≤10 µm (PM10) from motorized traffic at the residence of geocoded subjects. Serum Mn species generally showed higher levels in males and positive correlation with age, while no such differences were found according to smoking habits or use of dietary supplements. Among nutrients, only iron intake showed a relation with Mn [an inverse correlation with Mn‑ferritin (Mn‑Fer) and a direct one with inorganic‑Mn (Inorg‑Mn)]. Meat consumption directly correlated and fish and seafood inversely correlated with total Mn, Mn‑transferrin (Mn‑Tf) and Mn-citrate (Mn-Cit). Fruits and vegetables, including legumes and nuts, generally showed a positive correlation with all Mn species, especially Mn‑Cit, and an inverse one with Inorg‑Mn. Odds ratios (ORs) of having serum Mn levels above median value increased with increasing PM10 tertiles, with an OR for highest‑to‑lowest tertile of 7.40 (1.36‑40.25) in multivariate analysis. Analyses for Mn species did not highlight a clear comparable pattern. In conclusion, our results seem to demonstrate that PM10 exposure positively influences total Mn serum levels, while single Mn species show conflicting results.
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1 

Guo T, Zhang L, Konermann A, Zhou H, Jin F and Liu W: Manganese superoxide dismutase is required to maintain osteoclast differentiation and function under static force. Sci Rep. 5:80162015. View Article : Google Scholar : PubMed/NCBI

2 

Lucchini RG, Martin CJ and Doney BC: From manganism to manganese-induced parkinsonism: A conceptual model based on the evolution of exposure. Neuromolecular Med. 11:311–321. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Williams M, Todd GD, Roney N, Crawford J, Coles C, McClure PR, Garey JD, Zaccaria K and Citra M: Toxicological Profile for ManganeseAgency for Toxic Substances and Disease Registry. Atlanta, GA: 2012

4 

Turconi G, Minoia C, Ronchi A and Roggi C: Dietary exposure estimates of twenty-one trace elements from a Total Diet Study carried out in Pavia, Northern Italy. Br J Nutr. 101:1200–1208. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Carlo Agostoni, Roberto Berni Canani, Susan Fairweather-Tait, Marina Heinonen, Hannu Korhonen, La Sébastien Vieille, Rosangela Marchelli, Ambroise Martin, Androniki Naska, Monika Neuhäuser-Berthold, et al: EFSA NDA Panel (EFSA Panel on Dietetic Products NaA: Scientific opinion on dietary reference values for manganese. EFSA J. 11:34192013.

6 

Meltzer HM, Brantsaeter AL, Borch-Iohnsen B, Ellingsen DG, Alexander J, Thomassen Y, Stigum H and Ydersbond TA: Low iron stores are related to higher blood concentrations of manganese, cobalt and cadmium in non-smoking, Norwegian women in the HUNT 2 study. Environ Res. 110:497–504. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Institute of Medicine (US) Panel on Micronutrients (eds): ManganeseDietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. National Academies Press; Washington, DC: 2001

8 

Greger JL, Davis CD, Suttie JW and Lyle BJ: Intake, serum concentrations, and urinary excretion of manganese by adult males. Am J Clin Nutr. 51:457–461. 1990.PubMed/NCBI

9 

Cockell KA, Bonacci G and Belonje B: Manganese content of soy or rice beverages is high in comparison to infant formulas. J Am Coll Nutr. 23:124–130. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Michalke B and Fernsebner K: New insights into manganese toxicity and speciation. J Trace Elem Med Biol. 28:106–116. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Pavilonis BT, Lioy PJ, Guazzetti S, Bostick BC, Donna F, Peli M, Zimmerman NJ, Bertrand P, Lucas E, Smith DR, et al: Manganese concentrations in soil and settled dust in an area with historic ferroalloy production. J Expo Sci Environ Epidemiol. 25:443–450. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Schroeder WH, Dobson M, Kane DM and Johnson ND: Toxic trace elements associated with airborne particulate matter: A review. JAPCA. 37:1267–1285. 1987. View Article : Google Scholar : PubMed/NCBI

13 

Canepari S, Astolfi ML, Farao C, Maretto M, Frasca D, Marcoccia M and Perrino C: Seasonal variations in the chemical composition of particulate matter: A case study in the Po Valley. Part II: concentration and solubility of micro- and trace-elements. Environ Sci Pollut Res Int. 21:4010–4022. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Pappas RS, Gray N, Gonzalez-Jimenez N, Fresquez M and Watson CH: Triple Quad-ICP-MS measurement of toxic metals in mainstream cigarette smoke from spectrum research cigarettes. J Anal Toxicol. 40:43–48. 2016.PubMed/NCBI

15 

Freire C, Koifman RJ, Fujimoto D, de Oliveira Souza VC, Barbosa F Jr and Koifman S: Reference values of cadmium, arsenic and manganese in blood and factors associated with exposure levels among adult population of Rio Branco, Acre, Brazil. Chemosphere. 128:70–78. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Michalke B, Aslanoglou L, Ochsenkühn-Petropoulou M, Bergström B, Berthele A, Vinceti M, Lucio M and Lidén G: An approach for manganese biomonitoring using a manganese carrier switch in serum from transferrin to citrate at slightly elevated manganese concentration. J Trace Elem Med Biol. 32:145–154. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Vinceti M, Grill P, Malagoli C, Filippini T, Storani S, Malavolti M and Michalke B: Selenium speciation in human serum and its implications for epidemiologic research: A cross-sectional study. J Trace Elem Med Biol. 31:1–10. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Filippini T, Michalke B, Malagoli C, Grill P, Bottecchi I, Malavolti M, Vescovi L, Sieri S, Krogh V, Cherubini A, et al: Determinants of serum cadmium levels in a Northern Italy community: A cross-sectional study. Environ Res. 150:219–226. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Ebrahim AM, Eltayeb MH, Khalid H, Mohamed H, Abdalla W, Grill P and Michalke B: Study on selected trace elements and heavy metals in some popular medicinal plants from Sudan. J Nat Med. 66:671–679. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Jünemann AG, Stopa P, Michalke B, Chaudhri A, Reulbach U, Huchzermeyer C, Schlötzer-Schrehardt U, Kruse FE, Zrenner E and Rejdak R: Levels of aqueous humor trace elements in patients with non-exsudative age-related macular degeneration: A case-control study. PLoS One. 8:e567342013. View Article : Google Scholar : PubMed/NCBI

21 

Pala V, Sieri S, Palli D, Salvini S, Berrino F, Bellegotti M, Frasca G, Tumino R, Sacerdote C, Fiorini L, et al: Diet in the Italian EPIC cohorts: Presentation of data and methodological issues. Tumori. 89:594–607. 2003.PubMed/NCBI

22 

Malavolti M, Malagoli C, Fiorentini C, Longo C, Farnetani F, Ricci C, Albertini G, Lanzoni A, Reggiani C, Virgili A, et al: Association between dietary vitamin C and risk of cutaneous melanoma in a population of Northern Italy. Int J Vitam Nutr Res. 83:291–298. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Malagoli C, Malavolti M, Agnoli C, Crespi CM, Fiorentini C, Farnetani F, Longo C, Ricci C, Albertini G, Lanzoni A, et al: Diet quality and risk of melanoma in an Italian population. J Nutr. 145:1800–1807. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Vinceti M, Rothman KJ, Crespi CM, Sterni A, Cherubini A, Guerra L, Maffeis G, Ferretti E, Fabbi S, Teggi S, et al: Leukemia risk in children exposed to benzene and PM10 from vehicular traffic: A case-control study in an Italian population. Eur J Epidemiol. 27:781–790. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Vinceti M, Malagoli C, Malavolti M, Cherubini A, Maffeis G, Rodolfi R, Heck JE, Astolfi G, Calzolari E and Nicolini F: Does maternal exposure to benzene and PM10 during pregnancy increase the risk of congenital anomalies? A population-based case-control study. Sci Total Environ. 541:444–450. 2016. View Article : Google Scholar : PubMed/NCBI

26 

Poulakis E, Theodosi C, Bressi M, Sciare J, Ghersi V and Mihalopoulos N: Airborne mineral components and trace metals in Paris region: Spatial and temporal variability. Environ Sci Pollut Res Int. 22:14663–14672. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Li Z, Hopke PK, Husain L, Qureshi S, Dutkiewicz VA, Schwab JJ, Drewnick F and Demerjian KL: Sources of fine particle composition in New York city. Atmos Environ. 38:6521–6529. 2004. View Article : Google Scholar

28 

Vinceti M, Malagoli C, Teggi S, Fabbi S, Goldoni C, De Girolamo G, Ferrari P, Astolfi G, Rivieri F and Bergomi M: Adverse pregnancy outcomes in a population exposed to the emissions of a municipal waste incinerator. Sci Total Environ. 407:116–121. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Benson PE: Caline 4 - A dispersion model for predicting air pollution concentration near roadwaysDepartment of Transportation, Division of New Technology and Research. Sacramento, CA: 1989

30 

Drufuca A, Battaiotto S, Bengo I, Rossi D and Torriani L: Variante Generale al Piano Territoriale di Coordinamento Provinciale. Procedura di simulazione della mobilità delle personeProvincia di Modena-Polinomia. Milan: 2007, (In Italian).

31 

Willett WC: Nutritional epidemiology. 3rd. Oxford University Press; New York: 2013

32 

Long JS: Regression models for categorical and limited dependent variables. 7. Sage Publications, Inc.; Thousand Oaks: 1997

33 

Helsel DR: More than obvious: Better methods for interpreting nondetect data. Environ Sci Technol. 39:419A–423A. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Zoni S and Lucchini RG: Manganese exposure: Cognitive, motor and behavioral effects on children: A review of recent findings. Curr Opin Pediatr. 25:255–260. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Rosa MJ, Benedetti C, Peli M, Donna F, Nazzaro M, Fedrighi C, Zoni S, Marcon A, Zimmerman N, Wright R, et al: Association between personal exposure to ambient metals and respiratory disease in Italian adolescents: A cross-sectional study. BMC Pulm Med. 16:62016. View Article : Google Scholar : PubMed/NCBI

36 

Vollet K, Haynes EN and Dietrich KN: Manganese exposure and cognition across the lifespan: Contemporary review and argument for biphasic dose-response health effects. Curr Environ Health Rep. 3:392–404. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Minoia C, Sabbioni E, Apostoli P, Pietra R, Pozzoli L, Gallorini M, Nicolaou G, Alessio L and Capodaglio E: Trace element reference values in tissues from inhabitants of the European community. I. A study of 46 elements in urine, blood and serum of Italian subjects. Sci Total Environ. 95:89–105. 1990. View Article : Google Scholar : PubMed/NCBI

38 

Caroli S, Alimonti A, Coni E, Petrucci F, Senofonte O and Violante N: The assessment of reference values for elements in human biological tissues and fluids: A systematic review. Crit Rev Anal Chem. 24:363–398. 1994. View Article : Google Scholar

39 

Alimonti A, Bocca B, Mannella E, Petrucci F, Zennaro F, Cotichini R, DIppolito C, Agresti A, Caimi S and Forte G: Assessment of reference values for selected elements in a healthy urban population. Ann Ist Super Sanita. 41:181–187. 2005.PubMed/NCBI

40 

Bocca B, Mattei D, Pino A and Alimonti A: Italian network for human biomonitoring of metals: Preliminary results from two regions. Ann Ist Super Sanita. 46:259–265. 2010.PubMed/NCBI

41 

Adamska-Dyniewska H, Trela R, Trojanowska B and Kowalska G: Serum manganese concentration in healthy population of the city of Lódź. Acta Physiol Pol. 34:299–303. 1983.PubMed/NCBI

42 

Iyengar V and Woittiez J: Trace elements in human clinical specimens: Evaluation of literature data to identify reference values. Clin Chem. 34:474–481. 1988.PubMed/NCBI

43 

Nève J and Leclercq N: Factors affecting determinations of manganese in serum by atomic absorption spectrometry. Clin Chem. 37:723–728. 1991.PubMed/NCBI

44 

Kapaki E, Zournas C, Kanias G, Zambelis T, Kakami A and Papageorgiou C: Essential trace element alterations in amyotrophic lateral sclerosis. J Neurol Sci. 147:171–175. 1997. View Article : Google Scholar : PubMed/NCBI

45 

Rükgauer M, Klein J and Kruse-Jarres JD: Reference values for the trace elements copper, manganese, selenium, and zinc in the serum/plasma of children, adolescents, and adults. J Trace Elem Med Biol. 11:92–98. 1997. View Article : Google Scholar : PubMed/NCBI

46 

Díaz C, López F, Henríquez P, Rodríguez E and Serra-MaJem L: Serum manganese concentrations in a representative sample of the Canarian population. Biol Trace Elem Res. 80:43–51. 2001. View Article : Google Scholar : PubMed/NCBI

47 

Forrer R, Gautschi K and Lutz H: Simultaneous measurement of the trace elements Al, As, B, Be, Cd, Co, Cu, Fe, Li, Mn, Mo, Ni, Rb, Se, Sr, and Zn in human serum and their reference ranges by ICP-MS. Biol Trace Elem Res. 80:77–93. 2001. View Article : Google Scholar : PubMed/NCBI

48 

Torra M, Rodamilans M and Corbella J: Biological monitoring of environmental exposure to manganese in blood samples from residents of the city of Barcelona, Spain. Sci Total Environ. 289:237–241. 2002. View Article : Google Scholar : PubMed/NCBI

49 

Baruthio F, Guillard O, Arnaud J, Pierre F and Zawislak R: Determination of manganese in biological materials by electrothermal atomic absorption spectrometry: A review. Clin Chem. 34:227–234. 1988.PubMed/NCBI

50 

Yiin SJ, Lin HY, Yang MH, Shih TS and Lin TH: Pre-analytical for biological monitoring of manganese. Kaohsiung J Med Sci. 14:161–167. 1998.PubMed/NCBI

51 

Hodnett D, Wood DM, Raja K, Dargan PI and Shah AD: A healthy volunteer study to investigate trace element contamination of blood samples by stainless steel venepuncture needles. Clin Toxicol (Phila). 50:99–107. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Sánchez C, López-Jurado M, Aranda P and Llopis J: Plasma levels of copper, manganese and selenium in an adult population in southern Spain: Influence of age, obesity and lifestyle factors. Sci Total Environ. 408:1014–1020. 2010. View Article : Google Scholar : PubMed/NCBI

53 

Meltzer HM, Alexander J, Brantsæter AL, Borch-Iohnsen B, Ellingsen DG, Thomassen Y, Holmen J and Ydersbond TA: The impact of iron status and smoking on blood divalent metal concentrations in Norwegian women in the HUNT2 Study. J Trace Elem Med Biol. 38:165–173. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Eastman RR, Jursa TP, Benedetti C, Lucchini RG and Smith DR: Hair as a biomarker of environmental manganese exposure. Environ Sci Technol. 47:1629–1637. 2013.PubMed/NCBI

55 

Reiss B, Simpson CD, Baker MG, Stover B, Sheppard L and Seixas NS: Hair manganese as an exposure biomarker among welders. Ann Occup Hyg. 60:139–149. 2016. View Article : Google Scholar : PubMed/NCBI

56 

Kim Y, Lobdell DT, Wright CW, Gocheva VV, Hudgens E and Bowler RM: Blood metal concentrations of manganese, lead, and cadmium in relation to serum ferritin levels in Ohio residents. Biol Trace Elem Res. 165:1–9. 2015. View Article : Google Scholar : PubMed/NCBI

57 

Lucchini RG, Guazzetti S, Zoni S, Benedetti C, Fedrighi C, Peli M, Donna F, Bontempi E, Borgese L, Micheletti S, et al: Neurofunctional dopaminergic impairment in elderly after lifetime exposure to manganese. Neurotoxicology. 45:309–317. 2014. View Article : Google Scholar : PubMed/NCBI

58 

Lucchini RG, Guazzetti S, Zoni S, Donna F, Peter S, Zacco A, Salmistraro M, Bontempi E, Zimmerman NJ and Smith DR: Tremor, olfactory and motor changes in Italian adolescents exposed to historical ferro-manganese emission. Neurotoxicology. 33:687–696. 2012. View Article : Google Scholar : PubMed/NCBI

59 

Colledge MA, Julian JR, Gocheva VV, Beseler CL, Roels HA, Lobdell DT and Bowler RM: Characterization of air manganese exposure estimates for residents in two Ohio towns. J Air Waste Manag Assoc. 65:948–957. 2015. View Article : Google Scholar : PubMed/NCBI

60 

Baldwin M, Mergler D, Larribe F, Bélanger S, Tardif R, Bilodeau L and Hudnell K: Bioindicator and exposure data for a population based study of manganese. Neurotoxicology. 20:343–353. 1999.PubMed/NCBI

61 

Hoet P, Vanmarcke E, Geens T, Deumer G, Haufroid V and Roels HA: Manganese in plasma: A promising biomarker of exposure to Mn in welders. A pilot study. Toxicol Lett. 213:69–74. 2012. View Article : Google Scholar : PubMed/NCBI

62 

Michalke B, Halbach S and Nischwitz V: JEM spotlight: Metal speciation related to neurotoxicity in humans. J Environ Monit. 11:939–954. 2009. View Article : Google Scholar : PubMed/NCBI

63 

Vinceti M, Solovyev N, Mandrioli J, Crespi CM, Bonvicini F, Arcolin E, Georgoulopoulou E and Michalke B: Cerebrospinal fluid of newly diagnosed amyotrophic lateral sclerosis patients exhibits abnormal levels of selenium species including elevated selenite. Neurotoxicology. 38:25–32. 2013. View Article : Google Scholar : PubMed/NCBI

64 

Vinceti M, Ballotari P, Steinmaus C, Malagoli C, Luberto F, Malavolti M and Rossi Giorgi P: Long-term mortality patterns in a residential cohort exposed to inorganic selenium in drinking water. Environ Res. 150:348–356. 2016. View Article : Google Scholar : PubMed/NCBI

65 

Neth K, Lucio M, Walker A, Kanawati B, Zorn J, Schmitt-Kopplin P and Michalke B: Diverse serum manganese species affect brain metabolites depending on exposure conditions. Chem Res Toxicol. 28:1434–1442. 2015. View Article : Google Scholar : PubMed/NCBI

66 

Michalke B: Review about the manganese speciation project related to neurodegeneration: An analytical chemistry approach to increase the knowledge about manganese related parkinsonian symptoms. J Trace Elem Med Biol. 37:50–61. 2016. View Article : Google Scholar : PubMed/NCBI

67 

Pasanisi P, Berrino F, Bellati C, Sieri S and Krogh V: Validity of the Italian EPIC questionnaire to assess past diet. IARC Sci Publ. 156:41–44. 2002.PubMed/NCBI

68 

Ferrante G, Minardi V, Possenti V, Quarchioni E, Masocco M, Salmaso S, Braggion M, Campostrini S and Baldissera S: Gruppo Tecnico PASSI: Smoke: Prevalence is decreasing, but the gap between socioeconomic categories remains. Epidemiol Prev. 36:3712012.PubMed/NCBI

69 

Gruppo Tecnico PASSI Emilia-Romagna: Sovrappeso e obesità in Emilia-Romagna: dati del sistema di sorveglianza PASSI (anni 2008–2011). 2012.http://www.epicentro.iss.it/passi/pdf2012/EccessoPond_PassiER_08_11.pdf(In Italian).

70 

Samara C and Voutsa D: Size distribution of airborne particulate matter and associated heavy metals in the roadside environment. Chemosphere. 59:1197–1206. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Filippini T, Michalke B, Grill P, Malagoli C, Malavolti M, Vescovi L, Sieri S, Krogh V, Cherubini A, Maffeis G, Maffeis G, et al: Determinants of serum manganese levels in an Italian population. Mol Med Rep 15: 3340-3349, 2017.
APA
Filippini, T., Michalke, B., Grill, P., Malagoli, C., Malavolti, M., Vescovi, L. ... Vinceti, M. (2017). Determinants of serum manganese levels in an Italian population. Molecular Medicine Reports, 15, 3340-3349. https://doi.org/10.3892/mmr.2017.6379
MLA
Filippini, T., Michalke, B., Grill, P., Malagoli, C., Malavolti, M., Vescovi, L., Sieri, S., Krogh, V., Cherubini, A., Maffeis, G., Lucchini, R., Ferrante, M., Vinceti, M."Determinants of serum manganese levels in an Italian population". Molecular Medicine Reports 15.5 (2017): 3340-3349.
Chicago
Filippini, T., Michalke, B., Grill, P., Malagoli, C., Malavolti, M., Vescovi, L., Sieri, S., Krogh, V., Cherubini, A., Maffeis, G., Lucchini, R., Ferrante, M., Vinceti, M."Determinants of serum manganese levels in an Italian population". Molecular Medicine Reports 15, no. 5 (2017): 3340-3349. https://doi.org/10.3892/mmr.2017.6379
Copy and paste a formatted citation
x
Spandidos Publications style
Filippini T, Michalke B, Grill P, Malagoli C, Malavolti M, Vescovi L, Sieri S, Krogh V, Cherubini A, Maffeis G, Maffeis G, et al: Determinants of serum manganese levels in an Italian population. Mol Med Rep 15: 3340-3349, 2017.
APA
Filippini, T., Michalke, B., Grill, P., Malagoli, C., Malavolti, M., Vescovi, L. ... Vinceti, M. (2017). Determinants of serum manganese levels in an Italian population. Molecular Medicine Reports, 15, 3340-3349. https://doi.org/10.3892/mmr.2017.6379
MLA
Filippini, T., Michalke, B., Grill, P., Malagoli, C., Malavolti, M., Vescovi, L., Sieri, S., Krogh, V., Cherubini, A., Maffeis, G., Lucchini, R., Ferrante, M., Vinceti, M."Determinants of serum manganese levels in an Italian population". Molecular Medicine Reports 15.5 (2017): 3340-3349.
Chicago
Filippini, T., Michalke, B., Grill, P., Malagoli, C., Malavolti, M., Vescovi, L., Sieri, S., Krogh, V., Cherubini, A., Maffeis, G., Lucchini, R., Ferrante, M., Vinceti, M."Determinants of serum manganese levels in an Italian population". Molecular Medicine Reports 15, no. 5 (2017): 3340-3349. https://doi.org/10.3892/mmr.2017.6379
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