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Article

Imazamethabenz inhibits human breast cancer cell proliferation, migration and invasion via combination with Pin1

  • Authors:
    • Chen Liu
    • Chaoyu Mu
    • Zeng Li
    • Liang Xu
  • View Affiliations / Copyright

    Affiliations: College of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, P.R. China
  • Pages: 3210-3214
    |
    Published online on: March 28, 2017
       https://doi.org/10.3892/mmr.2017.6399
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Abstract

Overexpression of peptidyl-prolyl cis/trans isomerase, NIMA interacting‑1 (Pin1) is a significant marker of the occurrence and development of tumors. In the present study, the imidazoline ketone herbicide imazamethabenz was investigated as a potential antitumor drug by inhibiting Pin1. Molecular docking and enzyme activity tests verified, for the first time, that the imidazoline ketone compound imazamethabenz effectively inhibited Pin1 in vitro. MTT assays, western blotting, wound healing assay and Matrigel invasion assays revealed that imazamethabenz induced apoptosis and inhibited migration and invasion of the breast cancer cell line MCF‑7, which overexpresses Pin1, by inhibiting the Pin1‑mediated signaling pathway involving vascular endothelial growth factor and matrix metalloproteinase 9. These findings indicated that imazamethabenz offers potential applications for the treatment of tumors as a Pin1 inhibitor.
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Copy and paste a formatted citation
Spandidos Publications style
Liu C, Mu C, Li Z and Xu L: Imazamethabenz inhibits human breast cancer cell proliferation, migration and invasion via combination with Pin1. Mol Med Rep 15: 3210-3214, 2017.
APA
Liu, C., Mu, C., Li, Z., & Xu, L. (2017). Imazamethabenz inhibits human breast cancer cell proliferation, migration and invasion via combination with Pin1. Molecular Medicine Reports, 15, 3210-3214. https://doi.org/10.3892/mmr.2017.6399
MLA
Liu, C., Mu, C., Li, Z., Xu, L."Imazamethabenz inhibits human breast cancer cell proliferation, migration and invasion via combination with Pin1". Molecular Medicine Reports 15.5 (2017): 3210-3214.
Chicago
Liu, C., Mu, C., Li, Z., Xu, L."Imazamethabenz inhibits human breast cancer cell proliferation, migration and invasion via combination with Pin1". Molecular Medicine Reports 15, no. 5 (2017): 3210-3214. https://doi.org/10.3892/mmr.2017.6399
Copy and paste a formatted citation
x
Spandidos Publications style
Liu C, Mu C, Li Z and Xu L: Imazamethabenz inhibits human breast cancer cell proliferation, migration and invasion via combination with Pin1. Mol Med Rep 15: 3210-3214, 2017.
APA
Liu, C., Mu, C., Li, Z., & Xu, L. (2017). Imazamethabenz inhibits human breast cancer cell proliferation, migration and invasion via combination with Pin1. Molecular Medicine Reports, 15, 3210-3214. https://doi.org/10.3892/mmr.2017.6399
MLA
Liu, C., Mu, C., Li, Z., Xu, L."Imazamethabenz inhibits human breast cancer cell proliferation, migration and invasion via combination with Pin1". Molecular Medicine Reports 15.5 (2017): 3210-3214.
Chicago
Liu, C., Mu, C., Li, Z., Xu, L."Imazamethabenz inhibits human breast cancer cell proliferation, migration and invasion via combination with Pin1". Molecular Medicine Reports 15, no. 5 (2017): 3210-3214. https://doi.org/10.3892/mmr.2017.6399
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