Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-2017 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2017 Volume 15 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Protective effects of oleanolic acid on oxidative stress and the expression of cytokines and collagen by the AKT/NF‑κB pathway in silicotic rats

  • Authors:
    • Hai‑Bing Peng
    • Rui‑Xun Wang
    • Hai‑Jing Deng
    • Yong‑Heng Wang
    • Jun‑Dong Tang
    • Fu‑Yuan Cao
    • Jian‑Hui Wang
  • View Affiliations / Copyright

    Affiliations: Medical Experimental Center of Jitang College, North China University of Science and Technology, Tangshan, Hebei 063210, P.R. China, Functional Laboratory of School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei 063210, P.R. China, Department of Pathogen and Microbiology, School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei 063210, P.R. China, Department of Clinical Medical, Jitang College, North China University of Science and Technology, Tangshan, Hebei 063210, P.R. China, Laboratory Animal Center, North China University of Science and Technology, Tangshan, Hebei 063210, P.R. China
  • Pages: 3121-3128
    |
    Published online on: March 28, 2017
       https://doi.org/10.3892/mmr.2017.6402
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Oleanolic acid (OA), a natural pentacyclic triterpenoid, has been reported to have several benefits and medicinal properties. However, its protective effects against silica‑induced lung injury and fibrosis remain to be elucidated. The aim of the present study was to investigate the effects of OA on oxidative stress, and the expression of cytokines and collagen in silicotic rats. Male rats were induced by intratracheal instillation of silicosis (250 mg/kg), with the exception of the control group (NS). The rats in the OA group were intragastrically administered with OA (60 mg/kg/d). The rats in the solvent control group were gavaged daily with 0.6% sodium carboxymethyl cellulose (10 ml/kg) solution for 56 consecutive days. The data showed that OA significantly attenuated the extent of silicosis fibrosis by histopathologic analysis of the lung tissues. In addition, oxidative stress activated by silica exposure, as evidenced by increasing of malondialdehyde content, and activities of superoxide dismutase and glutathione peroxidase in the lung, was regulated by treatment with OA. Furthermore, enzyme‑linked immunosorbent assay analysis showed that OA significantly decreased the levels of tumor necrosis factor‑α and transforming growth factor‑β1. Immunohistochemistry analysis showed that OA significantly decreased collagen types I and III. In investigating the mechanisms underlying the action of OA, it was found that OA decreased the level of phosphorylated AKT1, which in turn inactivated the transcriptional of nuclear factor (NF)‑κB in the development and progress of silicosis. In conclusion, these results suggested that the protective effects of OA were due, at least in part, to its anti‑oxidant activity and its ability to decrease the expression of cytokines and collagen by modulating the AKT/NF‑κB pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Rimal B, Greenberg AK and Rom WN: Basic pathogenetic mechanisms in silicosis: Current understanding. Curr Opin Pulm Med. 11:169–173. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Flynn MR and Susi P: Engineering controls for selected silica and dust exposures in the construction industry-a review. Appl Occup Environ Hyg. 18:268–277. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Leung CC, Yu IT and Chen W: Silicosis. Lancet. 379:2008–2018. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Thomas CR and Kelley TR: A Brief Review of silicosis in the United states. Environ Health Insights. 4:21–26. 2010.PubMed/NCBI

5 

Occupational Health Technical Service Network: Silicosis. http://www.zybw.com/zybw_list.aspx?c=31&a=60&t=xq&m=502Accessed. January 5–2014.

6 

Hamilton RF Jr, Thakur SA and Holian A: Silica binding and toxicity in alveolar macrophages. Free Radic Biol Med. 44:1246–1258. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Zhang L, He YL, Li QZ, Hao XH, Zhang ZF, Yuan JX, Bai YP, Jin YL, Liu N and Chen G: N-acetylcysteine alleviated silica-induced lung fibrosis in rats by down-regulation of ROS and mitochondrial apoptosis signaling. Toxicol Mech Methods. 24:212–219. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Porter DW, Millecchia LL, Willard P, Robinson VA, Ramsey D, McLaurin J, Khan A, Brumbaugh K, Beighley CM, Teass A and Castranova V: Nitric oxide and reactive oxygen species production causes progressive damage in rats after cessation of silica inhalation. Toxicol Sci. 90:188–197. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Liu J: Oleanolic acid and ursolic acid: Research perspectives. J Ethnopharmacol. 100:92–94. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Pollier J and Goossens A: Oleanolic acid. Phytochemistry. 77:10–15. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Chung S, Yoon HE, Kim SJ, Kim SJ, Koh ES, Hong YA, Park CW, Chang YS and Shin SJ: Oleanolic acid attenuates renal fibrosis in mice with unilateral ureteral obstruction via facilitating nuclear translocation of Nrf2. Nutr Metab (Lond). 11:22014. View Article : Google Scholar : PubMed/NCBI

12 

Kulkarni AA, Thatcher TH, Olsen KC, Maggirwar SB, Phipps RP and Sime PJ: PPAR-γ Ligands Repress TGFb-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: Implications for therapy of fibrosis. PLoS One. 6:e159092011. View Article : Google Scholar : PubMed/NCBI

13 

Thakur SA, Beamer CA, Migliaccio CT and Holian A: Critical role of MARCO in crystalline silica-induced pulmonary inflammation. Toxicol Sci. 108:462–471. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Lim Y, Kim JH, Kim KA, Chang HS, Park YM, Ahn BY and Phee YG: Silica-induced apoptosis in vitro and in vivo. Toxicol Lett. 108:335–339. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Sun Y, Yang F, Yan J, Li Q, Wei Z, Feng H, Wang R, Zhang L and Zhang X: New anti-fibrotic mechanisms of n-acetyl-seryl-aspartyl-lysyl-proline in silicon dioxide-induced silicosis. Life Sci. 87:232–239. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Fubini B and Hubbard A: Reactive Oxygen Species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis. Free Radic Biol Med. 34:1507–1516. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Palabiyik SS, Girgin G, Tutkun E, Yilmaz OH and Baydar T: Immunomodulation and oxidative stress in denim sandblasting workers: Changes caused by silica exposure. Arh Hig Rada Toksikol. 64:431–437. 2013.PubMed/NCBI

18 

Pelclová D, Fenclová Z, Syslová K, Vlčková S, Lebedová J, Pecha O, Běláček J, Navrátil T, Kuzma M and Kačer P: Oxidative stress markers in exhaled breath condensate in lung fibroses are not significantly affected by systemic diseases. Ind Health. 49:746–754. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Zhang JW, Lv GC, Yao JM and Hong XP: Assessment of serum antioxidant status in patients with silicosis. J Int Med Res. 38:884–889. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Scarfì S, Magnone M, Ferraris C, Pozzolini M, Benvenuto F, Benatti U and Giovine M: Ascorbic acid pre-treated quartz stimulates TNF-alpha release in RAW264.7 murine macrophages through ROS production and membrane lipid peroxidation. Respir Res. 10:252009. View Article : Google Scholar : PubMed/NCBI

21 

Jiang ZY, Zou L, Shi SS, Lu YR, Dong J, Yang CH, Lu YC and Dai GK: Effects of curcumin on TNF-alpha and TGF-beta1 in serum and lung tissue of SiO2-induced fibrosis in mice. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 25:399–401. 2009.(In Chinese). PubMed/NCBI

22 

Li Z, Xue J, Yan S, Chen P and Chen L: Association between tumor necrosis factor-α 308G/A gene polymorphism and silicosis susceptibility: A meta-analysis. PLoS One. 8:e766142013. View Article : Google Scholar : PubMed/NCBI

23 

Miao RM, Zhang XT, Yan YL, He EQ, Guo P, Zhang YY, Zhao DK, Yang ZG, Chen J, Yao MY, et al: Change of serum TGF-beta1 and TNF-alpha in silicosis patients. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 29:606–607. 2011.(In Chinese). PubMed/NCBI

24 

Slavov E, Miteva L, Prakova G, Gidikova P and Stanilova S: Correlation between TNF-alpha and IL-12p40-containing cytokines in silicosis. Toxicol Ind Health. 26:479–486. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Ortiz LA, Lasky J, Gozal E, Ruiz V, Lungarella G, Cavarra E, Brody AR, Friedman M, Pardo A and Selman M: Tumor necrosis factor receptor deficiency alters matrix metalloproteinase 13/tissue inhibitor of metalloproteinase 1 expression in murine silicosis. Am J Respir Crit Care Med. 163:244–252. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Xu H, Yang F, Sun Y, Yuan Y, Cheng H, Wei Z, Li S, Cheng T, Brann D and Wang R: A New Antifibrotic Target of Ac-SDKP: Inhibition of Myofibroblast Differentiation in Rat Lung with Silicosis. PLoS One. 7:e403012012. View Article : Google Scholar : PubMed/NCBI

27 

Fan LH, Liu TF, Guo M, Liu ML, Wang ZP and Si SJ: Effect of schisandrin B on lung mRNA expression of transforming growth factor-beta1 signal transduction molecule in rat lungs exposed to silica. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 29:255–259. 2011.(In Chinese). PubMed/NCBI

28 

Maron-Gutierrez T, Castiglione RC, Xisto DG, Oliveira MG, Cruz FF, Peçanha R, Carreira-Junior H, Ornellas DS, Moraes MO, Takiya CM, et al: Bone marrow-derived mononuclear cell therapy attenuates silica-induced lung fibrosis. Eur Respir J. 37:1217–1225. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Porter DW, Ye J, Ma J, Barger M, Robinson VA, Ramsey D, McLaurin J, Khan A, Landsittel D, Teass A and Castranova V: Time course of pulmonary response of rats to inhalation of crystalline silica: NF-kappa B activation, inflammation, cytokine production, and damage. Inhal Toxicol. 14:349–367. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Di Giuseppe M, Gambelli F, Hoyle GW, Lungarella G, Studer SM, Richards T, Yousem S, McCurry K, Dauber J, Kaminski N, et al: Systemic Inhibition of NF-kappaB activation protects from silicosis. PLoS One. 4:e56892009. View Article : Google Scholar : PubMed/NCBI

31 

Chen F and Shi X: NF-kappaB, a pivotal transcription factor in silica-induced diseases. Mol Cell Biochem. 234–235:169–176. 2002. View Article : Google Scholar

32 

Hubbard AK, Timblin CR, Shukla A, Rincón M and Mossman BT: Activation of NF-kappaB-dependent gene expression by silica in lungs of luciferase reporter mice. Am J Physiol Lung Cell Mol Physiol. 282:L968–L975. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Venkatesan B, Valente AJ, Prabhu SD, Shanmugam P, Delafontaine P and Chandrasekar B: EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via Rac1-dependent PI3K/Akt/IKK/NF-kappaB andMKK7/JNK/AP-1 signaling. J Mol Cell Cardiol. 49:655–663. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Jing Y, Liu LZ, Jiang Y, Zhu Y, Guo NL, Barnett J, Rojanasakul Y, Agani F and Jiang BH: Cadmium Increases HIF-1 and VEGF Expression through ROS, ERK, and AKT signaling pathways and induces malignant transformation of human bronchial epithelial cells. Toxicol Sci. 125:10–19. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Yasuda T: Activation of Akt leading to NF-κB up-regulation in chondrocytes stimulated with fibronectin fragment. Biomed Res. 32:209–215. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Takada K, Nakane T, Masuda K and Ishii H: Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-α-induced E-selectin expression by cultured umbilical vein endothelial cells. Phytomedicine. 17:1114–1119. 2010. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Peng HB, Wang RX, Deng HJ, Wang YH, Tang JD, Cao FY and Wang JH: Protective effects of oleanolic acid on oxidative stress and the expression of cytokines and collagen by the AKT/NF‑κB pathway in silicotic rats. Mol Med Rep 15: 3121-3128, 2017.
APA
Peng, H., Wang, R., Deng, H., Wang, Y., Tang, J., Cao, F., & Wang, J. (2017). Protective effects of oleanolic acid on oxidative stress and the expression of cytokines and collagen by the AKT/NF‑κB pathway in silicotic rats. Molecular Medicine Reports, 15, 3121-3128. https://doi.org/10.3892/mmr.2017.6402
MLA
Peng, H., Wang, R., Deng, H., Wang, Y., Tang, J., Cao, F., Wang, J."Protective effects of oleanolic acid on oxidative stress and the expression of cytokines and collagen by the AKT/NF‑κB pathway in silicotic rats". Molecular Medicine Reports 15.5 (2017): 3121-3128.
Chicago
Peng, H., Wang, R., Deng, H., Wang, Y., Tang, J., Cao, F., Wang, J."Protective effects of oleanolic acid on oxidative stress and the expression of cytokines and collagen by the AKT/NF‑κB pathway in silicotic rats". Molecular Medicine Reports 15, no. 5 (2017): 3121-3128. https://doi.org/10.3892/mmr.2017.6402
Copy and paste a formatted citation
x
Spandidos Publications style
Peng HB, Wang RX, Deng HJ, Wang YH, Tang JD, Cao FY and Wang JH: Protective effects of oleanolic acid on oxidative stress and the expression of cytokines and collagen by the AKT/NF‑κB pathway in silicotic rats. Mol Med Rep 15: 3121-3128, 2017.
APA
Peng, H., Wang, R., Deng, H., Wang, Y., Tang, J., Cao, F., & Wang, J. (2017). Protective effects of oleanolic acid on oxidative stress and the expression of cytokines and collagen by the AKT/NF‑κB pathway in silicotic rats. Molecular Medicine Reports, 15, 3121-3128. https://doi.org/10.3892/mmr.2017.6402
MLA
Peng, H., Wang, R., Deng, H., Wang, Y., Tang, J., Cao, F., Wang, J."Protective effects of oleanolic acid on oxidative stress and the expression of cytokines and collagen by the AKT/NF‑κB pathway in silicotic rats". Molecular Medicine Reports 15.5 (2017): 3121-3128.
Chicago
Peng, H., Wang, R., Deng, H., Wang, Y., Tang, J., Cao, F., Wang, J."Protective effects of oleanolic acid on oxidative stress and the expression of cytokines and collagen by the AKT/NF‑κB pathway in silicotic rats". Molecular Medicine Reports 15, no. 5 (2017): 3121-3128. https://doi.org/10.3892/mmr.2017.6402
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team