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Review

Role of autophagy in advanced atherosclerosis (Review)

  • Authors:
    • Yu‑Ning Zhu
    • Wen‑Jing Fan
    • Chi Zhang
    • Fang Guo
    • Wei Li
    • Yu‑Fei Wang
    • Zhi‑Sheng Jiang
    • Shun‑Lin Qu
  • View Affiliations / Copyright

    Affiliations: Institute of Cardiovascular Disease, Key Lab for Arteriosclerology of Hunan Province, University of South China, Hengyang, Hunan 421001, P.R. China
  • Pages: 2903-2908
    |
    Published online on: March 28, 2017
       https://doi.org/10.3892/mmr.2017.6403
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Abstract

Atherosclerosis (AS) remains the leading cause for global cardiovascular disease morbidity and mortality, and a major cause of cardiopathy, myocardial infarction and peripheral vascular diseases. Macrophages serve a critical role in atherosclerotic plaque stabilization and rupture, and the selective removal of macrophages may be beneficial in improving plaque stability. Autophagy is a process of self‑feeding, during which cytoplasmic proteins or organelles are packaged into vesicles and fused with the lysosome to form an autophagosome. The newly formed autophagosome can degrade internalized proteins, and this process may be used to serve the metabolic and self‑renewal requirements of the cell. Autophagy serves an important role in maintaining cell homeostasis and promoting cell survival, and therefore an imbalance in autophagy is closely associated with multiple diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu YN, Fan WJ, Zhang C, Guo F, Li W, Wang YF, Jiang ZS and Qu SL: Role of autophagy in advanced atherosclerosis (Review). Mol Med Rep 15: 2903-2908, 2017.
APA
Zhu, Y., Fan, W., Zhang, C., Guo, F., Li, W., Wang, Y. ... Qu, S. (2017). Role of autophagy in advanced atherosclerosis (Review). Molecular Medicine Reports, 15, 2903-2908. https://doi.org/10.3892/mmr.2017.6403
MLA
Zhu, Y., Fan, W., Zhang, C., Guo, F., Li, W., Wang, Y., Jiang, Z., Qu, S."Role of autophagy in advanced atherosclerosis (Review)". Molecular Medicine Reports 15.5 (2017): 2903-2908.
Chicago
Zhu, Y., Fan, W., Zhang, C., Guo, F., Li, W., Wang, Y., Jiang, Z., Qu, S."Role of autophagy in advanced atherosclerosis (Review)". Molecular Medicine Reports 15, no. 5 (2017): 2903-2908. https://doi.org/10.3892/mmr.2017.6403
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu YN, Fan WJ, Zhang C, Guo F, Li W, Wang YF, Jiang ZS and Qu SL: Role of autophagy in advanced atherosclerosis (Review). Mol Med Rep 15: 2903-2908, 2017.
APA
Zhu, Y., Fan, W., Zhang, C., Guo, F., Li, W., Wang, Y. ... Qu, S. (2017). Role of autophagy in advanced atherosclerosis (Review). Molecular Medicine Reports, 15, 2903-2908. https://doi.org/10.3892/mmr.2017.6403
MLA
Zhu, Y., Fan, W., Zhang, C., Guo, F., Li, W., Wang, Y., Jiang, Z., Qu, S."Role of autophagy in advanced atherosclerosis (Review)". Molecular Medicine Reports 15.5 (2017): 2903-2908.
Chicago
Zhu, Y., Fan, W., Zhang, C., Guo, F., Li, W., Wang, Y., Jiang, Z., Qu, S."Role of autophagy in advanced atherosclerosis (Review)". Molecular Medicine Reports 15, no. 5 (2017): 2903-2908. https://doi.org/10.3892/mmr.2017.6403
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